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Teodor T. Postolache, MD

Academic Title:


Primary Appointment:



685 W. Baltimore Street, 930

Phone (Primary):

(410) 706-2323

Education and Training


1971-1976       B.A., 24th Lycee in Bucharest, Romania

1976-1982       Medical School:

Years I-III, Preclinical, Bucharest School of Medicine, Romania

Years IV- VI, Clinical, Cluj-Napoca School of Medicine, Romania

Post Graduate Education

1982-1985       Post-graduate, Medicine, Coltea Hospital and the Bucharest School of Medicine, Romania.

1990-1991       Post-graduate, Cardiology, University of Vienna, Austria

1991-1992       Residency, Internal Medicine and Cardiovascular research, INSERM Hypertension Unit, Broussais Hospital, Paris, France

1992-1996       Residency, Psychiatry, Beth Israel Medical Center, New York, NY; affiliated with Mount Sinai School of Medicine (PGY I-II) and Albert Einstein College of Medicine (PGY III-IV)

1996-1998       Fellowship, NIMH/NIH Bethesda MD



1991                Foreign Medical Graduate Examination in Medical Sciences: Educational Commission for Foreign Medical Graduates certificate

1993                Federal Licensing Examination

1997-2007       Board Certification, American Board of Psychiatry and Neurology, Psychiatry

2005                Behavioral Sleep Medicine, American Academy of Sleep Medicine

2007-2017       Board Recertification, American Board of Psychiatry and Neurology, Psychiatry

2017-2027       Board Recertification, American Board of Psychiatry and Neurology, Psychiatry


Dr. Postolache is a Professor of Psychiatry at the University of Maryland School of Medicine, and a VA Research Investigator with the VA Rocky Mountain MIRECC for Suicide prevention in Denver Colorado and VISN 5 MIRECC in Baltimore, Maryland . He graduated medical school in Romania, with postgraduate studies in Vienna Austria and Paris France , residency training in psychiatry at Beth Israel Medical Center in New York , NY and fellowship in psychobiology at the Section of Biological Rhythms of the National Institutes of Health, Bethesda , Maryland. In his clinical practice in Washington DC he treats patients with mood and anxiety disorders, as well as disturbaces in biological rhythms. He is a clinical expert in seasonal changes in mood, appetite, weight, sleepiness, sleep duration, and sexuality, included in the syndrome of Seasonal Affective Disorder.  In addition to psychopharmacology and counselling, he uses nonpharmacological approaches including light treatment, light avoidance and exposure, cold and heat exposure, food and activity modification. Trained in circadian and seasonal rhythms at the Intramural NIMH, and certified  in Behavioral Sleep Medicine by the American Academy of Sleep Medicine, Dr. Postolache uses integrative approaches to treat jet leg, shift work, and optimizing wake-activity for health and performance. He took part in consulting elite athletes (including World Champions, Olympic medalists, and MLB pitchers) on reciprocally optimizing the alligment of internal rhythms in relationship to timing of training and competion. He is a psychiatrist focused on change, with a head-to-toes approach to the individual patient, with a strong consideration of the physical , chemical and biological environment of the patient and his social networks. He is recognized as a Top Doctor 2017 by the Washingtonian Magazine.

Dr Postolache has been the  teacher of many young trainees, some  of them who became independent investigators, and many of them good clinicians and critical readers of scientific literature. He received several Teaching Awards for postgraduate and physician education.

Dr. Postolache's most important contributions to research include a) associations between seasonal allergen exposure, depression and suicidal behavior b) the  role of the nasal cavity in mental health (smell function, environment-brain communication- molecules translating air pollution, allerges, brain molecular and behavioral changes c) seasonal affective disorder in African American, African immigrants, and the Amish d) immune changes in the brain e) Associations between Toxoplasma gondii, depression and suicidal behavior f) Obesity, neuroinflammation and mental health g) Pregnancy, neuroinflammation, mood changes and suicide risk.

His active research collaborations  and collaborators are geographically diverse, from the Old Order Amish in Lancaster, Pennsylvania, University of South Florida in Tampa, to South Africa, Sweden, Germany and Denmark. His research has been supported by NIMH, NIDDK, NHLB, FDA, NARSAD, and the VA (eg. currently PI on an ongoing multicenter VA Merit Award on Toxoplasma gondii, inflammation, kynurenines and suicidal behavior). He is a Senior Investigator on the Military and Veteran Microbiome consortium for research and education (Denver Co), and a recipient of a Distinguished Investigator Award of the American Foundation for Suicide Prevention. 

Research/Clinical Keywords

1. Seasonal affective disorder 2. Suicidal behavior, suicide 3. Depression 4. Bipolar disorder 5 Binge eating, Obesity (seasonal exacerbation) 6. Neuroimmunology 7. Circadian Sleep Disorder (Jet lag, Shift work, Non-24) 8 Peripartum depression 9. Latent infections: Toxoplasma gondii, CMV, Herpes 10 Allergens and Allergy 11 Special populations and minorities

Highlighted Publications

The most recent publications (as of Nov 2017)  include

1: Groer M, Fuchs D, Duffy A, Louis-Jacques A, D'Agata A, Postolache TT.
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Biol Res Nurs. 2017 Jan 1:1099800417738363. doi: 10.1177/1099800417738363. [Epub
ahead of print] PubMed PMID: 29141444.

2: Amritwar AU, Lowry CA, Brenner LA, Hoisington AJ, Hamilton R, Stiller JW,
Postolache TT. Mental Health in Allergic Rhinitis: Depression and Suicidal
Behavior. Curr Treat Options Allergy. 2017 Mar;4(1):71-97. doi:
10.1007/s40521-017-0110-z. Epub 2017 Mar 25. PubMed PMID: 28966902; PubMed
Central PMCID: PMC5614510.

3: Dimitrova TD, Reeves GM, Snitker S, Lapidus M, Sleemi AR, Balis TG, Manalai P,
Tariq MM, Cabassa JA, Karim NN, Johnson MA, Langenberg P, Rohan KJ, Miller M,
Stiller JW, Postolache TT. Prediction of outcome of bright light treatment in
patients with seasonal affective disorder: Discarding the early response,
confirming a higher atypical balance, and uncovering a higher body mass index at
baseline as predictors of endpoint outcome. J Affect Disord. 2017
Nov;222:126-132. doi: 10.1016/j.jad.2017.06.038. Epub 2017 Jun 22. PubMed PMID:

4. Raheja UK, Fuchs D, Lowry CA, Stephens SH, Pavlovich MA, Mohyuddin H, Yousufi
H, Ryan KA, O'Connell J, Brenner LA, Punzalan C, Hoisington AJ, Nijjar GK, Groer
M, Shuldiner AR, Pollin TI, Stiller JW, Mitchell BD, Postolache TT. Heritability
of plasma neopterin levels in the Old Order Amish. J Neuroimmunol. 2017 Jun
15;307:37-41. doi: 10.1016/j.jneuroim.2017.02.016. Epub 2017 Feb 22. PubMed PMID:

5. Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson ZR,
Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry CA, Renshaw PF, Rujescu D,
Smith EG, Turecki G, Zanos P, Zarate CA Jr, Zunszain PA, Postolache TT. Animal
models to improve our understanding and treatment of suicidal behavior. Transl
Psychiatry. 2017 Apr 11;7(4):e1092. doi: 10.1038/tp.2017.50. Review. PubMed PMID:
28398339; PubMed Central PMCID: PMC5416692.

Additional Publication Citations

1: Groer M, Fuchs D, Duffy A, Louis-Jacques A, D'Agata A, Postolache TT.
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Biol Res Nurs. 2017 Jan 1:1099800417738363. doi: 10.1177/1099800417738363. [Epub
ahead of print] PubMed PMID: 29141444.

2: Amritwar AU, Lowry CA, Brenner LA, Hoisington AJ, Hamilton R, Stiller JW,
Postolache TT. Mental Health in Allergic Rhinitis: Depression and Suicidal
Behavior. Curr Treat Options Allergy. 2017 Mar;4(1):71-97. doi:
10.1007/s40521-017-0110-z. Epub 2017 Mar 25. PubMed PMID: 28966902; PubMed
Central PMCID: PMC5614510.

