David Serre, Dr. rer. nat.

1997-2000: Engineering degree in Chemistry, Ecole Nationale Sup. de Chimie, Montpellier, France

2000-2004: PhD in Biology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

2004-2007: Postdoctoral fellowship, McGill and Genome Quebec Inn. Centre, Montreal, Canada

I am interested in developing genomic approaches to better understand the biology of eukaryotic pathogens and their interactions with their host(s).

My laboratory primarily focuses on Plasmodium vivax, an important human parasite responsible for most malaria cases outside Africa. Since this parasite cannot be continuously propagated in cultures and studied in vitro, we are using a variety of genomic assays to characterize its response to antimalarial drugs and other environmental stresses using patient samples and animal models. Our studies also include genomic analyses of the host response to infection and of the Anopheles mosquitoes that transmit the parasites.

Genomics, Plasmodium vivax, malaria, Anopheles

Popovici J, Friedrich LR, Kim S, Bin S, Run V, Lek D, Cannon MV, Menard D, Serre D (2018) Genomic Analyses Reveal the Common Occurrence and Complexity of Plasmodium vivax Relapses in Cambodia. MBio. 9(1). pii: e01888-17. PMC5784252.

Kim A, Popovici J, Menard D, Serre D (2019) Plasmodium vivax transcriptomes reveal stage-specific chloroquine response and differential regulation of male and female gametocytes. Nature Communications. 10: 371. PMC6342968

Sá JM, Cannon MV, Caleon RL, Wellems TE, Serre D (2020) Single-cell transcription analysis of Plasmodium vivax blood-stage parasites identifies stage- and species-specific profiles of expression. PLoS Biol. 18(5):e3000711. PMC7224573

Bogale HN, Pascini TV, Kanatani S, Sá JM, Wellems TE, Sinnis P, Vega-Rodriguez J, Serre D (2021) Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development. PNAS. 118(10):e2023438118. PMC7958459.

Tebben K, Dia A, Serre D (2022) Determination of the Stage Composition of Plasmodium Infections from Bulk Gene Expression Data. mSystems 30;7(4):e0025822. PMC9426464

Hazzard B, Sá JM, Ellis AC, Pascini TV, Amin S, Wellems TE, Serre D (2022) Long read single cell RNA sequencing reveals the isoform diversity of Plasmodium vivax PLoS Negl Trop Dis. 16(12):e0010991. PMC9803293