Academic Title:
Professor
Primary Appointment:
Microbiology and Immunology
Secondary Appointment(s):
Medicine
Administrative Title:
Director of Center for Advanced Microbiome Research & Innovation (CAMRI); Assistant Dean for Research Advancement
Email:
Location:
Health Sciences Facility III, 670 West Baltimore St, Baltimore 21201
Phone (Primary):
(410) 706-5674
Education and Training
- B.Sc., 1990, Biology and Chemistry, University of Nancy I, France
- M.Sc., 1992, Microbiology, University of Nancy I, France
- Ph.D., 1994-99, Microbial Ecology, University of Maryland at College Park (Dr. Russell Hill, advisor)
- Post-doctoral fellow, 1999-2002, The Johns Hopkins University, Chemistry Department (Dr. Craig Townsend)
- Assistant Investigator, 2002-2007, The Institute for Genomic Research (TIGR), Rockville, MD
- Associate Professor, 2007-2012, Dept. Microbiology and Immunology, University of Maryland School of Medicine
- Professor, 2012-present, Dept. Microbiology and Immunology, University of Maryland School of Medicine
- Associate Director for Genomics, 2010-Present, Institute for Genome Sciences (IGS), University of Maryland School of Medicine
- Acting Director, 2022-2025, Institute for Genome Sciences (IGS), University of Maryland School of Medicine
- Director, Center for Advanced Microbiome Research and Innovation (CAMRI)
Biosketch
Dr. Ravel is the Director of the Center for Advanced Microbiome Research and Innovation (CAMRI) (camri.umaryland.edu) at the Institute for Genome Sciences (IGS) (igs.som.umaryland.edu) and the John L. Whitehurst Professor of Medicine, Microbiology and Immunology at the University of Maryland School of Medicine in Baltimore, Maryland. He received his Ph.D. degree from the University of Maryland, College Park, in Environmental Molecular Microbiology and Ecology and performed his postdoctoral training as a Ruth L. Kirschstein National Research fellow at Johns Hopkins University in the Department of Chemistry, working on microbial natural product chemistry.
Before accepting his current position in 2007, Dr. Ravel was an Assistant Investigator at the Institute for Genomic Research (TIGR) in Rockville, MD, where the first microbial genome was sequenced in 1995. He was elected to the American Academy of Microbiology in 2012 and in 2015, he was awarded the Blaise Pascal International Research Chair (www.chaires-blaise-pascal.ens.fr). Dr. Ravel is the Editor in Chief of the journal Microbiome (www.microbiomejournal.com) and an Associate Editor for the journal mBio.
Research/Clinical Keywords
Human microbiome, vaginal microbiome, bacterial vaginosis, Chlamydia trachomatis, HPV, Trichomonas vaginalis, genomics, metagenomics, metatranscriptomics, multi-omics, bioinformatics, computational biology, 3D biomimetic models, live biotherapeutics products, probiotics, Lactobacillus, translational microbiome science.
Highlighted Publications
Ravel J, Gajer P, Abdo Z, Schneider GM, McCulle SL, Karlebach S, Gorle R, Russell J, Tacket CO, Brotman RM, Davis CC, Ault KA, Perralta L and Forney LJ. 2011. The vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences USA. 108 Suppl 1:4680-7.
Gajer P, Brotman RM, Bai G, Sakamoto J, Shutte UME, Zhong X, Koenig SSK, Fu L, Ma Z, Zhou X, Abdo Z, Forney LJ, and Ravel J. 2012. The temporal dynamics of the vaginal microbiota. Science Translational Medicine. 4, 132ra52.
Holm JB, Humphrys MS, Robinson CK, Settles ML, Ott S, Fu L, Yang H, Gajer P, He X, McComb E, Gravitt PE, Ghanem KG, Brotman RM, Ravel J. 2019. Ultrahigh-Throughput Multiplexing and Sequencing of >500-Base-Pair Amplicon Regions on the Illumina HiSeq 2500 Platform. mSystems. 2019; 4(1).