3: Mathai AJ, Lowry CA, Cook TB, Brenner LA, Brundin L, Groer MW, Peng X,
Giegling I, Hartmann AM, Konte B, Friedl M, Fuchs D, Rujescu D, Postolache TT.
Reciprocal moderation by Toxoplasma gondii seropositivity and blood phenylalanine
- tyrosine ratio of their associations with trait aggression. Pteridines. 2016
Dec;27(3-4):77-85. doi: 10.1515/pterid-2016-0006. Epub 2016 Oct 21. PubMed PMID:
28943719; PubMed Central PMCID: PMC5608274.

4: Mukherjee D, Krishnamurthy VB, Millett CE, Reider A, Can A, Groer M, Fuchs D,
Postolache TT, Saunders EFH. Total sleep time and kynurenine metabolism
associated with mood symptom severity in bipolar disorder. Bipolar Disord. 2017
Aug 23. doi: 10.1111/bdi.12529. [Epub ahead of print] PubMed PMID: 28833866.

5: Hemmings SMJ, Malan-Müller S, van den Heuvel LL, Demmitt BA, Stanislawski MA,
Smith DG, Bohr AD, Stamper CE, Hyde ER, Morton JT, Marotz CA, Siebler PH,
Braspenning M, Van Criekinge W, Hoisington AJ, Brenner LA, Postolache TT, McQueen
MB, Krauter KS, Knight R, Seedat S, Lowry CA. The Microbiome in Posttraumatic
Stress Disorder and Trauma-Exposed Controls: An Exploratory Study. Psychosom Med.
2017 Oct;79(8):936-946. doi: 10.1097/PSY.0000000000000512. PubMed PMID: 28700459.

6: Dimitrova TD, Reeves GM, Snitker S, Lapidus M, Sleemi AR, Balis TG, Manalai P,
Tariq MM, Cabassa JA, Karim NN, Johnson MA, Langenberg P, Rohan KJ, Miller M,
Stiller JW, Postolache TT. Prediction of outcome of bright light treatment in
patients with seasonal affective disorder: Discarding the early response,
confirming a higher atypical balance, and uncovering a higher body mass index at
baseline as predictors of endpoint outcome. J Affect Disord. 2017
Nov;222:126-132. doi: 10.1016/j.jad.2017.06.038. Epub 2017 Jun 22. PubMed PMID:

7: Millett CE, Mukherjee D, Reider A, Can A, Groer M, Fuchs D, Postolache TT,
Kelleher SL, Saunders EFH. Peripheral zinc and neopterin concentrations are
associated with mood severity in bipolar disorder in a gender-specific manner.
Psychiatry Res. 2017 Sep;255:52-58. doi: 10.1016/j.psychres.2017.05.022. Epub
2017 May 17. PubMed PMID: 28528241; PubMed Central PMCID: PMC5545151.

8: Raheja UK, Fuchs D, Lowry CA, Stephens SH, Pavlovich MA, Mohyuddin H, Yousufi
H, Ryan KA, O'Connell J, Brenner LA, Punzalan C, Hoisington AJ, Nijjar GK, Groer
M, Shuldiner AR, Pollin TI, Stiller JW, Mitchell BD, Postolache TT. Heritability
of plasma neopterin levels in the Old Order Amish. J Neuroimmunol. 2017 Jun
15;307:37-41. doi: 10.1016/j.jneuroim.2017.02.016. Epub 2017 Feb 22. PubMed PMID:

9: Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson ZR,
Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry CA, Renshaw PF, Rujescu D,
Smith EG, Turecki G, Zanos P, Zarate CA Jr, Zunszain PA, Postolache TT. Animal
models to improve our understanding and treatment of suicidal behavior. Transl
Psychiatry. 2017 Apr 11;7(4):e1092. doi: 10.1038/tp.2017.50. Review. PubMed PMID:
28398339; PubMed Central PMCID: PMC5416692.

10: Andorko ND, Mittal V, Thompson E, Denenny D, Epstein G, Demro C, Wilson C,
Sun S, Klingaman EA, DeVylder J, Oh H, Postolache TT, Reeves GM, Schiffman J. The
association between sleep dysfunction and psychosis-like experiences among
college students. Psychiatry Res. 2017 Feb;248:6-12. doi:
10.1016/j.psychres.2016.12.009. Epub 2016 Dec 11. PubMed PMID: 27988426.

11: Stamper CE, Hoisington AJ, Gomez OM, Halweg-Edwards AL, Smith DG, Bates KL,
Kinney KA, Postolache TT, Brenner LA, Rook GA, Lowry CA. The Microbiome of the
Built Environment and Human Behavior: Implications for Emotional Health and
Well-Being in Postmodern Western Societies. Int Rev Neurobiol. 2016;131:289-323.
doi: 10.1016/bs.irn.2016.07.006. Epub 2016 Sep 6. Review. PubMed PMID: 27793224.

12: Clark SM, Pocivavsek A, Nicholson JD, Notarangelo FM, Langenberg P, McMahon
RP, Kleinman JE, Hyde TM, Stiller J, Postolache TT, Schwarcz R, Tonelli LH.
Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal
cortex of depressed individuals. J Psychiatry Neurosci. 2016 Oct;41(6):386-394.
PubMed PMID: 27070351; PubMed Central PMCID: PMC5082509.

13: Hsu PC, Yolken RH, Postolache TT, Beckie TM, Munro CL, Groer MW. Association
of Depressed Mood With Herpes Simplex Virus-2 Immunoglobulin-G Levels in
Pregnancy. Psychosom Med. 2016 Oct;78(8):966-972. PubMed PMID: 27490851; PubMed
Central PMCID: PMC5067962.

14: Okusaga O, Fuchs D, Reeves G, Giegling I, Hartmann AM, Konte B, Friedl M,
Groer M, Cook TB, Stearns-Yoder KA, Pandey JP, Kelly DL, Hoisington AJ, Lowry CA,
Eaton WW, Brenner LA, Rujescu D, Postolache TT. Kynurenine and Tryptophan Levels
in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G
Antibodies. Psychosom Med. 2016 Oct;78(8):931-939. PubMed PMID: 27359171; PubMed
Central PMCID: PMC5338470.

15: Reber SO, Langgartner D, Foertsch S, Postolache TT, Brenner LA, Guendel H,
Lowry CA. Chronic subordinate colony housing paradigm: A mouse model for
mechanisms of PTSD vulnerability, targeted prevention, and treatment-2016 Curt
Richter Award Paper. Psychoneuroendocrinology. 2016 Dec;74:221-230. doi:
10.1016/j.psyneuen.2016.08.031. Epub 2016 Sep 9. Review. PubMed PMID: 27676359.

16: Mathai AJ, Kanwar J, Okusaga O, Fuchs D, Lowry CA, Peng X, Giegling I,
Hartmann AM, Konte B, Friedl M, Gragnoli C, Reeves GM, Groer MW, Rosenthal RN,
Rujescu D, Postolache TT. Blood Levels of Monoamine Precursors and Smoking in
Patients with Schizophrenia. Front Public Health. 2016 Aug 30;4:182. doi:
10.3389/fpubh.2016.00182. eCollection 2016. PubMed PMID: 27626030; PubMed Central
PMCID: PMC5003942.

17: Lund-Sørensen H, Benros ME, Madsen T, Sørensen HJ, Eaton WW, Postolache TT,
Nordentoft M, Erlangsen A. A Nationwide Cohort Study of the Association Between
Hospitalization With Infection and Risk of Death by Suicide. JAMA Psychiatry.
2016 Sep 1;73(9):912-9. doi: 10.1001/jamapsychiatry.2016.1594. PubMed PMID:

18: Brundin L, Sellgren CM, Lim CK, Grit J, Pålsson E, Landén M, Samuelsson M,
Lundgren K, Brundin P, Fuchs D, Postolache TT, Traskman-Bendz L, Guillemin GJ,
Erhardt S. An enzyme in the kynurenine pathway that governs vulnerability to
suicidal behavior by regulating excitotoxicity and neuroinflammation. Transl
Psychiatry. 2016 Aug 2;6(8):e865. doi: 10.1038/tp.2016.133. PubMed PMID:
27483383; PubMed Central PMCID: PMC5022080.

