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Michal Zalzman, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Biochemistry and Molecular Biology

Secondary Appointment(s):

Otorhinolaryngology-Head & Neck Surgery

Location:

108 N Greene Street, 002

Phone (Primary):

410-706-7879

Fax:

410-706-7886

Education and Training

  • Bar Ilan University, BS, Life Sciences, 1998
  • Tel Aviv University, MS, Human Molecular Genetics and Biochemistry, 2001
  • Tel Aviv University, PhD, Molecular Cell Biology, Stem Cell Research, 2007
  • NIA/National Institutes of Health, Postdoctoral Fellowship, Stem cell Research, Telomere Biology, 2012

Biosketch

Dr. Zalzman is a molecular cell biologist and a stem-cells expert who made significant discoveries related to telomere biology and cellular lifespan. Dr. Zalzman was the first to report that human stem cells can differentiate into insulin-producing cells, a finding which may translate into a potential treatment for type I Diabetes Mellitus. Her findings were published in major leading journals and are heavily cited. More recently, she made a seminal discovery of a novel mechanism that controls cellular lifespan and telomere maintenance in mouse embryonic stem cells. (Zalzman et al., Nature, 2010).

The Zalzman laboratory studies fundamental mechanisms controlling telomere maintenance and cellular lifespan in two major systems: adult stem cells and cancer cells. The cancer research projects goal in the lab is to allow the development of a new class of drugs designed to target cancer immortality. Her laboratory team generates adult stem cell lines from multiple adult tissue sources and in combination with 3D printing technology the team generates novel therapies for bone regeneration and reconstruction. In additional projects the technology is use for the treatment of Parkinson’s disease.

 

Research/Clinical Keywords

Stem cells, Telomere, Cancer, Parkinson's disease, Conductive hearing loss, Bone reconstruction, 3D Printing, Tissue reconstruction, Regenerative medicine, Molecular Biology, Biochemistry,

Highlighted Publications

NishiyamaA, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y,Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R,Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS. Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.Cell Stem Cell. 2009. 5(4):420-33.

ZalzmanM, Falco G, Sharova LV, Nishiyama A, Thomas M, Lee SL, Stagg CA, Hoang HG, Yang HT, Indig FE, Wersto RP, Ko MS. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature. 2010. 464(7290):858-63.

Nishiyama A, Sharov AA, Piao Y, Amano M, Amano T, Hoang HG, Binder BY, Tapnio R, Bassey U, Malinou JN, Correa-Cerro LS, Yu H, Xin L, Meyers E, Zalzman M, Nakatake Y, Stagg C, Sharova L, Qian Y, Dudekula D, Sheer S, Cadet JS, Hirata T, Yang HT, Goldberg I, Evans MK, Longo DL, Schlessinger D, Ko MS. Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. Sci Rep. 2013. 3:1390

Hwang B, Jin J, Gao Y, Shi G, Madabushi A, Yan A, Guan X, Zalzman M, Nakajima S, Lan L, and Lu A. SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9–Rad1–Hus1 checkpoint clamp. BMC-Mol Bio. 2015. 16(1):12.

Cherok E, Xu S, Li S, Das S, Meltzer WA, Zalzman M, Wang C, Karbowski M. Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics. Mol Biol Cell. 2017. 28(3):396-410.