Biochemistry and Molecular Biology
Director, Interdisciplinary Program in Muscle Biology
Education and Training
Yale University, BS Biochemistry (honors; magna cum laude)
Tufts University School of Medicine, completed 2 years of Medical School
University College, London, UK, 1 year as a special student in Biophysics and Physiology
Duke University, PhD in Physiology
Yale University School of Medicine, postdoctoral training in Physiology
Dr Schneider is an internationally known leader in skeletal muscle excitation-contraction coupling, the series of steps whereby electrical depolarization of the normally inside negative muscle membrane potential initiates release of calcium ions (Ca2+) from their intracellular storage location, the muscle sarcoplasmic reticulum (SR), allowing Ca2+ ions bind to regulatory sites on muscle contractile filaments, which serves as a switch to permit contractile filament interaction, producing force development and muscle shortening. In pioneering work in collaboration with his post doc mentor Dr W.K. Chandler (Yale University), Dr Schneider made the first measurements of tiny electrical currents (charge displacement currents or channel “gating” currents) due to the redistribution of charged voltage sensor proteins within the muscle membrane. Such gating currents were previously predicted in the classic studies of Hodgkin and Huxley on voltage dependent channel activation underlying the action potential in nerve axons, and were first detected in any excitable cell membrane by Schneider and Chandler in skeletal muscle, where they control Ca2+ release from Ca2+ release channels in the spatially immediately adjacent SR membrane. Analogous gating currents were subsequently identified by other groups for gating voltage dependent Na+, K+ and Ca2+ channels in other excitable cells.
As an Assistant Professor and Associate Professor (tenured) in the Department of Physiology at the University of Rochester School of Medicine, Dr Schneider examined the functional role of muscle intramembrane charge movement in the regulation of Ca2+ release from the SR in skeletal muscle fibers, developing single and double gap techniques for doing voltage clamp studies on muscle fibers with maintained or suppressed contraction, respectively. He also developed procedures for using dyes which changed absorbance on Ca2+ binding to monitor Ca2+ release from intracellular stores (sarcoplasmic reticulum) in response to membrane depolarization and the ensuing membrane charge movement. Dr Schneider also spent a year's sabbatical from the University of Rochester at the Neurobiology Laboratory, Ecole Normale Superieure, Paris, France, where he studied Na+ channel gating current, and its modification by several neuro toxins.
After moving to UMSOM, Dr Schneider investigated modulation of the coupling of voltage sensor charge displacement to the SR Ca2+ release channel activation in the process of excitation contraction coupling, including advanced imaging techniques with fluorescent Ca2+ indicators to characterize both global cytoplasmic Ca2+ signals during depolarization, as well as local Ca2+ release events, known as Ca2+ sparks. These local intracellular events were discovered and characterized in cardiac muscle cells by Dr Lederer at UM SOM, who collaborated with Dr Schneider in the initial studies on Ca2+ sparks in skeletal muscle. In addition, more recent work in the Schneider lab utilizes confocal fluorescence imaging to study nucleo-cytoplasmic movements of several transcriptional regulator molecules (NFAT, HDACs, Foxo) in skeletal muscle fibers. In addition, Dr Schneider is the founding and current director and PI of the NIH/NIAMS-funded Interdisciplinary Training Program in Muscle Biology (now in year 21 of continuous funding), which provides support annually for 5 pre doc and 5 post doc trainees studying various aspects of skeletal, cardiac or smooth muscle biology and disease at UMSOM.
Dr Schneider’s research contributions have been recognized by an NIH/NINDS Career Development Award, an NIH/NINDS Javits Neuroscience Investigator Award, an NIH/NIAMS MERIT Award (ongoing), chairmanship of a Gordon Research Conference on Muscle: Excitation-Contraction Coupling and an honorary degree from the University of Debrecen, Debrecen, Hungary. His current NIH research grant has been continuously funded for 32 years.
Skeletal muscle, calcium signaling, muscle cell signaling, excitation-contraction coupling, membrane voltage sensors, gating currents, Ca2+ channels, excitability, neuronal signaling, nucleo-cytoplasmic signaling, NFAT, HDAC, Foxo, cell membrane biophysics, cell electrical properties, muscle plasticity, muscle fiber type, muscle growth, muscular dystrophy, hypokalemic periodic paralysis, muscle membranes, muscle sarcoplasmic reticulum Ca2+ release, cytoplasmic Ca2+ transients, local Ca2+ signals, Ca2+ sparks, S100A1, calmodulin, calmodulation.
Prosser BL, Hernández-Ochoa EO, Schneider MF.
Cell calcium. 2011; 50(4):323-31. NIHMSID: NIHMS315208 PMID:21784520; PMCID:PMC3185186
Hernández-Ochoa EO, Schneider MF.
Progress in biophysics and molecular biology. 2012; 108(3):98-118. NIHMSID: NIHMS35243; PMID:22306655;
Schachter TN, Shen T, Liu Y, Schneider MF.
American journal of physiology. Cell physiology. 2012; 303(9):C977-90. PMID:22932683; PMCID:PMC3492827
Hernández-Ochoa EO, Olojo RO, Rebbeck RT, Dulhunty AF, Schneider MF.