19: Lowry CA, Smith DG, Siebler PH, Schmidt D, Stamper CE, Hassell JE Jr,
Yamashita PS, Fox JH, Reber SO, Brenner LA, Hoisington AJ, Postolache TT, Kinney
KA, Marciani D, Hernandez M, Hemmings SM, Malan-Muller S, Wright KP, Knight R,
Raison CL, Rook GA. The Microbiota, Immunoregulation, and Mental Health:
Implications for Public Health. Curr Environ Health Rep. 2016 Sep;3(3):270-86.
doi: 10.1007/s40572-016-0100-5. Review. PubMed PMID: 27436048.

20: Chiappelli J, Postolache TT, Kochunov P, Rowland LM, Wijtenburg SA, Shukla
DK, Tagamets M, Du X, Savransky A, Lowry CA, Can A, Fuchs D, Hong LE. Tryptophan
Metabolism and White Matter Integrity in Schizophrenia. Neuropsychopharmacology.
2016 Sep;41(10):2587-95. doi: 10.1038/npp.2016.66. Epub 2016 May 4. PubMed PMID:
27143602; PubMed Central PMCID: PMC4987857.

21: Gragnoli C, Reeves GM, Reazer J, Postolache TT. Dopamine-prolactin pathway
potentially contributes to the schizophrenia and type 2 diabetes comorbidity.
Transl Psychiatry. 2016 Apr 19;6:e785. doi: 10.1038/tp.2016.50. Review. PubMed
PMID: 27093067; PubMed Central PMCID: PMC4872408.

22: Coccaro EF, Lee R, Groer MW, Can A, Coussons-Read M, Postolache TT.
Toxoplasma gondii infection: relationship with aggression in psychiatric
subjects. J Clin Psychiatry. 2016 Mar;77(3):334-41. doi: 10.4088/JCP.14m09621.
PubMed PMID: 27046307.

23: Hoisington AJ, Brenner LA, Kinney KA, Postolache TT, Lowry CA. The microbiome
of the built environment and mental health. Microbiome. 2015 Dec 17;3:60. doi:
10.1186/s40168-015-0127-0. Review. PubMed PMID: 26674771; PubMed Central PMCID:

24: Okusaga O, Duncan E, Langenberg P, Brundin L, Fuchs D, Groer MW, Giegling I,
Stearns-Yoder KA, Hartmann AM, Konte B, Friedl M, Brenner LA, Lowry CA, Rujescu
D, Postolache TT. Combined Toxoplasma gondii seropositivity and high blood
kynurenine--Linked with nonfatal suicidal self-directed violence in patients with
schizophrenia. J Psychiatr Res. 2016 Jan;72:74-81. doi:
10.1016/j.jpsychires.2015.10.002. Epub 2015 Oct 9. PubMed PMID: 26594873.

25: Rohan KJ, Meyerhoff J, Ho SY, Evans M, Postolache TT, Vacek PM. Outcomes One
and Two Winters Following Cognitive-Behavioral Therapy or Light Therapy for
Seasonal Affective Disorder. Am J Psychiatry. 2016 Mar 1;173(3):244-51. doi:
10.1176/appi.ajp.2015.15060773. Epub 2015 Nov 5. PubMed PMID: 26539881; PubMed
Central PMCID: PMC4939843.

26: Kochunov P, Fu M, Nugent K, Wright SN, Du X, Muellerklein F, Morrissey M,
Eskandar G, Shukla DK, Jahanshad N, Thompson PM, Patel B, Postolache TT, Strauss
KA, Shuldiner AR, Mitchell BD, Hong LE. Heritability of complex white matter
diffusion traits assessed in a population isolate. Hum Brain Mapp. 2016
Feb;37(2):525-35. doi: 10.1002/hbm.23047. Epub 2015 Nov 5. PubMed PMID: 26538488;
PubMed Central PMCID: PMC4718876.

27: Brundin L, Erhardt S, Bryleva EY, Achtyes ED, Postolache TT. The role of
inflammation in suicidal behaviour. Acta Psychiatr Scand. 2015
Sep;132(3):192-203. doi: 10.1111/acps.12458. Review. PubMed PMID: 26256862;
PubMed Central PMCID: PMC4531386.

28: Raheja UK, Fuchs D, Giegling I, Brenner LA, Rovner SF, Mohyuddin I, Weghuber
D, Mangge H, Rujescu D, Postolache TT. In psychiatrically healthy individuals,
overweight women but not men have lower tryptophan levels. Pteridines. 2015
Jun;26(2):79-84. PubMed PMID: 26251562; PubMed Central PMCID: PMC4523236.

29: Cook TB, Reeves GM, Teufel J, Postolache TT. Persistence of racial
disparities in prescription of first-generation antipsychotics in the USA.
Pharmacoepidemiol Drug Saf. 2015 Nov;24(11):1197-206. doi: 10.1002/pds.3819. Epub
2015 Jul 1. PubMed PMID: 26132170.

30: Duffy AR, Beckie TM, Brenner LA, Beckstead JW, Seyfang A, Postolache TT,
Groer MW. Relationship Between Toxoplasma gondii and Mood Disturbance in Women
Veterans. Mil Med. 2015 Jun;180(6):621-5. doi: 10.7205/MILMED-D-14-00488. PubMed
PMID: 26032378.

31: Rohan KJ, Mahon JN, Evans M, Ho SY, Meyerhoff J, Postolache TT, Vacek PM.
Randomized Trial of Cognitive-Behavioral Therapy Versus Light Therapy for
Seasonal Affective Disorder: Acute Outcomes. Am J Psychiatry. 2015 Sep
1;172(9):862-9. doi: 10.1176/appi.ajp.2015.14101293. Epub 2015 Apr 10. PubMed
PMID: 25859764.

32: Uzoma HN, Reeves GM, Langenberg P, Khabazghazvini B, Balis TG, Johnson MA,
Sleemi A, Scrandis DA, Zimmerman SA, Vaswani D, Nijjar GV, Cabassa J, Lapidus M,
Rohan KJ, Postolache TT. Light treatment for seasonal Winter depression in
African-American vs Caucasian outpatients. World J Psychiatry. 2015 Mar
22;5(1):138-46. doi: 10.5498/wjp.v5.i1.138. PubMed PMID: 25815263; PubMed Central
PMCID: PMC4369543.

33: Byrne EM; Psychiatric Genetics Consortium Major Depressive Disorder Working
Group, Raheja UK, Stephens SH, Heath AC, Madden PA, Vaswani D, Nijjar GV, Ryan
KA, Youssufi H, Gehrman PR, Shuldiner AR, Martin NG, Montgomery GW, Wray NR,
Nelson EC, Mitchell BD, Postolache TT. Seasonality shows evidence for polygenic
architecture and genetic correlation with schizophrenia and bipolar disorder. J
Clin Psychiatry. 2015 Feb;76(2):128-34. doi: 10.4088/JCP.14m08981. PubMed PMID:
25562672; PubMed Central PMCID: PMC4527536.

34: Mangge H, Zelzer S, Meinitzer A, Stelzer I, Schnedl WJ, Weghuber D, Fuchs D,
Postolache TT, Aigner E, Datz C, Reininghaus EZ. 25OH-Vitamin D3 Levels in
Obesity and Metabolic Syndrome-Unaltered in Young and not Correlated to Carotid
IMT in All Ages. Curr Pharm Des. 2015;21(17):2243-9. PubMed PMID: 25557634.

35: Zhang L, Evans DS, Raheja UK, Stephens SH, Stiller JW, Reeves GM, Johnson M,
Ryan KA, Weizel N, Vaswani D, McLain H, Shuldiner AR, Mitchell BD, Hsueh WC,
Snitker S, Postolache TT. Chronotype and seasonality: morningness is associated
with lower seasonal mood and behavior changes in the Old Order Amish. J Affect
Disord. 2015 Mar 15;174:209-14. doi: 10.1016/j.jad.2014.11.039. Epub 2014 Nov 28.
PubMed PMID: 25527990; PubMed Central PMCID: PMC4356625.

36: Okusaga O, Hamilton RG, Can A, Igbide A, Giegling I, Hartmann AM, Konte B,
Friedl M, Reeves GM, Rujescu D, Postolache TT. Phadiatop Seropositivity in
Schizophrenia Patients and Controls: A Preliminary Study. AIMS Public Health.
2014 Mar 24;1(2):43-50. PubMed PMID: 25346942; PubMed Central PMCID: PMC4205967.

