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Lin Zou

Lin Zou, MD, PhD

  • July 01, 2021 - Congratulations to Lin Zou MD, PhD on her promotion to Associate Professor with the University of Maryland, School of Medicine; Department of Anesthesiology.

Briana Shimada, PhD

  • September 9, 2021Briana Shimada, PhD publication in SHOCK "Pyruvate-Driven Oxidative Phosphorylation is Downregulated in Sepsis-Induced Cardiomyopathy: A Study Of Mitochondrial Proteome". Sepsis-induced cardiomyopathy (SIC) is a major contributing factor for morbidity and mortality in sepsis. Accumulative evidence has suggested that cardiac mitochondrial oxidative phosphorylation is attenuated in sepsis, but the underlying molecular mechanisms remain incompletely understood. In this study, published in SHOCK, Dr. Briana Shimada and her collaborators conducted unbiased proteomics analysis of mitochondria isolated from the hearts of healthy mice and mice with sepsis-induced cardiomyopathy (SIC) and found a mitochondrial remodeling involving various energy metabolism pathways including subunits of the electron transport chain, fatty acid catabolism, and carbohydrate oxidative metabolism. They also identified a significant increase of pyruvate dehydrogenase (PDH) kinase 4 (PDK4) and inhibition of PDH activity in septic hearts. Moreover, compared to sham mice, mitochondrial oxygen consumption of septic mice was significantly reduced when pyruvate was provided as a substrate. However, it was unchanged when PDH was bypassed by directly supplying the Complex I substrate NADH, or by using the Complex II substrate succinate, or using Complex IV substrate, or by providing the beta-oxidation substrate palmitoylcarnitine, neither of which require PDH for mitochondrial oxygen consumption. These data demonstrate a broad mitochondrial protein remodeling, PDH inactivation, and impaired pyruvate-fueled oxidative phosphorylation during SIC, and provide a molecular framework for further exploration (Figure 1). For more details please click here.

   Figure 1: 

 

pyruvate-fueled oxidative phosphorylation during SIC


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 Wei Chao, MD, PhD

  • May 1, 2021- Wei Chao, MD, PhD, FAHA, was awarded an R35 grant, $1,931,250.00, from the National Institute of General Medical Sciences (NIH/NIGMS) to study “Extracellular miRNAs, innate immunity, and critical illness”. According to NIH, the goal of the R35 award, also known as Maximizing Investigators' Research Award, is to provide investigators with greater stability and flexibility, thereby enhancing scientific productivity and the chances for important breakthroughs. Dr. Chao's team will investigate the role of innate immunity in sepsis and ischemic myocardial infarction (MI), two critical illnesses with very high mortality. While their etiologies are distinctively different, they share similar features of innate immune activation, marked tissue inflammation, and acute cardiac dysfunction. The specific goal of the R35 project is to delineate the mechanistic role of cell-free miRNAs and extracellular vehicles in innate immune activation and in the pathogenesis of sepsis and myocardial ischemic injury. Click here for more information on this grant.

Wei Chao, MD, PhD

  • March 22, 2021- Congratulations to both Samuel M. Galvagno, DO, PhD, and Wei Chao, MD, PhD, FAHA as the inaugural awardees of the 2021 Colin Mackenzie and Cristina Imle Mentoring Prize. Professor Emeritus Colin F. Mackenzie, MB, ChB, MD, and his wife, Cristina Imle, PT, made a generous donation to the Department of Anesthesiology to support an Annual Mentoring Prize. The Mentoring Prize recognizes a faculty member(s) who has consistently demonstrated quality mentorship and has impacted professional development and career advancement in one or more of the following areas: clinical medicine, research, local and regional service, and teaching. 

