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Yuanyuan Liang, PhD, MSc

Academic Title:


Primary Appointment:

Epidemiology & Public Health


109B, Howard Hall, 660 W. Redwood Street, Baltimore, MD 21201

Phone (Primary):

(410) 706-4103


(410) 706-8548

Education and Training

B.Sc. in Computer Science and Applied Mathematics, Department of Mathematics, Beijing Normal University, Beijing, China, 2000

M.Sc. in Biostatistics, Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, Alberta, Canada, 2003

Ph.D. in Statistics, Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, Alberta, Canada, 2006


Dr. Liang is a Professor in the Department of Epidemiology and Public Health at the University of Maryland School of Medicine. She has over a decade of experience in the development, management and analysis of epidemiological, clinical and health services data with an emphasis on applying state-of-the-art statistical methodologies. Her research focuses on study design for clinical trials using both traditional and innovative design methods such as crossover designs and adaptive designs, data analysis of longitudinal studies, meta-analysis for systematic reviews and risk prediction models, especially for health disparities research in the field of substance use, obesity, diabetes and cancer. She is also experienced with using large electronic medical databases to evaluate care and identify health disparities. Dr. Liang served or has served as a Co-Investigator and the Lead Statistician for over 30 federal or state research grants, including 14 NIH R01 grants, and has over 100 peer-reviewed publications.

Research/Clinical Keywords

Design and Analysis of Repeated Measures Data; Construction of Optimal Designs; Meta-Analysis for Systematic Reviews; Risk Prediction Models with Special Application to Cancer and Population Health Research

Highlighted Publications

Liang Y, Carrière KC. The stratified and randomized play-the-winner rule. Statistical Methods in Medical Research 2008; 17(6):581-593.

Liang Y, Carrière KC. Multiple-objective response-adaptive repeated measurement designs for clinical trials. Journal of Statistical Planning and Inference 2009; 139:1134-1145.

Liang Y, Ankerst DP, Sanchez M, Leach RJ, Thompson IM. Body mass index adjusted prostate-specific antigen and its application for prostate cancer screening. Urology 2010; 76(5): 1268 e1261-1266.

Liang Y, Carrière KC. On the role of baseline measurements for crossover designs under the self and mixed carryover effects model. Biometrics 2010; 66(1):140-148.

Liang Y, Ankerst DP, Ketchum NS, Ercole B, Shah G, Shaughnessy JD, Leach RJ, Thompson IM. Prospective evaluation of operating characteristics of prostate cancer detection biomarkers. The Journal of Urology 2011; 185(1): 104-110.

Liang Y, Du F, Thompson IM, Turner BJ. Limited PSA testing in indigent men in South Texas: An appropriate care or missing a prevention opportunity? Cancer Epidemiology, Biomarkers & Prevention 2012; 21(9):1489-1496.

Liang Y, Yin Li, Wang J, Carrière KC. Multiple-objective response-adaptive repeated measurement designs in clinical trials for binary responses. Statistics in Medicine 2014; 33(4):607-617.

Liang Y, Ehler BR, Hollenbeak CS, Turner BJ. Behavioral support intervention for uncontrolled hypertension: A complier average causal effect (CACE) analysis. Medical Care  2015; 53(2): e9-e15.

Liang Y, Turner BJ. Assessing risk for drug overdose in a national cohort: Role for both daily and total opioid dose? Journal of Pain 2015; 16(4): 318-325.

Liang Y, Goros MW, Turner BJ. Drug overdose: Differing risk models for women and men. Pain Medicine Epub April 2016.

Additional Publication Citations

Complete List of Published Work in MyBibliography:


Grants and Contracts

R01-HD093946-01 Turan (PI)        09/2018-08/2023
Contrast-Enhanced/microbubble and B-flow/M-mode Ultrasonography to Quantify Uteroplacental Perfusion during Baboon and Human Pregnancy
This study will establish contrast-enhanced/microbubble and B-flow/M-mode ultrasonography as novel, cutting-edge, safe, real-time imaging to investigate early uteroplacental vascular development in a unique non-human primate model and translate findings to human pregnancy.
Role: Co-investigator

R01-DA026868    Dougherty (PI)    5/2017 - 4/2022
Consequences of Substance Use on the Development of Impulse Control
This study aims to examine when, how, and to what extent individual differences in impulse control and family histories of substance use disorders contribute to the initiation of substance use, and how subsequent substance use affects developmental trajectories of impulse control.
Role: PI for the UMB subaward

R01-AA014988    Dougherty (PI)    5/2017 - 4/2022
Leveraging Transdermal Alcohol Monitoring to Reduce Drinking Among DWI Defendants
This study aims to examine the effects of contingency management procedures among DWI defendants who continue to use alcohol during court-mandated transdermal alcohol monitoring.
Role: PI for the UMB subaward

1R21-ES028060-01    Grattan (PI)    4/2017 - 3/2019
Rapid Risk Assessment of Chronic Domoic Acid Exposure in WA Razor Clam Harvesters
This study aims to conduct a risk assessment survey of recreational razor clam harvesters to determine whether their levels of consumption are of concern and to conduct a formal toxicological risk assessment of exposure to inform current policy and protective measures.
Role: Co-investigator            

17-17219G    Tracy (PI)    1/2017 – 6/2018                
DHMH OPASS                                                          
Research and Evaluation for the Maryland Center of Excellence for Problem Gambling
The purpose of this contract is to establish a comprehensive and organized research program within the Maryland Center of Excellence for Problem Gambling.
Role: Co-investigator            

University of Texas Health Science Center at San Antonio    Liang (PI)    10/2016 - 8/2017
Statistical Support for the Center for Research to Advance Community Health (ReACH)
This grant aims to provide statistical assistance and support for the ReACH center.
Role: PI

University of Maryland Medical System (UMMS)    Magaziner (PI)    10/2016 - 7/2017
UMMS Population Health                                
This grant aims to develop population health related projects for the UMMS.
Role: Co-investigator           

R01-DK109323    Yin/Parra-Medina (PI)    9/2016 - 8/2021    
Obesity Prevention in Head Start: The Miranos! Program
The proposed study is designed to test the efficacy of a multi-level early childhood obesity prevention program, which promotes healthy growth in predominantly Latino children attending Head Start.
Role: PI for the UMB subaward

R01-NR016269    Parra-Medina (PI)    9/2016 - 8/2021    
Healthy Frio: A Rural Community Partnership to Address Hispanic Obesity
In this study, two parallel delivery methods of an existing family-focused intervention will be developed and tested: 1) in-person group setting at a community center and 2) home-based delivered remotely with technology and e-Learning to increase program availability, accessibility and program participation in rural settings.
Role: PI for the UMB subaward

R01-HD075936    Parra-Medina (PI)    5/2014 - 4/2020               
Pediatric Obesity Management Intervention Trial for Hispanic Families                       
The purpose of the proposed Pediatric Obesity Management (POM) Trial for Hispanic Families is to assess the efficacy of a comprehensive, culturally and linguistically relevant, family-based intervention targeting Hispanic overweight and obese children.
Role: PI for the UMB subaward

R01-DA033997    Acheson/Dougherty (PI)    06/2012-04/2017
Relating Brain Maturation to Impulse Control and Substance Use Development
The objectives of this study are to identify relationships between maturation of frontostriatal circuitry, impulse control development, and progression of substance use involvement across adolescence.
Role: PI for the UMB subaward