Academic Title:
Professor
Primary Appointment:
Surgery
Administrative Title:
Surgical Director of the Children's Heart Program (CHP), Department of Surgery; Program Director of Cardiac Surgery
Location:
110 S. Paca Street Baltimore, MD 21201
Phone (Primary):
410-328-5842
Fax:
410-328-2750
Education and Training
Education
1982-1986 B. A., Biology, Harvard College (Cum Laude)
1986-1990 M.D., Harvard Medical School
2014-2016 M.B.A., University of Texas at Dallas School of Management
Post Graduate Education and Training
1990-1991 Internship, Duke University Medical Center
1991-1992 Residency, General and Thoracic Surgery, Duke University Medical Center
1992-1994 Fellowship, Cardiovascular Surgery, Boston Children’s Hospital
1994-1996 Residency, General and Thoracic Surgery, Duke University Medical Center
1996-1997 Residency, General Surgery, Duke University Medical Center
1997-1999 Fellowship, Thoracic Surgery, Duke University Medical Center
Biosketch
BIOGRAPHICAL SKETCH
NAME: Forbess, Joseph M.
eRA COMMONS USER NAME (credential, e.g., agency login): JFORBE
POSITION TITLE: Professor of Surgery Division of Pediatric Cardiothoracic Surgery
EDUCATION/TRAINING
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Harvard College, Cambridge, MA Harvard Medical School, Boston, MA Duke University Medical Center, Durham, NC Children’s Hospital, Boston, MA Duke University Medical Center, Durham, NC Duke University Medical Center, Durham, NC Duke University Medical Center, Durham, NC Univ. of Texas – Dallas, Dallas, TX
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A.B. M.D.
M.B.A.
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06/1986 06/1990 06/1992 06/1994 06/1996 06/1997 06/1999 05/2016 |
Biology Medicine Gen, Thoracic Surgery Cardiovascular Surgery Gen, Thoracic Surgery General Surgery Thoracic Surgery
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- Personal Statement
- Wang J, Zhang QJ, Pirolli TJ, Liu ZP, Powell L, Thorp EB, Jessen M, Forbess JM. Cardio-omentopexy Reduces Cardiac Fibrosis and Heart Failure After Experimental Pressure Overload. Ann Thorac Surg. 2019 May;107(5):1448-1455. doi: 10.1016/j.athoracsur.2018.11.019. Epub 2018 Dec 12. PMID: 30552887; PMCID: PMC6478504.
- Ge Z, Boyd R, Lantz C, Thorp EB, Forbess JM. Cardio-Omentopexy Requires a Cardioprotective Innate Immune Response to Promote Myocardial Angiogenesis. J Thorac Cardiovasc Surg Open. In Press.
Myocardial regeneration offers the possibility, previously thought impossible or highly unlikely, for the heart to “heal” and regain or at least maintain adequate cardiac performance after cardiac injury. Recently, we have examined the effects of cardio-omentopexy(COP), wherein the pedicled greater omentum is surgically affixed to the surface of the left ventricle, in a myocardial pressure overload injury model(Thoracic Aortic Constriction:TAC) in both rats and mice. When performed some weeks after TAC, COP has been observed to reverse myocardial fibrosis, increase capillary density, and reduce myocardial hypertrophy with a corresponding improvement in myocardial function on echocardiography. Our latest work in mice has also shown that macrophage depletion eliminated the beneficial effects of COP. In order to trial this potential therapeutic strategy in humans, we are planning to perform COP in a porcine model of clinically relevant right ventricular(RV) injury. In brief, a transmural right ventricular free wall cryo-lesion will be created. Experimental animals will have the pedicled greater omentum affixed to the injured area at that same procedure. Histologic and functional analysis of these animals versus a cryo injury alone control group will ensue at various time points. We hypothesize that COP might mitigate the deleterious effects of the transmural myocardial injury. Transmural RV injuries such as this are seen in congenital heart patients requiring incisions on their RV free wall as part of their repair. It is our plan to trial COP in human patients if the preclinical porcine model demonstrates a beneficial effect.
