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Teodor T. Postolache, MD

Academic Title:


Primary Appointment:



685 W. Baltimore Street, 930

Phone (Primary):

(410) 706-2323

Education and Training


1971-1976       B.A., 24th Lycee in Bucharest, Romania

1976-1982       Medical School:

Years I-III, Preclinical, Bucharest School of Medicine, Romania

Years IV- VI, Clinical, Cluj-Napoca School of Medicine, Romania

Post Graduate Education

1982-1985       Post-graduate, Medicine, Coltea Hospital and the Bucharest School of Medicine, Romania.

1990-1991       Post-graduate, Cardiology, University of Vienna, Austria

1991-1992       Residency, Internal Medicine and Cardiovascular research, INSERM Hypertension Unit, Broussais Hospital, Paris, France

1992-1996       Residency, Psychiatry, Beth Israel Medical Center, New York, NY; affiliated with Mount Sinai School of Medicine (PGY I-II) and Albert Einstein College of Medicine (PGY III-IV)

1996-1998       Fellowship, NIMH/NIH Bethesda MD



1991                Foreign Medical Graduate Examination in Medical Sciences: Educational Commission for Foreign Medical Graduates certificate

1993                Federal Licensing Examination

1997-2007       Board Certification, American Board of Psychiatry and Neurology, Psychiatry

2005                Behavioral Sleep Medicine, American Academy of Sleep Medicine

2007-2017       Board Recertification, American Board of Psychiatry and Neurology, Psychiatry

2017-2027       Board Recertification, American Board of Psychiatry and Neurology, Psychiatry


Dr. Postolache is a Professor of Psychiatry at the University of Maryland School of Medicine, and a VA Research Investigator with the VA Rocky Mountain MIRECC for Suicide prevention in Denver Colorado and VISN 5 MIRECC in Baltimore, Maryland . He graduated medical school in Romania, with postgraduate studies in Vienna Austria and Paris France , residency training in psychiatry at Beth Israel Medical Center in New York , NY and fellowship in psychobiology at the Section of Biological Rhythms of the National Institutes of Health, Bethesda , Maryland. In his clinical practice in Washington DC he treats patients with mood and anxiety disorders, as well as disturbaces in biological rhythms. He is a clinical expert in seasonal changes in mood, appetite, weight, sleepiness, sleep duration, and sexuality, included in the syndrome of Seasonal Affective Disorder.  In addition to psychopharmacology and counselling, he uses nonpharmacological approaches including light treatment, light avoidance and exposure, cold and heat exposure, food and activity modification. Trained in circadian and seasonal rhythms at the Intramural NIMH, and certified  in Behavioral Sleep Medicine by the American Academy of Sleep Medicine, Dr. Postolache uses integrative approaches to treat jet leg, shift work, and optimizing wake-activity for health and performance. He took part in consulting elite athletes (including World Champions, Olympic medalists, and MLB pitchers) on reciprocally optimizing the alligment of internal rhythms in relationship to timing of training and competion. He is a psychiatrist focused on change, with a head-to-toes approach to the individual patient, with a strong consideration of the physical , chemical and biological environment of the patient and his social networks. He is recognized as a Top Doctor 2017 by the Washingtonian Magazine.

Dr Postolache has been the  teacher of many young trainees, some  of them who became independent investigators, and many of them good clinicians and critical readers of scientific literature. He received several Teaching Awards for postgraduate and physician education.

Dr. Postolache's most important contributions to research include a) associations between seasonal allergen exposure, depression and suicidal behavior b) the  role of the nasal cavity in mental health (smell function, environment-brain communication- molecules translating air pollution, allerges, brain molecular and behavioral changes c) seasonal affective disorder in African American, African immigrants, and the Amish d) immune changes in the brain e) Associations between Toxoplasma gondii, depression and suicidal behavior f) Obesity, neuroinflammation and mental health g) Pregnancy, neuroinflammation, mood changes and suicide risk.

His active research collaborations  and collaborators are geographically diverse, from the Old Order Amish in Lancaster, Pennsylvania, University of South Florida in Tampa, to South Africa, Sweden, Germany and Denmark. His research has been supported by NIMH, NIDDK, NHLB, FDA, NARSAD, and the VA (eg. currently PI on an ongoing multicenter VA Merit Award on Toxoplasma gondii, inflammation, kynurenines and suicidal behavior). He is a Senior Investigator on the Military and Veteran Microbiome consortium for research and education (Denver Co), and a recipient of a Distinguished Investigator Award of the American Foundation for Suicide Prevention. 

Research/Clinical Keywords

1. Seasonal affective disorder 2. Suicidal behavior, suicide 3. Depression 4. Bipolar disorder 5 Binge eating, Obesity (seasonal exacerbation) 6. Neuroimmunology 7. Circadian Sleep Disorder (Jet lag, Shift work, Non-24) 8 Peripartum depression 9. Latent infections: Toxoplasma gondii, CMV, Herpes 10 Allergens and Allergy 11 Special populations and minorities

Highlighted Publications

The most recent publications (as of Nov 2017)  include

1: Groer M, Fuchs D, Duffy A, Louis-Jacques A, D'Agata A, Postolache TT.
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Biol Res Nurs. 2017 Jan 1:1099800417738363. doi: 10.1177/1099800417738363. [Epub
ahead of print] PubMed PMID: 29141444.

2: Amritwar AU, Lowry CA, Brenner LA, Hoisington AJ, Hamilton R, Stiller JW,
Postolache TT. Mental Health in Allergic Rhinitis: Depression and Suicidal
Behavior. Curr Treat Options Allergy. 2017 Mar;4(1):71-97. doi:
10.1007/s40521-017-0110-z. Epub 2017 Mar 25. PubMed PMID: 28966902; PubMed
Central PMCID: PMC5614510.

3: Dimitrova TD, Reeves GM, Snitker S, Lapidus M, Sleemi AR, Balis TG, Manalai P,
Tariq MM, Cabassa JA, Karim NN, Johnson MA, Langenberg P, Rohan KJ, Miller M,
Stiller JW, Postolache TT. Prediction of outcome of bright light treatment in
patients with seasonal affective disorder: Discarding the early response,
confirming a higher atypical balance, and uncovering a higher body mass index at
baseline as predictors of endpoint outcome. J Affect Disord. 2017
Nov;222:126-132. doi: 10.1016/j.jad.2017.06.038. Epub 2017 Jun 22. PubMed PMID:

4. Raheja UK, Fuchs D, Lowry CA, Stephens SH, Pavlovich MA, Mohyuddin H, Yousufi
H, Ryan KA, O'Connell J, Brenner LA, Punzalan C, Hoisington AJ, Nijjar GK, Groer
M, Shuldiner AR, Pollin TI, Stiller JW, Mitchell BD, Postolache TT. Heritability
of plasma neopterin levels in the Old Order Amish. J Neuroimmunol. 2017 Jun
15;307:37-41. doi: 10.1016/j.jneuroim.2017.02.016. Epub 2017 Feb 22. PubMed PMID:

5. Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson ZR,
Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry CA, Renshaw PF, Rujescu D,
Smith EG, Turecki G, Zanos P, Zarate CA Jr, Zunszain PA, Postolache TT. Animal
models to improve our understanding and treatment of suicidal behavior. Transl
Psychiatry. 2017 Apr 11;7(4):e1092. doi: 10.1038/tp.2017.50. Review. PubMed PMID:
28398339; PubMed Central PMCID: PMC5416692.

Additional Publication Citations

1: Hoisington AJ, Stearns-Yoder KA, Kovacs EJ, Postolache TT, Brenner LA.
Airborne Exposure to Pollutants and Mental Health: A Review with Implications
for United States Veterans. Curr Environ Health Rep. 2024 Mar 8. doi:
10.1007/s40572-024-00437-8. Epub ahead of print. PMID: 38457036.

2: Amin M, Rafla B, Wu R, Postolache TT, Gragnoli C. The role of melatonin
receptor 1B gene (<i>MTNR1B</i>) in the susceptibility to depression and type 2
diabetes comorbidity. Genes Dis. 2023 Aug 4;11(3):101067. doi:
10.1016/j.gendis.2023.06.036. PMID: 38292205; PMCID: PMC10825273.

3: Amin M, Wu R, Postolache TT, Gragnoli C. The prolactin receptor (<i>PRLR</i>)
gene is linked to and associated with the comorbidity of depression and type 2
diabetes in Italian families. Genes Dis. 2023 Jul 28;11(3):101048. doi:
10.1016/j.gendis.2023.06.018. PMID: 38274369; PMCID: PMC10806260.

4: Postolache TT, Al Tinawi QM, Gragnoli C. The melatonin receptor genes are
linked and associated with the risk of polycystic ovary syndrome. J Ovarian Res.
2024 Jan 13;17(1):17. doi: 10.1186/s13048-024-01343-1. PMID: 38217063; PMCID:

5: Rohan KJ, Terman JM, Iyiewuare P, Perez J, Camuso JA, Postolache TT, DeSarno
MJ, Vacek PM. Prospectively assessed summer mood status in major depression,
recurrent with seasonal pattern: Evidence for SAD's construct validity. J Affect
Disord. 2024 Mar 15;349:32-38. doi: 10.1016/j.jad.2023.12.070. Epub 2023 Dec 30.
PMID: 38160889; PMCID: PMC10923172.

6: Hoisington AJ, Stearns-Yoder KA, Stamper CE, Holliday R, Brostow DP, Penzenik
ME, Forster JE, Postolache TT, Lowry CA, Brenner LA. Association of homelessness
and diet on the gut microbiome: a United States-Veteran Microbiome Project (US-
VMP) study. mSystems. 2024 Jan 23;9(1):e0102123. doi: 10.1128/msystems.01021-23.
Epub 2023 Dec 22. PMID: 38132705; PMCID: PMC10804991.

