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Vaccine Impact on Diarrhea in Africa (VIDA)

Vaccine Impact on Diarrhea in AfricaVaccine Impact on Diarrhea in Africa (VIDA) is a global health study to assess the causes and burden of diarrhea in children under five and determine the effectiveness of rotavirus vaccine at three sites in sub-Saharan Africa: Mali, Kenya, and The Gambia.

VIDA is a follow-on to the Global Enteric Multicenter Study (GEMS), the largest and most comprehensive study of diarrheal diseases ever conducted in developing countries. Building on the GEMS infrastructure and methodology, VIDA is a 36-month case-control study of moderate-to-severe diarrhea (MSD) in three prototypic low-income countries.

As rotavirus vaccine uptake increases, VIDA will inform progress on the control of diarrheal diseases. Data, used to develop and prioritize strategies, will ensure efforts are relevant and appropriate to the causes and consequences of future diarrheal diseases.

Study Objectives

  • Assess the impact of rotavirus vaccine introduction on the incidence, etiology, and adverse clinical consequences of MSD
  • Provide a well-characterized library of stool samples to more precisely define the pathogen-specific diarrheal disease burden
  • Determine the effectiveness of a full course of the rotavirus vaccine

Field Sites

Le Centre pour le Développement des Vaccines du Mali (CVD-Mali), Bamako, Mali

Medical Research Center (MRC), Basse, The Gambia

Centers for Disease Control and Prevention (CDC)

Kenya Medical Research Institute (KEMRI)

Centre for Global Health Research (CGHR), Kisumu, Kenya

ASTMH Posters

Change in prevalence of risk factors for diarrhea mortality between across a 10-year period between Global Enteric Multicenter Study (GEMS) and Vaccine Impact on Diarrhea in Africa (VIDA)

Epidemiology and burden of Cryptosporidium diarrheal diseases in under five children in three sub-Saharan African countries, 2015-2018

Prevalence, antimicrobial resistance, and distribution of Shigella among children under five in three sub-Saharan African countries in the Vaccine Impact on Diarrhea in Africa Study

Trends in non-typhoidal Salmonella gastrointestinal infections in children under five from three countries in sub-Saharan Africa