- Position and Honors
- John Harvard Scholarship
Positions
1999 Assistant in Cardiovascular Surgery Children’s Hospital, Boston, MA
2000 Associate in Cardiovascular Surgery Children’s Hospital, Boston, MA
2002 Cardiothoracic Surgeon Emory Hospitals, Atlanta, GA
2004 Vice Chair, Cardiothoracic Surgery Children’s Healthcare of Atlanta
2004 Chair, Division of Pediatric Cardiothoracic Surgery UT Southwestern Children’s Hospital
2004 Active Attending Parkland Hospital System, Dallas
2005 Assoc. Attending, CT Surgery UTSW – St. Paul, Dallas, TX
2006 Active Attending Parkland Hospital System, Dallas
2006 Dir. CT Surgery Children’s Medical Center Dallas
2006 Active Attending UTSW – St. Paul, Dallas, TX
2006 Consultant Methodist Dallas Hospital, Dallas, TX
2009 Consultant Odessa Reg. Med. Ctr., Odessa, TX
2009 Active Dell Children’s Med. Ctr., Austin, TX
2009 Active - Univ. Med. Ctr. Brackenridge, Austin, TX
2009 Active - Seton Medical Center Austin, TX
2011 Program Dir., Reg. Heart Program- Dell Children’s Med. Ctr., Austin, TX
2012 Program Dir., Reg. Heart Program - El Paso Children’s Hospital, El Paso, TX
2016 Program Dir., Reg. Heart Program- Texas Health Presbyterian, Dallas, TX
2016 Chief, Pediatric Cardiovascular Surgery - Oak Lawn & Park Ridge, IL
2016 Co-Director, Advocate Children’s Heart Institute
2017 Associate Division Head and Attending Surgeon - Ann & Robert H. Lurie Hospital Chicago, Cardiovascular-Thoracic Surgery
2018 Program Director, Congenital Cardiac Surgery- Ann & Robert H. Lurie Hospital Chicago
2018 Division Head and Attending Surgeon
2019 Attending Surgeon, Pediatric Cardiovascular Surgery Rush University Medical Center
Academic Appointments
1999 - 2002 Instructor in Surgery - Harvard Medical School
2002 - 2004 Asst. Professor of Surgery – Emory University School of Medicine
2004 - 2011 Assoc. Professor of Surgery-UT Southwestern Medical Center Chairman, Division of Pediatric Cardiothoracic Surgery Pogue Distinguished Chair in Pediatric Cardiac Surgery Research
2006 - 2011 Assoc. Professor of Pediatrics-UT Southwestern Medical Center
2011 - 2014 Professor of Surgery – UT Southwestern Medical Center, Chairman, Division of Pediatric Cardiothoracic Surgery Pogue Distinguished Chair in Pediatric Cardiac Surgery Research
2011 - 2016 Professor of Pediatrics – UT Southwestern Medical Center
2012 - 2016 Faculty Member – UT Southwestern Graduate School of Biomedical Sciences, Biomedical Engineering, Division of Applied Science
2014 - 2016 Professor – University of Texas Southwestern Medical Center. Division of Pediatric Cardiothoracic Surgery, Department of Thoracic and Cardiovascular Surgery, Pogue Distinguished Chair in Pediatric Cardiac Surgery Research
2017– 2020 Professor of Surgery – Northwestern University Feinberg School of Medicine
2018 – 2020 Professor of Pediatrics – Northwestern University Feinberg School of Medicine
2021 - Current Professor of Surgery-University of Maryland School of Medicine
2021 - Current Director of Children’s Heart Program- University of Maryland School of Medicine
Other Experience and Professional Memberships
2001 Member, Council on Cardiothoracic and Vascular Surgery, American Heart Association
2001 Fellow, American College of Cardiology
2002 Fellow, American College of Surgeons
2002 Member, Southern Thoracic Surgical Association
2002 Member, Society of Thoracic Surgeons
2004 Member, Workforce on Annual Meeting, Society of Thoracic Surgeons
2004 Member, Congenital Heart Surgeons Society
2005 Member, Workforce on Annual Meeting, Society of Thoracic Surgeons
2006 Member, 21st Century Cardiothoracic Surgical Society
2007 Founding Member, World Society for Pediatric Congenital Heart Surgery
2008 Member, Workforce on Annual Meeting, Society of Thoracic Surgeons
2009 Member, American Association for Thoracic Surgery
2009 Member, AATS Academy 2009
2010 Member, AATS Education Committee
2014 Member, CHSS Education Committee
Honors
1986 Harvard College Scholarship
2006 Meritorious Service Award, presented at the 2006 AmSECT Pediatric Conf., Atlanta, Georgia
2007 Top Pediatric Specialists – named by D Magazine
2007 Thoracic Surgery Foundation for Research and Education (TSFRE) scholarship – Leadership Program in Health Policy and Management at the Heller School for Social Policy/Management Brandeis University
2011 - 2016 Best Pediatric Specialists – named by D Magazine
2017 - 2020 Best Pediatric Specialists – named by Chicago Magazine
2021- 2022 Best Pediatric Specialists – named by Baltimore Magazine
- Contribution to Science
- Development of Biodegradable Stents for Treatment of Congenital Heart Disease.
