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Nirav G. Shah, MD

Academic Title:

Associate Professor

Primary Appointment:

Medicine

Administrative Title:

Co-Director Of The Dc-Baltimore Critical Care Educational Consortium

Location:

110 S. Paca Street, 2N-144

Phone (Primary):

(410) 328-8141

Fax:

(410) 328-0177

Education and Training

Dr. Shah graduated from the University of North Carolina in Chapel Hill, North Carolina with a BS in Biology with Honors and a Minor in Chemistry and then went on to pursue his medical education at St. George's University School of Medicine in Grenada, West Indies. Upon graduating from St. George's University with Honors, he did his internship and residency in Internal Medicine at the Georgetown University Hospital/Washington Hospital Center Program in Washington, D.C. He completed his fellowship in Critical Care Medicine at the National Institutes of Health and his fellowship in Pulmonary Diseases at the University of Maryland Medical Center. Dr. Shah is board certified in Pulmonary Diseases and Critical Care Medicine.

Research/Clinical Keywords

Acute Lung Injury, ARDS, Sepsis, Medical Education, Thermobiology, Hypothermia

Highlighted Publications

  1. Shah NG, Tulapurkar ME, Damarla M, Singh I, Goldblum S, Shapiro P, Hasday JD. "Febrile-range Hyperthermia Augments Reversible TNFa-induced Hyperpermeability in Human Lung Microvascular Endothelial Cells" Int J Hyperthermia 2012; 28(7):627-35.
  2. Shah NG, Cowan M, Pickering E, Sareh H, Afshar M, Fox D, Marron J, Davis J, Herold K, Shanholtz C, Hasday JD. “Nonpharmacologic Approach to Minimizing 
  3. Shah NG, Seam N, Woods C, Fessler H, Goyal M, McAreavey D, Lee B. “A Longitudinal Regional Educational Model for Pulmonary and Critical Care Fellows Emphasizing Small Group and Simulation-Based Learning.” Annals ATS 2016; 13(4):469-74.
  4. Dixon R, Britt EJ, Netzer G, Afshar A, Burke A, Liu S, Jeudy J, Shah NG. "10-year Single Center Experience of Pulmonary Carcinoid Tumors and Diagnostic Yield of Bronchoscopic Biopsy." Lung 2016 (Epub ahead of print)

Additional Publication Citations

  1. Longtine M, McKenzie A, Demarini D, Shah NG, Wach A, Brachat A, Philippsen P, Pringle J. “Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae.” Yeast 1998; 14:953-61.     
  2. Bahler J, Wu J, Longtine M, Shah NG, McKenzie A, Steever A, Philippsen P, Pringle J.  “Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe.” Yeast 1998; 14:943-51.
  3. Nagarsekar A, Greenberg R, Shah NG, Singh I, Hasday JD. “Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils.”  Journal of Immunology 2008; 181:2636-2643.
  4. Shah NG, Tularpurkar ME, Singh I, Shelhamer J, Cowan M, Hasday JD. “Prostaglandin E2 Potentiates Heat Shock-Induced Heat Shock Protein 72 Expression in A549 Cells.” Prostaglandins and Other Lipid Mediators 2010; 93(1-2):1-7.
  5. Choi A, Reynolds H et al.  “NHLBI Workshop:  Respiratory Medicine-Related Research Training for Adult and Pediatric Fellows.” Lung 2009; 187:347-366.
  6. Hasday JD, Shah NG, Mackowiak P, Tulapurkar ME, Nagarsekar A, Singh I. “Fever, hyperthermia, and the lung: it’s all about context and timing.” Trans Am Clin Climatol Assoc, 2010; 122:34-37.
  7. Sareh H, Tulapurkar ME, Shah NG, Singh I, Hasday JD. “Response of Mice to Continuous 5-day Passive Hyperthermia Resembles Human Heat Acclimation.” Cell Stress and Chaperones, 2011; 16(3):297-307.
  8. Maity T, Henry M, Tulapurkar ME, Shah NG, Hasday JD, Singh I.  “Distinct, gene-specific effect of heat shock and heat shock factor-1 recruitment and gene expression on CXC chemokine genes.” Cytokine 2011; 54:61-7.
  9. Shah NG, Hasday JD. “Does temperature make a difference? It depends on how hot (or cold), for how long, and in what clinical context.” Crit Care Med 2012; 40:326-7.
  10. Tulapurkar ME, Almutairy E, Shah NG, He J, Puche A, Shapiro P, Singh I, Hasday JD. “Febrile-range Hyperthermia Modifies Endothelial and Neutrophil Functions to Promote Extravasation.” Am J Respir Cell Mol Biol 2012; 46:807-14.
  11. Nagarsekar A, Tulapurkar M, Singh I, Atamas S, Shah NG, Hasday JD. “Hyperthermia Promotes and Prevents Respiratory Epithelial Apoptosis through Distinct Mechanisms.” Am J Respir Cell Mol Biol; 2012; 47(6):824-33.
  12. Bridges T, Tulapurkar M, Shah NG, Singh I, Hasday JD. “Tolerance for chronic heat exposure is greater in female than male mice.” Int J Hyperthermia 2012; 28(8):747-55.
  13. Netzer G, Dowdy D, Harrington T, Chandolu S, Dinglas V, Shah NG, Colantuoni E, Mendez-Tellez P, Shanholtz C, Hasday JD, Needham D. “Fever is Associated with Delayed Ventilator Liberation in Acute Lung Injury.” Annals ATS 2013; 10(6):608-15.
  14. Liu S, Staats P, Goicochea L, Alexiev B, Shah NG, Dixon R, Burke A. “Automated Quantification of Ki-67 Proliferative Index of Excised Neuroendocrine Tumors of the Lung.” Diagn Pathol 2014; 16(9):174.
  15. Thomas G, Dixon R, Zimrin A, Papadimitriou J, Shah NG. “Pulmonary Langerhans Cell Histiocytosis with Systemic Features.” Am J Med 2015; 128(10):e7-9.
  16. Holden V, Shah NG, Verceles A. “Implications of an Incidental Pulmonary Arteriovenous Malformation.” J Investig Med High Impact Case Rep 2016; 8;4(1).
  17. McSparron JI, Hayes MM, Poston JT, Thomson CC, Fessler HE, Stapleton RD, Carlos WG, Hinkle L, Liu K, Shieh S, Ali A, Rogers A, Shah NG, Slack D, Patel B, Wolfe K, Schweickert WD, Bakhru RN, Shin S, Sell RE, Luks AM. “ATS Core Curriculum 2016: Part II. Adult Critical Care Medicine.” Ann Am Thorac Soc. 2016 May;13(5):731-40.
  18. McSparron J, Hayes MM, Poston, J, Thomson CC, Fessler HE, Stapleton RD, Carlos WG, Hinkle L, Liu K, Shieh S, Ali A, Rogers A, Shah NG, Slack D, Patel B, Wolfe K, Schweickert WD, Bakhru R, Shin S, Sell RE, Luks A. “ATS/ABIM Maintenance of Certification Self-Assessment Module: ATS Core Curriculum 2016: Part II. Critical Care Medicine.” Ann Am Thorac Soc. 2016

