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DeAnna J. Friedman-Klabanoff, MD, MS

Academic Title:

Assistant Professor

Primary Appointment:



685 W. Baltimore St.

Phone (Primary):




Education and Training

University of Wisconsin-Madison, B.S., Medical Microbiology and Immunology, 2004

University of Wisconsin School of Medicine and Public Health, M.D., 2009

Residency, University of Minnesota, Pediatrics, 2012

Fellowship, University of Maryland School of Medicine, Pediatric Infectious Diseases, 2019

University of Maryland, Baltimore, M.S., Epidemiology and Clinical Research, 2023


Dr. Friedman-Klabanoff is a board-certified pediatric infectious disease specialist with a primary research interest in malaria vaccine development and natural and vaccine-induced immunity to Plasmodium falciparum, the most common and deadly cause of malaria worldwide. She has helped to lead multiple Phase 1 clinical trials of malaria and vector-borne disease vaccines. She also utilizes peptide microarray technologies to examine humoral immune responses, most recently to study vaccine-induced responses to a full-length circumsporozoite protein based vaccine, supported by the NIH Vaccine and Treatment Evaluation Unit, and to examine natural immunity to the pre-erythrocytic stages of malaria and protection from infection in a cohort of children in Malawi, supported by a K23 from the National Institute of Allergy and Infectious Diseases under the mentorship of Dr. Miriam Laufer. The overall goal of these projects is to examine the fine specificity and in vitro functional activity of pre-erythrocytic antibodies to refine future malaria vaccine efforts. 

During the COVID-19 pandemic, Dr. Friedman-Klabanoff expanded her research to also study the use of serological assays to track the spread of SARS-CoV-2 in the community through the COVID-19 Community Research Partnership. She also conducts vaccine trials for malaria, mosquito-borne diseases, and SARS-CoV-2. 

Research/Clinical Keywords

Malaria, malaria vaccine development, humoral immunity, SARS-CoV-2 serology, clinical vaccine trials, peptide microarray, human challenge studies, controlled human infection

Highlighted Publications

Friedman-Klabanoff DJ, Berry AA, Travassos MA, Shriver M, Cox C, Butts J, Lundeen JS, Strauss KA, Joshi S, Shrestha B, Mo AX, Nomicos EYH, Deye GA, Regules JA, Bergmann-Leitner ES, Pasetti MF, Laurens MB. Recombinant full-length Plasmodium falciparum circumsporozoite protein-based vaccine adjuvanted with GLA-LSQ: Results of Phase 1 testing with malaria challenge. J Infect Dis. 2024 Feb 8:jiae062. doi: 10.1093/infdis/jiae062. Epub ahead of print. PMID: 38330357.

Friedman-Klabanoff DJ, Adu-Gyasi D, Asante KP. Malaria prevention in children: an update. Curr Opin Pediatr. 2024 Jan 23. doi: 10.1097/MOP.0000000000001332. Epub ahead of print. PMID: 38299986.

Friedman-Klabanoff DJ, Birkhold M, Short MT, Wilson TR, Meneses CR, Lacsina JR, Oliveira F, Kamhawi S, Valenzuela JG, Hunsberger S, Mateja A, Stoloff G, Pleguezuelos O, Memoli MJ, Laurens MB. Safety and immunogenicity of AGS-v PLUS, a mosquito saliva peptide vaccine against arboviral diseases: A randomized, double-blind, placebo-controlled Phase 1 trial. EBioMedicine. 2022 Nov 24;86:104375. doi: 10.1016/j.ebiom.2022.104375. Online ahead of print. PMID: 36436281.

Friedman-Klabanoff DJ, Fitzpatrick MC, Deming ME, Agrawal V, Sitar S, Schaafsma T, Brown E, Neuzil KM, Barnabas RV, Laufer MK; Hydroxychloroquine COVID-19 PEP Study Team. Risk of SARS-CoV-2 acquisition is associated with individual exposure but not community-level transmission. J Infect Dis. 2022 Feb 2:jiac029. doi: 10.1093/infdis/jiac029. Online ahead of print. PMID: 35134185.

Friedman-Klabanoff DJ, Berry AA, Travassos MA, Cox C, Zhou Y, Mo AX, Nomicos EYH, Deye GA, Pasetti MF, Laurens MB. Low dose recombinant full-length circumsporozoite protein-based Plasmodium falciparum vaccine is well-tolerated and highly immunogenic in Phase 1 first-in-human clinical testing. 2021 Feb 22;39(8): 1195-1200. doi: 10.1016/j.vaccine.2020.12.023. Epub 2021 Jan 22. PMID: 33494963.

Friedman-Klabanoff DJ, Travassos MA, Ifeonu OO, Agrawal S, Ouattara A, Pike A, Bailey JA, Adams M, Coulibaly D, Lyke KE, Laurens MB, Takala-Harrison S, Kouriba B, Kone AK, Doumbo OK, Patel JJ, Thera MA, Felgner PL, Tan JC, Plowe CV, Berry AA. Epitope-specific antibody responses to a Plasmodium falciparum subunit vaccine target in a malaria-endemic population. J Infect Dis. 2021 Jun 4;223(11): 1943-1947. doi:10.1093/infdis/jiaa611. PMID: 32992328.

Friedman-Klabanoff DJ, Laurens MB, Berry AA, Travassos MA, Adams M, Strauss KA, Shrestha B, Levine MM, Edelman R, Lyke KE. The controlled human malaria infection experience at the University of Maryland. Am J Trop Med Hyg. 2019; 100(3): 556-565.

Additional Publication Citations

Friedman-Klabanoff DJ, Campbell JD. A 29-day-old Infant with Poor Feeding and a Rash. Pediatr Rev. 2021 Jan;42(Suppl 1):S15-S18. doi: 10.1542/pir.2019-0096.



Clinical Specialty Details

Dr. Friedman-Klabanoff is a board-certified pediatric infectious disease specialist. She attends on the pediatric infectious disease consult service, on which she also teaches medical students, residents, and fellows. 

Awards and Affiliations

2018 – 2020, 2021-2023  National Institutes of Health Loan Repayment Program

2019 – 2021  Burroughs Wellcome Fund/American Society of Tropical Medicine and Hygiene Postdoctoral Fellowship in Tropical Infectious Diseases

2019 – 2021  Pichichero Family Foundation Research Development, Vaccines for Children Initiative Award in Pediatric Infectious Diseases

2021 - 2023  Passano Foundation Clinician-Investigator Award for Career Development

Grants and Contracts

Dr. Friedman-Klabanoff works on numerous contracts; a select number are included below. Please refer to her CV for a full listing.

DeAnna Friedman-Klabanoff, M.D. (PI)
2021 – present
Serological markers of natural immunity to Plasmodium falciparum infection
DeAnna Friedman-Klabanoff, M.D. (PI)
2019 – present
Burroughs-Wellcome Fund/American Society of Tropical Medicine and Hygiene Postdoctoral Fellowship in Tropical Infectious Diseases
In search of natural immunity: finding serologic markers of immunity after exposure to malaria
DeAnna Friedman-Klabanoff, M.D. (PI)
2019 – present
Pichichero Family Foundation Vaccines for Children Initiative Research Award in Pediatric Infectious Diseases
A novel, translational approach to malaria vaccine development
Andrea Berry, M.D. (PI)
Role: Co-Investigator
2017 – present
A sub-study to evaluate epitope mapping of antibodies elicited by controlled human malaria infection, vaccination, and natural infection with Plasmodium falciparum malaria in 14-0040, 15-0052, and 13-0088