Currently, many children with coarctation, pulmonary artery stenosis, etc. who can easily be treated with a stent are referred for surgical treatment because of the known long-term disadvantages associated with the use of a metal stent at a young age. There are no biodegradable stents available for use in the pediatric population. Our multidisciplinary team at UT Southwestern has formed the Biodegradable Stent research team. The goal of this team is to develop a BD stent that can be used to treat children with CHD that will drastically improve patient outcomes and avoid multiple surgical re-interventions. To our knowledge, we are one of the 3-4 research teams in the world who are currently working towards this goal. Our team has developed a novel design BD stent made of poly-l-lactic acid and this design allows us to fabricate larger diameter stents, needed for treatment of large size vessels like the pulmonary arteries and aorta. The results of our completed studies have led to subsequent evaluation of the stent in animal models. Evaluation of our novel design stent in porcine coarctation and pulmonary artery stenosis models and an additional long term study to evaluate vessels after complete biodegradation of the stent are currently underway
1) Welch T, Eberhart RC, Veeram Reddy S, Wang J, Nugent A, Forbess J. Novel Bioresorbable Stent Design and Fabrication: Congenital Heart Disease Applications. Cardiovasc Eng Tech 2013; 4:171-182.
2) Veeram Reddy SR, Welch T, Wang J, Bernstein F, Richardson J, Eberhart R, Forbess J, Nugent A. A Novel Biodegradable Stent Applicable for Use in Congenital Heart Disease: Bench Testing and Feasibility Results in a Rabbit Model. Catheter Cardiovasc Interv 2014;83:448-56.
3) Veeram Reddy SR, Welch T, Wang J, Richardson J, Forbess J, Nugent AW. A novel design biodegradable stent for use in congenital heart disease: Mid-term results in rabbit descending aorta. Catheter Cardiovasc Interv. 2015;85:629-39.
- Goodfriend AC, Welch TR, Barker G, Ginther R, Riegel MS, Reddy SV, Wang J, Nugent A, Forbess J. Novel bioresorbable stent coating for drug release in congenital heart disease applications. J Biomed Mater Res A. 2015;103:1761-70.
- The Utilization of Bilateral Pulmonary Artery Banding for Resuscitation and Stabilization Prior to Conventional First Stage Palliation for Critical Single Ventricle Congenital Heart Disease.
Many children born with single ventricle heart defects and systemic outflow tract obstruction are still not diagnosed prenatally. They also may have low birth rate or syndromes which make conventional single ventricle palliation very high risk. Another high risk population are those patients with an intact atrial septum in utero. For any or all of these situations we have developed a strategy to implement an intermediate surgical stage for these patients wherein bilateral pulmonary artery bands are placed to increase the systemic output and decrease pulmonary blood flow. We have now published our results utilizing this technique and feel it is a significant contribution to the field of congenital heart surgery.
- Guleserian KJ, Barker GM, Sharma MS, Macaluso J, Huang R, Nugent AW, Forbess JM. Bilateral pulmonary artery banding for resuscitation in high-risk, single-ventricle neonates and infants: A single-center experience. J Thorac Cardiovasc Surg. 2013 Jan;145(1):206-14. doi: 10.1016/j.jtcvs.2012.09.063.
- Welch TR, Eberhart RC, Reddy SV, Wang J, Nugent A, Forbess J. Novel Bioresorbable Stent Design and Fabrication: Congenital Heart Disease Applications. Cardiovasc Eng Technol. 2013. doi: 1007/s13239-013-0136-8.
- Goodfriend AC, Welch TR, Barker G, Ginther R Jr, Riegel MS, Reddy SV, Wang J, Nugent A, Forbess J. Novel bioresorbable stent coating for drug release in congenital heart disease applications. J Biomed Mater Res A. 2014 Sep 8. doi: 10.1002/jbm.a.35313. PMID: 25196819.
- Large Animal Circulatory Arrest Models.
During 2 research years as part of a hiatus in my clinical training I developed a quite reproducible survival model of hypothermic cardiopulmonary bypass with circulatory arrest in immature pigs. The development of this model was somewhat laborious but I was able to author a paper describing the initial use of this model. My laboratory mentor Richard A. Jonas MD, subsequently obtained an RO1 grant based upon this porcine model of cardiopulmonary bypass.
