Academic Title:
Associate Professor
Primary Appointment:
Epidemiology & Public Health
Location:
Howard Hall, 109C
Phone (Primary):
410-706-8523
Fax:
410-706-8548
Education and Training
Ph.D. in Computer Engineering, Virginia Polytechnic Institute and State University.
M.S. in Bioinformatics, Southeast University, China.
B.S. in Biomedical Engineering, Southeast University, China.
Biosketch
Dr. Zhang’s research focuses on developing translational informatics approaches to reveal novel human disease mechanisms. She has solid interdisciplinary trainings in bioinformatics and Computer Engineering. Dr. Zhang has years of research experience in integrative analysis of multi-source high-dimensional biological data for novel association discovery between different biological entities (e.g., gene, drug, and gene) under different biological states. In addition, she has extensive collaborative research experience in medical informatics, ontology, software engineering, and biomedical and basic science fields. Her current research mission is to leverage the gap between the analytical needs of arising from multi-source biological “big” data in biomedical research and advanced informatics approaches. As the lead of the bioinformatics core at University of Maryland Greenebaum Comprehensive Cancer Center and University of Maryland School of Medicine, Dr. Zhang has been serving as co-principle investigator/co-investigator leading the bioinformatics and statistical analyses in numerous federal funded research projects including the International Consortium for Prostate Cancer Genetics (ICPCG) and the consortium of Extracellular non-coding RNA biomarker discovery of hepatocellular cancer. She has also been organizing/co-organizing several international workshops in the informatics field since 2012.
Research/Clinical Keywords
Translational Bioinformatics, Network Medicine, Systems Biology, Next Generation Sequencing, Systems Pharmocogenomics, Non Coding RNA mechanisms
Highlighted Publications
- Wang J, Zhao L, Ye Y, Zhang Y. Adverse event detection by integrating Twitter data and VAERS. Journal of Biomedical Semantics, 2018 Jun 20; 9:19.
- Wang L, Felts SJ, Van Keulen VP, Scheid AD, Block MS, Markovic SN, Pease LR, Zhang Y. Integrative genome-wide analysis of long noncoding RNAs in diverse immune cell types of melanoma patients. Cancer Research, 2018 Jun 12; pii: canres.0529.2018.
- Zhang Y, Shen F, Mojarad MR, Li D, Tao C, Yu Y, Liu S, Liu H. Systematic identification of latent disease-gene relationships from PubMed articles. PLOS ONE, 2018 Jan 16; 13(1): e0191568.
- Wang L, Ma X, Xu X, Zhang Y. Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish. Scientific Reports, 2017 Apr 28;7(1):1250.
- Zhang Y, Zhu Q, Liu H. Next generation informatics for big data in precision medicine era. BioData Mining, 2015 Nov 3;8:34.
- Thibodeau SN, French AJ, McDonnell SK, Cheville J, Middha S, Tillmans L, Riska S, Baheti S, Larson MC, Fogarty Z, Zhang Y, Larson N, Nair A, O’Brien D, Wang L, Schaid DJ. Identification of candidate genes for prostate cancer-risk SNPs utilizing a normal prostate tissue eQTL data set. Nature communications, 2015 Nov 27;6:8653.
- Zhang Y, Tao C, Jiang G, Nair AA, Su J, Chute CG, Liu H. Network-based analysis reveals distinct association patterns in a semantic MEDLINE-based drug-disease-gene network. Journal of Biomedical Semantics, 2014 Aug 6;5:33.
- Zhang Y, Tao C, He Y, Kanjamala P, Liu H. Network-based analysis of vaccine-related associations reveals consistent knowledge with the vaccine ontology. Journal of Biomedical Semantics, 2013 Nov 11;4(1):33.
- Wang J, Zhang Y, Marian C, Ressom HW. Identification of aberrant pathways and network activities from high-throughput data. Briefings in Bioinformatics, 2012;13(4):406-19.
Additional Publication Citations
- Zhang Y, Zhu J, Sun X, Lu Z. A method of oligonucleotide synthesis optimization. 2002;12(4):26-28.
