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Brittney Williams, MD

Academic Title:

Associate Professor

Primary Appointment:



UMMC, S11C00

Phone (Primary):

(410) 328-3990

Phone (Secondary):

(410) 328-9813


(410) 328-3092

Education and Training

2003: B.S., Biology, The American University

2007: M.D., State University of New York, Upstate Medical University


Post Graduate Education and Training

2011-2012: Internship, University of Maryland Medical Center, Baltimore, MD

2012-2015: Residency, Department of Anesthesiology, University of Maryland Medical Center, Baltimore, MD

2015-2016: Fellowship, Cardiothoracic Anesthesiology, University of Maryland Medical Center, Baltimore, MD


Dr. Williams received her bachelor’s degree from the American University and her medical degree from State University of New York Upstate Medical School in Syracuse, NY. She completed a residency in anesthesiology and a fellowship in cardiothoracic anesthesiology at the University of Maryland.

Currently, Dr. Williams is an assistant professor at the University of Maryland where she can pursue her research interests which include cardiopulmonary bypass associated coagulopathy and sepsis induced coagulopathy.

Research/Clinical Keywords

Cardiopulmonary Bypass Associated Coagulopathy Sepsis Induced Coagulopathy

Highlighted Publications

  1. Wang S, Yang y, Suen A, Zhu J, Williams B, Karathanos T, Hu P, Kozar R, Shen S, Jeyaram A, Jay S, Zou L, Chao W. Extracellular microRNA-146a-5p Regulates Innate Immune Response and Plays a Pivotal Role in Polymicrobial Sepsis.
  2. Hu Y, Williams B, Galai I, Nathan N, Smallman B. Tongue protrusion as an extubation criterion in pediatric surgery. Paediatr Anaesth. 2014;24(9):1021-2. PMID: 25092454.
  3. Williams B, McNeil J, Crabbe A, Tanaka KA. Practical Use of Thromboelastometry in the Management of Perioperative Coagulopathy and Bleeding. Transfus Med Rev. 2016;31(1):11-25. PMID: 27622549.
  4. Williams B, Bernstein W. Review of Venoarterial Extracorporeal Membrance Oxygenation and Development of Intracardiac Thrombosis in Adult Cardiothoracic Patients. J Extra Corpor Technol. 2016;48(4):162-167. PMID: 27994255.
  5. Tanaka KA, Mazzeffi MA, Williams B. Acute Traumatic Coagulopathy: Thrombin Is the Driver! Anesthesiology. 2017;127(3):585. PMID: 28816786.
  6. Williams B, Mazzeffi MA, Sanchez PG, Pham SM, Kon Z, Tanaka KA. Case Report of Severe Antithrombin Deficiency During Extracorporeal Membrane Oxygenation and Therapeutic Plasma Exchange for Double Lung Transplantation. A A Case Rep. 2017;8(1):11-13. PMID: 28036320.
  7. Henderson RS, Deshpande S, Williams B, Taylor BS, Tanaka KA. Idarucizumab for Dabigatran Reversal in Emergency Type-A Aortic Dissection. J Cardiothorac Vasc Anesth. 2017;31(6):e80-e81. PMID: 27498256.
  8. Odonkor P, Srinivas A, Strauss E, Williams B, Mazzeffi M, Tanaka KA. Perioperative Coagulation Management of a Hemophilia A Patient During Cardiac Surgery. Semin Cardiothorac Vasc Anesth. 2017;21(4):312-320. PMID: 28388863.
  9. Strauss ER, Mazzeffi MA, Williams B, Key NS, Tanaka KA. Perioperative management of rare coagulation factor deficiency states in cardiac surgery. Brit J Anesth. 2017;119(3):354-368. PMID: 28969316.
  10. Williams B, Wehman B, Mazzeffi MA, Odonkor P, Harris RL, Kon Z, Tanaka K. Acute Intracardiac Thrombosis and Pulmonary Thromboembolism After Cardiopulmonary Bypass: A Systematic Review of Reported Cases. Anesth Analg. 2018;126(2):126(2):425-434. PMID: 28682954.
  11. Hasan S, Abuelkasem E, Williams B, Henderson R, Mazzeffi MA, Tanaka KA. Factor IX From Prothrombin Complex Concentrate Augments Low Dose Tissue Factor-triggered Thrombin Generation - an in vitro study. Brit J Anaesth. 2018;121(4):936-943. PMID: 30236256.
  12. Mazzeffi MA, See JM, Williams B, Richards J, Zimmerman D, Galvagno S, Fontaine M, Tanaka K. Five-year trends in perioperative red blood cell transfusion from index cases in five surgical specialties: 2011 to 2015. Transfusion. 2018;58(5):1271-1278. PMID: 29542136.
  13. Williams B, Chriss E, Kaplan J, Cartron A, Taylor B, Gammie J, Tanaka K, Mazzeffi M. Hypothermia, pH and Postoperative Red Blood Cell Transfusion in Massively Transfused Adult Cardiac Surgery Patients: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. 2018;32(4):1642-1647. PMID: 29290382.
  14. Williams B, Sikorski R, Anders M, Galvagno S, Rock P, Mazzeffi M. Should We Use Perioperative Transesophageal Echocardiography More in Non-Cardiac Surgery? J Cardiothorac Vasc Anesth. 2018;32(3):e71-e73. PMID: 27474334.
  15. Tanaka KA, Bharadwaj S, Hasan S, Judd M, Abuelkasem E, Henderson R, Chow JH, Williams B, Mazzeffi MA, Crimmins SD, Malinow AM. Elevated fibrinogen, von Willebrand factor, and Factor VIII confer resistance to dilutional coagulopathy and activated protein C in normal pregnant women. Br J Anaesth. 2019;122(6):751-759. PMID: 30916034.
  16. Tanaka KA, Henderson R, Williams B. Heparin-Induced Thrombocytopenia and Cardiac Surgery: Can We Do It All With Cangrelor? A A Pract. 2019;13(9):366. PMID: 31567127.
  17. Henderson RA, Mazzeffi MA, Strauss ER, Williams B, Wipfli C, Dawood M, Taylor BS, Tanaka KA. Impact of intraoperative high-volume autologous blood collection on allogeneic transfusion during and after cardiac surgery: a propensity score matched analysis. Transfusion. 2019;59(6):2023-2029. PMID: 30882929.
  18. Jian W, Gu L, Williams B, Feng Y, Chao W, Zou L. Toll-like Receptor 7 Contributes to Inflammation, Organ Injury, and Mortality in Murine Sepsis. Anesthesiology. 2019;131(1):105-118. PMID: 31045897.
