Fuwen Zhou, BM, MM, Dr. rer. nat.

Dr. Zhou received his Bachelor Degree of Medicine (in Dental Medicine, BM) and Master Degree of Medicine (in Pharmacology, MM) from the Central South University Xiang-Ya School of Medicine in China. He then received his Dr. rer.nat. (in Cell Biology) from the University of Rostock, Germany. He was a post-doctoral fellow and research associate at the University of Tennessee, Memphis, USA.

Dr. Zhou combines state of the art of electrophysiological (including in vivo and in vitro), optogentical, chemogenetical, fiber photometry, multiphoton imaging, immunohistochemical, molecular biological (e.g., single cell PCR), knockdown and overexpression, stereotaxic and behavioral techniques, to investigate the neural function and behaviors (including: HCN and TRP mediated neuronal excitability, chemical and electrical interconnection (local and centrifugal), short- and long-term plasticity, and sensory and cognitive behaviors)) in different brain regions (mainly olfactory bulb) in healthy animals and animal models of human diseases (mainly Alzheimer’s disease).

Olfactory bulb, neurophysiology, neuroanatomy, imaging, cation channels, olfactory dysfunction (in aging and neurodegenerative diseases)

Zhou FW, Xu JJ, Zhao Y, LeDoux MS, Zhou FM. Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata. J Neurophysiol. 2006;96(3):1581-91. Epub 20060531. doi: 10.1152/jn.00148.2006. PubMed PMID: 16738217.

Chen R, Tilley MR, Wei H, Zhou FW, Zhou FM, Ching S, et al. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci U S A. 2006;103(24):9333-8. Epub 20060605. doi: 10.1073/pnas.0600905103. PubMed PMID: 16754872; PubMed Central PMCID: PMC1482610.

Strauss U, Zhou FW, Henning J, Battefeld A, Wree A, Kohling R, et al. Increasing extracellular potassium results in subthalamic neuron activity resembling that seen in a 6-hydroxydopamine lesion. J Neurophysiol. 2008;99(6):2902-15. Epub 20080402. doi: 10.1152/jn.00402.2007. PubMed PMID: 18385482.

Zhou FW, Matta SG, Zhou FM. Constitutively active TRPC3 channels regulate basal ganglia output neurons. J Neurosci. 2008;28(2):473-82. doi: 10.1523/JNEUROSCI.3978-07.2008. PubMed PMID: 18184790; PubMed Central PMCID: PMC3652281.

Zhou FW, Chen HX, Roper SN. Balance of inhibitory and excitatory synaptic activity is altered in fast-spiking interneurons in experimental cortical dysplasia. J Neurophysiol. 2009;102(4):2514-25. Epub 20090819. doi: 10.1152/jn.00557.2009. PubMed PMID: 19692507; PubMed Central PMCID: PMC2775391.

Zhou FW, Jin Y, Matta SG, Xu M, Zhou FM. An ultra-short dopamine pathway regulates basal ganglia output. J Neurosci. 2009;29(33):10424-35. doi: 10.1523/JNEUROSCI.4402-08.2009. PubMed PMID: 19692618; PubMed Central PMCID: PMC3596265.

Zhou FW, Roper SN. Densities of glutamatergic and GABAergic presynaptic terminals are altered in experimental cortical dysplasia. Epilepsia. 2010;51(8):1468-76. Epub 20100430. doi: 10.1111/j.1528-1167.2010.02583.x. PubMed PMID: 20477846.

Zhou FW^#, Rani A, Martinez-Diaz H, Foster TC, Roper SN. Altered behavior in experimental cortical dysplasia. Epilepsia. 2011;52(12):2293-303. Epub 20110920. doi: 10.1111/j.1528-1167.2011.03267.x. PubMed PMID: 21933180; PubMed Central PMCID: PMC4364520. ^#Corresponding author.

Zhou FW, Roper SN. Altered firing rates and patterns in interneurons in experimental cortical dysplasia. Cereb Cortex. 2011;21(7):1645-58. Epub 20101117. doi: 10.1093/cercor/bhq234. PubMed PMID: 21084454.

Zhou FW^#, Roper SN. Impaired hippocampal memory function and synaptic plasticity in experimental cortical dysplasia. Epilepsia. 2012;53(5):850-9. Epub 20120314. doi: 10.1111/j.1528-1167.2012.03431.x. PubMed PMID: 22417090.

Zhou FW^#, Roper SN. TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia. J Neurophysiol. 2014;111(6):1227-37. Epub 20131218. doi: 10.1152/jn.00607.2013. PubMed PMID: 24353305.

Zhou FW^#, Roper SN. Reduced chemical and electrical connections of fast-spiking interneurons in experimental cortical dysplasia. J Neurophysiol. 2014;112(6):1277-90. Epub 2014 Jun 18. doi: 10.1152/jn.00126.2014. PubMed PMID: 24944214.

Zhou FW^#, Fortin JM, Chen HX, Martinez-Diaz H, Chang LJ, Reynolds BA, et al. Functional integration of human neural precursor cells in mouse cortex. PLoS One. 2015;10(3):e0120281. Epub 20150312. doi: 10.1371/journal.pone.0120281. PubMed PMID: 25763840; PubMed Central PMCID: PMC4357458.

Zhou FW^#, Dong HW, Ennis M. Activation of beta-noradrenergic receptors enhances rhythmic bursting in mouse olfactory bulb external tufted cells. J Neurophysiol. 2016;116(6):2604-14. Epub 20160914. doi: 10.1152/jn.00034.2016. PubMed PMID: 27628203; PubMed Central PMCID: PMC5133314.

Zhou FW, Puche AC, Shipley MT. Short-Term Plasticity at Olfactory Cortex to Granule Cell Synapses Requires Ca(V)2.1 Activation. Front Cell Neurosci. 2018;12:387. Epub 20181026. doi: 10.3389/fncel.2018.00387. PubMed PMID: 30416429; PubMed Central PMCID: PMC6212651.

Zhou FW^#, Shao ZY, Shipley MT, Puche AC. Short-term plasticity in glomerular inhibitory circuits shapes olfactory bulb output. J Neurophysiol. 2020;123(3):1120-32. Epub 20200129. doi: 10.1152/jn.00628.2019. PubMed PMID: 31995427; PubMed Central PMCID: PMC7099473.

Zhou FW^#, Puche AC. Short-Term Plasticity in Cortical GABAergic Synapses on Olfactory Bulb Granule Cells Is Modulated by Endocannabinoids. Front Cell Neurosci. 2021;15:629052. Epub 20210209. doi: 10.3389/fncel.2021.629052. PubMed PMID: 33633545; PubMed Central PMCID: PMC7899975.

Zhou FW^#, Hook C, Puche AC. Frequency-dependent centrifugal modulation of the activity of different classes of mitral and tufted cells in olfactory bulb. J Neurophysiol. 2023;129(6):1515-33. Epub 20230524. doi: 10.1152/jn.00390.2022. PubMed PMID: 37222431; PubMed Central PMCID: PMC10281792.

Puche AC, Hook C, Zhou FW^#. Cell type-specific and frequency-dependent centrifugal modulation in olfactory bulb output neurons in vivo. J Neurophysiol. 2024;131(6):1226-39. Epub 20240501. doi: 10.1152/jn.00078.2024. PubMed PMID: 38691531; PubMed Central PMCID: PMC11381121.