7: Del Bosque-Plata L, Amin M, González-Ramírez R, Wu R, Postolache TT, Vergare
M, Gordon D, Gragnoli C. LD block disorder-specific pleiotropic roles of novel
CRHR1 in type 2 diabetes and depression disorder comorbidity. Eur Arch
Psychiatry Clin Neurosci. 2023 Dec 14. doi: 10.1007/s00406-023-01710-x. Epub
ahead of print. PMID: 38092990.

8: Mohyuddin H, Laffon B, Teixeira JP, Costa S, Teixeira-Gomes A, Pásaro E,
Constantine N, Dagdag A, Ortmeyer HK, Tizenberg B, Afram L, Yen P, Marano C,
Lowry CA, Hoisington AJ, RachBeisel JA, Valdiglesias V, Lema-Arranz C,
Fernández-Bertólez N, Maseda A, Millán-Calenti JC, Kovacs EJ, Gostner JM, Fuchs
D, Brenner LA, Lorenzo-López L, Postolache TT. Toxoplasma gondii IgG
Serointensity Is Positively Associated With Frailty. J Gerontol A Biol Sci Med
Sci. 2024 Mar 1;79(3):glad228. doi: 10.1093/gerona/glad228. PMID: 37939652;
PMCID: PMC10851338.

9: Amin M, Wu R, Postolache TT, Gragnoli C. Author Correction: Linkage and
association of novel DRD2 variants to the comorbidity of type 2 diabetes and
depression. Eur Rev Med Pharmacol Sci. 2023 Sep;27(18):8322. doi:
10.26355/eurrev_202309_33748. PMID: 37782147.

10: Prescott S, Mutka T, Baumgartel K, Yoo JY, Morgan H, Postolache TT, Seyfang
A, Gostner JM, Fuchs D, Kim K, Groer ME. Tryptophan metabolism and immune
alterations in pregnant Hispanic women with chronic Toxoplasma gondii infection.
Am J Reprod Immunol. 2023 Sep;90(3):e13768. doi: 10.1111/aji.13768. PMID:
37641377; PMCID: PMC10538252.

11: Reis DJ, Yen P, Tizenberg B, Gottipati A, Postolache SY, De Riggs D, Nance
M, Dagdag A, Plater L, Federline A, Grassmeyer R, Dagdag A, Akram F, Ozorio
Dutra SV, Gragnoli C, RachBeisel JA, Volkov J, Bahraini NH, Stiller JW, Brenner
LA, Postolache TT. Longitude-based time zone partitions and rates of suicide. J
Affect Disord. 2023 Oct 15;339:933-942. doi: 10.1016/j.jad.2023.07.080. Epub
2023 Jul 20. PMID: 37481129; PMCID: PMC10870927.

12: Amin M, Wu R, Postolache TT, Gragnoli C. Novel implication of the prolactin
(PRL) gene in the comorbidity of type 2 diabetes and depression. Eur Rev Med
Pharmacol Sci. 2023 May;27(9):4080-4084. doi: 10.26355/eurrev_202305_32315.
PMID: 37203833.

13: Hoisington AJ, Stamper CE, Bates KL, Stanislawski MA, Flux MC, Postolache
TT, Lowry CA, Brenner LA. Human microbiome transfer in the built environment
differs based on occupants, objects, and buildings. Sci Rep. 2023 Apr
20;13(1):6446. doi: 10.1038/s41598-023-33719-6. PMID: 37081054; PMCID:

14: Del Bosque-Plata L, Amin M, Wu R, Postolache TT, Gragnoli C. Novel TCF7L2
familial linkage and association with Type 2 diabetes, depression, and their
comorbidity. Eur Rev Med Pharmacol Sci. 2023 Jan;27(2):694-703. doi:
10.26355/eurrev_202301_31072. PMID: 36734726.

15: Amin M, Wu R, Postolache TT, Gragnoli C. Linkage and association of novel
DRD2 variants to the comorbidity of type 2 diabetes and depression. Eur Rev Med
Pharmacol Sci. 2022 Nov;26(22):8370-8375. doi: 10.26355/eurrev_202211_30372.
PMID: 36459020.

16: Malan-Müller S, Postolache TT. Editorial: The oral microbiota in mental
health. Front Psychiatry. 2022 Oct 7;13:1048179. doi:
10.3389/fpsyt.2022.1048179. PMID: 36276331; PMCID: PMC9585619.

17: Amin M, Syed S, Wu R, Postolache TT, Gragnoli C. Familial Linkage and
Association of the <i>NR3C1</i> Gene with Type 2 Diabetes and Depression
Comorbidity. Int J Mol Sci. 2022 Oct 8;23(19):11951. doi: 10.3390/ijms231911951.
PMID: 36233250; PMCID: PMC9569497.

18: Amin M, Ott J, Gordon D, Wu R, Postolache TT, Vergare M, Gragnoli C.
Comorbidity of Novel <i>CRHR2</i> Gene Variants in Type 2 Diabetes and
Depression. Int J Mol Sci. 2022 Aug 29;23(17):9819. doi: 10.3390/ijms23179819.
PMID: 36077219; PMCID: PMC9456299.

19: Amin M, Ott J, Wu R, Postolache TT, Gragnoli C. Implication of Melanocortin
Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression.
Int J Mol Sci. 2022 Jul 28;23(15):8350. doi: 10.3390/ijms23158350. PMID:
35955479; PMCID: PMC9369258.

20: Brenner LA, Stearns-Yoder KA, Stamper CE, Hoisington AJ, Brostow DP,
Hoffmire CA, Forster JE, Donovan ML, Ryan AT, Postolache TT, Lowry CA.
Rationale, design, and methods: A randomized placebo-controlled trial of an
immunomodulatory probiotic intervention for Veterans with PTSD. Contemp Clin
Trials Commun. 2022 Jun 28;28:100960. doi: 10.1016/j.conctc.2022.100960. PMID:
35812820; PMCID: PMC9260450.

21: Rohan KJ, Franzen PL, Roeckelin KA, Siegle GJ, Kolko DJ, Postolache TT,
Vacek PM. Elucidating treatment targets and mediators within a confirmatory
efficacy trial: study protocol for a randomized controlled trial of cognitive-
behavioral therapy vs. light therapy for winter depression. Trials. 2022 May
12;23(1):383. doi: 10.1186/s13063-022-06330-9. PMID: 35550645; PMCID:

22: Postolache TT, Upadhyaya SK, Spector AM, Mohyuddin I, Constantine N, Ernst
RK, Wadhawan A, Dutra SVO, Dagdag A, Makkar H, Lowry CA, Akram F, Fuchs D,
Brenner LA, Groer MW, Reynolds MA. Decreasing Tryptophan and Increasing
Neopterin Plasma Levels During Pregnancy are Associated with High First
Trimester <i>Porphyromonas gingivalis</i> K-Serotype IgG Serointensity in a
Cohort of Hispanic Women. Curr Top Med Chem. 2022;22(25):2126-2144. doi:
10.2174/1568026622666220404115543. PMID: 35379151.

23: Martínez M, Postolache TT, García-Bueno B, Leza JC, Figuero E, Lowry CA,
Malan-Müller S. The Role of the Oral Microbiota Related to Periodontal Diseases
in Anxiety, Mood and Trauma- and Stress-Related Disorders. Front Psychiatry.
2022 Jan 27;12:814177. doi: 10.3389/fpsyt.2021.814177. PMID: 35153869; PMCID:

24: Sha Q, Madaj Z, Keaton S, Escobar Galvis ML, Smart L, Krzyzanowski S,
Fazleabas AT, Leach R, Postolache TT, Achtyes ED, Brundin L. Cytokines and
tryptophan metabolites can predict depressive symptoms in pregnancy. Transl
Psychiatry. 2022 Jan 26;12(1):35. doi: 10.1038/s41398-022-01801-8. PMID:
35078975; PMCID: PMC8789799.

25: Stanislawski MA, Stamper CE, Stearns-Yoder KA, Hoisington AJ, Brostow DP,
Forster JE, Postolache TT, Lowry CA, Brenner LA. Characterization of the gut
microbiota among Veterans with unique military-related exposures and high
prevalence of chronic health conditions: A United States-Veteran Microbiome
Project (US-VMP) study. Brain Behav Immun Health. 2021 Sep 14;18:100346. doi:
10.1016/j.bbih.2021.100346. PMID: 34988495; PMCID: PMC8710413.

26: Postolache TT, Medoff DR, Brown CH, Fang LJ, Upadhyaya SK, Lowry CA, Miller
M, Kreyenbuhl JA. Lipophilic vs. hydrophilic statins and psychiatric
hospitalizations and emergency room visits in US Veterans with schizophrenia and
bipolar disorder. Pteridines. 2021 Jan;32(1):48-69. doi:
10.1515/pteridines-2020-0028. Epub 2021 Sep 23. PMID: 34887622; PMCID:

27: Zubizarreta JR, Umhau JC, Deuster PA, Brenner LA, King AJ, Petukhova MV,
Sampson NA, Tizenberg B, Upadhyaya SK, RachBeisel JA, Streeten EA, Kessler RC,
Postolache TT. Evaluating the heterogeneous effect of a modifiable risk factor
on suicide: The case of vitamin D deficiency. Int J Methods Psychiatr Res. 2022
Mar;31(1):e1897. doi: 10.1002/mpr.1897. Epub 2021 Nov 5. PMID: 34739164; PMCID:

28: Tizenberg BN, Brenner LA, Lowry CA, Okusaga OO, Benavides DR, Hoisington AJ,
Benros ME, Stiller JW, Kessler RC, Postolache TT. Biological and Psychological
Factors Determining Neuropsychiatric Outcomes in COVID-19. Curr Psychiatry Rep.
2021 Oct 1;23(10):68. doi: 10.1007/s11920-021-01275-3. PMID: 34648081; PMCID:

29: Iyiewuare P, Rohan KJ, Postolache TT. Body mass index and atypical balance
as predictors of winter depression remission in cognitive-behavioral therapy and
light therapy. J Affect Disord. 2022 Jan 1;296:9-16. doi:
10.1016/j.jad.2021.08.154. Epub 2021 Sep 25. PMID: 34583100; PMCID: PMC8609469.