- Ressom HW*, Zhang Y*, Xuan J, Wang Y, Clarke R. Inference of gene regulatory networks from time course gene expression data using neural networks and swarm intelligence. Proceedings of 2006 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology (CIBCB '06). 2006 Sep 28;435-442. (primary author to design the experiment, perform the analysis, and write the manuscript)
- Ressom HW*, Zhang Y*, Xuan J, Wang Y, Clarke R. Inferring network interactions using recurrent neural networks and swarm intelligence. Proceedings of the 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2006). 2006 Aug 30;4241-4244. (primary author to design the experiment, perform the analysis, and write the manuscript)
- Ressom HW*, Zhang Y*, Xuan J, Wang Y, Clarke R. Integrating multi-source biological data for transcriptional regulatory module discovery. Proceedings of IEEE/NIH Life Science Systems and Applications Workshop 2007 (LISA 2007). 2007 Nov 8;184-187. (primary author to design the experiment, perform the analysis, and write the manuscript)
- Zhang Y, Xuan J, de los Reyes BG, Clarke R, Ressom HW. Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data. BMC Bioinformatics. 2008 Apr 21;9(1):203.
- Zhang Y, Xuan J, de los Reyes BG, Clarke R, Ressom HW. Reverse engineering module networks by PSO-RNN hybrid modeling. Proceedings of the 2008 International Conference on Bioinformatics and Computational Biology (BIOCOMP 2008). 2008; 401–407.
- Zhang Y, Xuan J, de Los Reyes BG, Clarke R, Ressom HW. Network motif-based identification of breast cancer susceptibility genes. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2008). 2008 Aug 20;5696-5699.
- Zhang Y, Xuan J, de los Reyes BG, Clarke R, Ressom HW. Reverse engineering module networks by PSO-RNN hybrid modeling. BMC Genomics. 2009 Jul 7;10(1):S15.
- Zhang Y, Xuan J, de los Reyes BG, Clarke R, Ressom HW. Module-based biomarker discovery for breast cancer. Proceedings of 2010 IEEE International Conference on Bioinformatics & Biomedicine. 2010 Dec 18;352-356.
- Zhang Y, Xuan J, de los Reyes BG, Clarke R, Ressom HW. Reconstruction of gene regulatory modules in cancer cell cycle by multi-source data integration. PLOS ONE. 2010 Apr 21;5(4):e10268.
- Sun Z, Baheti S, Middha S, Kanwar R, Zhang Y, Li X, Beutler AS, Klee E, Asmann YW, Thompson EA, Kocher JP. SAAP-RRBS: streamlined analysis and annotation pipeline for reduced representation bisulfite sequencing. Bioinformatics. 2012 Jan 15;28(2):277-278. (participated in determining analytic method, running analyses, and providing statistical interpretation)
- Craig TA*, Zhang Y*, McNulty MS, Middha S, Ketha H, Singh RJ, Magis AT, Funk C, Price ND. Ekker SC, Kumar R. Research resource: whole transcriptome RNA sequencing detects multiple 1alpha, 25-dihydroxyvitamin D(3)-sensitive metabolic pathways in developing zebrafish. Molecular Endocrinology. 2012 Jun 25;26(9):1630-1642. (primary author to design the experiment, perform the analysis, and write the manuscript)
- Wang J, Zhang Y*, Marian C, Ressom HW. Identification of aberrant pathways and network activities from high-throughput data. Briefings in Bioinformatics. 2012 Jan 27;13(4):406-419. (determined analytic method, provided statistical interpretation)
- Asmann YW, Middha S, Hossain A, Baheti S, Li Y, Chai HS, Sun Z, Duffy PH, Hadad AA, Nair A, Liu X, Zhang Y, Klee EW, Kalari KR, Kocher JP. TREAT: a bioinformatics tool for variant annotations and visualizations in targeted and exome sequencing data. Bioinformatics. 2012 Jan 15;28(2):277-278. (determined analytic method, ran analyses, provided statistical interpretation)
- Tao C, Zhang Y, Jiang G, Bouamrane MM, Chute CG. Optimizing semantic MEDLINE for translational science studies using semantic web technologies. MIXHS '12 Proceedings of the 2nd international workshop on Managing interoperability and compleXity in health systems. 2012 Oct 29;53-58. (determined analytic method, ran analyses, provided statistical interpretation)
- Zhang Y, Li D, Tao C, Shen F, Liu H. An integrative computational approach to identify disease-specific networks from PubMed literature information. Proceedings of IEEE International Conference on Bioinformatics and Biomedicine 2013. 2013 Dec 18;72-75.
