Obstetrics, Gynecology and Reproductive Sciences
F.C. Bressler Bldg. 11-027
Estrogen regulation of placental and fetal development.
Fetal programming of fetal vascular and adrenal development.
Programming effects upon vascular development and insulin sensitivity in offspring.
Aberdeen GW, Bonagura TW, Harman CR, Pepe GJ, Albrecht ED. Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: Impact on uterine and fetal blood flow dynamics. Am J Physiol Heart Circ Physiol. 302(10): H1936-1944, 2012.
Bonagura TW, Babischkin JS, Aberdeen GW, Pepe GJ, Albrecht ED. Prematurely elevating estrogen in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins. Endocrinology 153(6): 2897-2906, 2012.
Kyathanahalli C, Marks J, Nye K, Lao B, Albrecht ED, Aberdeen GW, Nathanielsz PW, Jeyasuria P, Condon JC. Cross-Species withdrawal of MCL1 facilitates postpartum uterine involution in both the mouse and baboon. Endocrinology 154(12): 4873-4884, 2013.
Dumitrescu A, Aberdeen GW, Pepe GJ, Albrecht ED. Placental estrogen suppresses cyclin D1 expression in the nonhuman primate fetal adrenal cortex. Endocrinology 155(12): 4774-4784, 2014.
Wang F, Wu Y, Gu H, Reece EA, Fang S, Gabbay-Benviz R, Aberdeen GW, Yang P. Ask1 gene deletion blocks maternal diabetes-induced endoplasmic reticulum stress in the developing embryo by disrupting the unfolded protein response signalosome. Diabetes, 64(3): 973-988, 2015.