30: Postolache TT, Wadhawan A, Rujescu D, Hoisington AJ, Dagdag A, Baca-Garcia
E, Lowry CA, Okusaga OO, Brenner LA. <i>Toxoplasma gondii</i>, Suicidal
Behavior, and Intermediate Phenotypes for Suicidal Behavior. Front Psychiatry.
2021 Jun 11;12:665682. doi: 10.3389/fpsyt.2021.665682. PMID: 34177652; PMCID:

31: Ryan AT, Postolache TT, Taub DD, Wilcox HC, Ghahramanlou-Holloway M, Umhau
JC, Deuster PA. Serum Fatty Acid Latent Classes Are Associated With Suicide in a
Large Military Personnel Sample. J Clin Psychiatry. 2021 Feb 23;82(2):20m13275.
doi: 10.4088/JCP.20m13275. PMID: 33988928; PMCID: PMC9308986.

32: Bruce HA, Kochunov P, Chiappelli J, Savransky A, Carino K, Sewell J,
Marshall W, Kvarta M, McMahon FJ, Ament SA, Postolache TT, O'Connell J,
Shuldiner A, Mitchell B, Hong LE. Genetic versus stress and mood determinants of
sleep in the Amish. Am J Med Genet B Neuropsychiatr Genet. 2021
Mar;186(2):113-121. doi: 10.1002/ajmg.b.32840. Epub 2021 Mar 1. PMID: 33650257;
PMCID: PMC8994156.

33: Taylor WL, Schuldt SJ, Delorit JD, Chini CM, Postolache TT, Lowry CA,
Brenner LA, Hoisington AJ. A framework for estimating the United States
depression burden attributable to indoor fine particulate matter exposure. Sci
Total Environ. 2021 Feb 20;756:143858. doi: 10.1016/j.scitotenv.2020.143858.
Epub 2020 Nov 27. PMID: 33293092.

34: Markon AO, Ryan KA, Wadhawan A, Pavlovich M, Groer MW, Punzalan C,
Gensheimer K, Jones JL, Daue ML, Dagdag A, Donnelly P, Peng X, Pollin TI,
Mitchell BD, Postolache TT. Risk factors for <i>Toxoplasma gondii</i>
seropositivity in the Old Order Amish. Epidemiol Infect. 2020 Nov 25;149:e89.
doi: 10.1017/S0950268820002897. PMID: 33234182; PMCID: PMC8080217.

35: Brenner LA, Forster JE, Stearns-Yoder KA, Stamper CE, Hoisington AJ, Brostow
DP, Mealer M, Wortzel HS, Postolache TT, Lowry CA. Evaluation of an
Immunomodulatory Probiotic Intervention for Veterans With Co-occurring Mild
Traumatic Brain Injury and Posttraumatic Stress Disorder: A Pilot Study. Front
Neurol. 2020 Oct 20;11:1015. doi: 10.3389/fneur.2020.01015. PMID: 33192959;
PMCID: PMC7641622.

36: Bourassa KA, Postolache TT, Dagdag A, Fuchs D, Okusaga OO. Plasma soluble
P-selectin correlates with triglycerides and nitrite in overweight/obese
patients with schizophrenia. Pteridines. 2020 Jan;31(1):61-67. doi:
10.1515/pteridines-2020-0012. Epub 2020 May 23. PMID: 32982068; PMCID:

37: Brenner LA, Stamper CE, Hoisington AJ, Stearns-Yoder KA, Stanislawksi MA,
Brostow DP, Hoffmire CA, Forster JE, Schneider AL, Postolache TT, Lowry CA.
Microbial Diversity and Community Structures Among Those With Moderate to Severe
TBI: A United States-Veteran Microbiome Project Study. J Head Trauma Rehabil.
2020 Sep/Oct;35(5):332-341. doi: 10.1097/HTR.0000000000000615. PMID: 32881767.

38: Goldenberg MDF, Huang X, Chen H, Kong L, Postolache TT, Stiller JW, Ryan KA,
Pavlovich M, Pollin TI, Shuldiner AR, Mailman RB, Mitchell BD. Parkinson's
Disease-Related Motor and Nonmotor Symptoms in the Lancaster Amish.
Neuroepidemiology. 2020;54(5):392-397. doi: 10.1159/000509394. Epub 2020 Jul 31.
PMID: 32739915; PMCID: PMC7792917.

39: Postolache TT, Benros ME, Brenner LA. Targetable Biological Mechanisms
Implicated in Emergent Psychiatric Conditions Associated With SARS-CoV-2
Infection. JAMA Psychiatry. 2020 Jul 31. doi: 10.1001/jamapsychiatry.2020.2795.
Epub ahead of print. PMID: 32735332.

40: Lee EE, Amritwar A, Hong LE, Mohyuddin I, Brown T, Postolache TT. Daily and
Seasonal Variation in Light Exposure among the Old Order Amish. Int J Environ
Res Public Health. 2020 Jun 21;17(12):4460. doi: 10.3390/ijerph17124460. PMID:
32575882; PMCID: PMC7344929.

41: Postolache TT, Akram F, Lee EE, Lowry CA, Stiller JW, Brenner LA, Streeten
EA, Turecki G, Dwivedi Y. Increased brain vitamin D receptor expression and
decreased expression of cathelicidin antimicrobial peptide in individuals who
died by suicide. J Psychiatr Res. 2020 Jun;125:75-84. doi:
10.1016/j.jpsychires.2020.02.027. Epub 2020 Feb 27. PMID: 32213352.

42: Postolache TT, Wadhawan A, Can A, Lowry CA, Woodbury M, Makkar H, Hoisington
AJ, Scott AJ, Potocki E, Benros ME, Stiller JW. Inflammation in Traumatic Brain
Injury. J Alzheimers Dis. 2020;74(1):1-28. doi: 10.3233/JAD-191150. PMID:
32176646; PMCID: PMC8190673.

43: Akram F, Gragnoli C, Raheja UK, Snitker S, Lowry CA, Stearns-Yoder KA,
Hoisington AJ, Brenner LA, Saunders E, Stiller JW, Ryan KA, Rohan KJ, Mitchell
BD, Postolache TT. Seasonal affective disorder and seasonal changes in weight
and sleep duration are inversely associated with plasma adiponectin levels. J
Psychiatr Res. 2020 Mar;122:97-104. doi: 10.1016/j.jpsychires.2019.12.016. Epub
2020 Jan 2. PMID: 31981963; PMCID: PMC7024547.

44: Wadhawan A, Reynolds MA, Makkar H, Scott AJ, Potocki E, Hoisington AJ,
Brenner LA, Dagdag A, Lowry CA, Dwivedi Y, Postolache TT. Periodontal Pathogens
and Neuropsychiatric Health. Curr Top Med Chem. 2020;20(15):1353-1397. doi:
10.2174/1568026620666200110161105. PMID: 31924157.

45: Zwir I, Del-Val C, Arnedo J, Pulkki-Råback L, Konte B, Yang SS, Romero-Zaliz
R, Hintsanen M, Cloninger KM, Garcia D, Svrakic DM, Lester N, Rozsa S, Mesa A,
Lyytikäinen LP, Giegling I, Kähönen M, Martinez M, Seppälä I, Raitoharju E, de
Erausquin GA, Mamah D, Raitakari O, Rujescu D, Postolache TT, Gu CC, Sung J,
Lehtimäki T, Keltikangas-Järvinen L, Cloninger CR. Three genetic-environmental
networks for human personality. Mol Psychiatry. 2021 Aug;26(8):3858-3875. doi:
10.1038/s41380-019-0579-x. Epub 2019 Nov 21. PMID: 31748689; PMCID: PMC8550959.

46: Achtyes E, Keaton SA, Smart L, Burmeister AR, Heilman PL, Krzyzanowski S,
Nagalla M, Guillemin GJ, Escobar Galvis ML, Lim CK, Muzik M, Postolache TT,
Leach R, Brundin L. Inflammation and kynurenine pathway dysregulation in post-
partum women with severe and suicidal depression. Brain Behav Immun. 2020
Jan;83:239-247. doi: 10.1016/j.bbi.2019.10.017. Epub 2019 Nov 5. PMID: 31698012;
PMCID: PMC6906225.

47: Akram F, Jennings TB, Stiller JW, Lowry CA, Postolache TT. Mood Worsening on
Days with High Pollen Counts is associated with a Summer Pattern of Seasonality.
Pteridines. 2019 Feb;30(1):133-141. doi: 10.1515/pteridines-2019-0016. Epub 2019
Aug 23. PMID: 31631951; PMCID: PMC6800045.

48: Duffy AR, O'Connell JR, Pavlovich M, Ryan KA, Lowry CA, Daue M, Raheja UK,
Brenner LA, Markon AO, Punzalan CM, Dagdag A, Hill DE, Pollin TI, Seyfang A,
Groer MW, Mitchell BD, Postolache TT. <i>Toxoplasma gondii</i> Serointensity and
Seropositivity: Heritability and Household-Related Associations in the Old Order
Amish. Int J Environ Res Public Health. 2019 Oct 3;16(19):3732. doi:
10.3390/ijerph16193732. PMID: 31623376; PMCID: PMC6801611.

