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Eugene D. Albrecht, PhD

Academic Title:

Professor

Primary Appointment:

Obstetrics, Gynecology and Reproductive Sciences

Secondary Appointment(s):

Physiology

Location:

655 West Baltimore St. BRB 11-019

Phone (Primary):

410-706-3391

Fax:

410-706-5747

Education and Training

BS in Biology from the University of Vermont

MS in Reproductive Endocrinology from the University of Vermont

PhD in Reproductive Endocrinology from Rutgers University

Staff Fellowship in Pregnancy Research at National Institutes of Health

 

 

Biosketch

Laboratory of Developmental and Perinatal Endocrinology

A multidisciplinary approach and a nonhuman primate model are used in this research laboratory to study the regulation of placental and fetal growth and development. We have shown that estrogen has a central integrative role in regulating several processes critical to the maintenance of pregnancy and development of physiological systems important to placental and fetal development. For example, we have shown that estrogen regulates placental trophoblast remodeling of the uterine spiral arteries critical to promoting blood flow to and growth of the placenta and fetus. Moreover, estrogen regulates development of the fetal adrenal gland and consequently production of steroid hormones required for neonatal and postnatal development. Estrogen also programs mechanisms within the fetus that lead to insulin sensitivity and glucose homeostasis in the offspring after birth. Research in this laboratory builds upon our continuing studies to elucidate the actions of estrogen in pregnancy, uses a nonhuman primate model with important translational value to the human, and permits an integrated investigation of maternal, placental, and fetal development. Our studies make conceptual advances in knowledge of the regulation of fetal-placental development and is expected to lead to new modalities to address pregnancy maintenance and maternal-placental-fetal developmental disorders, such as preeclampsia, preterm birth, fetal growth restriction, and metabolic diseases after birth in the offspring such as diabetes.

Highlighted Publications

(Last 2 years from list of over 160 publications)

 Kyathanahalli C, Marks J, Nye K, Lao B, Albrecht ED, Aberdeen GW, Nathanielsz PW, Jeyasuria P, Condon JC 2013 Cross-species withdrawal of MCL1 facilitates postpartum uterine involution in both the mouse and baboon.  Endocrinology 154:4873-4884

Dumitrescu A, Aberdeen GW, Pepe GJ, Albrecht ED 2014 Placental estrogen suppresses cyclin D1 expression in the nonhuman primate fetal adrenal cortex.  Endocrinology 155:4774-4784

Albrecht ED, Pepe GJ 2014 Placental endocrine function and hormone action.  In: Knobil and Neill's Physiology of Reproduction, 4th Edition, Plant TM, Zeleznik A (eds), Academic Press, New York, pp 1783-1834

Bonagura TW, Babischkin JS, Pepe GJ, Albrecht ED 2016 Assessment of protein expression by proximity ligation assay in the nonhuman primate endometrium, placenta, and fetal adrenal in response to estrogen.  In: Estrogen Receptors: Methods and Protocols, Methods in Molecular Biology, Vol 1366, Humana Press: Springer Science+Business Media, New York, pp 149-161

Babischkin JS, Aberdeen GW, Pepe GJ, Albrecht ED 2016 Estrogen suppresses interaction of melanocortin 2 receptor and its accessory protein in the primate fetal adrenal cortex.  Endocrinology 157:4588-4601

Pepe GJ, Maniu A, Aberdeen G, Lynch TJ, Albrecht ED 2016 Estrogen regulation of fetal adrenal cortical zone-specific development in the nonhuman primate impacts adrenal production of androgen and cortisol and response to ACTH in females in adulthood.  Endocrinology 157:1905-1913

Maniu A, Aberdeen GW, Lynch TJ, Nadler JL, Kim SO, Quon MJ, Pepe GJ, Albrecht ED 2016 Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring.  Journal of Endocrinology 230:171-183

Pepe GJ, Maniu A, Aberdeen G, Lynch TJ, Kim SO, Nadler J, Albrecht ED 2016 Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero.  Endocrine 54:788-797.

Research Interests

  • Regulation of maternal vascular remodeling and impact on vascular function in the offspring
  • Programming of cardiovascular development in the fetus and impact on insulin sensitivityin the offspringt
  • Regulation of fetal adrenal development

Awards and Affiliations

  • Endocrine Society
  • Society for the Study of Reproduction
  • Society for Reproductive Investigation
  • Perinatal Research Society

Grants and Contracts

NIH R01 DK93950 (Albrecht, Principal Investigator)     04/01/2013 - 03/31/2018

"Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth"

 

NIH R01 HD 093070-01 (Albrecht, Principal Investigator)    09/08/2017 - 06/30/2022

"Regulation of Uterine Spiral Artery Remodeling During Primate Pregnancy"

Professional Activity

  • Invited Plenary Speaker, Symposium on “Hormones and Angiogenesis,” Endocrine Society Annual Meeting
  • Plenary Speaker, 7th World Congress of the Developmental Origins of Health and Disease
  • Plenary Speaker, North American Society for Comparative Endocrinology
  • Keynote Speaker, M. Carlyle Crenshaw Lectureship in Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine
  • Plenary Speaker, Experimental Biology Symposium, American Physiological Society (APS), Endocrinology and Metabolism Section
  • Previous Member of Human Embryology and Development Study Section, NIH, PHS
  • Recent Member of Editorial Board of: Steroids, Reproductive Sciences, Placenta, Biology of Reproduction
  • Recent Member of Pregnancy and Neonatology Study Section, NIH, PHS

Key Areas of Expertise

  • Fetal/Perinatal Endocrinology
  • Placental Development
  • Fetal Development

Key Collaborators

  • Gerald J. Pepe, PhD, Eastern Virginia Medical School
  • Jonathan Lindner, MD, Oregon Health and Science University