Update Your ProfileAcademic Title:
Research Associate
Primary Appointment:
Microbiology and Immunology
Education and Training
- University of Maryland College Park, BS in Cellular Biology and Molecular Genetics 2011-2015
- University School of Medicine, PhD in Molecular Microbiology and Immunology 2015-2020
- Postdoctoral Fellow in the lab of Dr. Matthew Frieman, Center for Pathogen Research, Department of Microbiology and Immunology 2021-2023
Biosketch
My overall research goals are to create therapeutic interventions for respiratory pathogens of major concern to public and global health through research and discovery of novel mechanisms by which the viruses interact with the host. My research is focused on highly pathogenic coronaviruses such as Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS-CoV), Severe Acute Respiratory Syndrome 2 (SARS-CoV-2),and Influenza virus. These viruses inflict severe burdens on public health and cause severe respiratory disease. My work has been to study new mechanisms of viral pathogenesis, their interactions with host immune signaling and effectors, and specific pathways involved in disease progression with the goal developing therapeutic interventions targeting both the host and pathogen to mitigate disease.
Utilizing cellular models, in vivo mouse models, and airway-liquid interface organoid models for the characterization of novel mechanisms through which these viruses cause and exacerbate disease in humans. These models also facilitate the testing and implementation of therapeutics, vaccines, antibodies, repurposeing of drugs, and novel small molecules for the treatement and prevention disease development and morbidity/mortality.
Recent work has identified both host and viral factors that alter viral pathogenesis and immunopathogenesis utilizing these models.
Research/Clinical Keywords
Pathogenesis, allergy, asthma ,diabetes, coronavirus, influenzavirus, respiratory disease, host-pathogen interaction
Highlighted Publications
Ardanuy, J., Johnson, R., Dillen, C., Taylor, L., Hammond, H., Weston, S., & Frieman, M. (2023). Pyronaridine tetraphosphate is an efficacious antiviral and anti-inflammatory active against multiple highly pathogenic coronaviruses.mBio,14(5), e0158723. https://doi.org/10.1128/mbio.01587-23. PMID: 37581442
Ardanuy, J., Skerry, C., Scanlon, K., Fuchs, SY., Carbonetti, NH. (2020). Age-dependent Effects of Type I and Type III Interferons in the Pathogenesis of Bordetella Pertussis Infection and Disease. The Journal of Immunology. PMID: 32152071. DOI: 4049/jimmunol.1900912
Carlin, A., Beadle, J., Ardanuy, J., Clark, A., Rhodes, V., Garretson, A., Murphy, J., Valiaeva, N., Schooley, R., Frieman, M., & Hostetler, K. (2024) Oral Pharmacokinetics and Efficacy of Oral Phospholipid Remdesivir Nucleoside Prodrugs Against SARS-CoV-2 in Mice. Antimicrobial Agents and Chemotherapy.
Johnson, R. M., Ardanuy, J., Hammond, H., Logue, J., Jackson, L., Baracco, L., McGrath, M., Dillen, C., Patel, N., Smith, G., & Frieman, M. (2023). Diet-induced obesity and diabetes enhance mortality and reduce vaccine efficacy for SARS-CoV-2.Journal of virology,97(11), e0133623. https://doi.org/10.1128/jvi.01336-23. PMID: 37846985
Additional Publication Citations
McGrath, M. E., Xue, Y., Taylor, L., Dillen, C., Ardanuy, J., Gonzalez-Juarbe, N., Baracco, L., Kim, R., Hart, R., Assad-Garcia, N., Vashee, S., & Frieman, M. B. (2024). SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.PLoS pathogens,20(5), e1011669. https://doi.org/10.1371/journal.ppat.101166. PMID: 38781259
Ardanuy, J., Scanlon, K. M., Skerry, C., & Carbonetti, N. H. (2023). DNA-Dependent Interferon Induction and Lung Inflammation inBordetella pertussisJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,43(10), 478–486. https://doi.org/10.1089/jir.2023.0066.PMID: 37651198
Davenport, B., Catala, A., Weston, S., Johnson, R., Ardanuy, J., Hammond, H., Dillen, C., Frieman, M., Catalano, C., Morrison, T. (2022) Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease. NPJ Vaccines. PMID:35618725. DOI; 10.1038/s41541-022-00481-1.