37: Cook TB, Brenner LA, Cloninger CR, Langenberg P, Igbide A, Giegling I,
Hartmann AM, Konte B, Friedl M, Brundin L, Groer MW, Can A, Rujescu D, Postolache
TT. "Latent" infection with Toxoplasma gondii: association with trait aggression
and impulsivity in healthy adults. J Psychiatr Res. 2015 Jan;60:87-94. doi:
10.1016/j.jpsychires.2014.09.019. Epub 2014 Sep 28. PubMed PMID: 25306262.

38: Chiappelli J, Kochunov P, DeRiso K, Thangavelu K, Sampath H, Muellerklein F,
Nugent KL, Postolache TT, Carpenter WT Jr, Hong LE. Testing trait depression as a
potential clinical domain in schizophrenia. Schizophr Res. 2014 Oct;159(1):243-8.
doi: 10.1016/j.schres.2014.08.003. Epub 2014 Aug 27. PubMed PMID: 25171855;
PubMed Central PMCID: PMC4177287.

39: Stiller JW, Yu SS, Brenner LA, Langenberg P, Scrofani P, Pannella P, Hsu EB,
Roberts DW, Monsell RM, Binks SW 3rd, Guzman A, Postolache TT. Sparring and
neurological function in professional boxers. Front Public Health. 2014 Jul
21;2:69. doi: 10.3389/fpubh.2014.00069. eCollection 2014. PubMed PMID: 25101253;
PubMed Central PMCID: PMC4104643.

40: Mangge H, Stelzer I, Reininghaus EZ, Weghuber D, Postolache TT, Fuchs D.
Disturbed tryptophan metabolism in cardiovascular disease. Curr Med Chem. 2014
Jun;21(17):1931-7. Review. PubMed PMID: 24606499; PubMed Central PMCID:

41: Okusaga O, Muravitskaja O, Fuchs D, Ashraf A, Hinman S, Giegling I, Hartmann
AM, Konte B, Friedl M, Schiffman J, Hong E, Reeves G, Groer M, Dantzer R, Rujescu
D, Postolache TT. Elevated levels of plasma phenylalanine in schizophrenia: a
guanosine triphosphate cyclohydrolase-1 metabolic pathway abnormality? PLoS One.
2014 Jan 21;9(1):e85945. doi: 10.1371/journal.pone.0085945. eCollection 2014.
PubMed PMID: 24465804; PubMed Central PMCID: PMC3897774.

42: Reeves GM, Mazaheri S, Snitker S, Langenberg P, Giegling I, Hartmann AM,
Konte B, Friedl M, Okusaga O, Groer MW, Mangge H, Weghuber D, Allison DB, Rujescu
D, Postolache TT. A Positive Association between T. gondii Seropositivity and
Obesity. Front Public Health. 2013 Dec 25;1:73. doi: 10.3389/fpubh.2013.00073.
eCollection 2013. PubMed PMID: 24400300; PubMed Central PMCID: PMC3872312.

43: Mangge H, Weghuber D, Prassl R, Haara A, Schnedl W, Postolache TT, Fuchs D.
The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a Bystander
than a Player? Curr Vasc Pharmacol. 2015;13(3):392-8. Review. PubMed PMID:

44: Warren KR, Postolache TT, Groer ME, Pinjari O, Kelly DL, Reynolds MA. Role of
chronic stress and depression in periodontal diseases. Periodontol 2000. 2014
Feb;64(1):127-38. doi: 10.1111/prd.12036. Review. PubMed PMID: 24320960.

45: Kanwar J, Okusaga O, Giegling I, Konte B, Vaswani D, Sleemi A, Vaswani R,
Hartmann AM, Friedl M, Hong LE, Reeves G, Stephens S, Dixon L, Rujescu D,
Postolache TT. In patients with schizophrenia, non-fatal suicidal self-directed
violence is positively associated with present but not past smoking. Schizophr
Res. 2013 Sep;149(1-3):194-5. doi: 10.1016/j.schres.2013.06.010. Epub 2013 Jun
27. PubMed PMID: 23810528.

46: Qin P, Waltoft BL, Mortensen PB, Postolache TT. Suicide risk in relation to
air pollen counts: a study based on data from Danish registers. BMJ Open. 2013
May 28;3(5). pii: e002462. doi: 10.1136/bmjopen-2012-002462. PubMed PMID:
23793651; PubMed Central PMCID: PMC3669712.

47: Patel F, Postolache N, Mohyuddin H, Vaswani D, Balis T, Raheja UK, Postolache
TT. Seasonality patterns of mood and behavior in the Old Order Amish. Int J
Disabil Hum Dev. 2012 Dec;12(1):53-60. PubMed PMID: 23667796; PubMed Central
PMCID: PMC3648994.

48: Postolache TT, Cook TB. Is latent infection with Toxoplasma gondii a risk
factor for suicidal behavior? Expert Rev Anti Infect Ther. 2013 Apr;11(4):339-42.
doi: 10.1586/eri.13.20. PubMed PMID: 23566142.

49: Kuehner RM, Vaswani D, Raheja UK, Sleemi A, Yousufi H, Mohyuddin H,
Postolache N, Nijjar GV, Postolache TT. Test-retest reliability of the Seasonal
Pattern Assessment Questionnaire in Old Order Amish. Int J Disabil Hum Dev. 2013
Feb;12(1):87-90. PubMed PMID: 23565353; PubMed Central PMCID: PMC3615025.

50: Weber NS, Fisher JA, Cowan DN, Postolache TT, Larsen RA, Niebuhr DW.
Descriptive epidemiology and underlying psychiatric disorders among
hospitalizations with self-directed violence. PLoS One. 2013;8(3):e59818. doi:
10.1371/journal.pone.0059818. Epub 2013 Mar 26. PubMed PMID: 23555791; PubMed
Central PMCID: PMC3608546.

51: Rohan KJ, Evans M, Mahon JN, Sitnikov L, Ho SY, Nillni YI, Postolache TT,
Vacek PM. Cognitive-behavioral therapy vs. light therapy for preventing winter
depression recurrence: study protocol for a randomized controlled trial. Trials.
2013 Mar 21;14:82. doi: 10.1186/1745-6215-14-82. PubMed PMID: 23514124; PubMed
Central PMCID: PMC3652773.

52: Mangge H, Zelzer S, Puerstner P, Schnedl WJ, Reeves G, Postolache TT,
Weghuber D. Uric acid best predicts metabolically unhealthy obesity with
increased cardiovascular risk in youth and adults. Obesity (Silver Spring). 2013
Jan;21(1):E71-7. doi: 10.1002/oby.20061. Epub 2013 Jan 29. PubMed PMID: 23401248.

53: Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M,
Lundberg K, Postolache TT, Träskman-Bendz L, Guillemin GJ, Brundin L. Connecting
inflammation with glutamate agonism in suicidality. Neuropsychopharmacology. 2013
Apr;38(5):743-52. doi: 10.1038/npp.2012.248. Epub 2012 Dec 3. PubMed PMID:
23299933; PubMed Central PMCID: PMC3671988.

54: Okusaga O, Yolken RH, Langenberg P, Sleemi A, Kelly DL, Vaswani D, Giegling
I, Hartmann AM, Konte B, Friedl M, Mohyuddin F, Groer MW, Rujescu D, Postolache
TT. Elevated gliadin antibody levels in individuals with schizophrenia. World J
Biol Psychiatry. 2013 Sep;14(7):509-15. doi: 10.3109/15622975.2012.747699. Epub
2013 Jan 3. PubMed PMID: 23282016.

55: Sleemi A, Johnson MA, Rohan KJ, Okusaga O, Adediran T, Uzoma H, Walsh C,
Reeves G, Postolache TT. Reading increases ocular illuminance during light
treatment. Int J Adolesc Med Health. 2012;24(4):339-42. doi:
10.1515/ijamh.2012.049. PubMed PMID: 23183735; PubMed Central PMCID: PMC5600184.

56: Raheja UK, Stephens SH, Mitchell BD, Rohan KJ, Vaswani D, Balis TG, Nijjar
GV, Sleemi A, Pollin TI, Ryan K, Reeves GM, Weitzel N, Morrissey M, Yousufi H,
Langenberg P, Shuldiner AR, Postolache TT. Seasonality of mood and behavior in
the Old Order Amish. J Affect Disord. 2013 May;147(1-3):112-7. doi:
10.1016/j.jad.2012.10.019. Epub 2012 Nov 17. PubMed PMID: 23164460; PubMed
Central PMCID: PMC3606685.