Brittney Williams, MD

  • August 25, 2020- Brittney Williams, MD awarded the Mentored Clinical Scientist Research Career Development Award. Her project entitled "Role of miRNA-TLR7 Signaling in Platelet Activation and Dysfunction in Sepsis" was approved for funding by the National Heart, Lung, and Blood Institute (NHLBI). Dr. Williams stated she was very pleased with the new NIH support and that her work in the next 3-5 years will focus on delineating platelet signaling pathways involved in immune-mediated thrombotic complications in sepsis.

Kerri Lopez, MD

  • July 28, 2020Kerri Lopez, MD awarded the SHOCK Society Diversity Enhancement Award for her abstract entitled "Impact of Hypobaric Exposure on Inflammation and Organ Injury in a Non-Hemorrhagic Mouse Model of Polytrauma". Dr. Lopez is a PGY-3 surgical resident and has just completed her two-year research training in the Anesthesiology Translational Research Program working on a research project funded by the US Air Force.

Kerri Lopez, MD

  • 2020Kerri Lopez, MD awarded third place in the University of Maryland Department of Surgery Annual Charles Getz Research Retreat for her oral presentation titled “Transport after Traumatic Injury – the Effects of Hypobaria.”

Brittney Williams, MD

  • 2019- Brittney Williams, MD awarded the Mentored Research Training Grant (MRTG) by the Foundation for Anesthesia Education and Research (FAER) for her research project titled "Role of TLR7 in Platelet Activation and Dysfunction in Sepsis". The award, $250,000 over two years, helps physician-scientists develop the skills, preliminary data for subsequent grant applications, and research publications needed to become independent investigators. In 2019, FAER received 58 high-quality applications for research training grants. Dr. Williams was selected as one of the 5 recipients of this prestigious award. Click Here for more information on this award. 

Briana Shimada, PhD


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Wei Chao, MD, PhD and Lin Zou, MD, PhD

  • 2019Wei Chao, MD, PhD, Junfang Wu, PhD, and Lin Zou, MD, PhD R01 funded grant titled "Targeting Brain Inflammation and Neurocognitive Dysfunction in Sepsis" from the National Institute of Neurological Disorders and Stroke. Click Here for more information. 

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Andrew Suen, MD

  • 2019Andrew Suen, MD awarded first place in the Univerisity of Maryland Department of Anesthesiology 2019 Research Retreat for his basic science poster titled Circulating Plasma MiRNAs Trigger Innate Immune Activation in a Mouse Model of Polytrauma”

Brittney Williams, MD

  • 2019- Brittney Williams, MD awarded first place in the Univerisity of Maryland Department of Anesthesiology 2019 Research Retreat for her basic science presentation titled "Molecular Link Between Inflammation and Coagulation Dysfunction in Polymicrobial Sepsis" 

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Wei Chao, MD, PhD

  • 2018- Wei Chao, MD, PhD, named the recipient of the prestigious 2018 Frontiers in Anesthesia Research Award, given by the International Anesthesia Research Society (IARS). This $750,000 award is only given by the IARS once every three years. Dr. Chao will use this funding to support his research into the molecular pathogenesis of sepsis. 

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Andrew Suen, MD

  • 2018- Andrew Suen, MD for being awarded the Association of University Anesthesiologists (AUA) Resident Travel Award for his oral presentation titled "Extracellular miRNAs and Innate Immune Activation Following Polytraumatic Injury" during the 2018 IARS, AUA, and SOOCA Annual Meetings.

Brittney Williams, MD


Lin Zou

Lin Zou, MD, PhD

  • 2017Lin Zou, MD, PhD received R35 funded grant titled "Function and Mechanisms of extracellular microRNAs in sepsis-induced lung injury" from the National Institute of General Medical Sciences. Click Here for more information. 

Lin Zou

Lin Zou, MD, PhD

  • 2017- Lin Zou, MD, PhD awarded the prestigious Faculty Research Award from the Shock Society. The award is given in support of a faculty member at his/her early career stage to develop research in the areas related to trauma, shock, and sepsis, and who has the intent to become an outstanding independent investigator.