49: Zhang M, Ryan KA, Wickwire E, Postolache TT, Xu H, Daue M, Snitker S, Pollin
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50: Bruce HA, Kochunov P, Mitchell B, Strauss KA, Ament SA, Rowland LM, Du X,
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51: Sharma A, Richardson M, Cralle L, Stamper CE, Maestre JP, Stearns-Yoder KA,
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52: Corona CC, Zhang M, Wadhawan A, Daue ML, Groer MW, Dagdag A, Lowry CA,
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53: Wadhawan A, Stiller JW, Potocki E, Okusaga O, Dagdag A, Lowry CA, Benros ME,
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54: Postolache TT, Del Bosque-Plata L, Jabbour S, Vergare M, Wu R, Gragnoli C.
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55: Makkar H, Reynolds MA, Wadhawan A, Dagdag A, Merchant AT, Postolache TT.
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56: Keaton SA, Madaj ZB, Heilman P, Smart L, Grit J, Gibbons R, Postolache TT,
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suicide risk. J Affect Disord. 2019 Mar 15;247:57-65. doi:
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57: Gjervig Hansen H, Köhler-Forsberg O, Petersen L, Nordentoft M, Postolache
TT, Erlangsen A, Benros ME. Infections, Anti-infective Agents, and Risk of
Deliberate Self-harm and Suicide in a Young Cohort: A Nationwide Study. Biol
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58: Brenner LA, Hoisington AJ, Stearns-Yoder KA, Stamper CE, Heinze JD,
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States-Veteran Microbiome Project (US-VMP). Front Cell Infect Microbiol. 2018
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59: Akram F, Fuchs D, Daue M, Nijjar G, Ryan A, Benros ME, Okusaga O, Baca-
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syndrome in the Old Order Amish. Obes Sci Pract. 2018 Aug 1;4(5):468-476. doi:
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60: Zwir I, Arnedo J, Del-Val C, Pulkki-Råback L, Konte B, Yang SS, Romero-Zaliz
R, Hintsanen M, Cloninger KM, Garcia D, Svrakic DM, Rozsa S, Martinez M,
Lyytikäinen LP, Giegling I, Kähönen M, Hernandez-Cuervo H, Seppälä I, Raitoharju
E, de Erausquin GA, Raitakari O, Rujescu D, Postolache TT, Sung J, Keltikangas-
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61: Zwir I, Arnedo J, Del-Val C, Pulkki-Råback L, Konte B, Yang SS, Romero-Zaliz
R, Hintsanen M, Cloninger KM, Garcia D, Svrakic DM, Rozsa S, Martinez M,
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E, de Erausquin GA, Raitakari O, Rujescu D, Postolache TT, Sung J, Keltikangas-
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62: Peng X, Brenner LA, Mathai AJ, Cook TB, Fuchs D, Postolache N, Groer MW,
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relationship between Toxoplasma gondii seropositivity and trait impulsivity in
younger men by the phenylalanine-tyrosine ratio. Psychiatry Res. 2018
Dec;270:992-1000. doi: 10.1016/j.psychres.2018.03.045. Epub 2018 Mar 22. PMID:
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63: Wadhawan A, Hill DE, Dagdag A, Mohyuddin H, Donnelly P, Jones JL, Postolache
TT. No evidence for airborne transmission of <i>Toxoplasma gondii</i> in a very
high prevalence area in Lancaster County. Pteridines. 2018 Feb;29(1):172-178.
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64: Groer M, Fuchs D, Duffy A, Louis-Jacques A, D'Agata A, Postolache TT.
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65: Amritwar AU, Lowry CA, Brenner LA, Hoisington AJ, Hamilton R, Stiller JW,
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Behavior. Curr Treat Options Allergy. 2017 Mar;4(1):71-97. doi:
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66: Mathai AJ, Lowry CA, Cook TB, Brenner LA, Brundin L, Groer MW, Peng X,
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67: Mukherjee D, Krishnamurthy VB, Millett CE, Reider A, Can A, Groer M, Fuchs
D, Postolache TT, Saunders EFH. Total sleep time and kynurenine metabolism
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68: Hemmings SMJ, Malan-Müller S, van den Heuvel LL, Demmitt BA, Stanislawski
MA, Smith DG, Bohr AD, Stamper CE, Hyde ER, Morton JT, Marotz CA, Siebler PH,
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69: Dimitrova TD, Reeves GM, Snitker S, Lapidus M, Sleemi AR, Balis TG, Manalai
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patients with seasonal affective disorder: Discarding the early response,
confirming a higher atypical balance, and uncovering a higher body mass index at
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70: Millett CE, Mukherjee D, Reider A, Can A, Groer M, Fuchs D, Postolache TT,
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71: Raheja UK, Fuchs D, Lowry CA, Stephens SH, Pavlovich MA, Mohyuddin H,
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72: Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson ZR,
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73: Ahmad Z, Moustafa YW, Stiller JW, Pavlovich MA, Raheja UK, Gragnoli C,
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2017;28(3-4):195-204. doi: 10.1515/pterid-2017-0010. Epub 2017 Nov 28. PMID:
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74: Wadhawan A, Dagdag A, Duffy A, Daue ML, Ryan KA, Brenner LA, Stiller JW,
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association between <i>Toxoplasma gondii</i> IgG serointensity and current
dysphoria/hopelessness scores in the Old Order Amish: a preliminary study.
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75: Mohyuddin H, Georgiou P, Wadhawan A, Daue ML, Brenner LA, Gragnoli C,
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76: Andorko ND, Mittal V, Thompson E, Denenny D, Epstein G, Demro C, Wilson C,
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college students. Psychiatry Res. 2017 Feb;248:6-12. doi:
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77: Stamper CE, Hoisington AJ, Gomez OM, Halweg-Edwards AL, Smith DG, Bates KL,
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78: Clark SM, Pocivavsek A, Nicholson JD, Notarangelo FM, Langenberg P, McMahon
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cortex of depressed individuals. J Psychiatry Neurosci. 2016 Oct;41(6):386-394.
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79: Hsu PC, Yolken RH, Postolache TT, Beckie TM, Munro CL, Groer MW. Association
of Depressed Mood With Herpes Simplex Virus-2 Immunoglobulin-G Levels in
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80: Okusaga O, Fuchs D, Reeves G, Giegling I, Hartmann AM, Konte B, Friedl M,
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81: Reber SO, Langgartner D, Foertsch S, Postolache TT, Brenner LA, Guendel H,
Lowry CA. Chronic subordinate colony housing paradigm: A mouse model for
mechanisms of PTSD vulnerability, targeted prevention, and treatment-2016 Curt
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82: Mathai AJ, Kanwar J, Okusaga O, Fuchs D, Lowry CA, Peng X, Giegling I,
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83: Lund-Sørensen H, Benros ME, Madsen T, Sørensen HJ, Eaton WW, Postolache TT,
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84: Brundin L, Sellgren CM, Lim CK, Grit J, Pålsson E, Landén M, Samuelsson M,
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85: Lowry CA, Smith DG, Siebler PH, Schmidt D, Stamper CE, Hassell JE Jr,
Yamashita PS, Fox JH, Reber SO, Brenner LA, Hoisington AJ, Postolache TT, Kinney
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86: Chiappelli J, Postolache TT, Kochunov P, Rowland LM, Wijtenburg SA, Shukla
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87: Gragnoli C, Reeves GM, Reazer J, Postolache TT. Dopamine-prolactin pathway
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88: Coccaro EF, Lee R, Groer MW, Can A, Coussons-Read M, Postolache TT.
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subjects. J Clin Psychiatry. 2016 Mar;77(3):334-41. doi: 10.4088/JCP.14m09621.
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89: Hoisington AJ, Brenner LA, Kinney KA, Postolache TT, Lowry CA. The
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90: Okusaga O, Duncan E, Langenberg P, Brundin L, Fuchs D, Groer MW, Giegling I,
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D, Postolache TT. Combined Toxoplasma gondii seropositivity and high blood
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91: Rohan KJ, Meyerhoff J, Ho SY, Evans M, Postolache TT, Vacek PM. Outcomes One
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92: Kochunov P, Fu M, Nugent K, Wright SN, Du X, Muellerklein F, Morrissey M,
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KA, Shuldiner AR, Mitchell BD, Hong LE. Heritability of complex white matter
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93: Brundin L, Erhardt S, Bryleva EY, Achtyes ED, Postolache TT. The role of
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94: Raheja UK, Fuchs D, Giegling I, Brenner LA, Rovner SF, Mohyuddin I, Weghuber
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95: Cook TB, Reeves GM, Teufel J, Postolache TT. Persistence of racial
disparities in prescription of first-generation antipsychotics in the USA.
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96: Duffy AR, Beckie TM, Brenner LA, Beckstead JW, Seyfang A, Postolache TT,
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97: Rohan KJ, Mahon JN, Evans M, Ho SY, Meyerhoff J, Postolache TT, Vacek PM.
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98: Uzoma HN, Reeves GM, Langenberg P, Khabazghazvini B, Balis TG, Johnson MA,
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99: Byrne EM; Psychiatric Genetics Consortium Major Depressive Disorder Working
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100: Mangge H, Zelzer S, Meinitzer A, Stelzer I, Schnedl WJ, Weghuber D, Fuchs
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101: Zhang L, Evans DS, Raheja UK, Stephens SH, Stiller JW, Reeves GM, Johnson
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102: Okusaga O, Hamilton RG, Can A, Igbide A, Giegling I, Hartmann AM, Konte B,
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103: Cook TB, Brenner LA, Cloninger CR, Langenberg P, Igbide A, Giegling I,
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104: Chiappelli J, Kochunov P, DeRiso K, Thangavelu K, Sampath H, Muellerklein
F, Nugent KL, Postolache TT, Carpenter WT Jr, Hong LE. Testing trait depression
as a potential clinical domain in schizophrenia. Schizophr Res. 2014
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105: Stiller JW, Yu SS, Brenner LA, Langenberg P, Scrofani P, Pannella P, Hsu
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106: Mangge H, Stelzer I, Reininghaus EZ, Weghuber D, Postolache TT, Fuchs D.
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107: Okusaga O, Muravitskaja O, Fuchs D, Ashraf A, Hinman S, Giegling I,
Hartmann AM, Konte B, Friedl M, Schiffman J, Hong E, Reeves G, Groer M, Dantzer
R, Rujescu D, Postolache TT. Elevated levels of plasma phenylalanine in
schizophrenia: a guanosine triphosphate cyclohydrolase-1 metabolic pathway
abnormality? PLoS One. 2014 Jan 21;9(1):e85945. doi:
10.1371/journal.pone.0085945. PMID: 24465804; PMCID: PMC3897774.

