685 West Baltimore St, Baltimore, Maryland 21201
Education and Training
Dr. Zhou received his Bachelor Degree of Medicine (in Dental Medicine, BM) and Master Degree of Medicine (in Pharmacology, MM) from the Central South University Xiang-Ya School of Medicine in China. He then received his Dr. rer.nat. (in Cell Biology) from the University of Rostock, Germany. He was a post-doctoral fellow and research associate at the University of Tennessee.
Dr. Zhou has been pursuing neuroscience research for >20 years, mainly using patch clamp electrophysiological, optogentical, chemogenetical, immunohistological, molecular biological and stereotaxic techniques, to investigate the neuroelectrophysiology of different neuronal types in different brain regions (mainly olfactory bulb, cortex and basal ganglia), and the pathophysiology of these neurons in neurological disorders (Alzheimer's disease, Parkinson's disease and epilepsy), and has mainly examined neuronal intrinsic properties, chemical and electrical interconnection, synchronization of neuronal populations and synaptic plasticity.
olfactory bulb; local and centrifugal circuits; neural excitation in health and disease; in vivo and in vitro neural electrophysiology; neuroanatomy with fiber photometry and miltiphoton imaging
Zhou FW#, Hook C, Puche AC#. Frequency-dependent centrifugal modulation of the activity of different classes of mitral and tufted cells in olfactory bulb. Journal of Neurophysiology 2023, 129: 1515-1533.
Zhou FW#, Puche AC#. Short-term plasticity in cortical GABAergic synapses on olfactory bulb granule cells is modulated by endocannabinoids. Frontiers Cellular Neuroscience. 2021, 15: 629052.
Zhou FW#, Shao ZY, Shipley MT, Puche AC#. Short-term plasticity in glomerular inhibitory circuits shapes olfactory bulb output. Journal of Neurophysiology 2020, 123(3): 1120-1132.
Shao Z, Liu S, Zhou FW, Puche AC, Shipley MT. Reciprocal inhibitory glomerular circuits contribute to excitation-inhibition balance in the mouse olfactory bulb. eNeuro 2019, 6(3). pii: ENEURO.0048-19.2019.
Zhou FW, Puche AC, Shipley MT. Short-term plasticity at olfactory cortex to granule cell synapses requires Cav2.1 activation. Frontiers in Cellular Neuroscience 2018, 12: 387.
Zhou FW#, Dong HW, Ennis M. Activation of β noradrenergic receptors enhances rhythmic bursting in mouse olfactory bulb external tufted cells. Journal of Neurophysiology 2016, 116(6): 2604-2614.
Zhou FW#, Fortin JM, Chen HX, Martinez-Diaz H, Chang LJ, Reynolds BA, Roper SN. Functional integration of human neural precursor cells in mouse cortex. PLoS One 2015, 10(3): e0120281.
Acevedo-Rodriguez A, Zhang L, Zhou FW, Gong S, Gu H, De Biasi M, Zhou FM, Dani JA. Cocaine inhibition of nicotinic acetylcholine receptors influences dopamine release. Frontiers in Synaptic Neuroscience 2014, 6: 19.
Zhou FW#, Roper SN. Reduced synaptic and electrical connections of fast-spiking interneurons in experimental cortical dysplasia. Journal of Neurophysiology 2014, 112(6): 1277-1290.
Zhou FW#, Roper SN. TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia. Journal of Neurophysiology 2014, 111(6): 1227-1237.
Zhou FW#, Roper SN. Impaired spatial recognition memory and synaptic plasticity in experimental cortical dysplasia. Epilepsia 2012, 53(5): 850-859.
Zhou FW, Roper SN. Altered firing rates and patterns in interneurons in experimental cortical dysplasia. Cerebral Cortex, 2011, 21(7): 1645-1658.
Zhou FW#, Rani A., Martinez-Diaz H, Foster TC, Roper SN. Altered behavior in experimental cortical dysplasia. Epilepsia 2011, 52(12): 2293-2303.
Zhou FW, Roper SN. Densities of glutamatergic and GABAergic pre-synaptic terminals are altered in experimental cortical dysplasia. Epilepsia 2010, 51(8): 1468-1476.
Zhou FW, Jin Y, Matta SG, Xu M, Zhou FM. An ultra-short dopamine pathway regulates basal ganglia output. Journal of Neuroscience 2009, 29(33): 10424-10435.
Zhou FW, Chen HX, Roper SN. Balance of inhibitory and excitatory synaptic activity is altered in fast-spiking interneurons in experimental cortical dysplasia. Journal of Neurophysiology 2009, 102: 2514-2525.
Strauss U, Zhou FW (co-first author), Henning J, Battefeld A, Wree A, Köhling R, Haas SJP, Benecke R, Rolfs A, Gimsa U. Increase of extracellular potassium shapes the activity of subthalamic neurons similarly to a 6-hydroxydopamine lesion. Journal of Neurophysiology 2008, 99(6): 2902-2915.
Zhou FW, Matta SG, Zhou FM. Constitutively active TRPC3 channels regulate basal ganglia output neurons. Journal of Neuroscience 2008, 28(2): 473-482 (TWIJ article).
Chen R, Tilley MR, Wei H, Zhou FW, Zhou FM, Ching S, Quan N, Stephens RL, Hill ER, Nottoli T, Han DD, Gu HH. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(24): 9333-9338.
Zhou FW, Xu JJ, Zhao Y, Ledoux MS, Zhou FM. Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulta. Journal of Neurophysiology 2006, 96(3): 1581-1591.
Tang YJ, Zhou FW (co-first author), Luo ZQ, Li XZ, Yan HM, Wang MJ, Huang FR, Yue SJ. Multiple therapeutic effects of adjunctive baicalin therapy in experimental bacterial meningitis. Inflammation 2010, 33(3): 180-188.
Dai W, Zhou FW, Song QJ, Li YJ, Deng HW. Protective effects of calcitonin gene-related peptide on guinea-pig cardiac anaphylaxis. Naunyn-Schmiedeberg'sArchives ofPharmacology 2000, 361(2): 161-165.
Zhou FW, Li YJ, Lu R, Deng HW. Protection of calcitonin gene-related peptide-mediated preconditioning against coronary endothelial dysfunction induced by reperfusion in the isolated rat heart. Life Science 1999, 64(13): 1091-1097.
Zhou FW, Li YJ, Deng HW. Early and delayed protection by capsaicin against reperfusion injury in rat hearts. Acta Pharmacologica Sinica 1999, 20(10): 912-916.
Zhou FW, Li YJ, Deng HW. Mediation of calcitonin gene-related peptide in protection of ischemic preconditioning in rat hindlimbs. Acta Pharmacologica Sinica 1998, 19(5): 477-480.
Luo ZQ, Feng DD, Zhou FW, Zhang CQ, Qin XQ, Sun XH. Protective effect of low concentration endothelin-1 on the reactive oxygen-induced inhibition of pulmonary surfactant lipid synthesis. Acta Physiologica Sinica 2002, 54 (2), 89-93.
Li L., Luo ZQ, Zhou FW, Feng DD, Guang CX, Zhang CQ, Sun XH. Effect of vasoactive intestinal peptide on pulmonary surfactants phospholipid synthesis in lung explants. Acta Pharmacologica Sinica2004, 25(12): 1652-658.