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Lin Zou, MD, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Anesthesiology

Location:

HH, 560

Phone (Primary):

(410) 706-2547

Fax:

(410) 706-2410

Education and Training

1997 - 2002: M.D., Medicine, Xiangya School of Medicine, Central South University, China
2006 - 2010: Ph.D., Ultrasound Medicine, Xiangya School of Medicine, Central South University, China
2008 - 2012: Postdoc Fellow, Massachusetts General Hospital, Harvard Medical School, Boston, MA
2012 - 2016: Instructor, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Highlighted Publications

  1. Zou L, Feng Y, Chen YJ, Si R, Shen S, Zhou Q, Ichinose F, Scherrer-Crosbie M, Chao W. Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Critical care medicine. 2010;38(5):1335-42.
  2. Zhang Y, Zhou QC, Pu DR, Zou L, Tan Y. Differences in left ventricular twist related to age: speckle tracking echocardiographic data for healthy volunteers from neonate to age 70 years. Echocardiography (Mount Kisco, N.Y.). 2010;27(10):1205-10.
  3. Tournoux F, Petersen B, Thibault H, Zou L, Raher MJ, Kurtz B, Halpern EF, Chaput M, Chao W, Picard MH, Scherrer-Crosbie M. Validation of noninvasive measurements of cardiac output in mice using echocardiography. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2010;24(4):465-70.
  4. Feng Y, Zou L, Si R, Nagasaka Y, Chao W. Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury. American journal of physiology. Cell physiology. 2010;299(4):C760-9.
  5. Li L, Bahtiyar MO, Buhimschi CS, Zou L, Zhou QC, Copel JA. Assessment of the fetal thymus by two- and three-dimensional ultrasound during normal human gestation and in fetuses with congenital heart defects. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2010;37(4):404-9.
  6. Li L, Zhou Qc, Zou L, Pu D, Zhang M, Joshua C, Mert B. Prenatal assessment of the fetal thymus: utility of 2D and 3D ultrasound healthy fetuses. Chinese J. Ultrasonography. 2011;(20):53-57.
  7. Wang E, Feng Y, Zhang M, Zou L, Li Y, Buys ES, Huang P, Brouckaert P, Chao W. Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms. Anesthesiology. 2011;114(3):603-13.
  8. Zou L, Feng Y, Zhang M, Li Y, Chao W. Nonhematopoietic toll-like receptor 2 contributes to neutrophil and cardiac function impairment during polymicrobial sepsis. Shock (Augusta, Ga.). 2011;36(4):370-80.
  9. Li Y, Si R, Feng Y, Chen HH, Zou L, Wang E, Zhang M, Warren HS, Sosnovik DE, Chao W. Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. The Journal of biological chemistry. 2011;286(36):31308-19.
  10. Feng Y, Zou L, Zhang M, Li Y, Chen C, Chao W. MyD88 and Trif signaling play distinct roles in cardiac dysfunction and mortality during endotoxin shock and polymicrobial sepsis. Anesthesiology. 2011;115(3):555-67.
  11. Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu YM, Fischman AJ, Tompkins RG, Yao S, Kaneki M. Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance. The Journal of pharmacology and experimental therapeutics. 2011;339(3):832-41.
  12. Wang X, Zhou Q, Pu D, Peng Q, Zou L, Tang Y, Zhang J. Study of cardiac torsion in fetuses with gestational diabetes mellitus by velocity vector imaging. Chinese J. Ultrasonography. 2012;(21):292-295.
  13. Sips PY, Irie T, Zou L, Shinozaki S, Sakai M, Shimizu N, Nguyen R, Stamler JS, Chao W, Kaneki M, Ichinose F. Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression. American journal of physiology. Heart and circulatory physiology. 2013;304(8):H1134-46.
  14. Zou L, Feng Y, Li Y, Zhang M, Chen C, Cai J, Gong Y, Wang L, Thurman JM, Wu X, Atkinson JP, Chao W. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. Journal of immunology. 2013;191(11):5625-35.
  15. Chen C, Feng Y, Zou L, Wang L, Chen HH, Cai JY, Xu JM, Sosnovik DE, Chao W. Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury. Journal of the American Heart Association. 2014;3(1):e000683.
  16. Zhang M, Zou L, Feng Y, Chen YJ, Zhou Q, Ichinose F, Chao W. Toll-like receptor 4 is essential to preserving cardiac function and survival in low-grade polymicrobial sepsis. Anesthesiology. 2014;121(6):1270-80.
  17. Zeng X, Zou L, Levine RA, Guerrero JL, Handschumacher MD, Sullivan SM, Braithwaite GJ, Stone JR, Solis J, Muratoglu OK, Vlahakes GJ, Hung J. Efficacy of polymer injection for ischemic mitral regurgitation: persistent reduction of mitral regurgitation and attenuation of left ventricular remodeling. JACC. Cardiovascular interventions. 2014;8(2):355-63.
  18. Feng Y, Zou L, Chen C, Li D, Chao W. Role of cardiac- and myeloid-MyD88 signaling in endotoxin shock: a study with tissue-specific deletion models. Anesthesiology. 2014;121(6):1258-69.
  19. Gong Y, Zou L, Feng Y, Li D, Cai J, Chen D, Chao W. Importance of Toll-like receptor 2 in mitochondrial dysfunction during polymicrobial sepsis. Anesthesiology. 2014;121(6):1236-47.
  20. Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W, Peterson RT. Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Science translational medicine. 2014;6(266):266ra170.
  21. Feng Y, Chen H, Cai J, Zou L, Yan D, Xu G, Li D, Chao W. Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling. J Biol Chem. 2015; 290 (44): 26688-26698
  22. Zou L, Chen HH, Li D, Xu G, Feng Y, Chen C, Wang L, Sosnovik DE, Chao W. Imaging Lymphoid Cell Death In Vivo During Polymicrobial Sepsis. Critical care medicine. 2015; 43(11):2303-12.
  23. Li D, Zou L, Feng Y, Xu G, Gong Y, Shao G, Ouyang W, Thurman JM, Chao W. Complement factor B production in renal tubular cells and its role in sodium transporter expression during polymicrobial sepsis. Crit Care Med. 2016 Jan 11. [Epub ahead of print]
  24. Zou L, Feng Y, Xu G, Jian W, Chao W. Splenic RNA and MicroRNA Mimics Promote Complement Factor B Production and Alternative Pathway Activation via Innate Immune Signaling. The Journal of Immunology. 2016; 196 (6): 2788-2798.

Research Interests

My research interest is to understand the molecular mechanisms of sepsis and septic shock, a life-threatening clinical condition caused by a dysregulated host response to infection. I have investigated in the role of innate immunity, including Toll-like receptors (TLRs) and the complement system, in the development of septic cardiac dysfunction. We found that complement factor B is highly expressed in cardiomyocytes and renal tubular cells in sepsis, regulated by multiple TLRs, and contributes to cardiac dysfunction and acute kidney injury during polymicrobial sepsis. We have recently identified a novel role of host cellular RNA and microRNA mimics in promoting complement factor B de novo sysnthesis as well as the complement alternative pathway activation in sepsis. Part of my research has been supported by International Anesthesia Research Society Mentored Research Award.