108: Reeves GM, Mazaheri S, Snitker S, Langenberg P, Giegling I, Hartmann AM,
Konte B, Friedl M, Okusaga O, Groer MW, Mangge H, Weghuber D, Allison DB,
Rujescu D, Postolache TT. A Positive Association between T. gondii
Seropositivity and Obesity. Front Public Health. 2013 Dec 25;1:73. doi:
10.3389/fpubh.2013.00073. PMID: 24400300; PMCID: PMC3872312.

109: Mangge H, Weghuber D, Prassl R, Haara A, Schnedl W, Postolache TT, Fuchs D.
The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a
Bystander than a Player? Curr Vasc Pharmacol. 2015;13(3):392-8. doi:
10.2174/1570161111666131209125454. PMID: 24329737.

110: Warren KR, Postolache TT, Groer ME, Pinjari O, Kelly DL, Reynolds MA. Role
of chronic stress and depression in periodontal diseases. Periodontol 2000. 2014
Feb;64(1):127-38. doi: 10.1111/prd.12036. PMID: 24320960; PMCID: PMC7167640.

111: Kanwar J, Okusaga O, Giegling I, Konte B, Vaswani D, Sleemi A, Vaswani R,
Hartmann AM, Friedl M, Hong LE, Reeves G, Stephens S, Dixon L, Rujescu D,
Postolache TT. In patients with schizophrenia, non-fatal suicidal self-directed
violence is positively associated with present but not past smoking. Schizophr
Res. 2013 Sep;149(1-3):194-5. doi: 10.1016/j.schres.2013.06.010. Epub 2013 Jun
27. PMID: 23810528.

112: Qin P, Waltoft BL, Mortensen PB, Postolache TT. Suicide risk in relation to
air pollen counts: a study based on data from Danish registers. BMJ Open. 2013
May 28;3(5):e002462. doi: 10.1136/bmjopen-2012-002462. PMID: 23793651; PMCID:

113: Patel F, Postolache N, Mohyuddin H, Vaswani D, Balis T, Raheja UK,
Postolache TT. Seasonality patterns of mood and behavior in the Old Order Amish.
Int J Disabil Hum Dev. 2012 Dec;12(1):53-60. doi: 10.1515/ijdhd-2012-0127. PMID:
23667796; PMCID: PMC3648994.

114: Postolache TT, Cook TB. Is latent infection with Toxoplasma gondii a risk
factor for suicidal behavior? Expert Rev Anti Infect Ther. 2013
Apr;11(4):339-42. doi: 10.1586/eri.13.20. PMID: 23566142.

115: Kuehner RM, Vaswani D, Raheja UK, Sleemi A, Yousufi H, Mohyuddin H,
Postolache N, Nijjar GV, Postolache TT. Test-retest reliability of the Seasonal
Pattern Assessment Questionnaire in Old Order Amish. Int J Disabil Hum Dev. 2013
Feb;12(1):87-90. doi: 10.1515/ijdhd-2012-0125. PMID: 23565353; PMCID:

116: Weber NS, Fisher JA, Cowan DN, Postolache TT, Larsen RA, Niebuhr DW.
Descriptive epidemiology and underlying psychiatric disorders among
hospitalizations with self-directed violence. PLoS One. 2013;8(3):e59818. doi:
10.1371/journal.pone.0059818. Epub 2013 Mar 26. PMID: 23555791; PMCID:

117: Rohan KJ, Evans M, Mahon JN, Sitnikov L, Ho SY, Nillni YI, Postolache TT,
Vacek PM. Cognitive-behavioral therapy vs. light therapy for preventing winter
depression recurrence: study protocol for a randomized controlled trial. Trials.
2013 Mar 21;14:82. doi: 10.1186/1745-6215-14-82. PMID: 23514124; PMCID:

118: Mangge H, Zelzer S, Puerstner P, Schnedl WJ, Reeves G, Postolache TT,
Weghuber D. Uric acid best predicts metabolically unhealthy obesity with
increased cardiovascular risk in youth and adults. Obesity (Silver Spring). 2013
Jan;21(1):E71-7. doi: 10.1002/oby.20061. Epub 2013 Jan 29. PMID: 23401248.

119: Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M,
Lundberg K, Postolache TT, Träskman-Bendz L, Guillemin GJ, Brundin L. Connecting
inflammation with glutamate agonism in suicidality. Neuropsychopharmacology.
2013 Apr;38(5):743-52. doi: 10.1038/npp.2012.248. Epub 2012 Dec 3. PMID:
23299933; PMCID: PMC3671988.

120: Okusaga O, Yolken RH, Langenberg P, Sleemi A, Kelly DL, Vaswani D, Giegling
I, Hartmann AM, Konte B, Friedl M, Mohyuddin F, Groer MW, Rujescu D, Postolache
TT. Elevated gliadin antibody levels in individuals with schizophrenia. World J
Biol Psychiatry. 2013 Sep;14(7):509-15. doi: 10.3109/15622975.2012.747699. Epub
2013 Jan 3. PMID: 23282016.

121: Sleemi A, Johnson MA, Rohan KJ, Okusaga O, Adediran T, Uzoma H, Walsh C,
Reeves G, Postolache TT. Reading increases ocular illuminance during light
treatment. Int J Adolesc Med Health. 2012;24(4):339-42. doi:
10.1515/ijamh.2012.049. PMID: 23183735; PMCID: PMC5600184.

122: Raheja UK, Stephens SH, Mitchell BD, Rohan KJ, Vaswani D, Balis TG, Nijjar
GV, Sleemi A, Pollin TI, Ryan K, Reeves GM, Weitzel N, Morrissey M, Yousufi H,
Langenberg P, Shuldiner AR, Postolache TT. Seasonality of mood and behavior in
the Old Order Amish. J Affect Disord. 2013 May;147(1-3):112-7. doi:
10.1016/j.jad.2012.10.019. Epub 2012 Nov 17. PMID: 23164460; PMCID: PMC3606685.

123: Zhang Y, Träskman-Bendz L, Janelidze S, Langenberg P, Saleh A, Constantine
N, Okusaga O, Bay-Richter C, Brundin L, Postolache TT. Toxoplasma gondii
immunoglobulin G antibodies and nonfatal suicidal self-directed violence. J Clin
Psychiatry. 2012 Aug;73(8):1069-76. doi: 10.4088/JCP.11m07532. Epub 2012 Jul 10.
PMID: 22938818.

124: Sublette ME, Postolache TT. Neuroinflammation and depression: the role of
indoleamine 2,3-dioxygenase (IDO) as a molecular pathway. Psychosom Med. 2012
Sep;74(7):668-72. doi: 10.1097/PSY.0b013e318268de9f. Epub 2012 Aug 24. PMID:

125: Pedersen MG, Mortensen PB, Norgaard-Pedersen B, Postolache TT. Toxoplasma
gondii infection and self-directed violence in mothers. Arch Gen Psychiatry.
2012 Nov;69(11):1123-30. doi: 10.1001/archgenpsychiatry.2012.668. PMID:

126: Woo JM, Okusaga O, Postolache TT. Seasonality of suicidal behavior. Int J
Environ Res Public Health. 2012 Feb;9(2):531-47. doi: 10.3390/ijerph9020531.
Epub 2012 Feb 14. PMID: 22470308; PMCID: PMC3315262.

127: Manalai P, Hamilton RG, Langenberg P, Kosisky SE, Lapidus M, Sleemi A,
Scrandis D, Cabassa JA, Rogers CA, Regenold WT, Dickerson F, Vittone BJ, Guzman
A, Balis T, Tonelli LH, Postolache TT. Pollen-specific immunoglobulin E
positivity is associated with worsening of depression scores in bipolar disorder
patients during high pollen season. Bipolar Disord. 2012 Feb;14(1):90-8. doi:
10.1111/j.1399-5618.2012.00983.x. PMID: 22329476; PMCID: PMC3293700.

128: Reeves GM, Rohan KJ, Langenberg P, Snitker S, Postolache TT. Calibration of
response and remission cut-points on the Beck Depression Inventory-Second
Edition for monitoring seasonal affective disorder treatment outcomes. J Affect
Disord. 2012 Apr;138(1-2):123-7. doi: 10.1016/j.jad.2011.12.003. Epub 2012 Jan
25. PMID: 22277151; PMCID: PMC5270383.

129: Stelzer I, Zelzer S, Raggam RB, Prüller F, Truschnig-Wilders M, Meinitzer
A, Schnedl WJ, Horejsi R, Möller R, Weghuber D, Reeves G, Postolache TT, Mangge
H. Link between leptin and interleukin-6 levels in the initial phase of obesity
related inflammation. Transl Res. 2012 Feb;159(2):118-24. doi:
10.1016/j.trsl.2011.10.001. Epub 2011 Nov 4. PMID: 22243796.

130: Reeves GM, Nijjar GV, Langenberg P, Johnson MA, Khabazghazvini B, Sleemi A,
Vaswani D, Lapidus M, Manalai P, Tariq M, Acharya M, Cabassa J, Snitker S,
Postolache TT. Improvement in depression scores after 1 hour of light therapy
treatment in patients with seasonal affective disorder. J Nerv Ment Dis. 2012
Jan;200(1):51-5. doi: 10.1097/NMD.0b013e31823e56ca. PMID: 22210362; PMCID:

131: Okusaga O, Postolache TT. <i>Toxoplasma gondii</i>, the Immune System, and
Suicidal Behavior. In: Dwivedi Y, editor. The Neurobiological Basis of Suicide.
Boca Raton (FL): CRC Press/Taylor & Francis; 2012. Chapter 19. PMID: 23035283.

132: Tariq MM, Streeten EA, Smith HA, Sleemi A, Khabazghazvini B, Vaswani D,
Postolache TT. Vitamin D: a potential role in reducing suicide risk? Int J
Adolesc Med Health. 2011;23(3):157-65. doi: 10.1515/ijamh.2011.038. PMID:

133: Woo JM, Gibbons RD, Rogers CA, Qin P, Kim JB, Roberts DW, Noh ES, Mann JJ,
Postolache TT. Pollen counts and suicide rates. Association not replicated. Acta
Psychiatr Scand. 2012 Feb;125(2):168-75. doi: 10.1111/j.1600-0447.2011.01813.x.
Epub 2011 Dec 19. PMID: 22176539; PMCID: PMC6452436.

