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Philip H. Iffland, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Neurology

Secondary Appointment(s):

Anatomy Neurobiology

Additional Title:

Director of Neurology Labs

Phone (Primary):

410-706-6015

Education and Training

BA - Zoology; Miami University - 2009

MA - Biology; Kent State University - 2012

Ph.D - Cellular and Molecular Biology; Cleveland Clinic/Kent State Collaborative Doctoral Program - 2015

Postdoctoral Fellowship - Molecular Neuroscience; Lewis Katz School of Medicine at Temple University - 2017

Biosketch

Dr. Iffland is an Assistant Professor in the Department of Neurology at the University of Maryland School of Medicine. His research involves using in vivo and in vitro methods to functionally validate and define the pathophysiological consequence of mutations associated with cortical malformations and epilepsy. Diseases studied in the Iffland lab include Focal Cortical Dypslasia, Tuberous Sclerosis Complex, Hemimegalencephaly, and Megalencephaly.

Dr. Iffland is particularly interested in mutations in the amino acid regulatory arm of the mTOR pathway (e.g., DEPDC5 and NPRL3; "GATORopathies") and how they impact neuronal morphology, function, and brain development. In additon he has interest in the changes in protein expression that occur as a result of mTOR pathway hyperactivation and how those changes contribute to cortical lesion formation and epileptogenesis with the ultimate aim of discovering novel targets for treatment.

The Iffland lab uses both in vivo and in vitro approaches to model various aspects of cortical malformations associated with mTOR pathway variants. These include live-cell imaginng, multi-well multielectrode array, in utero electroporation, long-term vido-EEG recording in rodents, morphometry, and cell signaling assays.

 

 

Research/Clinical Keywords

Cortical malformations, epilepsy, GATORopathies, mTORopathies, hemimegalencephaly, focal cortical dysplasia, PMSE, KPTN

Highlighted Publications

Iffland, PH 2nd, Barnes AE, Baybis M, Crino PB. Dynamic analysis of 4E-BP1 phosphorylation in neurons in Tsc2 or Depdc5 knockout. Experimental Neurology. 2020; 334:113432.

Iffland PH 2nd, Baybis M, Leventer R, Lockhart PJ, Crino PB. DEPDC5 and NPRL3 knockdown produces mTOR-dependent changes in cellular morphology and function. Neurobiology of Disease. 2018; 114: 184-193.

Iffland PH 2nd, Crino PB. Focal Cortical Dysplasia: Gene mutations, Cell Signaling and Therapeutic Implications. Annual Reviews of Pathology: Mechanisms of Disease. 2017; 12:547-71.

Iffland PH 2nd, Crino PB. Sending mixed signals: The expanding role of molecular cascade mutations in malformations of cortical development and epilepsy. Epilepsy Currents. 2016 May.

Janigro, D, Iffland, PH 2nd, Marchi, N, Granata T. A role for inflammation in status epilepticus is revealed by a review of current therapeutic approachesEpilepsia. 2013 Sep; 54 Suppl 6: 30-2.

Iffland, PH 2nd, Carvalho-Tavares J, Trigunaite, A, Man, S, Rasmussen, P, Alexopoulos, A, Ghosh, C, Jorgensen TN, Janigro, D. Intracellular and circulating neuronal antinuclear antibodies in human epilepsy. Neurobiol of Dis. 2013 November.

Additional Publication Citations

Iffland, PH 2nd, Barnes AE, Babus JK, Baybis M, Romanowski A, Poulopoulos A, Carson V, Crino PB. Nprl3: Direct Effects on Human Phenotypic Variability, mTOR signaling, subcellular mTOR localization, cortical lamination and seizure susceptibility. 2021 (Submitted).

- Available as a pre-print on BioRxiv (https://doi.org/10.1101/2020.12.11.421214)

Awards and Affiliations

2021    Young Investigator Award, American Epilepsy Society

2020    NIH Travel Award for Curing the Epilepsies Conference

2017    “Investigators Workshop” poster selection at American Epilepsy Society Meeting

2015    Tier IV Caregiver Award, Cleveland Clinic

2014    Fellows Program, American Epilepsy Society

2014    Tier I Caregiver Appreciation Award, Cleveland Clinic

2014    Alumni, San Servolo Advanced International Course in Epilepsy, Venice Intl. University

  • Course Title: Bridging basic and clinical epileptology
  • Mentors: Peter Engel, MD, Ph.D and Matthew Walker, MD

2014    International Travel Award, Kent State University

2013    Domestic Travel Award, Kent State University

2013    Honorable Mention, National Center of Regenerative Medicine

2008    College of Arts and Sciences Deans Scholar, Miami University

2008    Doctoral/Undergraduate Opportunities for Scholarship Award, Miami University

2007    Undergraduate Summer Scholars Award, Miami University

Links of Interest

https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/350101

https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/195901

https://etd.ohiolink.edu/ap/10?0::NO:10:P10_ETD_SUBID:105042