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655 W Baltimore Street, Baltimore, MD 21201
-Paris University, Paris, France, PhD
Major: Physiology and Pathophysiology, Supervisor: Prof. Mario PENDE
-Wuhan Institute of Virology, Chinese Academy of Sciences, Master
Major: Biochemistry and Molecular Biology, Supervisor: Dr. Zhenhua Zheng& Hong Tang
-College of Marine and Biotechnology, Guangxi University for Nationalities, Bachelor of Science
My doctoral research at the University of Paris, conducted under the mentorship of Professor Mario Pende, focused on elucidating the role of the YAP oncogene in mitochondrial function and cancer metabolism. This work fostered a lasting research interest in oncogenic signaling pathways and their integration with metabolic processes. Subsequently, I pursued postdoctoral training at the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, where I investigated the regulatory role of PRPF19 through VGLL4 in hepatocellular carcinoma, under the guidance of Dr. Lei Zhang.
Virus, Hippo pathways, Cancer, Immunology, Metabolism
1. Chunyu Wei, Zhenhua Zheng*, Caishang Zheng, Jianhong Sun, Dan Luo, Hanzhong Wang. 2019. Viperin inhibits Enterovirus A71 replication and interacts with viral 2C protein by its N terminal domain. Viruses-basel 11.
2. Zheng C, Zheng Z*, Sun J, Zhang Y, Wei C, Ke X, Liu Y, Deng L, Wang H. 2017. MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication. Scientific Reports 7:16422.
1. Virus infection and immunity
2. Inflammatory response and immunopathogenesis
3. Cancer metabolism
National Scholarship and Excellent Student Leader recognition from the University of Chinese Academy of Sciences.
National Natural Science Foundation of China-Youth Science Foundation (32300595,2024.01-2026.12), host
1. Molecular and cell biology: cell culture, virus infection, qPCR, Molecular cloning, Protein extraction and purification, Western blot, Co-IP, Mito-CHIP, Immunofluorescence, IHC, ELISA, Seahorse, Metabolic analysis, constructing knockout cell line, Extracellular vesicles isolation and quantification, 3D construction for confocal images, PLA, would healing, luciferase testing, flow cytometry.
2. Animal experiment: Building mouse infection model, Tail intravenous injection, IP injection, Mouse Pan-T/CD4+T/CD8+T cell isolation, Subcutaneous tumor size measurement，GVHD, mouse colony breeding, mouse genotyping, mouse tissue perfusion, mouse liver tissue protein extraction.
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