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Carl B. Shanholtz, MD

Academic Title:


Primary Appointment:


Additional Title:

Director, Medical Intensive Care Unit


Paca-Pratt Building, 110 S. Paca Street, 2N147

Phone (Primary):


Education and Training

MD          Jefferson Medical College, Philadelphia, PA  1983

Intern  US Naval Hospital, San Diego, CA  1984

Other training, Naval Aerospace Medical Institute, 1985

Resident  University of Maryland Medical System, Internal Medicine 1989

Fellow     Johns Hopkins University, Critical Care  1992

Fellow     University of Maryland, Medical Oncology, 1993



Dr. Shanholtz is the University of Maryland Medical Center (UMMC) Medical Intensive Care Unit (MICU) medical director, the medical director of the UMMC Department of Respiratory Care, and a prior ARDSnet investigator. He has had a longstanding interest in improving management of critically ill patients. He has been involved in clinical research in critical illness in general, and acute respiratory distress syndrome specifically, for over 20 years. He began his research career with Roy Brower in 1991 while a fellow in critical care medicine at the Johns Hopkins University School of Medicine and has collaborated on clinical research projects thereafter.  Shortly after receiving a faculty appointment at the University of Maryland, Dr. Shanholtz helped organize a four-hospital consortium in Baltimore to conduct a phase II clinical trial (n= 52 patients) of low tidal volume ventilation to reduce the risk of ventilator-induced lung injury in patients with the acute respiratory distress syndrome (ARDS).  The methodology and experience of this study provided a substantial basis for the large, phase III trial of mechanical ventilation with lower tidal volumes in ARDS subsequently conducted by the original ARDSnet and chaired by Dr.Brower. Dr. Shanholtz was later the University of Maryland site PI for three clinical projects as part of an NIH NHLBI-sponsored grant for a Specialized Center for Clinically Oriented Research in Acute Lung Injury (ALI SCCOR).   Dr. Shanholtz has also worked with the Chief of the University of Maryland Division of Pulmonary and Critical Care Medicine, Dr. Hasday, for the past 20 years and together they have 9 co-authored publications and are currently collaborating on a clinical research project of targeted temperature management for the treatment of moderate to severe ARDS. In addition, Dr. Shanholtz is a multiple PI on an NIH NINR-sponsored grant for the management of acute pain in non-communicative critically ill patients.


Research/Clinical Keywords

Dr. Shanholtz has been involved in numerous multicenter clinical trials in critically ill medical patients with acute lung injury and the acute respiratory distress syndrome, sepsis, and critically ill oncology patients. He has collaborated with colleagues at the Johns Hopkins School of Medicine on ventilatory strategies in acute lung injury (ARDSnet) and is collaborating with Surgical Critical Care in creating a multidisciplinary critical care research, education, and clinical service. Another interest has been in medical informatics and the development of computerized physician documentation for the School of Medicine.

Highlighted Publications

Brower RG, Shanholtz CB, Fessler HE, Shade DM, White P Jr, Wiener CM, Teeter JG, Dodd-o JM, Almog Y, Piantadosi S. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med. 1999 Aug;27(8):1492-8. PubMed PMID: 10470755.

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000 May 4;342(18):1301-8. PubMed PMID: 10793162.

Shah NG, Cowan MJ, Pickering E, Sareh H, Afshar M, Fox D, Marron J, Davis J, Herold K, Shanholtz CB, Hasday JD. Nonpharmacologic approach to minimizing shivering during surface cooling: a proof of principle study. J Crit Care. 2012 Dec;27(6):746.e1-8. PubMed PMID: 22762936; PubMed Central PMCID: PMC3494806.

Netzer G, Dowdy DW, Harrington T, Chandolu S, Dinglas VD, Shah NG, Colantuoni E, Mendez-Tellez PA, Shanholtz C, Hasday JD, Needham DM. Fever is associated with delayed ventilator liberation in acute lung injury. Ann Am Thorac Soc. 2013 Dec;10(6):608-15. PubMed PMID: 24024608; PubMed Central PMCID: PMC3960965.

Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5;370(23):2191-200. PubMed PMID: 24835849; PubMed Central PMCID: PMC4241052.

Additional Publication Citations

Complete List of Published Work in My Bibliography:

Research Interests

Current Research Interests:

  • Acute Respiratory Distress Syndrome (ARDS)
  • Sepsis
  • Managing Acute Pain in Non-Communicative Critically Ill Patients



Clinical Specialty Details

Special Interests:

  • Mechanical Ventilation
  • ARDS
  • Sepsis
  • Oncologic Critical care
  • Blood and Marrow Transplantation (BMT)

Awards and Affiliations

1978  Alpha Epsilon Delta Honor Society, La Salle College

1979  BA, magna cum laude, La Salle College

1985  Surgeon General's Award, US Navy

2012  Best Doctors, Baltimore Magazine

Grants and Contracts

R01 NR013664-03



Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients

Role: PI