134: Woo JM, Gibbons RD, Qin P, Komarow H, Kim JB, Rogers CA, Mann JJ,
Postolache TT. Suicide and prescription rates of intranasal corticosteroids and
nonsedating antihistamines for allergic rhinitis: an ecological study. J Clin
Psychiatry. 2011 Oct;72(10):1423-8. doi: 10.4088/JCP.10m06765. PMID: 22075102.

135: Okusaga O, Langenberg P, Sleemi A, Vaswani D, Giegling I, Hartmann AM,
Konte B, Friedl M, Groer MW, Yolken RH, Rujescu D, Postolache TT. Toxoplasma
gondii antibody titers and history of suicide attempts in patients with
schizophrenia. Schizophr Res. 2011 Dec;133(1-3):150-5. doi:
10.1016/j.schres.2011.08.006. Epub 2011 Sep 3. PMID: 21890329.

136: Ling VJ, Lester D, Mortensen PB, Langenberg PW, Postolache TT. Toxoplasma
gondii seropositivity and suicide rates in women. J Nerv Ment Dis. 2011
Jul;199(7):440-4. doi: 10.1097/NMD.0b013e318221416e. PMID: 21716055; PMCID:

137: Sublette ME, Galfalvy HC, Fuchs D, Lapidus M, Grunebaum MF, Oquendo MA,
Mann JJ, Postolache TT. Plasma kynurenine levels are elevated in suicide
attempters with major depressive disorder. Brain Behav Immun. 2011
Aug;25(6):1272-8. doi: 10.1016/j.bbi.2011.05.002. Epub 2011 May 14. PMID:
21605657; PMCID: PMC3468945.

138: Reeves G, Blaisdell C, Lapidus M, Langenberg P, Ramagopal M, Cabassa J,
Bollinger MB, Nijjar GV, Anthony B, Achenbach T, Postolache TT. Sleep
architecture and behavioral abnormalities in children and adolescents. Int J
Adolesc Med Health. 2010 Oct-Dec;22(4):535-45. doi: 10.1515/ijamh.2010.22.4.535.
PMID: 21404884; PMCID: PMC5270380.

139: Groër MW, Yolken RH, Xiao JC, Beckstead JW, Fuchs D, Mohapatra SS, Seyfang
A, Postolache TT. Prenatal depression and anxiety in Toxoplasma gondii-positive
women. Am J Obstet Gynecol. 2011 May;204(5):433.e1-7. doi:
10.1016/j.ajog.2011.01.004. Epub 2011 Feb 23. PMID: 21345406; PMCID: PMC3144318.

140: Qin P, Mortensen PB, Waltoft BL, Postolache TT. Allergy is associated with
suicide completion with a possible mediating role of mood disorder - a
population-based study. Allergy. 2011 May;66(5):658-64. doi:
10.1111/j.1398-9995.2010.02523.x. Epub 2010 Dec 8. PMID: 21143241; PMCID:

141: Okusaga O, Yolken RH, Langenberg P, Lapidus M, Arling TA, Dickerson FB,
Scrandis DA, Severance E, Cabassa JA, Balis T, Postolache TT. Association of
seropositivity for influenza and coronaviruses with history of mood disorders
and suicide attempts. J Affect Disord. 2011 Apr;130(1-2):220-5. doi:
10.1016/j.jad.2010.09.029. Epub 2010 Oct 27. PMID: 21030090; PMCID: PMC3043161.

142: Virk G, Reeves G, Rosenthal NE, Sher L, Postolache TT. Short exposure to
light treatment improves depression scores in patients with seasonal affective
disorder: A brief report. Int J Disabil Hum Dev. 2009 Jul;8(3):283-286. doi:
10.1901/jaba.2009.8-283. PMID: 20686638; PMCID: PMC2913518.

143: Roecklein KA, Rohan KJ, Postolache TT. Is seasonal affective disorder a
bipolar variant? Curr Psychiatr. 2010 Feb;9(2):42-54. PMID: 20495687; PMCID:

144: Guzmán A, Koons A, Postolache TT. Suicidal behavior in Latinos: focus on
the youth. Int J Adolesc Med Health. 2009 Oct-Dec;21(4):431-9. doi:
10.1515/ijamh.2009.21.4.431. PMID: 20306758.

145: Tonelli LH, Postolache TT. Airborne inflammatory factors: "from the nose to
the brain". Front Biosci (Schol Ed). 2010 Jan 1;2(1):135-52. doi: 10.2741/s52.
PMID: 20036935.

146: Fang BJ, Tonelli LH, Soriano JJ, Postolache TT. Disturbed sleep: linking
allergic rhinitis, mood and suicidal behavior. Front Biosci (Schol Ed). 2010 Jan
1;2(1):30-46. doi: 10.2741/s44. PMID: 20036927.

147: Arling TA, Yolken RH, Lapidus M, Langenberg P, Dickerson FB, Zimmerman SA,
Balis T, Cabassa JA, Scrandis DA, Tonelli LH, Postolache TT. Toxoplasma gondii
antibody titers and history of suicide attempts in patients with recurrent mood
disorders. J Nerv Ment Dis. 2009 Dec;197(12):905-8. doi:
10.1097/NMD.0b013e3181c29a23. PMID: 20010026.

148: Postolache TT, Mortensen PB, Tonelli LH, Jiao X, Frangakis C, Soriano JJ,
Qin P. Seasonal spring peaks of suicide in victims with and without prior
history of hospitalization for mood disorders. J Affect Disord. 2010
Feb;121(1-2):88-93. doi: 10.1016/j.jad.2009.05.015. Epub 2009 Jun 16. PMID:
19535151; PMCID: PMC2837087.

149: Manalai P, Woo JM, Postolache TT. Suicidality and montelukast. Expert Opin
Drug Saf. 2009 May;8(3):273-82. doi: 10.1517/14740330902932688. PMID: 19505261.

150: Tonelli LH, Katz M, Kovacsics CE, Gould TD, Joppy B, Hoshino A, Hoffman G,
Komarow H, Postolache TT. Allergic rhinitis induces anxiety-like behavior and
altered social interaction in rodents. Brain Behav Immun. 2009 Aug;23(6):784-93.
doi: 10.1016/j.bbi.2009.02.017. Epub 2009 Mar 5. PMID: 19268702; PMCID:

151: Kewalramani A, Bollinger ME, Postolache TT. Asthma and Mood Disorders. Int
J Child Health Hum Dev. 2008;1(2):115-123. PMID: 19180246; PMCID: PMC2631932.

152: Postolache TT, Roberts DW, Langenberg P, Muravitskaja O, Stiller JW,
Hamilton RG, Tonelli LH. Allergen Specific IgE, Number and Timing of Past
Suicide Attempts, and Instability in Patients with Recurrent Mood Disorders. Int
J Child Health Hum Dev. 2008;1(3):297-304. PMID: 19043595; PMCID: PMC2586113.

153: Reeves GM, Postolache TT, Snitker S. Childhood Obesity and Depression:
Connection between these Growing Problems in Growing Children. Int J Child
Health Hum Dev. 2008 Aug;1(2):103-114. PMID: 18941545; PMCID: PMC2568994.

154: Scrandis DA, Langenberg P, Tonelli LH, Sheikh TM, Manogura AC, Alberico LA,
Hermanstyne T, Fuchs D, Mighty H, Hasday JD, Boteva K, Postolache TT. Prepartum
Depressive Symptoms Correlate Positively with C-Reactive Protein Levels and
Negatively with Tryptophan Levels: A Preliminary Report. Int J Child Health Hum
Dev. 2008 Aug;1(2):167-174. PMID: 18924606; PMCID: PMC2567806.

155: Woo JM, Postolache TT. The impact of work environment on mood disorders and
suicide: Evidence and implications. Int J Disabil Hum Dev. 2008;7(2):185-200.
doi: 10.1515/ijdhd.2008.7.2.185. PMID: 18836547; PMCID: PMC2559945.

156: Bikson M, Bulow P, Stiller JW, Datta A, Battaglia F, Karnup SV, Postolache
TT. Transcranial direct current stimulation for major depression: a general
system for quantifying transcranial electrotherapy dosage. Curr Treat Options
Neurol. 2008 Sep;10(5):377-85. doi: 10.1007/s11940-008-0040-y. PMID: 18782510.

157: Postolache TT, Komarow H, Tonelli LH. Allergy: a risk factor for suicide?
Curr Treat Options Neurol. 2008 Sep;10(5):363-76. doi:
10.1007/s11940-008-0039-4. PMID: 18782509; PMCID: PMC2592251.

158: McCloskey DJ, Postolache TT, Vittone BJ, Nghiem KL, Monsale JL, Wesley RA,
Rick ME. Selective serotonin reuptake inhibitors: measurement of effect on
platelet function. Transl Res. 2008 Mar;151(3):168-72. doi:
10.1016/j.trsl.2007.10.004. Epub 2007 Nov 20. PMID: 18279816; PMCID: PMC2391274.

159: Postolache TT, Lapidus M, Sander ER, Langenberg P, Hamilton RG, Soriano JJ,
McDonald JS, Furst N, Bai J, Scrandis DA, Cabassa JA, Stiller JW, Balis T,
Guzman A, Togias A, Tonelli LH. Changes in allergy symptoms and depression
scores are positively correlated in patients with recurrent mood disorders
exposed to seasonal peaks in aeroallergens. ScientificWorldJournal. 2007 Dec
17;7:1968-77. doi: 10.1100/tsw.2007.286. PMID: 18167612; PMCID: PMC2196438.

160: Tonelli LH, Hoshino A, Katz M, Postolache TT. Acute Stress Promotes
Aggressive-Like Behavior in Rats Made Allergic to Tree Pollen. Int J Child
Health Hum Dev. 2008;1(3):305-312. PMID: 20622938; PMCID: PMC2900930.