Biophysical journal. 2014; 106(3):535-47. PMID:24507594; PMCID:PMC3944469
Hernández-Ochoa EO, Vanegas C, Iyer SR, Lovering RM, Schneider MF.
Skelet Muscle. 2016 Feb 5;6:6. doi: 10.1186/s13395-016-0076-8. eCollection 2016. PMID: 26855765
iN CHRONOLOGICAL ORDER:
The Journal of general physiology. 1970; 56(5):640-71. PMID:5475999; PMCID:PMC2225972
Schneider MF, Chandler WK.
Nature. 1973; 242(5395):244-6. PMID:4540479
Kovács L, Ríos E, Schneider MF.
Nature. 1979; 279(5712):391-6. PMID:16068161
Horowicz P, Schneider MF.
The Journal of physiology. 1981; 314:595-633.PMID:6975815; PMCID:PMC1249452
Melzer W, Rios E, Schneider MF.
Biophysical journal. 1984; 45(3):637-41. PMID:6608964; PMCID:PMC1434889
Melzer W, Schneider MF, Simon BJ, Szucs G.
The Journal of physiology. 1986; 373:481-511. PMID:3489092; PMCID: PMC1182549
Melzer W, Rios E, Schneider MF.
Biophysical journal. 1987; 51(6):849-63. PMID:3496921; PMCID:PMC1330019
Schneider MF, Simon BJ.
The Journal of physiology. 1988; 405:727-45. PMID:2855645; PMCID: PMC1191001
Simon BJ, Klein MG, Schneider MF.
Biophysical journal. 1989; 55(4):793-7. PMID: 2720072; PMCID: PMC1330563
Klein MG, Kovacs L, Simon BJ, Schneider MF.
The Journal of physiology. 1991; 441:639-71. PMID:1667802; PMCID: PMC1180218
Jacquemond V, Schneider MF.
The Journal of general physiology. 1992; 100(1):115-35. PMID:1512554; PMCID: PMC2229124
Klein MG, Cheng H, Santana LF, Jiang YH, Lederer WJ, Schneider MF.
Nature. 1996; 379(6564):455-8. PMID: 8559251
Klein MG, Lacampagne A, Schneider MF.
Proceedings of the National Academy of Sciences of the United States of America. 1997; 94(20):11061-6. PMID:9380759; PMCID:PMC23600
Lacampagne A, Klein MG, Ward CW, Schneider MF.
Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(14):7823-8. PMID:10884414; PMCID: PMC16629
Shtifman A, Ward CW, Wang J, Valdivia HH, Schneider MF.
Biophysical journal. 2000; 79(2):814-27. PMID:10920014; PMCID:PMC1300980
Liu Y, Cseresnyés Z, Randall WR, Schneider MF.
The Journal of cell biology. 2001; 155(1):27-39. PMID:11581284; PMCID: PMC2150785
Chun LG, Ward CW, Schneider MF.
American journal of physiology. Cell physiology. 2003; 285(3):C686-97. PMID:12724135
Liu Y, Randall WR, Schneider MF.
The Journal of cell biology. 2005; 168(6):887-97.PMID:15767461; PMCID: PMC2171787
Parallel mechanisms for resting nucleo-cytoplasmic shuttling and activity dependent translocation provide dual control of transcriptional regulators HDAC and NFAT in skeletal muscle fiber type plasticity.
Shen T, Liu Y, Randall WR, Schneider MF.
Journal of muscle research and cell motility. 2006; 27(5-7):405-11. PMID:16874450
Brown LD, Rodney GG, Hernández-Ochoa E, Ward CW, Schneider MF.
American journal of physiology. Cell physiology. 2007; 292(3):C1156-66. NIHMSID: NIHMS93257. PMID:17065203; PMCID: PMC2654399
Hernández-Ochoa EO, Contreras M, Cseresnyés Z, Schneider MF.
Cell calcium. 2007; 41(6):559-71. NIHMSID: NIHMS23810 PMID:17125834; PMCID: PMC3164312
Prosser BL, Wright NT, Hernãndez-Ochoa EO, Varney KM, Liu Y, Olojo RO, Zimmer DB, Weber DJ, Schneider MF.
The Journal of biological chemistry. 2008; 283(8):5046-57. NIHMSID: NIHMS765845. PMID:18089560; PMCID: PMC4821168
Liu Y, Contreras M, Shen T, Randall WR, Schneider MF.
The Journal of physiology. 2009; 587(Pt 5):1101-15. PMID:19124542; PMCID: PMC2673778
Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF.
The Journal of physiology. 2009; 587(Pt 18):4523-41. PMID:19651767; PMCID: PMC2766655
Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF.
The Journal of physiology. 2009; 587(Pt 18):4543-59. PMID:19651766; PMCID:PMC2766656
Liu Y, Hernández-Ochoa EO, Randall WR, Schneider MF.
American journal of physiology. Cell physiology. 2012; 303(3):C334-47. PMID:22648949; PMCID:PMC3423023