  19. Williams B, Neder J, Cui P, Suen A, Tanaka K, Zou L, Chao W. Toll-like receptors 2 and 7 mediate coagulation activation and coagulopathy in murine sepsis. J Thromb Haemost. 2019;17(10):1683-1693. PMID: 31211901.
  20. DiChiacchio L, Singh AK, Lewis B, Zhang T, Hardy N, Pasrija C, Morales D, Odonkor P, Strauss E, Williams B, Deatrick KB, Kaczorowski DJ, Ayares D, Griffith BP, Bartlett ST, Mohiuddin MM. Early experience with preclinical peri-operative cardiac xenograft dysfunction in a single program. Ann Thorac Surg. 2020;109(5):1357-1361. PMID: 31589847.
  21. Williams B, Henderson RS, Reformato VS, Pham T, Taylor BS, Tanaka KA. Hemostasis Management of Patients Undergoing Emergent Cardiac Surgery After Ticagrelor Loading. Case Report. J Cardiothorac Vasc Anesth. 2020;34(1):168-174. PMID: 31375405.
  22. Goerlich CE, Kaczorowski D, Singh A, Abdullah M, Lewis B, Zhang T, Tatarov I, Sentz F, Hershfeld A, Odonkor P, Williams B, Strauss E, Ayares D, Griffith B, Mohiuddin M. Human Thrombomodulin Transgene Expression Prevents Intracardiac Thrombus in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation. J Heart Lung Transplant. 2020;39(4):S145.
  23. Goerlich C, Singh A, Kaczorowski D, Abdullah M, Lewis B, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Ayares D, Griffith B, Mohiuddin M. Lack of Human Thrombomodulin Gene Expression in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation Models Accelerate Antibody Mediated Rejection. Transplantation. 2020;104(S3):S635.
  24. Tanaka KA, Mondal S, Morita Y, Williams B, Strauss ER, Cicardi M. Perioperative Management of Patients With Hereditary Angioedema With Special Considerations for Cardiopulmonary Bypass. Anesth Analg. 2020;131(1):155-169. PMID: 32102012.
  25. Goerlich C, Singh A, Kaczorowski D, Abdullah M, Lewis B, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Ayares D, Griffith B, Mohiuddin M. The Use of Minimally Ischemic Cardiac Preservation Techniques to Overcome Perioperative Cardiac Xenograft Dysfunction (PCDX) in Life-Supporting Cardiac Xenotransplantation Model. Transplantation. 2020;104(S3):S636.
  26. Goerlich CE, Griffith B, Avneesh S, Mohamed A, Shreya S, Kolesnik I, Lewis B, Sentz F, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Tabatabai A, Bhutta A, Ayares D, Kaczorowski D, Mohiuddin M. Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation. Frontiers in Immunology. 2021;12: 667093. PMID: 34177906.
  27. Mondal S, Hollander KN, Ibekwe SO, Williams B, Tanaka KA. Heyde Syndrome-Pathophysiology and Perioperative Implications. J Cardiothorac Vasc Anesth. 2021;35(11):3331-3339. PMID: 33132021.
  28. Wang S, Yang Y, Suen A, et al. Role of extracellular microRNA-146a-5p in host innate immunity and bacterial sepsis. iScience. 2021;24(12):103441. Published 2021 Nov 13. doi:10.1016/j.isci.2021.103441
  29. Lopez K, Suen A, Yang Y, Wang S, Williams B, Zhu J, Hu J, Fiskum G, Cross A, Kozar R, Miller C, Zou L, Chao W. Hypobaria Exposure Worsens Cardiac Function and Endothelial Injury in an Animal Model of Polytrauma: Implications for Aeromedical Evacuation. Shock. 2021;56(4):601-610. PMID: 33394971.
  30. Chen F, Zou L, Williams B, Chao W. Targeting Toll-Like Receptors in Sepsis - From Bench to Clinical Trials. Antioxid Redox Signal. 2021;35(15):1324-1339. PMID: 33588628.
  31. Strauss ER, Dahmane E, Judd M, Guo D, Williams B, Meyer MS, Gammie JS, Taylor BS, Mazzeffi MA, Gobburu JA, Tanaka KA. A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic acid regimen designed for the context of cardiac surgery with cardiopulmonary bypass. J Cardiothor Vasc Anesth. 2022;35(2):406-417. PMID: 2811752.
  32. Strauss ER, Li S, Henderson R, Carpenter R, Guo D, Thangaraju K, Katneni U, Buehler PW, Gobburu JV, Tanaka KA. A Pharmacokinetic and Plasmin-Generation Pharmacodynamic Assessment of a Tranexamic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2022;36(8 Pt A):2473-2482. PMID: 35094925.
  33. Odonkor PN, Strauss E, Williams B. Ethical considerations during a pioneering surgical procedure: porcine cardiac xenotransplantation. Br J Hosp Med (Lond). 2022;83(6):1-7. PMID: 35787171.
  34. Strauss ER, Odonkor PN, Williams B. Porcine Orthotopic Cardiac Xenotransplantation: The Role and Perspective of Anesthesiologists. J Cardiothorac Vasc Anesth. 2022;36(8 Pt B):2847-2850. PMID: 35537973.
  35. Huang H, Zhu J, Gu L, et al. TLR7 Mediates Acute Respiratory Distress Syndrome in Sepsis by Sensing Extracellular miR-146a. Am J Respir Cell Mol Biol. 2022;67(3):375-388. doi:10.1165/rcmb.2021-0551OC
  36. Mohiuddin MM, Goerlich CE, Singh AK, Zhang T, Tatarov I, Lewis B, Sentz F, Hershfeld A, Braileanu G, Odonkor P, Strauss, Williams B, Burke A, Hittman J, Bhutta A, Tabatabai A, Gupta A, Vaught T, Sorrells L, Kuravi K, Dandro A, Eyestone W, Kaczorowski DJ, Ayares D, Griffith BP. Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months. Xenotransplantation. 2022;29:e12744. PMID: 35357044.
  37. Mazzeffi MA, Henderson R, Powell E, Strauss E, Williams B, Tanaka K, Yang S, Deatrick K, Madathil R. Thrombopoietin, Soluble CD40 Ligand, and Platelet Count During Veno-arterial Extracorporeal Membrane Oxygenation. ASAIO J. 2022;68(5):e77-e79. PMID: 34081052.
  38. Strauss ER, Odonkor PN, Williams B, Choi S, Mueller J, Taylor B, Shah A, Goerlich CE, Mohiuddin MM, Griffith BP. Intraoperative Management of an Orthotopic Porcine-to-Human Cardiac Xenotransplant. Ann Thorac Surg. 2023;115(3):784-786. PMID: 36621667.

