About Us
Led by investigators at the University of Maryland Baltimore (UMB), the Center for Orthopaedics, Injury, and Research Innovation (COIRI) is a service center dedicated to conducting high-quality orthopaedic fracture surgery research.
Our leadership team has received over $20 million in federal research funding, and we support a national network of orthopaedic trauma surgeon-researchers.
The Center for Orthopaedics, Injury, and Research Innovation is committed to making significant advancements in orthopaedic clinical research. Together, we can make a lasting impact for emerging surgeon-scientists, our patients, and our community.
COIRI leverages a large clinical trial network, the unparalleled experience and data sets of McMaster University’s Center for Evidenced-Based Orthopaedics (CEO) and the Major Extremity Trauma Research Consortium (METRC), and the expansive institutional research facilities of UMB.
Working closely with METRC and CEO, COIRI leadership's expertise has been instrumental in the design, implementation, and analysis of several landmark studies, including two of the largest orthopaedic trauma trials published in The Lancet and the New England Journal of Medicine.
Published in the New England Journal of Medicine, PREVENT CLOT, led by Dr. Robert O’Toole, was the largest orthopaedic trauma trial ever and demonstrated that aspirin was non-inferior to low-molecular-weight heparin in preventing death at 90 days.
Led by Dr. Gerard Slobogean, the study Aqueous-PREP, was published in The Lancet and found that two antiseptic solutions routinely used by surgeons before fracture surgery are equally effective for preventing post-surgical infections.
COIRI consists of three Cores designed to expand the community’s research expertise, develop new research ideas, and implement rigorous research studies.