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Wednesday, August 24, 2022
UM School of Medicine Study Finds a New Way to Optimize Treatment Success for Fecal Transplants
Fecal transplants have been successful in treating serious diarrheal infections but have often failed when tried with other diseases. Up until now, no one could predict why these treatments sometimes failed to help restore healthy bacteria in the colon. Researchers from the University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) have discovered important clues that could lead more personalized approaches to optimize treatment success. They published their findings in Cell Reports Medicine online earlier this month.
Thursday, July 28, 2022
Researchers Discover One of the Largest Known Bacteria-to-Animal Gene Transfer Inside a Fruit Fly
A fruit fly genome is not a just made up of fruit fly DNA – at least for one fruit fly species. New research from the University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) shows that one fruit fly species contains whole genomes of a kind of bacteria, making this finding the largest bacteria-to-animal transfer of genetic material ever discovered. The new research also sheds light on how this happens.
Monday, July 18, 2022
New Genomic Research Shows Why Testing Malaria Vaccines in the Clinic is as Rigorous as Natural Exposure in the Field
Malaria is the deadliest mosquito-borne parasitic infection of humans. In 2021, after a century of research, the World Health Organization (WHO) approved the world’s first malaria vaccine. That vaccine reduces the incidence of malaria infections in young children aged 5-17 months by only 30 percent, meaning that it remains critical to continue developing and testing more effective vaccines.
Thursday, March 18, 2021
UM School of Medicine Helps Maryland Conduct State-Wide Sequencing of Variants in Positive COVID-19 Test Specimens
In an effort to monitor the spread of COVID-19 variants in the State of Maryland, University of Maryland School of Medicine (UMSOM) Dean E. Albert Reece, MD, PhD, MBA, announced that UMaryland Genomics at UMSOM will perform genome sequencing of variants in at least 10 percent of COVID-19 test samples, reaching an important benchmark set by the federal government to help control the spread of these variants.
Thursday, February 25, 2021
UM School of Medicine Researchers Participate in Landmark Study Detailing Sequencing of Full Human Genomes to Better Capture Genetic Diversity
Researchers at the University of Maryland School of Medicine (UMSOM) co-authored a study, published today in the journal Science, that details the sequencing of 64 full human genomes. This reference data includes individuals from around the world and better captures the genetic diversity of the human species. Among other applications, the work will enable population-specific studies on genetic predispositions to human diseases as well as the discovery of more complex forms of genetic variation.
Wednesday, February 26, 2020
Researchers Develop First Catalogue of Genes that Comprise Community of Microbes in Vaginal Microbiome
University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) researchers have created the first catalogue of genes that comprise the community of microbes, which inhabit the human vagina. The catalogue, called human vaginal non-redundant gene catalog (VIRGO), was recently released as a public resource that can be used by researchers to facilitate a more in-depth understanding of the role of vaginal microorganisms in women’s health and to potentially develop future treatments for certain gynecologic conditions.
Tuesday, December 03, 2019
UM School of Medicine Researchers Institute for Genome Sciences' Researchers Discover Potential New Treatment for Tropical Parasitic Disease Using Genomics
Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine (UMSOM) Institute for Genome Sciences identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat. The potential new therapy is an experimental cancer drug called JQ1 and targets proteins found prominently in the worm’s genome; it appears to effectively kill the adult worms in a laboratory setting, according to the study which was published today in the journal mSystems.
Tuesday, August 13, 2019
Researchers Identify How Vaginal Microbiome Can Elicit Resistance or Susceptibility to Chlamydia
The vaginal microbiome is believed to protect women against Chlamydia trachomatis, the etiological agent of the most prevalent sexually transmitted infections (STIs) in developed countries. New research by the University of Maryland School of Medicine (UMSOM) shows how the microbiome can either protect or make a woman more susceptible to these serious infections.
Thursday, April 04, 2019
UM School of Medicine's Institute for Genome Sciences Awarded $17.5 Million Grant for Infectious Disease Research
The Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine (UMSOM) was awarded $17.5 million from the National Institute of Allergy and Infectious Diseases (NIAID) to fund the IGS Genome Center for Infectious Diseases (GCID) for another five years.
Wednesday, March 27, 2019
New Study Finds That Bacteria and Immunity in the Cervix May be Key to Predicting Premature Birth
Spontaneous preterm birth (sPTB), defined as birth before 37 weeks of gestation, and the related complications, are the largest contributors to infant death in the United States and worldwide, according to the World Health Organization. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered that bacteria and innate immune factors in a woman’s birth canal and cervix may increase the risk of spontaneous preterm birth or provide protection against such births.
Tuesday, February 12, 2019
UMSOM Scientists Call for Unrestricted Usage of Public Genome Data
Researchers at the Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine (UMSOM) called for open access to genome data, stating that unrestricted usage is needed for progress in combating the world’s most serious diseases.
Friday, February 08, 2019
University of Maryland School of Medicine Genome Scientists Develop Novel Approaches to Studying the Most Widespread Form of Malaria
Scientists at the Institute of Genome Sciences (IGS) at the University of Maryland School of Medicine (UMSOM) have developed a novel way with genome sequences to study and better understand transmission, treat and ultimately eradicate Plasmodium vivax, the most widespread form of malaria.
Thursday, September 27, 2018
University of Maryland School of Medicine Scientist Receives Prestigious Microbiome Award
Owen White, PhD, professor of epidemiology and public health, and Associate Director for Informatics at the Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine (UMSOM), has received the 2018 Microbiome Pioneer Award. The prestigious honor is part of the Bioinformatics for the Microbiome Symposium organized by Stanford University. The microbiome is the name given collectively to the community of trillions of microbial organisms that live on and within our bodies.
Monday, May 14, 2018
New Research: Some Gut Bacteria May Protect Against Intestinal Infection
Scientists at the University of Maryland School of Medicine (UMSOM) have for the first time found evidence that the presence of a key species in the human gut microbiome is associated with protection from infection with typhoid fever. If the research is borne out, it could offer an exciting new way to reduce intestinal infections from microbes.