57: Okusaga O, Postolache TT. Toxoplasma gondii, the Immune System, and Suicidal
Behavior. In: Dwivedi Y, editor. The Neurobiological Basis of Suicide. Boca Raton
(FL): CRC Press/Taylor & Francis; 2012. Chapter 19.
PubMed PMID: 23035283.

58: Zhang Y, Träskman-Bendz L, Janelidze S, Langenberg P, Saleh A, Constantine N,
Okusaga O, Bay-Richter C, Brundin L, Postolache TT. Toxoplasma gondii
immunoglobulin G antibodies and nonfatal suicidal self-directed violence. J Clin
Psychiatry. 2012 Aug;73(8):1069-76. doi: 10.4088/JCP.11m07532. Epub 2012 Jul 10.
PubMed PMID: 22938818.

59: Sublette ME, Postolache TT. Neuroinflammation and depression: the role of
indoleamine 2,3-dioxygenase (IDO) as a molecular pathway. Psychosom Med. 2012
Sep;74(7):668-72. doi: 10.1097/PSY.0b013e318268de9f. Epub 2012 Aug 24. PubMed
PMID: 22923699.

60: Pedersen MG, Mortensen PB, Norgaard-Pedersen B, Postolache TT. Toxoplasma
gondii infection and self-directed violence in mothers. Arch Gen Psychiatry. 2012
Nov;69(11):1123-30. PubMed PMID: 22752117.

61: Woo JM, Okusaga O, Postolache TT. Seasonality of suicidal behavior. Int J
Environ Res Public Health. 2012 Feb;9(2):531-47. doi: 10.3390/ijerph9020531. Epub
2012 Feb 14. Review. PubMed PMID: 22470308; PubMed Central PMCID: PMC3315262.

62: Manalai P, Hamilton RG, Langenberg P, Kosisky SE, Lapidus M, Sleemi A,
Scrandis D, Cabassa JA, Rogers CA, Regenold WT, Dickerson F, Vittone BJ, Guzman
A, Balis T, Tonelli LH, Postolache TT. Pollen-specific immunoglobulin E
positivity is associated with worsening of depression scores in bipolar disorder
patients during high pollen season. Bipolar Disord. 2012 Feb;14(1):90-8. doi:
10.1111/j.1399-5618.2012.00983.x. PubMed PMID: 22329476; PubMed Central PMCID:

63: Reeves GM, Rohan KJ, Langenberg P, Snitker S, Postolache TT. Calibration of
response and remission cut-points on the Beck Depression Inventory-Second Edition
for monitoring seasonal affective disorder treatment outcomes. J Affect Disord.
2012 Apr;138(1-2):123-7. doi: 10.1016/j.jad.2011.12.003. Epub 2012 Jan 25. PubMed
PMID: 22277151; PubMed Central PMCID: PMC5270383.

64: Stelzer I, Zelzer S, Raggam RB, Prüller F, Truschnig-Wilders M, Meinitzer A,
Schnedl WJ, Horejsi R, Möller R, Weghuber D, Reeves G, Postolache TT, Mangge H.
Link between leptin and interleukin-6 levels in the initial phase of obesity
related inflammation. Transl Res. 2012 Feb;159(2):118-24. doi:
10.1016/j.trsl.2011.10.001. Epub 2011 Nov 4. PubMed PMID: 22243796.

65: Reeves GM, Nijjar GV, Langenberg P, Johnson MA, Khabazghazvini B, Sleemi A,
Vaswani D, Lapidus M, Manalai P, Tariq M, Acharya M, Cabassa J, Snitker S,
Postolache TT. Improvement in depression scores after 1 hour of light therapy
treatment in patients with seasonal affective disorder. J Nerv Ment Dis. 2012
Jan;200(1):51-5. doi: 10.1097/NMD.0b013e31823e56ca. PubMed PMID: 22210362; PubMed
Central PMCID: PMC5336550.

66: Tariq MM, Streeten EA, Smith HA, Sleemi A, Khabazghazvini B, Vaswani D,
Postolache TT. Vitamin D: a potential role in reducing suicide risk? Int J
Adolesc Med Health. 2011;23(3):157-65. Review. PubMed PMID: 22191178.

67: Woo JM, Gibbons RD, Rogers CA, Qin P, Kim JB, Roberts DW, Noh ES, Mann JJ,
Postolache TT. Pollen counts and suicide rates. Association not replicated. Acta
Psychiatr Scand. 2012 Feb;125(2):168-75. doi: 10.1111/j.1600-0447.2011.01813.x.
Epub 2011 Dec 19. PubMed PMID: 22176539.

68: Woo JM, Gibbons RD, Qin P, Komarow H, Kim JB, Rogers CA, Mann JJ, Postolache
TT. Suicide and prescription rates of intranasal corticosteroids and nonsedating
antihistamines for allergic rhinitis: an ecological study. J Clin Psychiatry.
2011 Oct;72(10):1423-8. doi: 10.4088/JCP.10m06765. PubMed PMID: 22075102.

69: Okusaga O, Langenberg P, Sleemi A, Vaswani D, Giegling I, Hartmann AM, Konte
B, Friedl M, Groer MW, Yolken RH, Rujescu D, Postolache TT. Toxoplasma gondii
antibody titers and history of suicide attempts in patients with schizophrenia.
Schizophr Res. 2011 Dec;133(1-3):150-5. doi: 10.1016/j.schres.2011.08.006. Epub
2011 Sep 3. PubMed PMID: 21890329.

70: Ling VJ, Lester D, Mortensen PB, Langenberg PW, Postolache TT. Toxoplasma
gondii seropositivity and suicide rates in women. J Nerv Ment Dis. 2011
Jul;199(7):440-4. doi: 10.1097/NMD.0b013e318221416e. PubMed PMID: 21716055;
PubMed Central PMCID: PMC3128543.

71: Sublette ME, Galfalvy HC, Fuchs D, Lapidus M, Grunebaum MF, Oquendo MA, Mann
JJ, Postolache TT. Plasma kynurenine levels are elevated in suicide attempters
with major depressive disorder. Brain Behav Immun. 2011 Aug;25(6):1272-8. doi:
10.1016/j.bbi.2011.05.002. Epub 2011 May 14. PubMed PMID: 21605657; PubMed
Central PMCID: PMC3468945.

72: Reeves G, Blaisdell C, Lapidus M, Langenberg P, Ramagopal M, Cabassa J,
Bollinger MB, Nijjar GV, Anthony B, Achenbach T, Postolache TT. Sleep
architecture and behavioral abnormalities in children and adolescents. Int J
Adolesc Med Health. 2010 Oct-Dec;22(4):535-45. PubMed PMID: 21404884; PubMed
Central PMCID: PMC5270380.

73: Groër MW, Yolken RH, Xiao JC, Beckstead JW, Fuchs D, Mohapatra SS, Seyfang A,
Postolache TT. Prenatal depression and anxiety in Toxoplasma gondii-positive
women. Am J Obstet Gynecol. 2011 May;204(5):433.e1-7. doi:
10.1016/j.ajog.2011.01.004. Epub 2011 Feb 23. PubMed PMID: 21345406; PubMed
Central PMCID: PMC3144318.

74: Qin P, Mortensen PB, Waltoft BL, Postolache TT. Allergy is associated with
suicide completion with a possible mediating role of mood disorder - a
population-based study. Allergy. 2011 May;66(5):658-64. doi:
10.1111/j.1398-9995.2010.02523.x. Epub 2010 Dec 8. PubMed PMID: 21143241; PubMed
Central PMCID: PMC3482428.

75: Okusaga O, Yolken RH, Langenberg P, Lapidus M, Arling TA, Dickerson FB,
Scrandis DA, Severance E, Cabassa JA, Balis T, Postolache TT. Association of
seropositivity for influenza and coronaviruses with history of mood disorders and
suicide attempts. J Affect Disord. 2011 Apr;130(1-2):220-5. doi:
10.1016/j.jad.2010.09.029. Epub 2010 Oct 27. PubMed PMID: 21030090; PubMed
Central PMCID: PMC3043161.

76: Virk G, Reeves G, Rosenthal NE, Sher L, Postolache TT. Short exposure to
light treatment improves depression scores in patients with seasonal affective
disorder: A brief report. Int J Disabil Hum Dev. 2009 Jul;8(3):283-286. PubMed
PMID: 20686638; PubMed Central PMCID: PMC2913518.