Elovitz MA, Gajer P, Riis V, Brown AG, Humphrys MS, Holm JB, Ravel J. 2019. Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery. Nature Communications. 10(1):1305.
Ma B, France MT, Crabtree J, Holm JB, Humphrys MS, Brotman RM, Ravel J. 2020. A comprehensive non-redundant gene catalog reveals extensive within-community intraspecies diversity in the human vagina. Nature Communications. 11(1):940.
France MT, Fu L, Rutt L, Yang H, Humphrys MS, Narina S, Gajer PM, Ma B, Forney LJ, Ravel J. 2022. Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data. Genome Biology. 23(1):66.
Additional Publication Citations
A complete list of Dr. Ravel's >350 publications can be found here:
https://www.ncbi.nlm.nih.gov/myncbi/1fSS3RRbN7lQ1/bibliography/public/
Research Interests
Dr. Ravel's research program (www.ravel-lab.net) focuses on applying modern genomics technologies and ecological principles to characterize the role and dynamics of the microbial communities inhabiting the human body in health and disease and better define the interactions between the host, the microbes, and the environment that drive these ecological systems. Specifically, he is interested in deciphering the role of the vaginal microbiome in women's health using clinical genomics and systems biology approaches to develop improved strategies for managing gynecological and obstetric conditions.
He is the co-Director of the NIH funded Collaborative Research Center on Sexually Transmitted Diseases entitled "Structure, immunity and microbiome: Human 3D biomimetics cervicovaginal models for sexually transmitted infections (SIM-STI)" which aims to develop an innovative biomimetic model of the lower reproductive tract to study aspects of the sexually transmitted infections (STIs), chlamydia and gonorrhea, that are not achievable in humans or with current animal or cell models. The ultimate impact of this Program will be to improve public health by reducing the incidence of STIs in humans. In addition, he is the principal investigator or co-investigator on several NIH grants that aim at understanding the interactions between the vaginal microbiome, the environment, and the host in the context of preterm initiation of labor, signs, and symptoms associated with menopause and vaginal symptoms.
Grants and Contracts
NIH-U19AI158930: Structure, immunity and microbiome: Human 3D biomimetics cervicovaginal models for sexually transmitted infections (SIM-STI) (PI: Ravel, J. [contact]/Bavoil, P./Gleghorn, J.), 04/20/2021 – 03/31/2026.
NIH-R01AG069915: Methods to Test the Role of Age-related Lifestyle and Vaginal Microenvironment Changes and the Prevention, Treatment, and Progression of Genitourinary Syndrome of Menopause (PI: Shardell, M./Brotman, R.) 09/01/2021 – 05/31/2026.
NIH-R01AI167629: Cervicovaginal microbiome, mucosal immunity, and pathogen factors that contribute to spontaneous clearance of Chlamydia trachomatis (MPI: Brotman, R./Ravel, J.) 06/01/2022 – 05/31/2026.
BMGF-INV-048976: Design and evaluation of novel vaginal live biotherapeutics formulations (PI: Ravel, J.)10/05/2022 – 10/31/2027.
BMGF-INV-048956: Omics data analysis and integration tools development in support of VMRC (PI: Ravel, J.) 10/06/2022 – 10/31/2026.
BMGF-INV-033071: The JiVitA Vaginal Microbiome Study (PI: Erchick, D.) 12/01/21-3/31/2026.
BMGF-INV-037901: Primary Analyses in Support of VMRC Clinical Trials (PI: Mitchell, C.) 11/18/2022-12/31/2025.
BMGF-INV-093289: The Vaginal Microbiome Research Consortium Shared Data Portal (PI: Ravel, J.) 07/07/2025-12/31/2025.
NIH-R01AI182384: Factors associated with Refractory and Early Recurrent Bacterial Vaginosis (PI: Tuddenham, S.) 2/1/2024– 01/31/2029.