725 W Lombard St., Baltimore, MD 21201
Education and Training
BS, Microbiology and Biochemistry at Université François Rabelais, Tours, France
MS, Infectious diseases and Vaccines at Université François Rabelais, Tours, France
Ph.D., Cellular and Molecular Virology, Immunology at Sorbonne University, UPMC, Paris, France
Postdoctoral Fellow, Virology and Immunology at University of North Carolina Chapel Hill, NC, USA
Dr. James Ahodantin grew up in France and received a training in Infectious diseases and Vaccines followed by a Ph.D. degree in Virology and Immunology at Sorbonne University in Paris where he discovered that hepatitis B virus X protein (HBx) promotes the development of hepatocellular carcinoma through the dyruption of liver polyploidization. Dr. James Ahodantin has also significantly contributed to the development of humanized mouse model for HBV study. Then, he completed his postdoctoral training at University of North Carolina Chapel Hill in Prof. Lishan Su's lab. Through over several years of work, training, and teaching/mentoring, Dr. James Ahodantin have developed extensive expertise in Virology, Immunology and Liver Biology.
Virology, Immunology, Immunotherapy, humanized mice, Liver diseases
- Ahodantin J, Nio K, Funaki M, Zhai X, Wilson E, Kottilil S, Cheng L, Li G, Su L. “Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy”. JCI Insights, 2022 May 31;e152738.
- Ahodantin J, Lekbaby B, Bou Nader M, Soussan P, Kremsdorf “Hepatitis B virus X protein enhances the development of liver fibrosis and the expression of genes associated with epithelial-mesenchymal transitions and tumor progenitor cells”. Carcinogenesis, 2020, 41(3):358-367.
- Ahodantin J, Li F, Su L. “Modeling HBV infection and therapy in immunodeficient NOD-Rag1-/- IL2RgammaC-null (NRG) fumarylacetoacetate hydrolase (FAH) knockout mice with human chimeric liver”. ICE-HBV Protocol.
- Ahodantin J, Bou-Nader M, Cordier C., Mégret J, Soussan P, Desdouets C, Kremsdorf D. “Hepatitis B virus X protein mediates aberrant polyploidization in the liver and enhances hepatocellular carcinoma initiation ”. Oncogene, 2018, Apr;38(14):2645-2657.
- Dusséaux M, Masse-Ranson G, Darche , Ahodantin J, Li Y, Fiquet O, Beaumont E, Moreau P, Rivière L, Neuveut C, Soussan P, Roingeard P, Kremsdorf D, Di Santo JP, Strick-Marchand H. “Viral load affects the immune response to HBV in mice with humanized immune system and liver ”. Gastroenterology, 2017 Dec;153(6):1647-166.
- Duriez M, Mandouri Y, Lekbaby B, Wang H, Schnuriger A, Redelsperger F, Guerrera CI, Lefevre M, Fauveau V, Ahodantin J., Quetier I, Chhuon C., Gourari S., Boissonnas A., Gill U, Kennedy P., Debzi N, Sitterlin D., Maini MK., Kremsdorf D., Soussan P. “Alternative splicing of hepatitis B virus : A novel virus/host interaction altering liver immunity”. Journal of Hepatology, 2017 ; 67(4):687-699.
- Strick-Marchand H, Dusseaux M, Darche S, Huntington ND, Legrand N, Masse-Ranson G, Corcuff, Ahodantin J, Weijer K, Spits H., Kremsdorf, D., Di Santo, JP. “A novel mouse model for stable engraftment of a human immune system and human hepatocytes”. PLoS One, 2015; 10:e0119820.
- Quetier I, Brezillon N, Revaud J, Ahodantin J, DaSilva L, Soussan P, Kremsdorf D “C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis”. Journal of General Virology, 2015; 96:614-25.
- Pol JG, Lekbaby B, Redelsperger F, Klamer S, Mandouri Y, Ahodantin J, Bieche I, Lefevre M, Souque P, Charneau P, Gadessaud N, Kremsdorf D, Soussan P, “Alternative splicing-regulated protein of hepatitis B virus hacks the TNF-alpha-stimulated signaling pathways and limits the extent of liver inflammation”. Faseb Journal, 2015 ; 29:1879-89.
- Quetier I, Brezillon N, Duriez, Massinet H, Giang E, Ahodantin J, Lamant C, Brunelle, MN, Soussan P, Kremsdorf D, “Hepatitis B virus HBx protein impairs liver regeneration through enhanced expression of IL-6 in transgenic mice”. Journal of Hepatology, 2013 ; 59: 285-91.
Dr. James Ahodantin current research focuses on HBV and HIV infections/co-infection, and related liver diseases using mouse model. Co-infection with HBV and HIV-1 is common, and HIV co-infection can exacerbate the progression of viral hepatitis and accelerate liver disease progression. Thus, understanding how both viruses interact, and the impact on the host immune system and liver is crucial. His research focuses on deciphering and targeting key factors favoring viral immune escape leading to chronic inflammation and disease, and ultimately to developing the next generation of clinical interventions.
Awards and Affiliations
2021 Review Editor for Microbial Immunology,Frontiers in Immunology and Frontiers in Microbiology
2019 International HBV Meeting award, Melbourne, Australia.
2019 Philippe Foundation award, France and USA.
2018 Philippe Foundation award, France and USA.
2017 International HBV Meeting award, Washington, DC, USA.
2016 AFEF Meeting award, Bordeaux, France.
2016 International HBV Meeting award, Seoul, South Korea.
2014 Agence Nationale de Recherche sur le Sida et les Hépatites award, France.
2012 Fondation Recherche Médicale award, France.
Links of Interest