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Awadhesh K. Arya, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Emergency Medicine

Email:

aarya@som.umaryland.edu

Location:

100 S Penn Street, 540-B

Phone (Primary):

410-706-8296

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Education and Training

  • DDU Gorakhpur University, BS, Biology, 2003
  • University of Calicut, MS, Biotechnology, 2006
  • Banaras Hindu University, PhD, Biotechnology, 2013
  • Ben Gurion University of the Negev, PBC-Postdoctoral fellowship, T cell signaling, 2013-2016
  • NICHD/National Institute of Health, Visiting Fellowship, T cell development, 2016-2018
  • University of Maryland, Postdoctoral Fellow, Hemorrhagic shock, 2018-2022
  • University of Maryland, Research Associate, Neuroimmunology, 2022-2024

Biosketch

Dr. Awadhesh K. Arya is an Immunologist specializing in T cell biology, neuroinflammation, translational, and clinical research. He earned his Ph.D. from Banaras Hindu University, India, where he studied lymphocyte function in diabetic wound healing and received multiple national fellowships and awards. He completed postdoctoral training at Ben-Gurion University of the Negev, Israel, uncovering a novel role of cyclophilin A in regulating T cell activation, and at the NIH, where he investigated T cell development and signaling.

Since 2018, Dr. Arya has been at the University of Maryland, Baltimore, contributing to studies on neurodegeneration, neuroinflammation, and hemorrhagic shock. Currently, his research focuses on microparticle-mediated brain–immune interactions in carbon monoxide poisoning and decompression sickness, identifying neutrophil activation as a key driver of neuroinflammation. His recent work demonstrates that recombinant human plasma gelsolin can mitigate these effects (Science Advances, 2025). Dr. Arya continues to explore microparticle-driven mechanisms in neurological disorders and repair.

Research/Clinical Keywords

Neuroinflammation, microparticles, exosomes, carbon monoxide poisoning, decompression sickness, neutrophil activation, hyperbaric oxygen therapy, stem/progenitor cells, neurological disorders

Highlighted Publications

  1. Arya AK, Sethuraman K, Waddell J, Cha YS, Bhopale VM, Bhat AR, Imtiyaz Z, Dakessian A, Sward DG, Rosenthal RE, Moayedi S, Lee Y, Kim H, Liang Y, Thom SR. Science Advances 2025; eado9751.
  2. Arya AK, Balestra C, Bhopale VM, Tuominen LJ, Sokolowski AR, Dugrenot E, L’Her E, Abid R. Bhat and Stephen R. Thom. Elevations of extracellular vesicles and inflammatory biomarkers in closed-circuit SCUBA divers. Int. J. Mol. Sci. 2023, 24, 5969.
  3. Thom SR, Bhopale VM, Arya AK, Ruhela D, Bhat AR, Mitra N, Hoffstad O, Malay DS, Mirza ZK, Lantis JC, Lev-Tov HA, Kirsner RS, Hsia RC, Levinson SL, DiNubile MJ, Margolis DJ. Blood-Borne Microparticles Are an Inflammatory Stimulus in Type 2 Diabetes Mellitus. Immunohorizons. 2023, 7 (1): 71–80.
  4. Arya AK, Hu K, Chen A, Olivas-Garcia Y, Coyne C, Tanaka H, Liu C, Doucet J, Chan T, Hu B. Intracolon cooling increases survival rate in the rat model of lethal hemorrhage. Shock. 2023, 1;60(6):762-770. 
  5. Arya AK, Hu B. Brain-gut axis after stroke. Brain Circulation (2018); 4:165-73.