Schultz, D., Johnson, R., Ayyanathan, K., Miller, J., Whig, K., Kamalia, B., Dittmar, M., Weston, S., Hammond, H., Dillen, C., Ardanuy, , Taylor, L., Lee, J., Li, M., Lee, E., Petucci, C., Constant, S., Ferrer, M., Thaiss, C., Frieman, N., Cherry, S. (2022). Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature. PMID: 35130559. DOI: 10.1038/s41586-022-04482-x
Gallop, D., Ardanuy, J., Carbonetti, N., Skerry, C. Triggering Receptor expressed on myeloid cells-1 (TREM-1) contributes to Bordetella pertussis inflammatory pathology. Infection and Immunity. PMID: 34097504. DOI: 10.1128/IAI.00126
Prindeze, N. J., Ardanuy, J. G., Carney, B. C., Moffatt, L. T., & Shupp, J. W. (2019). Photobiomodulation Elicits a Differential Cytokine Response in a Cultured Analogue of Human Skin. Eplasty, 19, e3. PMID: 30858901.
Skerry, C., Scanlon, K., Ardanuy, J., Roberts, D., Zhang, L., Rosen, H., & Carbonetti, N. H. (2017). Reduction of Pertussis Inflammatory Pathology by Therapeutic Treatment With Sphingosine-1-Phosphate Receptor Ligands by a Pertussis Toxin-Insensitive Mechanism. The Journal of infectious diseases, 215(2), 278–286. PMID: 27815382. DOI: 10.1093/infdis/jiw536
Prindeze, N. J., Hoffman, H. A., Ardanuy, J. G., Zhang, J., Carney, B. C., Moffatt, L. T., & Shupp, J.W. (2016) Activedynamic thermography is a sensitive method for distinguishing burn wound conversion. J Burn Care Res2016; 37(6): e559– e568. PMID:26284633. DOI: 10.1097/bcr296
Prindeze, N. & Carney, Bonnie & Ardanuy, J. & Zhang, J. & Moffatt, L. & Shupp, Jeffrey. (2015). Dermal penetration and virulence factor secretion of methicillin resistant staphylococcus aureus in murine burn wounds. Wound Repair and Regeneration. 23. A36-A36.
Prindeze, Nicholas & Carney, Bonnie & Ardanuy, Jeremy & Jo, Daniel & Paul, Dereck & Moffatt, Lauren & Shupp, Jeffrey. (2014). Light therapy elicits a dose-dependent anti-inflammatory response in a human full-thickness skin analog. Lasers in Surgery and Medicine. Volume 46, 37:37.
Research Interests
Coronavirus Pathogenesis
My research is driven by a fundamental interest in how respiratory viruses, particularly coronaviruses, establish infection and cause disease within the host. I focus on the pathogenesis of SARS-CoV-2, MERS-CoV, and SARS-CoV, especially its progression from initial upper airway infection to more severe lower respiratory tract involvement. I'm particularly interested in the viral mechanisms that enable immune evasion, such as suppression of early interferon responses and activation of pathogenic inflammasome signaling. By studying how the virus exploits host cellular pathways, I aim to better understand the factors that drive variability in disease severity and transmission.
Therapeutic Development
A central goal of my work is to contribute to the development of host-directed antiviral therapies. Building on my background in interferon signaling and inflammatory regulation, I am involved in efforts to identify therapeutic strategies that modulate host responses rather than target the virus directly. I’m especially interested in therapeutic combinations that exploit host metabolism or innate immune pathways to achieve antiviral synergy. My work aims to uncover treatment strategies that can be rapidly deployed and broadly effective against emerging respiratory viruses.
Immune Interactions with Respiratory Pathogens
I have long been fascinated by the dynamic interplay between respiratory pathogens and the host immune system. My PhD research focused on age-dependent innate immune responses to Bordetella pertussis, and I continue to explore how respiratory infections differentially engageinflammatory pathways in allergic asthma, diabetes, and other altered immune states. In the context of coronavirus and influenza infection, I am investigating how dysregulation of immune signaling and differential chemokine/cytokine signaling can translate into strategies that improve host resilience, mitigate immunopathology, and guide more precise immunomodulatory therapies for viral respiratory diseases.
Awards and Affiliations
2017-2018 T32 Infection and Immunity training grant awarded (T32 AI007540), University of Maryland Baltimore, Baltimore, MD, USA.
2018 J. Howard Brown award at local American Society of Microbiology- University of Maryland Baltimore, Baltimore, MD, USA.
2018-2020 F31 Fellowship grant awarded (F31 AI136377-01A1), National Institute of Allergy and Infectious Disease, Bethesda, MD, USA.
2020-2021 Signaling Pathways in Innate Immunity (T32 AI1095190-02), University of Maryland Baltimore, Baltimore, MD, USA
2015-2020 American Society of Microbiology Member
2020-Present American Society of Virology Member