David R. Benavides, MD, PhD

B.S., Biology, St. Mary’s University (Summa Cum Laude)       

Ph.D., Neuroscience, The University of Texas Southwestern Medical Center

M.D., The University of Texas Southwestern Medical Center   

Internship, Sinai Hospital of Baltimore

Residency, Neurology, The Johns Hopkins Hospital

Fellowship, Neuroimmunology and Neurological Infections, Johns Hopkins University School of Medicine

Postdoctoral Fellowship, Neuroscience, Johns Hopkins University School of Medicine

Dr. Benavides joined the faculty as Assistant Professor of Neurology in April 2017. He earned M.D. and Ph.D. degrees from the Medical Scientist Training Program at The University of Texas Southwestern Medical Center in Dallas, Texas. As a neuroscience graduate student in the laboratory of James A. Bibb, Ph.D., he employed a multidisciplinary approach using biochemistry, electrophysiology, transgenic rodent models, and animal behavior to study reward signaling, learning and memory, and mood-related behavior. Dr. Benavides completed adult neurology residency training at Johns Hopkins University School of Medicine in Baltimore, Maryland followed by fellowship training in the Division of Neuroimmunology and Neurological Infections. He also completed postdoctoral fellowship training in neuroscience at Johns Hopkins in the laboratory of Richard L. Huganir, Ph.D., where he used neuronal culture models to investigate the effects of autoantibodies on intracellular signal transduction cascades. Dr. Benavides directs a translational clinical neuroscience research program to investigate immune regulation of neuronal function, with particular interest in autoimmune encephalitis. The research program uses cell culture, primary neuronal culture, and rodent animal models combined with a multidisciplinary approach involving pharmacology, protein biochemistry, proteomics, cell biology, and molecular biology. The unifying goal of this research program is to identify novel therapeutic targets for neurologic diseases. Dr. Benavides holds board certification from the American Board of Psychiatry and Neurology and is involved in the Maryland Center for Multiple Sclerosis Treatment and Research.

Clinical Neuroscience, Neuroimmunology, Neuroinflammatory and Demyelinating Diseases, Multiple Sclerosis (MS), Neuromyelitis Optica (NMO), Transverse Myelitis (TM), Autoimmune Encephalitis (AE), Neuronal Plasticity, Signal Transduction

Dean CA, Metzbower SR, Dessain SK, Blanpied TA, Benavides DR. Regulation of NMDA receptor signaling at single synapses by human anti-NMDA receptor antibodies. Frontiers in Molecular Neuroscience. 2022 Jul 28;15:940005. 

Metzbower SR, Joo Y, Benavides DR, Blanpied TA. Properties of individual hippocampal synapses influencing NMDA-receptor activation by spontaneous neurotransmission. eNeuro. 2019, 6 (3).

Williams TJ^†, Benavides DR^†, Patrice KA, Dalmau JO, de Avila ALR, Le DT, Lipson EJ, Probasco JC, Mowry EM. Association of autoimmune encephalitis with combined immune checkpoint inhibitor treatment for metastatic cancer. JAMA Neurology. 2016;73(8):928-933. ^†Co-first authors.

Hawasli AH^†, Benavides DR^†, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA. Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nature Neuroscience. 2007;10(7):880-886. ^†Co-first authors.