161: Balis T, Postolache TT. Ethnic Differences in Adolescent Suicide in the
United States. Int J Child Health Hum Dev. 2008 Jan 1;1(3):281-296. PMID:
20352033; PMCID: PMC2845977.

162: Postolache TT, Langenberg P, Zimmerman SA, Lapidus M, Komarow H, McDonald
JS, Furst N, Dzhanashvili N, Scrandis D, Bai J, Postolache B, Soriano JJ,
Vittone B, Guzman A, Woo JM, Stiller J, Hamilton RG, Tonelli LH. Changes in
Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients
with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of
Aeroallergens. Int J Child Health Hum Dev. 2008;1(3):313-322. PMID: 19430577;
PMCID: PMC2678838.

163: Boker SM, Leibenluft E, Deboeck PR, Virk G, Postolache TT. Mood
Oscillations and Coupling Between Mood and Weather in Patients with Rapid
Cycling Bipolar Disorder. Int J Child Health Hum Dev. 2008;1(2):181-203. PMID:
19266057; PMCID: PMC2651091.

164: Tonelli LH, Stiller J, Rujescu D, Giegling I, Schneider B, Maurer K,
Schnabel A, Möller HJ, Chen HH, Postolache TT. Elevated cytokine expression in
the orbitofrontal cortex of victims of suicide. Acta Psychiatr Scand. 2008
Mar;117(3):198-206. doi: 10.1111/j.1600-0447.2007.01128.x. Epub 2007 Dec 13.
PMID: 18081924; PMCID: PMC2612100.

165: Scrandis DA, Sheikh TM, Niazi R, Tonelli LH, Postolache TT. Depression
after delivery: risk factors, diagnostic and therapeutic considerations.
ScientificWorldJournal. 2007 Oct 22;7:1670-82. doi: 10.1100/tsw.2007.207. PMID:
17982562; PMCID: PMC5901138.

166: Volkov J, Rohan KJ, Yousufi SM, Nguyen MC, Jackson MA, Thrower CM,
Postolache TT. Seasonal changes in sleep duration in African American and
African college students living in Washington, D.C. ScientificWorldJournal. 2007
Jun 12;7:880-7. doi: 10.1100/tsw.2007.128. PMID: 17619774; PMCID: PMC5901316.

167: Soriano JJ, Ciupagea C, Rohan KJ, Neculai DB, Yousufi SM, Guzman A,
Postolache TT. Seasonal variations in mood and behavior in Romanian postgraduate
students. ScientificWorldJournal. 2007 Jun 12;7:870-9. doi:
10.1100/tsw.2007.127. PMID: 17619773; PMCID: PMC5900948.

168: Tonelli LH, Holmes A, Postolache TT. Intranasal immune challenge induces
sex-dependent depressive-like behavior and cytokine expression in the brain.
Neuropsychopharmacology. 2008 Apr;33(5):1038-48. doi: 10.1038/sj.npp.1301488.
Epub 2007 Jun 27. PMID: 17593929; PMCID: PMC2268621.

169: Guzman A, Rohan KJ, Yousufi SM, Nguyen MC, Jackson MA, Soriano JJ,
Postolache TT. Mood sensitivity to seasonal changes in African college students
living in the greater Washington D.C. metropolitan area. ScientificWorldJournal.
2007 May 1;7:584-91. doi: 10.1100/tsw.2007.114. PMID: 17525823; PMCID:

170: Guzman A, Zebrak R, Rohan KJ, Sumar IA, Savchenko S, Stiller JW, Valadez-
Meltzer A, Olsen C, Lapidus M, Soriano JJ, Postolache TT. A prospective
longitudinal study of seasonality in African students living in the greater
Washington, D.C. metropolitan area. ScientificWorldJournal. 2007 May 1;7:577-83.
doi: 10.1100/tsw.2007.110. PMID: 17525822; PMCID: PMC5901278.

171: Reeves GM, Tonelli LH, Anthony BJ, Postolache TT. Precipitants of
adolescent suicide: possible interaction between allergic inflammation and
alcohol intake. Int J Adolesc Med Health. 2007 Jan-Mar;19(1):37-43. doi:
10.1515/ijamh.2007.19.1.37. PMID: 17458322.

172: Guzman A, Tonelli LH, Roberts D, Stiller JW, Jackson MA, Soriano JJ,
Yousufi S, Rohan KJ, Komarow H, Postolache TT. Mood-worsening with high-pollen-
counts and seasonality: a preliminary report. J Affect Disord. 2007
Aug;101(1-3):269-74. doi: 10.1016/j.jad.2006.11.026. Epub 2007 Jan 12. PMID:
17222915; PMCID: PMC1949487.

173: Tonelli LH, Postolache TT. Tumor necrosis factor alpha, interleukin-1 beta,
interleukin-6 and major histocompatibility complex molecules in the normal brain
and after peripheral immune challenge. Neurol Res. 2005 Oct;27(7):679-84. doi:
10.1179/016164105X49463. PMID: 16197804.

174: Postolache TT, Hung TM, Rosenthal RN, Soriano JJ, Montes F, Stiller JW.
Sports chronobiology consultation: from the lab to the arena. Clin Sports Med.
2005 Apr;24(2):415-56, xiv. doi: 10.1016/j.csm.2005.01.001. PMID: 15892932.

175: Postolache TT, Oren DA. Circadian phase shifting, alerting, and
antidepressant effects of bright light treatment. Clin Sports Med. 2005
Apr;24(2):381-413, xii. doi: 10.1016/j.csm.2004.12.005. PMID: 15892931.

176: Stiller JW, Postolache TT. Sleep-wake and other biological rhythms:
functional neuroanatomy. Clin Sports Med. 2005 Apr;24(2):205-35, vii. doi:
10.1016/j.csm.2004.12.008. PMID: 15892920.

177: Komarow HD, Postolache TT. Seasonal allergy and seasonal decrements in
athletic performance. Clin Sports Med. 2005 Apr;24(2):e35-50, xiii. doi:
10.1016/j.csm.2004.12.006. PMID: 15892916; PMCID: PMC7119062.

178: Postolache TT, Stiller JW, Herrell R, Goldstein MA, Shreeram SS, Zebrak R,
Thrower CM, Volkov J, No MJ, Volkov I, Rohan KJ, Redditt J, Parmar M, Mohyuddin
F, Olsen C, Moca M, Tonelli LH, Merikangas K, Komarow HD. Tree pollen peaks are
associated with increased nonviolent suicide in women. Mol Psychiatry. 2005
Mar;10(3):232-5. doi: 10.1038/ PMID: 15599378; PMCID: PMC7100718.

179: Tonelli LH, Postolache TT, Sternberg EM. Inflammatory genes and neural
activity: involvement of immune genes in synaptic function and behavior. Front
Biosci. 2005 Jan 1;10:675-80. doi: 10.2741/1562. PMID: 15569608.

180: Agumadu CO, Yousufi SM, Malik IS, Nguyen MC, Jackson MA, Soleymani K,
Thrower CM, Peterman MJ, Walters GW, Niemtzoff MJ, Bartko JJ, Postolache TT.
Seasonal variation in mood in African American college students in the
Washington, D.C., metropolitan area. Am J Psychiatry. 2004 Jun;161(6):1084-9.
doi: 10.1176/appi.ajp.161.6.1084. PMID: 15169697.

181: Aeschbach D, Sher L, Postolache TT, Matthews JR, Jackson MA, Wehr TA. A
longer biological night in long sleepers than in short sleepers. J Clin
Endocrinol Metab. 2003 Jan;88(1):26-30. doi: 10.1210/jc.2002-020827. PMID:

182: Postolache TT, Wehr TA, Doty RL, Sher L, Turner EH, Bartko JJ, Rosenthal
NE. Patients with seasonal affective disorder have lower odor detection
thresholds than control subjects. Arch Gen Psychiatry. 2002 Dec;59(12):1119-22.
doi: 10.1001/archpsyc.59.12.1119. PMID: 12470128.

183: Wehr TA, Duncan WC Jr, Sher L, Aeschbach D, Schwartz PJ, Turner EH,
Postolache TT, Rosenthal NE. A circadian signal of change of season in patients
with seasonal affective disorder. Arch Gen Psychiatry. 2001 Dec;58(12):1108-14.
doi: 10.1001/archpsyc.58.12.1108. PMID: 11735838.

184: Sher L, Matthews JR, Turner EH, Postolache TT, Katz KS, Rosenthal NE. Early
response to light therapy partially predicts long-term antidepressant effects in
patients with seasonal affective disorder. J Psychiatry Neurosci. 2001
Sep;26(4):336-8. PMID: 11590974; PMCID: PMC167188.

185: Aeschbach D, Postolache TT, Sher L, Matthews JR, Jackson MA, Wehr TA.
Evidence from the waking electroencephalogram that short sleepers live under
higher homeostatic sleep pressure than long sleepers. Neuroscience.
2001;102(3):493-502. doi: 10.1016/s0306-4522(00)00518-2. PMID: 11226688.

186: Postolache TT, Doty RL, Wehr TA, Jimma LA, Han L, Turner EH, Matthews JR,
Neumeister A, No C, Kroger H, Bruder GE, Rosenthal NE. Monorhinal odor
identification and depression scores in patients with seasonal affective
disorder. J Affect Disord. 1999 Nov;56(1):27-35. doi:
10.1016/s0165-0327(99)00027-0. PMID: 10626777.

187: Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA.
Two circadian rhythms in the human electroencephalogram during wakefulness. Am J
Physiol. 1999 Dec;277(6):R1771-9. doi: 10.1152/ajpregu.1999.277.6.R1771. PMID:

188: Postolache TT, Rosenthal RN, Hellerstein DJ, Aromin R, Kelton GM, Muran JC,
Londono JH. Early augmentation of sertraline with methylphenidate. J Clin
Psychiatry. 1999 Feb;60(2):123-4. doi: 10.4088/jcp.v60n0210c. PMID: 10084641.

