Obstetrics, Gynecology and Reproductive Sciences
655 Baltimore St
Education and Training
1992-1995 St. Joseph’s College, Bangalore University, Bangalore, India; Biological Sciences.Undergraduate (B.S): GPA: 3.85/4
1995-1997 Central College, Bangalore University, Bangalore, India; Biochemistry Graduate (M.S). GPA:3.8/4
1998-2003 Graduate (Ph.D.) University of Nebraska-Lincoln, Lincoln, USA; Biochemistry. GPA:3.9/4
Thesis: Structural Stability and Refolding of the Soybean Kunitz Trypsin Inhibitor. Thesis Advisor: Prof. John P. Markwell.
2003-2006 Post-doctoral Fellowship; 2003-2006; Harvard Medical School, Boston, MA
2006-2008 Post-doctoral Fellowship; 2006-2008; UCLA School of Medicine, Los Angeles, CA.
2008-2014 Research Associate; UCLA School of Medicine; Dept. of Neurology; Prof. David B. Teplow.
2014-2022 Research Associate (non-tenure faculty); Johns Hopkins School of Medicine; Dept. of Neuroscience; Prof. Solomon H. Snyder.
Neurodevelopment, Adult Neurogenesis, D-amino acids, and Novel neurotransmitters.
1. Robin Roychaudhuri, Hasti Atashi, and Solomon H. Snyder. Serine Racemase mediates adult SVZ neurogenesis in mice via fatty acid metabolism. (In Press; Stem Cell Reports. 2022). corresponding and first author.
2. Evan Semenza, Maged Harraz, Efrat Abramson, Adarsha Malla, Chirag Vasavda, Moataz Gadalla, Michael Kornberg, Solomon Snyder and Robin Roychaudhuri. D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalianbrain. Proc. Natl. Acad. of Sci. USA. 2021; 118 (39). corresponding author.
3. Robin Roychaudhuri and Solomon Snyder. Mammalian D-cysteine regulating neural progenitor cell proliferation. BioEssays. 2022; Vol 44; Issue 7. Invited review. corresponding author.
4. Robin Roychaudhuri, Mingfeng Yang, Atul Deshpande, Aleksey Lomakin, Sally Frautschy, Greg Cole, George Benedek and David B. Teplow. C terminal turn stability determines assembly differences between Ab40 and Ab42. J. Mol Biol. 2013; 425(2),292-308.
5. Robin Roychaudhuri, Mingfeng Yang, Minako Hoshi and David. B. Teplow. Amyloid beta-protein Assembly and Alzheimer Disease. J Biol Chem. 2009; Vol 284; 4749-4753.
Book Chapters (peer reviewed)
1. David Teplow, Mingfeng Yang, Robin Roychaudhuri, Eric Pang, Phat Huynh, Mei-Sha Chen, Shiela Beroukhim. The amyloidbeta-protein and Alzheimer’s disease. Alzheimer's Disease: Targets for New Clinical Diagnostic and Therapeutic Strategies; in CRC Press – Pg 2-85. (Book Chapter) 2012.
Submitted or In-Revision Peer-reviewed journal articles
1. Robin Roychaudhuri, Moataz Gadalla, Lauren Albacarys, Timothy West and Solomon H. Snyder. Mammalian D-cysteine is a physiologic downregulator of insulin promoter methylation. (Under Scientific Review; 2022). corresponding and first author.
2. Robin Roychaudhuri, Moataz M. Gadalla, Timothy West and Solomon H. Snyder. A Novel Stereospecific Assay for the Detection of Endogenous D-Cysteine. (ACS Chem Neuroscience 2022). corresponding and first author.
Nature has inherent asymmetry. This asymmetry translates to homochirality in biological systems, i.e, molecules existing in a particular configuration (L or D). Mammals strongly differentiate between these two configurations. Homochirality is critical for molecular recognition in substrate-enzyme reactions, ligand-receptor binding as well as template driven processes such as DNA replication, RNA transcription, and protein translation.