77: Roecklein KA, Rohan KJ, Postolache TT. Is seasonal affective disorder a
bipolar variant? Curr Psychiatr. 2010 Feb;9(2):42-54. PubMed PMID: 20495687;
PubMed Central PMCID: PMC2874241.

78: Guzmán A, Koons A, Postolache TT. Suicidal behavior in Latinos: focus on the
youth. Int J Adolesc Med Health. 2009 Oct-Dec;21(4):431-9. Review. PubMed PMID:

79: Tonelli LH, Postolache TT. Airborne inflammatory factors: "from the nose to
the brain". Front Biosci (Schol Ed). 2010 Jan 1;2:135-52. Review. PubMed PMID:

80: Fang BJ, Tonelli LH, Soriano JJ, Postolache TT. Disturbed sleep: linking
allergic rhinitis, mood and suicidal behavior. Front Biosci (Schol Ed). 2010 Jan
1;2:30-46. PubMed PMID: 20036927.

81: Arling TA, Yolken RH, Lapidus M, Langenberg P, Dickerson FB, Zimmerman SA,
Balis T, Cabassa JA, Scrandis DA, Tonelli LH, Postolache TT. Toxoplasma gondii
antibody titers and history of suicide attempts in patients with recurrent mood
disorders. J Nerv Ment Dis. 2009 Dec;197(12):905-8. doi:
10.1097/NMD.0b013e3181c29a23. PubMed PMID: 20010026.

82: Postolache TT, Mortensen PB, Tonelli LH, Jiao X, Frangakis C, Soriano JJ, Qin
P. Seasonal spring peaks of suicide in victims with and without prior history of
hospitalization for mood disorders. J Affect Disord. 2010 Feb;121(1-2):88-93.
doi: 10.1016/j.jad.2009.05.015. Epub 2009 Jun 16. PubMed PMID: 19535151; PubMed
Central PMCID: PMC2837087.

83: Manalai P, Woo JM, Postolache TT. Suicidality and montelukast. Expert Opin
Drug Saf. 2009 May;8(3):273-82. doi: 10.1517/14740330902932688. Review. PubMed
PMID: 19505261.

84: Tonelli LH, Katz M, Kovacsics CE, Gould TD, Joppy B, Hoshino A, Hoffman G,
Komarow H, Postolache TT. Allergic rhinitis induces anxiety-like behavior and
altered social interaction in rodents. Brain Behav Immun. 2009 Aug;23(6):784-93.
doi: 10.1016/j.bbi.2009.02.017. Epub 2009 Mar 5. PubMed PMID: 19268702; PubMed
Central PMCID: PMC2743459.

85: Kewalramani A, Bollinger ME, Postolache TT. Asthma and Mood Disorders. Int J
Child Health Hum Dev. 2008;1(2):115-123. PubMed PMID: 19180246; PubMed Central
PMCID: PMC2631932.

86: Postolache TT, Roberts DW, Langenberg P, Muravitskaja O, Stiller JW, Hamilton
RG, Tonelli LH. Allergen Specific IgE, Number and Timing of Past Suicide
Attempts, and Instability in Patients with Recurrent Mood Disorders. Int J Child
Health Hum Dev. 2008;1(3):297-304. PubMed PMID: 19043595; PubMed Central PMCID:

87: Reeves GM, Postolache TT, Snitker S. Childhood Obesity and Depression:
Connection between these Growing Problems in Growing Children. Int J Child Health
Hum Dev. 2008 Aug;1(2):103-114. PubMed PMID: 18941545; PubMed Central PMCID:

88: Scrandis DA, Langenberg P, Tonelli LH, Sheikh TM, Manogura AC, Alberico LA,
Hermanstyne T, Fuchs D, Mighty H, Hasday JD, Boteva K, Postolache TT. Prepartum
Depressive Symptoms Correlate Positively with C-Reactive Protein Levels and
Negatively with Tryptophan Levels: A Preliminary Report. Int J Child Health Hum
Dev. 2008 Aug;1(2):167-174. PubMed PMID: 18924606; PubMed Central PMCID:

89: Woo JM, Postolache TT. The impact of work environment on mood disorders and
suicide: Evidence and implications. Int J Disabil Hum Dev. 2008;7(2):185-200.
PubMed PMID: 18836547; PubMed Central PMCID: PMC2559945.

90: Bikson M, Bulow P, Stiller JW, Datta A, Battaglia F, Karnup SV, Postolache
TT. Transcranial direct current stimulation for major depression: a general
system for quantifying transcranial electrotherapy dosage. Curr Treat Options
Neurol. 2008 Sep;10(5):377-85. PubMed PMID: 18782510.

91: Postolache TT, Komarow H, Tonelli LH. Allergy: a risk factor for suicide?
Curr Treat Options Neurol. 2008 Sep;10(5):363-76. PubMed PMID: 18782509; PubMed
Central PMCID: PMC2592251.

92: McCloskey DJ, Postolache TT, Vittone BJ, Nghiem KL, Monsale JL, Wesley RA,
Rick ME. Selective serotonin reuptake inhibitors: measurement of effect on
platelet function. Transl Res. 2008 Mar;151(3):168-72. doi:
10.1016/j.trsl.2007.10.004. Epub 2007 Nov 20. PubMed PMID: 18279816; PubMed
Central PMCID: PMC2391274.

93: Postolache TT, Lapidus M, Sander ER, Langenberg P, Hamilton RG, Soriano JJ,
McDonald JS, Furst N, Bai J, Scrandis DA, Cabassa JA, Stiller JW, Balis T, Guzman
A, Togias A, Tonelli LH. Changes in allergy symptoms and depression scores are
positively correlated in patients with recurrent mood disorders exposed to
seasonal peaks in aeroallergens. ScientificWorldJournal. 2007 Dec 17;7:1968-77.
doi: 10.1100/tsw.2007.286. PubMed PMID: 18167612; PubMed Central PMCID:

94: Tonelli LH, Hoshino A, Katz M, Postolache TT. Acute Stress Promotes
Aggressive-Like Behavior in Rats Made Allergic to Tree Pollen. Int J Child Health
Hum Dev. 2008;1(3):305-312. PubMed PMID: 20622938; PubMed Central PMCID:

95: Balis T, Postolache TT. Ethnic Differences in Adolescent Suicide in the
United States. Int J Child Health Hum Dev. 2008 Jan 1;1(3):281-296. PubMed PMID:
20352033; PubMed Central PMCID: PMC2845977.

96: Postolache TT, Langenberg P, Zimmerman SA, Lapidus M, Komarow H, McDonald JS,
Furst N, Dzhanashvili N, Scrandis D, Bai J, Postolache B, Soriano JJ, Vittone B,
Guzman A, Woo JM, Stiller J, Hamilton RG, Tonelli LH. Changes in Severity of
Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent
Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens. Int J Child
Health Hum Dev. 2008;1(3):313-322. PubMed PMID: 19430577; PubMed Central PMCID:

97: Boker SM, Leibenluft E, Deboeck PR, Virk G, Postolache TT. Mood Oscillations
and Coupling Between Mood and Weather in Patients with Rapid Cycling Bipolar
Disorder. Int J Child Health Hum Dev. 2008;1(2):181-203. PubMed PMID: 19266057;
PubMed Central PMCID: PMC2651091.

98: Tonelli LH, Stiller J, Rujescu D, Giegling I, Schneider B, Maurer K, Schnabel
A, Möller HJ, Chen HH, Postolache TT. Elevated cytokine expression in the
orbitofrontal cortex of victims of suicide. Acta Psychiatr Scand. 2008
Mar;117(3):198-206. Epub 2007 Dec 13. PubMed PMID: 18081924; PubMed Central
PMCID: PMC2612100.

99: Scrandis DA, Sheikh TM, Niazi R, Tonelli LH, Postolache TT. Depression after
delivery: risk factors, diagnostic and therapeutic considerations.
ScientificWorldJournal. 2007 Oct 22;7:1670-82. Review. PubMed PMID: 17982562.

100: Volkov J, Rohan KJ, Yousufi SM, Nguyen MC, Jackson MA, Thrower CM,
Postolache TT. Seasonal changes in sleep duration in African American and African
college students living in Washington, D.C. ScientificWorldJournal. 2007 Jun
12;7:880-7. PubMed PMID: 17619774.