- Leonard B, Hart SN, Burns MB, Carpenter MA, Temiz NA, Rathore A, Isaksson Vogel R, Nikas JB, Law EK, Brown WL, Li Y, Zhang Y, Maurer MJ, Oberg AL, Cunningham JM, Shridhar V, Bell DA, April C, Bently D, Bibikova M, Cheetham RK, Fan JB, Grocock R, Humphray S, Kingsbury Z, Peden J, Chien J, Swisher EM, Hartmann LC, Kalli KR, Goode EL, Sicotte H, Kaufmann SH, & Harris RS APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma. Cancer Research. 2013 Dec 15;73(24):7222-7231. (determined analytic method, ran analyses, provided statistical interpretation)
- Hart SN, Therneau TM, Zhang Y, Poland GA, Kocher JP. Calculating sample size estimates for RNA sequencing data. Journal of Computational Biology. 2013 Dec 1;20(12):970-978. (determined analytic method, ran analyses, provided statistical interpretation)
- Zhang Y, Tao C, He Y, Kanjamala P, Liu H. Network-based analysis of vaccine-related associations reveals consistent knowledge with the vaccine ontology. Journal of Biomedical Semantics. 2013 Nov 11;4(1):33.
- Sun Z, Asmann YW, Nair A, Zhang Y, Wang L, Kalari KR, Bhagwate AV, Baker TR, Carr, JM, Kocher JP, Perez EA, Thompson EA. Impact of library preparation on downstream analysis and interpretation of RNA-Seq data: comparison between Illumina PolyA and NuGEN Ovation protocol. PLOS ONE. 2013;8(8):e71745. (determined analytic method, ran analyses, provided statistical interpretation)
- Pugazhenthi S, Zhang Y, Bouchard R, & Mahaffey G. Induction of an inflammatory loop by interleukin-1 beta and tumor necrosis factor-alpha involves NF- kappa B and STAT-1 in differentiated human neuroprogenitor cells. PLOS ONE. 2013;8(7): e69585. (determined analytic method, ran analyses, provided statistical interpretation)
- Zhang Y, Tao C, He Y, Kanjamala P, Liu H. Analysis of vaccine-related networks using Semantic MEDLINE and the vaccine ontology. CEUR Workshop Proceedings, 2013; 1061.
- Zhang Y, Xuan J, Clarke R, Ressom HW. Module-based breast cancer classification. International Journal of Data Mining and Bioinformatics. 2013;7(3):284-302.
- Zhang Y, Tao C. Network analysis of cancer-focused association network reveals distinct network association patterns. Cancer Informatics. 2014;13(S3):45.
- Tao C, Wu P, Zhang Y. Linked vaccine adverse event data representation from VAERS for biomedical informatics research. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2014 May 13;652-661.
- Craig, TA*, Zhang Y*, Magisc AT, Funk CC, Price ND, Ekker, SC, Kumar R. Detection of 1,25-Dihydroxyvitamin D-regulated miRNAs in zebrafish by whole transcriptome sequencing. Zebrafish. 2014 Jun1;11(3):207-218. (*co-first authorship)
- Zhang Y, Tao C. Correction to "Network analysis of cancer-focused association network reveals distinct network association patterns". Cancer Inform. 2014;13(Suppl 3):89.
- Zhang Y, Tao C, Jiang G, Nair A, Su J, Chute CG, Liu H. Network-based analysis reveals distinct association patterns in a Semantic MEDLINE-based Drug-Disease-Gene network. Journal of Biomedical Semantics. 2014 Aug 6;5(1):33.
- Zhang Y. Network-based analysis of time series RNA-seq gene expression data by integrating the interactome and gene ontology information. Proceedings of 2014 8th International Conference on Systems Biology (ISB). 2014 Oct 24;201-209.