189: Postolache TT, Hardin TA, Myers FS, Turner EH, Yi LY, Barnett RL, Matthews
JR, Rosenthal NE. Greater improvement in summer than with light treatment in
winter in patients with seasonal affective disorder. Am J Psychiatry. 1998
Nov;155(11):1614-6. doi: 10.1176/ajp.155.11.1614. PMID: 9812130.

190: Neumeister A, Turner EH, Matthews JR, Postolache TT, Barnett RL, Rauh M,
Vetticad RG, Kasper S, Rosenthal NE. Effects of tryptophan depletion vs
catecholamine depletion in patients with seasonal affective disorder in
remission with light therapy. Arch Gen Psychiatry. 1998 Jun;55(6):524-30. doi:
10.1001/archpsyc.55.6.524. PMID: 9633671.

191: Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA.
Dynamics of the human EEG during prolonged wakefulness: evidence for frequency-
specific circadian and homeostatic influences. Neurosci Lett. 1997 Dec
19;239(2-3):121-4. doi: 10.1016/s0304-3940(97)00904-x. PMID: 9469671.

192: Postolache TT, Londono JH, Halem RG, Newmark MD. Electroconvulsive therapy
in tardive dystonia. Convuls Ther. 1995 Dec;11(4):275-9. PMID: 8919581.

193: Postolache T, Londono J, Pinsker H, Luccerini S, Augustin L, Muran JC. A
study of religion and psychotherapy. Psychiatr Serv. 1997 Dec;48(12):1592. doi:
10.1176/ps.48.12.1592a. PMID: 9406272.

194: Postolache T, Gautier S, Laloux B, Safar M, Benetos A. Positive correlation
between the blood pressure and heart rate response to the cold pressor test and
the environmental temperature in older hypertensives. Am J Hypertens. 1993
May;6(5 Pt 1):376-81. doi: 10.1093/ajh/6.5.376. PMID: 8512662.

Research Interests

I am interested in modifiable risk factors for behavioral and affective dysregulation- targeting reducing mortality and morbidity and improving health, quality of life and / or performance.

I believe that no one level of inquiry is sufficient in answering questions in the doman of complex behaviors, such as suicidal behavior. Thus I actively engage  in clinical, epidemiological, postmortem, imaging, animal and molecular studies, and embrase the interactions between individual factors in defining synergistic elevations of risk, treatment targets or therapeutic modalites. This implies broad collaboration with experts and integrators, and finding the best people to form the best team for a  particular project at a specific time.

I am very optimistic that novel analytic techniques, especially the increased use of artificial intelligence, wil lead to breakthroughs where human intellligence has been "stuck", including in curbing the rates of suicide and obesity, climbing despite macro and microinvestments in controlling them.

 I think that it is important to study the human beings not in isolation, but in  interactions with  microorganisms that inhabit us and cohabitate with us in natural and built environments. I am attempting to identify major ingrediants in  food, air , waters, corrective and aggravating environmental/ emotional experience, able to bridge the substantial differences between the evolutionary environment, the developmental environment and our increasingly isolated microclimate.

Clinical Specialty Details

Board certified (and recertified) psychiatrist

NIMH trained in chronobiology and mood disorders expertise (focus on jet lag, shift work and seasonal affective disorder).

Certified in Behavioral Sleep Medicine by the American Academy of Sleep Medicine

Experienced in the treatment of severe mental ilness.

Ongoing practice in Mood and Anxiety Disorders.

Seasonal affective disorder, especially seasonal cycling in mood, winter bindge eating and weight gain, seasonal changes in sexuality, sleep duration and sleepines.

Light treatment.



Awards and Affiliations

Honors and Awards

1990               Award of the “Diakonishes Werk fur Osterreich,” Austria

1991                Award of the “College de Medecine des Hopitaux de Paris,” France

1996                Cynthia Horner Award for Excellence in Research, New York, NY

1996                Laughlin Fellowship Award, the American College of Psychiatrists, Tucson, AZ

2000                Fellows’ Award for Research Excellence (FARE 2000), National Institute of Health, Bethesda, MD

2004                Journal of Clinical Endocrinology & Metabolism/Pfizer International Award for Research Excellence, Endocrine Society

2004                Frontiers in Behavioral Science Award, FERMI Foundation

2004                Teacher of the Year Award, St. Elizabeth’s Residency Training.

2004                Walter Weintraub Award for the Teacher of the Year, University of Maryland / Sheppard-Pratt Psychiatry Residency Program

2005                Independent Investigator Award, NARSAD

2006                Mentor of the Year Award, St. Elizabeth’s Hospital, Washington, D.C.

2009                Faculty of the Year Award, St. Elizabeth’s Hospital and DC Department of Mental Health, rewarding an innovative evidence-based hands-on teaching program in psychiatric research

2009                Washingtonian: Top Psychiatrist.

2010                Patients’ choice award (by

2011                Superdocs 2011, Washington Post

2012                Superdocs 2012, Washington Post

2013                Distinguished Investigator Award from the American Foundation for Suicide Prevention

2017                Washingtonian Top Doctor 2017


Grants and Contracts

Grant Support




1R01MH104622-01                     Lena Brundin (PI)       08/01/14-07/30/18       NIH/NIMH

The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality

The project will determine whether women with altered levels of kynurenine pathway

metabolites are the ones developing depression and suicidal thoughts in pregnancy and the post-

partum period.

No overlap with proposed project


1R01HD086911-01A1                       Gragnoli (PI)                                       07/01/15-07/01/20


The goal is to understand whether the HPA axis receptor genes associated with the stress response may contribute to the depression-MetS/T2D co-morbidity and/or to metabolic and psychological associated traits. The genes of interest are corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) and the melanocortin receptor genes (MC1R-MC5R).

Role: Consultant


1I01CX001310-01                              Teodor Postolache (PI)                     09/01/15-08/31/19


Toxoplasma gondii, the kynurenine pathway, and suicidal behavior in Veterans

The purpose of the project is to investigate the neurochemical mechanisms underlying the

association between T. gondii  infection, kynurenine pathway activation and suicidal behavior.

Role PI


Alfred P. Sloan Foundation                Christopher A. Lowry (PI)                 07/01/16-12/31/17

Grant No:G-2016-7077($516,490.00)

Title: Longitudinal assessment of the influence of lifestyle homogenization on the MoBE in a cohort of United States Air Force Cadets

The purpose is to conduct a longitudinal analysis of the microbiomes of dormitories and their inhabitants at the US Air Force Academy (USAFA)

Role: Co-I


1I21RX002232-01 VA-Spire                         Lisa Brenner (PI)                    07/01/16-2018

Rehabilitation Research and Development Service ($199,960.00)

Title: Biological Signature and Safety of an Immunomodulatory Probiotic Intervention for Veterans with Co-Occurring Mild TBI and PTSD.

The aims of the study are to determine the: 1) effects of L. reuteri on biological signatures of gut microbiota, gut permeability, systemic inflammation processes, and stress responses; 2) feasibility of L. reuteri supplementation; 3) acceptability of L. reuteri supplementation; and 4) tolerability and safety of L. reuteri supplementation.

Role: Co-I


R01HD086805-01A1                                      Groer (PI)                            09/01/2017 - 08/31/2022           


Title: Chronic Toxoplasma gondii , Pregnancy reactivation and Perinatal Depression

The goal of this project is to study the relationships between latent T.gondii infection and depression through pregnancy and the postpartum in T. gondii positive Hispanic women.

Role: Co-I       





In the News

Media (selected)

  1. Discovery Channel (1997). Teodor Postolache: Sleep, mood and performance at high altitude
  2. New Scientist Olfaction and seasonality 8 Jan. 2000.
  3. SontaggsZeitung (Switzerland) Innovation in seasonal affective disorder 9 Jan. 2000.
  4. Reuters Health Patients with winter blues have a keener sense of smell Dec. 2002.
  5. Voice of America (2003). The Body Clock
  6. The Sun (2006). Jet Lag
  7. Washington Times (2006). Seasonal affective disorder.
  8. Psychiatric news: What accounts for the link between allergies and suicide? Interview by Jun Yan 2009
  9. CNN 2011: Allergy, depression and suicide
  10. Channel 4 2011: Weather, light and suicide
  11. Washington Post- included in the Superdocs list 2011
  12. The Atlantic Magazine 2012: Toxoplasma gondii and human behavior
  13. ABC News: July 2012 Study Links Cat Litter Box to Increased Suicide Risk
  14. NPR: July 2012 Common Parasite May Influence Human Behavior
  15. CNN (blog) July 2012: Kitty litter increases risk of suicide?
  16. Time July 2012 Are 'Cat Ladies' More Likely to Attempt Suicide?
  17. MSNBC  July 2012 Cat parasite linked to women's suicide attempts
  18. CBS July 2012Women with cats may have higher suicide risk due to feline fecal parasite
  19. Fox News July 2012 Common parasite found in cat litter may increase suicide risk
  20. Fox News Radio July 2012 Study: Cat Litter Associated With Suicide Risk
  21. Forbes 2012 Is Your Cat Hosting a Human Suicide Parasite?
  22. Web Med July 2012 Cat Litter Parasite May Raise Suicide Risk
  23. Reuters July 2012 Parasite tied to self-harm, suicide attempts
  24. New York Times 2013 Seasonal peaks of suicide
  25. Washington Post 2015 : Seasonal affective disorder
  26. KABC Radio 2017: Link between Allergies and Suicide
  27. Clues in the cycle of suicide: New York Times 2013
  28. Gut bacteria may predict PTSD lnk 2017
  29. Link between Spring and spiking suicide rates 2016  The Globe and the mail
  30. CBS news: Toxoplasma gondii linked to aggression  2016
  31. Is SAD real- Time magazine
  32. The troubling risk between allergy and suicide Reuters 2017 and Atlantic magazine
  33. VA researcher awarded a VA grant to explore impact of parasite o mental health 2017


Community Service




Links of Interest

Co-Founding Senior Researcher  of the Military and Veteran Microbiome Consortium for Research and Education - Denver CO