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Charles C. Hong, MD, PhD

Melvin Sharoky, MD Professor in Medicine

Academic Title:


Primary Appointment:


Secondary Appointment(s):


Administrative Title:

Director of Cardiology Research


Health Sciences Facility III, Room 7106, 670 West Baltimore Street, Baltimore, MD 21201

Phone (Primary):


Education and Training

B.S. Massachusetts Institute of Technology, Life Sciences

MD, PhD (Genetics), Yale University

Residency: Internal Medicine, Yale-New Haven Hospital

Fellowship: Cardiovascular Diseases, Massachusetts General Hospital

Fellowship: Chemical Biology, Harvard Medical School


Dr. Charles (Chaz) Hong is a physician-scientist whose research functions at the intersection of developmental biology, chemical biology, stem cell biology, and cardiovascular medicine. Dr. Hong’s work includes innovative chemical biologic approaches to study embryonic development as well as implementation of the induced pluripotent stem cell (iPSC) technology to better understand human cardiomyocyte biology and pathobiology at the cellular level.

His research has made important contributions to the emerging field of chemical genetics through the discovery of chemical modulators of several key developmental pathways, including the first small molecule inhibitor of bone morphogenetic protein (BMP) signaling and identification of phosphodiesterase-4 as a pharmacological target for hedgehog signal inhibition. Dr. Hong’s research has revealed both novel biological insights and new therapeutic opportunities. For example, his BMP inhibitor technology has been licensed toward clinical development of breakthrough therapies for devastating diseases.  In addition, Dr. Hong edited one of the first books focused on the role of chemical biology in stem cell and regenerative medicine, and a book covering the latest methods and protocols in chemical biology. His research has also made important contributions toward the utilization of human iPSC-derived cardiomyocytes (hiPSC-CMs) as an in vitro model for the study of human cardiomyocyte physiology. His clinical expertise is in cardiovascular genetics.  

Prior to joining the University of Maryland School of Medicine, he was on faculty at Harvard Medical School and Vanderbilt University School of Medicine, where he co-directed Center for Inherited Heart Disease and chaired Accelerating Drug Repositioning/Repurposing Incubator.

Lab Website:

Research/Clinical Keywords

General Cardiology Cardiovascular Genetics Chemical Biology Drug Discovery

Highlighted Publications

Books, Senior Editor

Selected Publications

Awards and Affiliations

1986 - 1988, Carl P. and Marie G. Dennett Scholarship

1989, Stanley J. Sarnoff Fellowship in Cardiovascular Research

1998, M.D./Ph.D. Prize, Yale School of Medicine

2002, William A. Schreyer Fellow Award, Massachusetts General Hospital

2005, Stanley J. Sarnoff Scholar Award

2007, GlaxoSmithKline Research & Education Foundation for Cardiovascular Disease International Competitive Grant Award for Young Investigators

2007, Finalist, AHA Irvin H. Page Young Investigator Research Award

2009, Department of Veterans Affairs Career Development Transition Award

2013, Elected, American Society for Clinical Investigation

2013, Fellow, American Heart Association

2014, Alumni Achievement Award, Sarnoff Cardiovascular Research Foundation


Member, Amish Complex Genetic Disease Research Program.

Member, Member, Center for Biomolecular Therapeutics.

Member, Greenbaum Comprehensive Cancer Center. 

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