Ambulos, Nicholas | University of Maryland School of Medicine

Academic Title:

Professor

Primary Appointment:

Microbiology and Immunology

Secondary Appointment(s):

Medicine, Administration

Administrative Title:

Acting Program Director; Associate Director

Additional Title:

Director, Center for Innovative Biomedical Resources; Associate Director for Shared Services, Marlene and Stewart Greenebaum Comprehensive Cancer Center Technical Supervisor, Translational Genomics Laboratory Director, Genomics Shared Resource

Email:

nambulos@som.umaryland.edu

Location:

Bressler 7-039

Phone (Primary):

(410) 706-0665

Phone (Secondary):

(410) 706-1240 (Administrative Office)

Download CV

Biosketch

I am currently a Professor in the Department of Microbiology and Immunology and the Department of Medicine. I have directed the Genomics Resource (formerly called the Biopolymer Laboratory for over 30 years, guiding the resource to the forefront of the field, adding new technologies and securing funding for state-of-the-art instrumentation. In 2012 I established the Translational Genomics Laboratory (TGL) to bridge the gap between genomic discoveries and clinical practice. The primary mission of the TGL is to provide rapid, clinically validated genomic testing that directly informs patient care and determine eligibility for patient accrual to clinical trials based on a patient’s molecular profile. The TGL specialize in testing patients with hematologic malignancies, offering targeted variant testing for FLT3, IDH1, and IDH2, and providing a comprehensive multi-gene sequencing panel to identify actionable variants with a rapid return of results.

Since 2013 I have served as the founding director of the UMSOM Center for Innovative Biomedical Resources (CIBR), the administrative home for core laboratories at the UMSOM. In this role, I provide an overall vision for the organization and management of all UMSOM core resources which includes UMGCCC Shared Resources. I have successfully written or co-written numerous NIH instrumentation grants and in 2009 I successfully competed for an NIH Core Facility Renovation, Repair and Improvement grant (G20) which enabled renovation of 30,000 gross square feet to co-locate many of our institutional shared resources within CIBR. In addition to this leadership role within the UMSOM, I serve as the Associate Director for Shared Resources in the University of Maryland School of Medicine’s Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC), a position held since 2004. In 2016 and 2021 I successfully led 7 UMGCC Shared Services through two 5-year NCI-CCSG (center grant) renewal and contributed to the Center’s designation as an NCI Comprehensive Cancer Center. I serve on scientific advisory boards of a number of NCI-designated Cancer Centers.

Research/Clinical Keywords

Core Facility, Shared Resource, Genomics, Molecular Genetics, Sequencing, Gene Expression, Genotyping, Core Management, Pharmacogenomics, Assay Development

Highlighted Publications

Ambulos, N.P., Jr., Mische, S.M., Fox, J.W. Greater Reliance on Shared Resources Can Enrich the Future Success of Academic Research. J. Biomol. Tech. 2025. DOI https://doi.org/10.7171/3fc1f5fe.e2548884.

Nowak, R.G., Ambulos, N.P., Schumaker, L.M., Mathias, T.J., White, R.A., Troyer, J., Wells, D., Charurat, M.E., Bentzen, S.M., Cullen, K.J. Genotyping of high-risk anal human papillomavirus (HPV): ion torrent-next generation sequencing vs. linear array. Virology J. 2017; 14(1):112. PMCID:PMC5470268.

Ambulos, Jr., N.P., Schumaker, L.M., Mathias, T.J., White, R., Troyer, J., Wells, D., Cullen, K.J. Next Generation Sequencing based HPV genotyping assay validated in formalin-fixed, paraffin-embedded oropharyngeal and cervical cancer specimens. J. Biomolec. Tech. 2016;27(2):46-52. PMCID: PMC4802743.

Shuldiner, A.R., Palmer, K., Pakyz, R.E., Alestock, T.D., Maloney, K.A., O’Neill, C., Bhatty, S., Schub, J., Overby, C.L., Horenstein, R.B., Pollin, T.I., Kelemen, M.D., Beitelshees, A.L., Robinson, S.W., Blitzer, M.G., McArdle, P.F., Brown, L., Jeng, L.J., Zhao, R.Y., Ambulos, Jr., N.P., Vesely, M.R. 2014. Implementation of Pharmcogenomics: The University of Maryland Personalized Anti-Platelet Pharmacogenomics Program. Am. J. Med. Genet. 166(1):76-84. PMCID: PMC4066997.

Shuldiner, A.R., Relling, M.V., Peterson, J.F., et. al. 2013. The Pharmacogenomics Research Network Translational Pharmacogenomics Program: Overcoming Challenges of Real-World Implementation. Clin. Pharmacol. Ther. 94(2):207-210. PMCID: PMC3720847.

Nicholas P. Ambulos, PhD

Biosketch

Research/Clinical Keywords

Highlighted Publications