My work at the Johns Hopkins School of Medicine identified endogenous mammalian D-cysteine, the fastest spontaneous racemizing amino acid that till now precluded detection. D-cysteine is present in substantial amounts in mouse and human brain and in cerebrospinal fluid in addition to few other organs.
My work in mammalian brain has revealed that D-cysteine regulates neural progenitor cell proliferation during development, an action mediated via Akt signaling by the FoxO family of transcription factors.
The goal of my lab is to elucidate the function of endogenous D-cysteine in mammalian development and understand the role of chirality in biology and medicine.
1997 University Grants Commission-Council for Scientific and Industrial Research (UGC-CSIR) Junior Research Fellowship by Govt. of India (Science and Technology).
1997 95th percentile in Graduate Aptitude Test (GATE) in Chemistry; All India
1998 U.K Cambridge Commonwealth Scholarship at University of Cambridge U.K.
2001 Milton E. Mohr Graduate Fellowship at University of Nebraska-Lincoln.
2011 Second Prize in UCLA Dept of Neurology Annual Science Day Poster presentation
2012 Third Prize at Seaborg Symposium Poster Presentation
2012 UCLA Department of Neurology Service Award
2013 Dean’s Prize finalist at UCLA Science Poster Day
2014 Curriculum Development and Educational Leadership at UCLA School of Medicine
7/01/22 (PI, 50% effort)
Role of D-cysteine in Neural Progenitor Cell Dynamics in the Developing Brain.
R21MH130832 (scored; pending resubmission); NIMH/NINDS Total Direct Costs: $450,313 (two years)
09/01/85-2/29/20 Snyder (PI)
Neurochemical Actions of Psychotropic Drugs R01 MH18501 Total Direct Costs: $2,499,210 Role: Key Personnel
09/15/18-5/31/23 Snyder (PI)
Targeting cell signaling pathways to disrupt drug abuse. 5 P50 DA044123 Total Direct Costs: $850,000 Role: Key Personnel
Local and National Service
2009-2010 Journal of Immunology (Ad hoc reviewer)
2010-2010 Biochemistry (Ad hoc reviewer)
2013-2013 Journal of American Chemical Society (Ad hoc reviewer)
2013-2013 Journal of Medicinal and Bioorganic Chemistry (Ad hoc reviewer)
2013-2013 Proceedings of the National Academy of Sciences (Ad hoc reviewer)
2016-2016 Science (Ad hoc reviewer)
Reviewed original manuscripts from the journals listed above.
2001-2002 Graduate Teaching Assistant (University of Nebraska-Lincoln), BIOC 321L, Biochemistry Lab and Lecture, 30 students, 4 hours/day, once a week for one semester (5 months). Two semesters total.
2004-2005 Mentored high school students (two) in summer lab research. Harvard Medical School, Boston. 4 months.
2014 Instructor; Winter Quarter (UCLA School of Medicine, Los Angeles), M262A and M262B: “Molecular Mechanisms of Human Disease”. 25 students, 3 hours/day, twice a week (3-4 months). One quarter total.
1. Invited speaker at the International Symposium on Chirality. July 2022, Chicago. Title: Mammalian D-Cysteine endogenously regulates neural progenitor cell proliferation in the mammalian brain.
2. Keynote speaker at the International Conference for D-Amino Acid Research (ICDAR). July 2022, University of Illinois at Urbana-Champaign. Title: Mammalian D-Cysteine is a regulator of neural progenitor cell proliferation in the mammalian brain.
1. Micro dissection of mouse brain sub ventricular zone (SVZ), isolation and culture of SVZ neural stem cells.
2. Mass Spectrometric (ESI) techniques and data analysis
3. Ion Mobility Spectroscopy
4. Islet isolation and culture from mouse
5. Enzyme kinetics
6. Cell Biology (mouse embryonic stem cells 3D culture, stem cell derived neuronal culture)
7. Biophysics and Circular Dichroism Spectroscopy (Peptide/Protein assembly, conformation and analysis)
8. Protein structure, expression, conformation and analysis.
9. Mouse procedures (stereotaxis, intraperitoneal injections, inflammatory cell isolations)
10. Biochemical Techniques.