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Lin Zou, MD, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Anesthesiology

Location:

HH, 598

Phone (Primary):

(410) 706-2547

Fax:

(410) 706-2410

Education and Training

1997-2002: M.D., Medicine, Xiangya School of Medicine, Central South University, China
2006-2010: Ph.D., Ultrasound Medicine, Xiangya School of Medicine, Central South University, China
2008-2012: Postdoc Fellow, Massachusetts General Hospital, Harvard Medical School, Boston, MA
2012-2016: Instructor, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Highlighted Publications

 

 

Research Interests

My research interest has been inflammation and organ injury in sepsis. During the past few years, I have gained extensive experience in studying the role of innate immune signaling, such as Toll-like receptors (TLRs) and complements, in the development of cardiac and renal injury during sepsis (Zou, et al., 2010, Zou, et al., 2013; Li, et al., 2016). Most recently, we demonstrate that extracellular RNAs/miRNAs are released during tissue ischemia or polymicrobial sepsis, are capable of activating the innate immune TLR7 signaling, and mediate a robust cytokine/complement production in cardiac cells and macrophages (Feng, et al., 2015, Zou, et al., 2016, Feng et al., 2017). My recent research funded by NIH R35 and R01 is focusing to study the role of extracellular miRNA in acute lung injury and encephalopathy in sepsis model.        

Grants and Contracts

Project 1: Function and Mechanisms of extracellular microRNAs in sepsis-induced lung injury.

R35 GM124775 (NIH/NIGMS) (09/01/2017-08/31/2022)

Role: PI

Project 2: Targeting brain inflammation and neurocognitive dysfunction in sepsis.

R01 NS110567 (05/01/2019-02/24/2024)

Role: MPI