- Zhu Q, Liu H, Zhang Y, Wang J. Evidence based computational drug repositioning candidate screening pipeline design: case study. Proceedings of 2014 8th International Conference on Systems Biology (ISB). 2014 Oct 24;210-218. (determined analytic method, ran analyses, provided statistical interpretation)
- Wang L, Chen J, Wang C, Uusküla-Reimand L, Chen K, Medina-Rivera A, Young E, Zimmermann M, Yan H, Sun Z, Zhang Y, Wu S, Huang H, Wilson MD, Kocher JP, Li W. MACE: model based analysis of ChIP-exo. Nucleic Acids Research. 2014, Nov 10;42(20):e156-e156. (determined analytic method, ran analyses, provided statistical interpretation)
- Tao C, Yu P, Luo Y, Zhang Y. Linked vaccine adverse event data from VAERS for biomedical data analysis and longitudinal studies. BioData Mining. 2014 Dec 31;7(1):36.
- Shih Y, Zhang Y, Ding Y, Ross CA, Li H, Olson TM, Xu X. The Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish. Circulation: Cardiovascular Genetics. 2015 Apr;8(2):261-269. (primary author to determine analytic method, run analyses, and provide statistical interpretation)
- Felts SJ, Van Keulen VP, Scheid AD, Allen KS, Bradshaw RK, Jen J, Peikert T, Middha S, Zhang Y, Block MS, Markovic SN, Pease LR. Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients. Cancer Immunology & Immunotherapy. 2015 Nov 1;64(11):1437-1447. (determined analytic method, ran analyses, provided statistical interpretation)
- Zhang Y. Network analysis reveals stage-specific changes in zebrafish embryo development using time course whole transcriptome profiling and prior biological knowledge. BioData Mining. 2015 Aug 28;8(1):26.
- Zhang Y, Yu P, & Tao C. Identification of sex-associated network patterns in vaccine-adverse event association network in VAERS. Journal of Biomedical Semantics. 2015 Aug 19;6(1):33.
- Thibodeau SN, French AJ, McDonnell SK, Cheville J, Middha S, Tillmans L, Riska S, Baheti S, Larson MC, Fogarty Z, Zhang Y, Larson N, Nair A, O’Brien D, Wang L, Schaid DJ. Identification of candidate genes for prostate cancer-risk SNPs utilizing a normal prostate tissue eQTL data set. Nature Communications. 2015 Nov 27;6:8653. (determined analytic method, ran analyses, provided statistical interpretation)
- Zhang Y, Zhu Q, Liu H. Next generation informatics for big data in precision medicine era. BioData Mining. 2015 Nov 3;8(1):34.
- Kitange GJ, Mladek AC, Schroeder MA, Pokorny JC, Carlson BL, Zhang Y, Nair AA, Lee JH, Yan H, Decker PA, Zhang Z, Sarkaria JN. Retinoblastoma binding protein 4 modulates temozolomide sensitivity in glioblastoma by regulating DNA repair proteins. Cell Reports. 2016 Mar 22;14(11):2587-98. (determined analytic method, ran analyses, provided statistical interpretation)
- Fan L, Peng G, Sahgal N, Fazli L, Gleave M, Zhang Y, Hussain A, Qi J. Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival. Oncogene. 2016 May 12;35(19):2441-52. (determined analytic method, ran analyses, provided statistical interpretation)
- Dong D, Zhang Y, Reece EA, Wang L, Harman CR, Yang P. microRNA expression profiling and functional annotation analysis of their targets modulated by oxidative stress during embryonic heart development in diabetic mice. Reproductive Toxicology. 2016 Oct 31;11(65):365-374. (determined analytic method, ran analyses, provided statistical interpretation)
- Jackson IL, Zhang Y, Bentzen S, Hu J, Zhang C, Katz BP, Vujaskovic Z. Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse among murine strains. Scientific Reports. 2016 Nov 15;6:36579. (determined analytic method, ran analyses, provided statistical interpretation)
- Wang L, Ma X, Xu X, Zhang Y. Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish. Scientific Reports. 2017 Apr 28;7(1):1250.