- Forbess JM, Ibla JC, Lidov HG, Cioffi MA, Hiramatsu T, Laussen P, Miura T, Jonas RA. University of Wisconsin cerebroplegia in a piglet survival model of circulatory arrest. Ann Thorac Surg 1995; 60(6suppl):494-500.
- Stephens EH, Wolfe BL, Talwar AA, Patel A, Camarda JA, Eltayeb O, Monge MC, Forbess JM. Applicability and Durability of Valve-Sparing Tetralogy of Fallot Repair. World J Pediatr Congenit Heart Surg. 2021 Sep;12(5):628-634. doi: 10.1177/21501351211031242. PMID: 34597206.
- Wright J, Nguyen A, D'Souza N, Forbess JM, Nugent A, Reddy SRV, Jaquiss R, Welch TR. Bioresorbable Stent to Manage Congenital Heart Defects in Children. Materialia (Oxf). 2021 May;16:101078. doi: 10.1016/j.mtla.2021.101078. Epub 2021 Mar 19. PMID: 34109305; PMCID: PMC8184019.
- Glinton K, DeBerge M, Fisher E, Schroth S, Sinha A, Wang JJ, Wasserstrom JA, Ansari MJ, Zhang ZJ, Feinstein M, Leventhal JR, Forbess JM, Lomasney J, Luo X, Thorp EB. Bone marrow-derived AXL tyrosine kinase promotes mitogenic crosstalk and cardiac allograft vasculopathy. J Heart Lung Transplant. 2021 Jun;40(6):435-446. doi: 10.1016/j.healun.2021.03.006. Epub 2021 Mar 13. PMID: 33846079; PMCID: PMC8169599.
- Pant T, Dhanasekaran A, Zhao M, Thorp EB, Forbess JM, Bosnjak ZJ, Benjamin IJ, Ge ZD. Identification and analysis of circulating long non-coding RNAs with high significance in diabetic cardiomyopathy. Sci Rep. 2021 Jan 28;11(1):2571. doi: 10.1038/s41598-021-82345-7. PMID: 33510471; PMCID: PMC7843621.
- Becker AC, Lantz CW, Forbess JM, Epting CL, Thorp EB. Cardiopulmonary Bypass- Induced Inflammation and Myocardial Ischemia and Reperfusion Injury Stimulates Accumulation of Soluble MER. Pediatr Crit Care Med. 2021 Sep 1;22(9):822-831. doi: 10.1097/PCC.0000000000002725. PMID: 33813548; PMCID: PMC8805604.
- Wolfe BL, Stephens EH, Tannous P, Kalinowski V, Lay AS, Forbess JM, Ramlogan SR. Obstructing Eustachian valve in a newborn presenting with profound hypoxemia and atrial arrhythmias. JTCVS Tech. 2020 Apr 11;3:265-266. doi: 10.1016/j.xjtc.2020.04.008. PMID: 34317895; PMCID: PMC8302921
- Qadir A, Tannous P, Stephens EH, Kalra A, Forbess JM, Nugent A. Use of a Dilatable exGraft Conduit in Single-Ventricle Palliation. Ann Thorac Surg. 2020 Aug;110(2):e131-e133. doi: 10.1016/j.athoracsur.2019.12.024. Epub 2020 Jan 25. PMID: 31991132.
- Stephens EH, Eltayeb O, Mongé MC, Forbess JM, Rastatter JC, Rigsby CK, Backer CL. Pediatric Tracheal Surgery: A 25-Year Review of Slide Tracheoplasty and Tracheal Resection. Ann Thorac Surg. 2020 Jan;109(1):148-153. doi: 10.1016/j.athoracsur.2019.06.042. Epub 2019 Aug 7. PMID: 31400322.
- Stephens EH, Tannous P, Mongé MC, Eltayeb O, Devlin PJ, Backer CL, Forbess JM, Pahl E. Normalization of hemodynamics is delayed in patients with a single ventricle after pediatric heart transplantation. J Thorac Cardiovasc Surg. 2020 May;159(5):1986-1996. doi: 10.1016/j.jtcvs.2019.09.135. Epub 2019 Oct 10. PMID: 31767361.
- Geoffrion TR, Pirolli TJ, Pruszynski J, Dyer AK, Davies RR, Forbess JM, Guleserian KJ. Mitral Valve Surgery in the First Year of Life. Pediatr Cardiol. 2020 Feb;41(2):334-340. doi: 10.1007/s00246-019-02262-5. Epub 2019 Dec 21. PMID: 31865441.
