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Tianshu Zhang, BM, PhD

Academic Title:

Assistant Professor

Primary Appointment:



10 S. Pine Street

Phone (Primary):



I received my MD from the Hebei Medical University (China) and my PhD from the Shinshu University (Japan). I then pursued postdoctoral training in the Lab of Richard N Pierson III (Surgery, University of Maryland). I then joined the Faculty at the University of Maryland Medical School.

Highlighted Publications

Zhang T, KoideN, Wada Y, Tsukioka K, Takayama K, Kono T, Kitahara H, Amano J. Significance of monocyte chemotactic protein-1 and thymidine phosphorylase in angiogenesis of human cardiac myxoma. Cir J. 2003 Jan;67(1):54-60.

Poirier N*, Azimzadeh AM*, Zhang T*, Dilek N, Mary C, Nguyen B, Tillou X, Wu G, Reneaudin K, Hervouet J, Martinet B, Coulon F, Allain-Launay E, Karam G, Soulillou JP, Pierson RN III, Blancho G, Vanhove B. Inducing CTLA-4–dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation. Sci Transl Med. 2010 Feb 3; 2(17): 17ra10. 

Kelishadi S*, Azimzadeh AM*, Zhang T*, Stoddard T, Welty E, Sangrampurkar N, Avon C, Higuchi M, Laaris A, Cheng XF, McMahon C, Pierson RN III. Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in cyclosporine-treated monkeys. J Clin Invest. 2010 Apr;120(4):1275-84.

Zhang T*, Fresnay S, Welty E, Sangrampurkar N, Rybak E, Zhou H, Cheng XF, Feng Q, Avon C, Laaris A, Whitters M, Nagelin AM, O'Hara RM Jr, Azimzadeh AM*. Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner. Am J Transplant. 2011 Aug;11(8):1599-609.

Zhang T, Pierson RN 3rd, Azimzadeh AM. Update on CD40 and CD154 blockade in transplant models. Immunotherapy. 2015 Aug;7(8):899-911. 

Li L, Shirkey MW, Zhang T, Xiong Y, Piao W, Saxena V, Paluskievicz C, Lee YS, Toney N, Cerel BM, Li Q, Simon T, Smith KD, Hippen KL, Blazar BR, Abdi R, Bromberg JS. The lymph node stromal laminin α5 shapes alloimmunity. J Clin Invest. 2020 May 1; 130(5):2602-2619. 

Li L, Shirkey MW, Zhang T, Piao W, Li X, Zhao J, Mei Z, Guo Y, Saxena V, Kensiski A, Gavzy SJ, Song Y, Ma B, Wu J, Xiong Y, Wu L, Fan X, Roussey H, Li M, Krupnick AS, Abdi R, Bromberg JS. Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin α4. J Clin Invest. 2022 Jul 1; 132 (13):e156994.

Mohiuddin MM, Singh AK, Scobie L, Goerlich CE, Grazioli A, Saharia K, Crossan C, Burke A, Drachenberg C, Oguz C, Zhang T, Lewis B, Hershfeld A, Sentz F, Tatarov I, Mudd S, Braileanu G, Rice K, Paolini JF, Bondensgaard K, Vaught T, Kuravi K, Sorrells L, Dandro A, Ayares D, Lau C, Griffith BP. Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report. Lancet. 2023 Jul 29;402(10399):397-410.