Research Interests

Dr. Shah's research interest lies in the field of thermal molecular biology and acute lung injury. In particular, he is interested in lung inflammation, injury, and repair and focuses on the molecular mechanisms through which febrile-range hyperthermia and therapeutic hypothermia exert their immunomodulatory effects on human microvascular endothelial cells in the lung. 

Clinical Specialty Details

Dr. Shah's clinical and teaching interests have continued to focus on acute lung injury, ARDS, sepsis and critical illness as well as consultative pulmonary medicine including advanced fiberoptic bronchoscopy. This includes endobronchial ultrasound, navigational bronchoscopy, and bronchial thermoplasty. He focuses on complex pulmonary issues in his outpatient clinic including interstitial lung disease, advanced COPD, sarcoidosis, and asthma.

Dr. Shah has a particular interest in medical education, curriculum development, and research in medical education and has been recognized for his teaching through teaching commendations as well as induction into Alpha Omega Alpha (AOA) by the Medical School Class of 2015.  He is the course director of Pathophysiology & Therapeutics I in the 2nd year medical school curriculum. In addition, Dr. Shah has been the Director of the Pulmonary & Critical Care fellowship program since 2014 and has been recognized for his teaching of residents and fellows by being awarded multiple “Faculty Teacher of the Year Awards.”  Dr. Shah was the recipient of the Theodore E. Woodward Faculty Prize in Medicine in 2016 For Exemplary Teaching and Patient Care, awarded by the Department of Medicine.  

Awards and Affiliations

2005                Saul Zukerman Humanitarianism in Medicine award

2010                Pulmonary & Critical Care Medicine Faculty of the Year award

2012                SCCM Presidential Citation for outstanding service

2014                Excellence in Cardiopulmonary Medicine – awarded by the Maryland/DC Society for Respiratory Care

2014                Innovations in Fellowship Education Award – awarded by the American Thoracic Society

2014                Fellow, American College of Chest Physicians

2014                Pulmonary & Critical Care Medicine Faculty Teacher of the Year Award

2015                Election to the Alpha Omega Alpha Honor Medical Society

2015                Attending of the Year, Awarded by the Nursing Staff of the Medical Intensive Care Unit

2016                Association of Pulmonary and Critical Care Medicine Program Directors Research in Medical Education 2nd Place Award

2016                Selected by Class of 2015 to be a Platform Party Marshall for Graduation

2016                Theodore E. Woodward Faculty Prize in Medicine For Exemplary Teaching and Patient Care, awarded by the Department of Medicine, University of Maryland School of Medicine

2016                Selected by the Gold Humanism Society and the Medical School to be the 2016 White Coat Ceremony Speaker