Research Interests

  • Cardiopulmonary Bypass Associated Coagulopathy 
  • Sepsis Induced Coagulopathy

Awards and Affiliations

2015 2015 Dripps Awards Recipient, UMSOM
2018 2018 Kosaka Best of Meeting Abstract Award, UMSOM, IARS-Annual Meeting
2019 2019 Best Basic Science Abstract, UMSOM, Anesthesiology Spring Research Retreat

Grants and Contracts

Active Grants

(PI, 75%)

Role of miRNA-TLR7 signaling in platelet activation and dysfunction in sepsis

NIH K08 Mentored Research Award

Award Total: $808,965.00

Annual Direct Cost: $150,300.00

Completed Grants


Targeting Inflammation in Sepsis-induced Coagulopathy 

STAR DRIF Fund, No Salary Support

Award Total: $50,849.00

Annual Direct Cost: $50,849.00


Targeting Inflammation in Sepsis-induced Coagulopathy 

STAR DRIF Fund, No Salary Support

Award Total: $50,849.00

Annual Direct Cost: $50,849.00



Role of TLR7 in platelet activation and dysfunction in sepsis

Foundation for Education and Anesthesia Research (FAER) Mentored Research Training Grant

Award Total: $250,000.00

Annual Direct Total: $125,000.00

Professional Activity

2014    General Member-Fellow Status, Society of Cardiovascular Anesthesiologist
2015    Member, International Anesthesia Research Society