- Kaczanowska S, Joseph AM, Guo J, Tsai AK, Lasola JJ, Younger K, Zhang Y, Gonzales CV, Davila E. A synthetic CD8α:MyD88 coreceptor enhances CD8+ T-cell responses to weakly immunogenic and lowly expressed tumor antigens. Cancer Research. 2017 Dec 15; 77(24):7049-7058. (determined analytic method, ran analyses, provided statistical interpretation)
- Jackson IL, Zhang Y, Bentzen S, Hu J, Zhang C, Katz BP, Vujaskovic Z. Corrigendum: Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse. Scientific Reports. Sci Rep. 2017 May 4;7:46782. (determined analytic method, ran analyses, provided statistical interpretation)
- Zhang Y, Shen F, Mojarad MR, Li D, Tao C, Yu Y, Liu S, Liu H. Systematic identification of latent disease-gene relationships from PubMed articles. PLOS ONE. 2018 Jan 16; 13(1): e0191568.
- Scheid AD, Keulen V, Felts SJ, Neier SC, Middha S, Nair AA, Techentin RW, Gilbert BK, Jen J, Neuhauser C, Zhang Y, Pease LR. Gene expression signatures characterized by longitudinal stability and interindividual variability delineate baseline phenotypic groups with distinct responses to immune stimulation. The Journal of Immunology. 2018 Mar 1; 200(5):1917-1928. (determined analytic method, ran analyses, provided statistical interpretation)
- Wang L, Felts SJ, Van Keulen VP, Scheid AD, Block MS, Markovic SN, Pease LR, Zhang Y. Integrative genome-wide analysis of long noncoding RNAs in diverse immune cell types of melanoma patients. Cancer Research. 2018 Aug 1;78(15):4411-4423.
- Wang J, Zhao L, Ye Y, Zhang Y. Adverse event detection by integrating Twitter data and VAERS. Journal of Biomedical Semantics. 2018 Jun 20; 9:19.
- Wang L, Felts SJ, Van Keulen VP, Pease LR, Zhang Y. Exploring the effect of library preparation on RNA sequencing experiments. Genomics. 2018 Dec 6; pii: S0888-7543(18)30367-7.
- Zandberg DP, Tallon LJ, Nagaraj S, Sadzewicz LK, Zhang Y, Strome MB, Zhao XE, Vavikolanu K, Zhang X, Papadimitriou JC, Hubbard FA, Bentzen SM, Strome SE, Fraser CM. Intratumor genetic heterogeneity in squamous cell carcinoma of the oral cavity. Head Neck. 2019 Aug;41(8):2514-2524. (determined analytic method, ran analyses, provided statistical interpretation)
- Petri M, Fu W, Ranger A, Allaire N, Cullen P, Magder LS, Zhang Y. Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus. BMC Medical Genomics. 2019 Jan 9;12(1):4.
- Ramalingam S, Ramamurthy VP, Gediya LK, Murigi FN, Purushottamachar P, Huang W, Choi EY, Zhang Y, Vasaitis TS, Kane MA, Lapidus RG, Njar VCO. The novel mnk1/2 degrader and apoptosis inducer VNLG-152 potently inhibits TNBC tumor growth and metastasis. Cancers (Basel). 2019 Mar 3;11(3). (determined analytic method, ran analyses, provided statistical interpretation)
- Kohli M, Oberg AL, Mahoney DW, Riska SM, Sherwood R, Zhang Y, Zenka RM, Sahasrabudhe D, Qin R, Zhang S. Serum Proteomics on the basis of discovery of predictive biomarkers of response to androgen deprivation therapy in advanced prostate cancer. Clinical Genitourinary Cancer. 2019 Aug;17(4):248-253. (determined analytic method, ran analyses, provided statistical interpretation)
- Ren JJ, Sun T, He Y, Zhang Y. A statistical analysis of vaccine-adverse event data. BMC Medical Informatics and Decision Making. 2019 May 28;19(1):101.