101: Soriano JJ, Ciupagea C, Rohan KJ, Neculai DB, Yousufi SM, Guzman A,
Postolache TT. Seasonal variations in mood and behavior in Romanian postgraduate
students. ScientificWorldJournal. 2007 Jun 12;7:870-9. PubMed PMID: 17619773.

102: Tonelli LH, Holmes A, Postolache TT. Intranasal immune challenge induces
sex-dependent depressive-like behavior and cytokine expression in the brain.
Neuropsychopharmacology. 2008 Apr;33(5):1038-48. Epub 2007 Jun 27. PubMed PMID:
17593929; PubMed Central PMCID: PMC2268621.

103: Guzman A, Rohan KJ, Yousufi SM, Nguyen MC, Jackson MA, Soriano JJ,
Postolache TT. Mood sensitivity to seasonal changes in African college students
living in the greater Washington D.C. metropolitan area. ScientificWorldJournal.
2007 May 1;7:584-91. PubMed PMID: 17525823.

104: Guzman A, Zebrak R, Rohan KJ, Sumar IA, Savchenko S, Stiller JW,
Valadez-Meltzer A, Olsen C, Lapidus M, Soriano JJ, Postolache TT. A prospective
longitudinal study of seasonality in African students living in the greater
Washington, D.C. metropolitan area. ScientificWorldJournal. 2007 May 1;7:577-83.
PubMed PMID: 17525822.

105: Reeves GM, Tonelli LH, Anthony BJ, Postolache TT. Precipitants of adolescent
suicide: possible interaction between allergic inflammation and alcohol intake.
Int J Adolesc Med Health. 2007 Jan-Mar;19(1):37-43. Review. PubMed PMID:

106: Guzman A, Tonelli LH, Roberts D, Stiller JW, Jackson MA, Soriano JJ, Yousufi
S, Rohan KJ, Komarow H, Postolache TT. Mood-worsening with high-pollen-counts and
seasonality: a preliminary report. J Affect Disord. 2007 Aug;101(1-3):269-74.
Epub 2007 Jan 12. PubMed PMID: 17222915; PubMed Central PMCID: PMC1949487.

107: Tonelli LH, Postolache TT. Tumor necrosis factor alpha, interleukin-1 beta,
interleukin-6 and major histocompatibility complex molecules in the normal brain
and after peripheral immune challenge. Neurol Res. 2005 Oct;27(7):679-84. Review.
PubMed PMID: 16197804.

108: Postolache TT, Hung TM, Rosenthal RN, Soriano JJ, Montes F, Stiller JW.
Sports chronobiology consultation: from the lab to the arena. Clin Sports Med.
2005 Apr;24(2):415-56, xiv. Review. PubMed PMID: 15892932.

109: Postolache TT, Oren DA. Circadian phase shifting, alerting, and
antidepressant effects of bright light treatment. Clin Sports Med. 2005
Apr;24(2):381-413, xii. Review. PubMed PMID: 15892931.

110: Stiller JW, Postolache TT. Sleep-wake and other biological rhythms:
functional neuroanatomy. Clin Sports Med. 2005 Apr;24(2):205-35, vii. Review.
PubMed PMID: 15892920.

111: Komarow HD, Postolache TT. Seasonal allergy and seasonal decrements in
athletic performance. Clin Sports Med. 2005 Apr;24(2):e35-50, xiii. Review.
PubMed PMID: 15892916.

112: Postolache TT, Stiller JW, Herrell R, Goldstein MA, Shreeram SS, Zebrak R,
Thrower CM, Volkov J, No MJ, Volkov I, Rohan KJ, Redditt J, Parmar M, Mohyuddin
F, Olsen C, Moca M, Tonelli LH, Merikangas K, Komarow HD. Tree pollen peaks are
associated with increased nonviolent suicide in women. Mol Psychiatry. 2005
Mar;10(3):232-5. PubMed PMID: 15599378.

113: Tonelli LH, Postolache TT, Sternberg EM. Inflammatory genes and neural
activity: involvement of immune genes in synaptic function and behavior. Front
Biosci. 2005 Jan 1;10:675-80. Print 2005 Jan 1. Review. PubMed PMID: 15569608.

114: Agumadu CO, Yousufi SM, Malik IS, Nguyen MC, Jackson MA, Soleymani K,
Thrower CM, Peterman MJ, Walters GW, Niemtzoff MJ, Bartko JJ, Postolache TT.
Seasonal variation in mood in African American college students in the
Washington, D.C., metropolitan area. Am J Psychiatry. 2004 Jun;161(6):1084-9.
PubMed PMID: 15169697.

115: Aeschbach D, Sher L, Postolache TT, Matthews JR, Jackson MA, Wehr TA. A
longer biological night in long sleepers than in short sleepers. J Clin
Endocrinol Metab. 2003 Jan;88(1):26-30. PubMed PMID: 12519823.

116: Postolache TT, Wehr TA, Doty RL, Sher L, Turner EH, Bartko JJ, Rosenthal NE.
Patients with seasonal affective disorder have lower odor detection thresholds
than control subjects. Arch Gen Psychiatry. 2002 Dec;59(12):1119-22. PubMed PMID:

117: Wehr TA, Duncan WC Jr, Sher L, Aeschbach D, Schwartz PJ, Turner EH,
Postolache TT, Rosenthal NE. A circadian signal of change of season in patients
with seasonal affective disorder. Arch Gen Psychiatry. 2001 Dec;58(12):1108-14.
PubMed PMID: 11735838.

118: Sher L, Matthews JR, Turner EH, Postolache TT, Katz KS, Rosenthal NE. Early
response to light therapy partially predicts long-term antidepressant effects in
patients with seasonal affective disorder. J Psychiatry Neurosci. 2001
Sep;26(4):336-8. PubMed PMID: 11590974; PubMed Central PMCID: PMC167188.

119: Aeschbach D, Postolache TT, Sher L, Matthews JR, Jackson MA, Wehr TA.
Evidence from the waking electroencephalogram that short sleepers live under
higher homeostatic sleep pressure than long sleepers. Neuroscience.
2001;102(3):493-502. PubMed PMID: 11226688.

120: Postolache TT, Doty RL, Wehr TA, Jimma LA, Han L, Turner EH, Matthews JR,
Neumeister A, No C, Kroger H, Bruder GE, Rosenthal NE. Monorhinal odor
identification and depression scores in patients with seasonal affective
disorder. J Affect Disord. 1999 Nov;56(1):27-35. PubMed PMID: 10626777.

121: Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA. Two
circadian rhythms in the human electroencephalogram during wakefulness. Am J
Physiol. 1999 Dec;277(6 Pt 2):R1771-9. PubMed PMID: 10600925.

122: Postolache TT, Rosenthal RN, Hellerstein DJ, Aromin R, Kelton GM, Muran JC,
Londono JH. Early augmentation of sertraline with methylphenidate. J Clin
Psychiatry. 1999 Feb;60(2):123-4. PubMed PMID: 10084641.

123: Postolache TT, Hardin TA, Myers FS, Turner EH, Yi LY, Barnett RL, Matthews
JR, Rosenthal NE. Greater improvement in summer than with light treatment in
winter in patients with seasonal affective disorder. Am J Psychiatry. 1998
Nov;155(11):1614-6. PubMed PMID: 9812130.

124: Neumeister A, Turner EH, Matthews JR, Postolache TT, Barnett RL, Rauh M,
Vetticad RG, Kasper S, Rosenthal NE. Effects of tryptophan depletion vs
catecholamine depletion in patients with seasonal affective disorder in remission
with light therapy. Arch Gen Psychiatry. 1998 Jun;55(6):524-30. PubMed PMID:

125: Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA.
Dynamics of the human EEG during prolonged wakefulness: evidence for
frequency-specific circadian and homeostatic influences. Neurosci Lett. 1997 Dec
19;239(2-3):121-4. PubMed PMID: 9469671.

126: Postolache TT, Londono JH, Halem RG, Newmark MD. Electroconvulsive therapy
in tardive dystonia. Convuls Ther. 1995 Dec;11(4):275-9. PubMed PMID: 8919581

127: Postolache T, Gautier S, Laloux B, Safar M, Benetos A. Positive correlation
between the blood pressure and heart rate response to the cold pressor test and
the environmental temperature in older hypertensives. Am J Hypertens. 1993
May;6(5 Pt 1):376-81. PubMed PMID: 8512662.