- Backer CL, Bharadwaj SN, Eltayeb OM, Forbess JM, Popescu AR, Mongé MC. Double Aortic Arch With Kommerell Diverticulum. Ann Thorac Surg. 2019 Jul;108(1):161-166. doi: 10.1016/j.athoracsur.2019.01.062. Epub 2019 Mar 5. PMID: 30849335
- Eltayeb OM, Readdy WJ, Mongé MC, Forbess JM, Sarwark AE, Patel A, Backer CL. Mitral Valve Replacement in Infants Using a 15-mm Mechanical Valve. Ann Thorac Surg. 2019 Aug;108(2):552-557. doi: 10.1016/j.athoracsur.2019.02.061. Epub 2019 Mar 27. PMID: 30928551. Pant T,
- Dhanasekaran A, Bai X, Zhao M, Thorp EB, Forbess JM, Bosnjak ZJ, Ge ZD. Genome-wide differential expression profiling of lncRNAs and mRNAs associated with early diabetic cardiomyopathy. Sci Rep. 2019 Oct 25;9(1):15345. doi: 10.1038/s41598-019-51872-9. PMID: 31653946; PMCID: PMC6814824.
- Research Support
Completed Research Support:
2009 – 2014 Design and Development of a Novel Biodegradable Stent for Pediatric Applications. Internal funding, UT Southwestern Medical Center. Principal Investigator.
2013 – 2014 Optimization of physiologic conditions for selective cerebral perfusion in immature piglets: a clinically relevant acute and survival model. Internal funding, UT Southwestern Medical Center. Principal Investigator.
2015 – 2017 Development of Large Diameter Biodegradable Stents for Congenital Heart Disease. Funding NIH NHLBI R21HL129095. Co-Investigator.
2015 – 2017 Novel Design Biodegradable Stent in Porcine Model of Aortic Coarctation.
Funding South West Affiliate Summer 2014 American Heart Association Beginning Grant-in-Aid (Award# 15BGIA22460027). Co-Investigator.
Research/Clinical Keywords
• Extracorporeal life support • Cardiopulmonary bypass • Thrombosis and hemostasis • Ex vivo organ perfusion and transplantation
Clinical Specialty Details
- Cardiac surgery
- Cardiac transplantation
- Extracorporeal life support
- Mechanical circulatory support
- Congenital heart surgery
Awards and Affiliations
Honors and Awards
2021 Best Pediatric Specialists- named by Baltimore Magazine
2017-2020 Best Pediatric Specialists-named by Chicago Magazine
2007-2016 Best Pediatric Specialists -named by D Magazine
2007 Thoracic Surgery Foundation for Research and Education (TSFRE) scholarship – Leadership Program in Health Policy and Management, Heller School for Social Policy/Management-Brandeis University.
2006 Meritorious Service Award, presented at the 2006 AmSECT Pediatric Conference, Atlanta, GA
1986 Harvard College Scholarship
1985 John Harvard Scholarship
Grants and Contracts
Grant Support
Northwestern Memorial Foundation
Advanced wireless wearable sensors for home monitoring in pediatric patients with congenital heart disease
01/01/2019-12/31/2019
Total amount awarded: $50,000
Joseph M. Forbess MD, Co-investigator (with BS Marino, JA Rogers, AW Nugent, S Xu (PI))
American Heart Association / Lawrence J. and Florence A. De George Award
Use of a novel design double opposing helical coil-based poly-L-lactic acid biodegradable stent to treat coarctation of aorta in a porcine animal model
07/2015 – 07/2017
Total amount awarded: $140,000
Joseph M. Forbess, MD, Co-PI
Development of large diameter biodegradable stents for congenital heart disease.
NIH, R21 HL129095
07/2015 – 07/2017
Total amount awarded: $275,000
Joseph M. Forbess, MD (with AW Nugent (PI))
Optimization of physiologic conditions for selective cerebral perfusion in immature piglets: a clinically relevant acute and survival model.
Internal Department and Endowed Chair funding, UT Southwestern Medical Center
12/15/2009 – 01/10/2014
Joseph M. Forbess, MD, PI
Design and development of a novel biodegradable stent for pediatric applications.
Internal Department and Endowed Chair funding, UT Southwestern Medical Center
12/15/2009 – 01/10/2014
Joseph M. Forbess, MD, PI