- Hu G, Zhang Y, Gupta M. RIP sequencing in mantle cell lymphoma identifies functional long non-coding RNAs associated with translation machinery. Blood Cancer Journal. 2019; 9: 55. (determined analytic method, ran analyses, provided statistical interpretation)
- Ding Y, Wang L, Zhang Y, Xu X. Haploinsufficiency of mechanistic target of rapamycin attenuates bag3 cardiomyopathy in adult zebrafish. Disease Models & Mechanisms. 2019 Oct 1; 12(10): dmm040154. (determined analytic method, ran analyses, provided statistical and bioinformatics interpretation)
- Kwegyir-Afful A, Ramalingam S, Ramamurthy V, Purushottamachar P, Murigi F, Vasaitis T, Huang W, Kane M, Zhang Y, Ambulos N, Tiwari S, Srivastava P, Nnane I, Hussain A, Qiu Y, Weber D, Njar V. Galeterone and the next generation galeterone analogs, VNPP414 and VNPP433-3β exert potent therapeutic effects in castration-/drug-resistant prostate cancer preclinical models in vitro and in vivo. Cancers (Basel). 2019 Oct 24;11(11):1637. (determined analytic method, ran analyses, provided statistical interpretation)
- Dorgan JF, Jung S, Dallal CM, Zhan M, Stennett CA, Zhang Y, Eckert RL, Snetselaar LG, Van Horn L. Alcohol consumption and serum metabolite concentrations in young women. Cancer Causes and Control. 2020 Feb;31(2):113-126. (determined analytic method, ran analyses, provided statistical interpretation)
- Fava A, Buyon J, Mohan C, Zhang T, Belmont HM, Izmirly P, Clancy R, Trujillo JM, Fine D, Zhang Y, Magder L, Rao DA, Arazi A, Berthier CC, Davidson A, Diamond B, Hacohen N, Wofsy D, Apruzzese W, the Accelerating Medicines Partnership in SLE network, Raychaudhuri S, Petri M. Integrated urine proteomics and renal single-cell genomics identify an IFN-γ response gradient in lupus nephritis. JCI Insight. 2020; 5(12): e138345. (determined analytic method, ran analyses, provided statistical interpretation)
- Geng D, Ciavattone N, Lasola JJ, Shrestha R, Sanchez A, Guo J, Vlk A, Younis R, Wang L, Brown A, Zhang Y, Velasco-Gonzalez C, Tan AC, Davila E. Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Communications Biology. 2020; 3:306. (determined analytic method, ran analyses, provided statistical interpretation)
- Barry KH, Mohanty K, Erickson P, Rose G, Cellini A, Clark K, Ambulos N, Yin J, Yan L, Poulin M, Meyer A, Zhang Y, Bentzen S, Burke A, Hussain A, Berndt S. MYC DNA methylation in prostate tumor tissue is associated with tumor aggressiveness. Genes. 2020;12(1):12. (determined analytic method, ran analyses, provided statistical interpretation)
- Inglut CT, Gray K, Vig S, Jung J, Stabile J, Zhang Y, Stroka KM, Huang HC. Photodynamic priming modulates endothelial cell-cell junction phenotype for light-activated remote control of drug delivery. IEEE Journal of Selected Topics in Quantum Electronics. 2021;27(4):7200311. (determined analytic method, ran analyses, provided statistical interpretation)
- Ferraris D, Lapidus R, Truong P, Bollino D, Carter-Cooper B, Lee M, Chang E, LaRossa-Garcia M, Dash S, Gartenhaus R, Choi EY, Kipe O, Lam V, Mason K, Palmer R, Williams E, Ambulos N, Kamangar F, Zhang Y, Kapadia B, Jing Y, Emadi A. Pre-Clinical activity of amino-alcohol dimeric naphthoquinones as potential therapeutics for acute myeloid leukemia. Anti-Cancer Agents in Medicinal Chemistry. 2021 Jun 2. doi: 10.2174/1871520621666210602131558. Epub ahead of print. PMID: 34080968. (determined analytic method, ran analyses, provided statistical interpretation)
- Serfecz JC, Saadin A, Santiago CP, Zhang Y, Bentzen SM, Vogel SN, Feldman RA. C5a activates a pro-inflammatory gene expression profile in human gaucher iPSC-derived macrophages. International Journal of Molecular Sciences. 2021; 22(18): 9912. (determined analytic method, ran analyses, provided statistical interpretation)