Research Interests

I am interested in modifiable risk factors for behavioral and affective dysregulation- targeting reducing mortality and morbidity and improving health, quality of life and / or performance.

I believe that no one level of inquiry is sufficient in answering questions in the doman of complex behaviors, such as suicidal behavior. Thus I actively engage  in clinical, epidemiological, postmortem, imaging, animal and molecular studies, and embrase the interactions between individual factors in defining synergistic elevations of risk, treatment targets or therapeutic modalites. This implies broad collaboration with experts and integrators, and finding the best people to form the best team for a  particular project at a specific time.

I am very optimistic that novel analytic techniques, especially the increased use of artificial intelligence, wil lead to breakthroughs where human intellligence has been "stuck", including in curbing the rates of suicide and obesity, climbing despite macro and microinvestments in controlling them.

 I think that it is important to study the human beings not in isolation, but in  interactions with  microorganisms that inhabit us and cohabitate with us in natural and built environments. I am attempting to identify major ingrediants in  food, air , waters, corrective and aggravating environmental/ emotional experience, able to bridge the substantial differences between the evolutionary environment, the developmental environment and our increasingly isolated microclimate.

Clinical Specialty Details

Board certified (and recertified) psychiatrist

NIMH trained in chronobiology and mood disorders expertise (focus on jet lag, shift work and seasonal affective disorder).

Certified in Behavioral Sleep Medicine by the American Academy of Sleep Medicine

Experienced in the treatment of severe mental ilness.

Ongoing practice in Mood and Anxiety Disorders.

Seasonal affective disorder, especially seasonal cycling in mood, winter bindge eating and weight gain, seasonal changes in sexuality, sleep duration and sleepines.

Light treatment.



Awards and Affiliations

Honors and Awards

1990               Award of the “Diakonishes Werk fur Osterreich,” Austria

1991                Award of the “College de Medecine des Hopitaux de Paris,” France

1996                Cynthia Horner Award for Excellence in Research, New York, NY

1996                Laughlin Fellowship Award, the American College of Psychiatrists, Tucson, AZ

2000                Fellows’ Award for Research Excellence (FARE 2000), National Institute of Health, Bethesda, MD

2004                Journal of Clinical Endocrinology & Metabolism/Pfizer International Award for Research Excellence, Endocrine Society

2004                Frontiers in Behavioral Science Award, FERMI Foundation

2004                Teacher of the Year Award, St. Elizabeth’s Residency Training.

2004                Walter Weintraub Award for the Teacher of the Year, University of Maryland / Sheppard-Pratt Psychiatry Residency Program

2005                Independent Investigator Award, NARSAD

2006                Mentor of the Year Award, St. Elizabeth’s Hospital, Washington, D.C.

2009                Faculty of the Year Award, St. Elizabeth’s Hospital and DC Department of Mental Health, rewarding an innovative evidence-based hands-on teaching program in psychiatric research

2009                Washingtonian: Top Psychiatrist.

2010                Patients’ choice award (by

2011                Superdocs 2011, Washington Post

2012                Superdocs 2012, Washington Post

2013                Distinguished Investigator Award from the American Foundation for Suicide Prevention

2017                Washingtonian Top Doctor 2017


Grants and Contracts

Grant Support




1R01MH104622-01                     Lena Brundin (PI)       08/01/14-07/30/18       NIH/NIMH

The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality

The project will determine whether women with altered levels of kynurenine pathway

metabolites are the ones developing depression and suicidal thoughts in pregnancy and the post-

partum period.

No overlap with proposed project


1R01HD086911-01A1                       Gragnoli (PI)                                       07/01/15-07/01/20


The goal is to understand whether the HPA axis receptor genes associated with the stress response may contribute to the depression-MetS/T2D co-morbidity and/or to metabolic and psychological associated traits. The genes of interest are corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) and the melanocortin receptor genes (MC1R-MC5R).

Role: Consultant


1I01CX001310-01                              Teodor Postolache (PI)                     09/01/15-08/31/19


Toxoplasma gondii, the kynurenine pathway, and suicidal behavior in Veterans

The purpose of the project is to investigate the neurochemical mechanisms underlying the

association between T. gondii  infection, kynurenine pathway activation and suicidal behavior.

Role PI


Alfred P. Sloan Foundation                Christopher A. Lowry (PI)                 07/01/16-12/31/17

Grant No:G-2016-7077($516,490.00)

Title: Longitudinal assessment of the influence of lifestyle homogenization on the MoBE in a cohort of United States Air Force Cadets

The purpose is to conduct a longitudinal analysis of the microbiomes of dormitories and their inhabitants at the US Air Force Academy (USAFA)

Role: Co-I


1I21RX002232-01 VA-Spire                         Lisa Brenner (PI)                    07/01/16-2018

Rehabilitation Research and Development Service ($199,960.00)

Title: Biological Signature and Safety of an Immunomodulatory Probiotic Intervention for Veterans with Co-Occurring Mild TBI and PTSD.

The aims of the study are to determine the: 1) effects of L. reuteri on biological signatures of gut microbiota, gut permeability, systemic inflammation processes, and stress responses; 2) feasibility of L. reuteri supplementation; 3) acceptability of L. reuteri supplementation; and 4) tolerability and safety of L. reuteri supplementation.

Role: Co-I


R01HD086805-01A1                                      Groer (PI)                            09/01/2017 - 08/31/2022           


Title: Chronic Toxoplasma gondii , Pregnancy reactivation and Perinatal Depression

The goal of this project is to study the relationships between latent T.gondii infection and depression through pregnancy and the postpartum in T. gondii positive Hispanic women.

Role: Co-I       





In the News

Media (selected)

  1. Discovery Channel (1997). Teodor Postolache: Sleep, mood and performance at high altitude
  2. New Scientist Olfaction and seasonality 8 Jan. 2000.
  3. SontaggsZeitung (Switzerland) Innovation in seasonal affective disorder 9 Jan. 2000.
  4. Reuters Health Patients with winter blues have a keener sense of smell Dec. 2002.
  5. Voice of America (2003). The Body Clock
  6. The Sun (2006). Jet Lag
  7. Washington Times (2006). Seasonal affective disorder.
  8. Psychiatric news: What accounts for the link between allergies and suicide? Interview by Jun Yan 2009
  9. CNN 2011: Allergy, depression and suicide
  10. Channel 4 2011: Weather, light and suicide
  11. Washington Post- included in the Superdocs list 2011
  12. The Atlantic Magazine 2012: Toxoplasma gondii and human behavior
  13. ABC News: July 2012 Study Links Cat Litter Box to Increased Suicide Risk
  14. NPR: July 2012 Common Parasite May Influence Human Behavior
  15. CNN (blog) July 2012: Kitty litter increases risk of suicide?
  16. Time July 2012 Are 'Cat Ladies' More Likely to Attempt Suicide?
  17. MSNBC  July 2012 Cat parasite linked to women's suicide attempts
  18. CBS July 2012Women with cats may have higher suicide risk due to feline fecal parasite
  19. Fox News July 2012 Common parasite found in cat litter may increase suicide risk
  20. Fox News Radio July 2012 Study: Cat Litter Associated With Suicide Risk
  21. Forbes 2012 Is Your Cat Hosting a Human Suicide Parasite?
  22. Web Med July 2012 Cat Litter Parasite May Raise Suicide Risk
  23. Reuters July 2012 Parasite tied to self-harm, suicide attempts
  24. New York Times 2013 Seasonal peaks of suicide
  25. Washington Post 2015 : Seasonal affective disorder
  26. KABC Radio 2017: Link between Allergies and Suicide
  27. Clues in the cycle of suicide: New York Times 2013
  28. Gut bacteria may predict PTSD lnk 2017
  29. Link between Spring and spiking suicide rates 2016  The Globe and the mail
  30. CBS news: Toxoplasma gondii linked to aggression  2016
  31. Is SAD real- Time magazine
  32. The troubling risk between allergy and suicide Reuters 2017 and Atlantic magazine
  33. VA researcher awarded a VA grant to explore impact of parasite o mental health 2017


Community Service




Links of Interest

Co-Founding Senior Researcher  of the Military and Veteran Microbiome Consortium for Research and Education - Denver CO