Additional Publication Citations

  1. Bhat AR, Arya AK, Bhopale VM, Imtiyaz Z, Thom SR. Recombinant human plasma gelsolin suppresses neuroinflammation and preserves hippocampal neurogenesis in murine decompression sickness model. Journal of Neurophysiology. 2024;132(6):1877-1886.
  2. Imtiyaz Z, Bhopale VM, Arya AK, Bhat AR, Thom SR. Microparticles in Human Perspiration as an Inflammatory Response Index. Diagnostics (Basel). 2024, 19;14(12):1293.
  3. Bhat AR, Arya AK, Bhopale VM, Imtiyaz Z, Xu S, Bedir D, Thom SR. Persistent neuroinflammation and functional deficits in a murine model of decompression sickness. J Appl Physiol (1985), 2024.
  4. Anto NP*, Arya AK*, Muraleedharan A, Shaik J, Nath PR, Livneh E, Sun Z, Braiman A, Isakov N. Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells. Cellular and Molecular Life Sciences. 2023,80:7. *Equal contributors
  5. Choi S, Lee J, Hatzihristidis T, Gaud G, Dutta A, Arya A, Clubb LM, Stamos DB, Markovics A, Mikecz K, Love PE. THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1. Sci. Signal. 2023, 9;16(784): eade1274.
  6. Choi S, Lee J, Hatzihristidis T, Gaud G, Dutta A, Lee J, Arya A, Clubb LM, Stamos DB, Markovics A, Mikecz K, Love P. GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1. J. Exp. Med. 2023, 220 No. 7 e20221649.
  7. Thom SR, Bhopale VM, Bhat AR, Arya AK, Ruhela D, Qiao D, Li X, Tang S, Xu S. Neuroinflammation with increased glymphatic flow in a murine model of decompression sickness. J Neurophysiol. 2023, 129: 662–671.
  8. Balestra, C, Arya AK, Leveque C, Virgili F, Germonpre P, Lambrechts K, Lafere P, Thom SR. Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward A Targeted Use of Oxygen? Int J Mol Sci. 2022, 23,7888.
  9. Arya AK, Hu K, Subedi L, Li T, Hu B. Focal Intra-Colon Cooling Reduces Organ Injury and Systemic Inflammation After REBOA Management of Lethal Hemorrhage in Rats. Scientific Reports. 2021, 11:13696: 1-12.
  10. Hu K, Gaire BP, Subedi L, Arya AK, Teramoto H, Liu C, Hu B. Interruption of Endolysosomal Trafficking After Focal Brain Ischemia. Frontiers in Molecular Neuroscience. 2021, 14:719100: 1-20.
  11. Arya AK, Pokharia D, Bhan S, Tripathi R, Tripathi K. Correlation between IL-7 and MCP-1 in diabetic chronic non-healing ulcer patients at higher risk of coronary artery disease. Cytokine. 2012, 60:767-771.
  12. Arya AK, Pokharia D, Tripathi K. Relationship between oxidative Stress and apoptotic markers in lymphocytes of diabetics with chronic non-healing. Diabetes research and clinical practice. 2011, 94:377–384.
  13. Arya AK, Tripathi R, Kumar S, Tripathi K. Recent advances on the association of apoptosis in chronic non-healing diabetic World J Diabetes. 2014, 5(6): 756-762.
  14. Arya AK, Tripathi K, Das P. Promising Role of ANGPTL-4 Gene in Diabetic Wound Healing. International Journal of Lower Extremity Wound. 2014, 13(1):58-63.
  15. Kumar H, Mishra M, Bajpai S, Pokharia D, Arya AK, Singh RK, Tripathi K. Correlation of insulin resistance, beta cell function, and insulin sensitivity with serum sFas and sFasL in newly diagnosed type 2 diabetes. Acta Diabetologica. 2013, 50:511-518.

Awards and Affiliations

Awards

2016- Visiting Postdoctoral Fellowship

National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.

2011-Young Scientist International Travel Award

Indian Council of Medical Research and Department of Science and Technology, India.

2011-Senior Research Fellowship

Council of Scientific and Industrial Research (CSIR), Government of India.

2011- First prize in the 8th technology-led entrepreneurship program

IICT Hyderabad, MHRD, and CSIR, Government of India.

2008- Junior Research Fellowship

Council of Scientific and Industrial Research (CSIR), Government of India.

2006-Graduate Aptitude Test in Engineering

The Indian Institute of Technology (IIT), Kharagpur, India.

Affiliations

2025- International Society of Neuroimmunology

2020- Associate Editor in Frontiers Journal of Neurodegeneration

2019- Member of the Society of Neurosciences, USA.

2018- Member of the American Association of Immunologists.

2011- Member of the Indian Science Congress, India.

Grants and Contracts

2013- Dr. D.S. Kothari Postdoctoral Fellowship

“Study on evaluation of epidermal differentiation in diabetic wound healing: Single Nucleotide Polymorphism (SNP) and genetic susceptibility”

University Grants Commission, Government of India, No.F.4-2/2006(BSR)/13-850/2013(BSR).

Annual direct cost:$8,225

Total direct cost: $24,675

2013-The Planning and Budgeting Committee (PBC) Fellowship Program

“The role of Crk adaptor proteins in the early steps of T lymphocyte activation and the potential regulation of Crk-regulated functions by immunophilins”

Council for Higher Education, Government of Israel

Annual direct cost:$103,500

Total direct cost: $34,500

 

 

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