- Basehore S, Bohlman S, Weber C, Swaminathan S, Zhang Y, Jang C, Arany Z, Clyne AM. Laminar flow on endothelial cells suppresses eNOS O-GlcNAcylation to promote eNOS activity. Circulation Research. 2021 Nov 12;129(11):1054-1066. (determined analytic method, ran analyses, provided statistical interpretation)
- Sorrin AJ, Liu C, Cicalo J, Reader J, Najafali D, Zhang Y, Roque DM, Huang HC. Photodynamic priming improves the anti-migratory activity of prostaglandin E receptor 4 antagonist in cancer cells. Cancers 2021, 13(21): 5259. (determined analytic method, ran analyses, provided statistical interpretation)
- Bu H, Ding Y, Li J, Zhu P, Shih YH, Wang M, Zhang Y, Lin X, Xu X. Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI Insight. 2021 Dec 22;6(24):e154215. (determined analytic method, ran analyses, provided statistical interpretation)
- Nian Y, Du J, Bu L, Li F, Hu X, Zhang Y, Tao C. Knowledge Graph-based Neurodegenerative Diseases and Diet Relationship Discovery. Proceedings of CIBB 2021. (in press)
Awards and Affiliations
2012 Travel Award, the 20th Annual International Conference on Intelligence Systems for Molecular Biology
2019 Merit Scholarship, Women in AMIA Leadership Program, American Medical Informatics Association
2020 Winner of WIA (Women in AMIA) Leadership 2020 Seed Grant, American Medical Informatics Association
Grants and Contracts
09/20/16 – 05/31/23 (Co-Inv) PI: M. Terrin
“PCTC Administrative Coordinating Center”
NHLBI/NIH, U24 HL134763
Lead Bioinformatician and Biostatistician
03/01/18 – 02/28/23 (Co-Inv) PI: V. Njar
“Development of next generation galeterone analogs for prostate cancer therapy”
NCI/NIH, R01 CA224696
Lead Bioinformatician and Biostatistician
03/15/19 – 02/28/24 (Collaborator) PI: M. Levine
“Active vaccination and passive antibody strategies to prevent disease caused by multidrug-resistant bacterial pathogens”
NIAID/NIH, U19 AI142725
Bioinformatician and Biostatistician
06/16/20 – 05/31/25 (Co-Inv) PI: M. Terrin
“CMCRC consortium-wide coordinating core”
NIAID/NIH, U19 AI150574
Lead Bioinformatician and Biostatistician
07/01/20 – 03/31/23 (Co-Inv) PI: H. Huang
“Photodynamic priming for bidirectional modulation of drug transport across the blood-brain tumor barrier”
NIBIB/NIH, R21 EB028508
Lead Bioinformatician and Biostatistician
07/01/20 – 06/30/25 (Co-Inv) PI: K. Cullen
“Cigarette Restitution Fund Program”
Maryland Department of Health and Mental Hygiene
Lead Bioinformatician
07/24/20 – 04/30/24 (Subaward-PI) PI: X. Xu
“Discovering cardiomyopathy modifiers and therapies via zebrafish genetics”
NHLBI/NIH, R01 HL107304
Lead Bioinformatician and Biostatistician
04/01/21 – 03/31/26 (Co-Inv) PI: H. Huang
“Addressing Chemoresistance in Pancreatic and Ovarian Cancers: Photodynamic Priming and Repurposing of Tetracyclines using Targeted Photo-Activable Multi-Inhibitor Liposome”
NIBIB/NIH, R01 CA260340
Lead Bioinformatician and Biostatistician
05/01/21 – 04/30/22 (Co-Inv) PI: J Magaziner
“University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)”
NHLBI/NIA, P30 AG028747 15S2
Bioinformatician and Biostatistician
06/01/21 – 05/31/26 (Co-Inv) PI: S. Adebamowo
“CARdiometabolic Disorders IN African-ancestry PopuLations (CARDINAL) Study Site”
NCI/NIH, U01 HG011717
Lead Bioinformatician and Biostatistician
07/01/21 – 06/30/26 (Co-Inv) PI: H. Wang
“Novel noncanonical actions of CAR in human liver”
NCI/NIH, R01 CA262084
Lead Bioinformatician and Biostatistician
08/01/21 – 07/31/26 (Co-Inv) PI: K. Cullen
“University of Maryland Comprehensive Cancer Center Support Grant”
NCI/NIH, P30 CA134274
Lead Bioinformatician