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Carole Sztalryd Woodle, PhD

Academic Title:

Adjunct Associate Professor

Primary Appointment:



HH 445A, labs 421/427/430

Phone (Primary):


Education and Training

1980    BS Biochemistry, Univ. of Sciences, Paris VII, France

1981    MS Cell Physiology, Univ. of Sciences, Paris VII, France

1981    MS Human Biology, Univ. of Sciences, Paris VII, France

1984    PhD Nutrition, Univ. of Sciences, Paris VII, France


Post Graduate Education and Training

1985-1986       Post-doctoral Associate, Laboratory of Human Behavior and Metabolism. The RockefellerUniv., NY, Profs. Jules Hirsh and Irving Faust, Mentors

1986-1987       Adjunct Assist. Professor, Department of Biology, Vassar College, NY, Professors. Marcie Greenwood and Irving Faust, Mentors

1988-1992       Research Associate, VAH Palo Alto, Division of Endocrinology, Stanford, University School of Medicine, Stanford, CA, Prof. Gerald Reaven

1993-1997       Research Associate, VAH Palo Alto, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, Prof. Fredrick Kraemer

1998-2003       Research Fellow, NIDDK, Bethesda, MD, Dr. Constantine Londos Advisor


Professional Experience

 2003-present   VA Research Physiologist, VAMC under the supervision of Dr. Andrew Goldberg (until 2014) then Dr. Leslie Katz.

2003-2009       Assistant Professor, Department of Medicine, Division of Gerontology, University of MarylandSchool of Medicine

2009-present   Associate Professor, Department of Medicine, Division of Endocrinology. University of MarylandSchool of Medicine

2007-2009       Adipose Core manager (NORC)

2009-present  Co-Director Biological Mechanisms Core Laboratory (NIH Mid-Atlantic Nutrition Obesity Research Center (NORC))


Research/Clinical Keywords

Obesity, diabetes, metabolic complications of obesity, adipose tissue, fatty liver, lipid metabolism, lipid droplet

Highlighted Publications

  1. Bell M., Wang H., Chen H, McLenithan J., Yang R, Yu D., Fried S.K.,  Quon M.J.,  Londos C. and Sztalryd C.  Consequences of lipid droplet coat proteins down –regulation in liver cells: Abnormal lipid droplet metabolism and induction of insulin resistance.  Diabetes 2008 57(8):2037-45.
  2. Beller M, Sztalryd C, Southall N, Bell M, Jäckle H, Auld DS, Oliver B. COPI complex is a regulator of lipid homeostasis. PLoS Biol. 2008 6(11) e29
  3. Kimmel A.R., Brasaemle D.L., McAndrews-Hill M., Sztalryd C., Londos C.. Adoption of.PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular, lipid storage droplet proteins. J Lipid Res. 2009 Jul 28. [Epub ahead of print]
  4. Wang H., Hu L., Dalen K., Dorward H., Marcinkiewicz A., Russel D., Gong D., Londos C.,Yamaguchi T., Holm C., Rizzo M.A., Brasaemle D., Sztalryd C. Activation of hormone-sensitive lipase requires two steps: protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J Biol Chem. 2009  284 (46):32116-321125
  5. Wang H. and Sztalryd C. Oxidative tissue: perilipin 5 links storage with the furnace.  Trends in Endocrinology. 2011. 22(6):197-203.
  6. Wang H, Sreenevasan U, Hu H, Saladino A, Polster BM, Lund LM, Gong DW, Stanley WC, Sztalryd C. Perilipin 5, lipid droplet associated protein provides physical and metabolic linkage to mitochondria. J Lipid Res. 2011. 52(12):2159-2168.
  7. Wang X, Yang R, Jadhao SB, Yu D, Hu H, Glynn-Cunningham N, Sztalryd C, Silver KD, Gong DW.Transmembrane emp24 protein transport domain 6 is selectively expressed in pancreatic islets and implicated in insulin secretion and diabetes.. Pancreas. 2012.41(1):10-14.
  8. Konige M, Wang H, Sztalryd C. Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis. Biochim Biophys Acta. 2013 1842(3):393-401
  9. Wang H, Sreenivasan U, Gong DW, O'Connell KA, Dabkowski ER, Hecker PA, Ionica N, Konig M, Mahurkar A, Sun Y, Stanley WC, Sztalryd C. Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction. J Lipid Res. 2013 Apr;54(4):953-65.
  10. Sztalryd C, Kimmel AR. Perilipins: Lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection. Biochimie. 2013 Jan;96:96-101
  11. Albert, JS, Yerges-Armstrong, LM, Horenstein, RB, Pollin, TI, Sreenivasan, UT, Chai S, Blaner, WS, Snitker, S, O'Connell, JR, Gong D-W, Breyer III, RJ, Ryan, AS, McLenithan, JC, Shuldiner, AR, Sztalryd, C*, Damcott, CM*..Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes. New England Journal of Medicine, N Engl J Med. 2014 Jun 12;370(24):2307-15. * Authors have equally contributed to the work.
  12. Tschapalda K, Zhang Y-Q, Liu Li, Golovnina K, Schlemper T,. Eichmann T O, Lal-Nag M, Sreenivasan U, McLenithan J, Ziegler S, Sztalryd C, Achim L, Auld D, Oliver B, Waldmann H, Li Zhuyin, Shen M, Boxer M B., Beller. A novel class of diacylglycerol acyltransferase 1 inhibitors identified by a combination of phenotypic high-throughput screening, genomics, and genetics EBioMedicine, 2016 Jun;8:49-59.
  13. Kimmel A, Sztalryd C. The perilipins: Major cytosolic lipid droplet-associated proteins and their roles in cellular lipid storage mobilization, and systemic homeostasis. Annu. Rev. Nutr. Annu Rev Nutr. 2016 Jul 17;36:471-509. 

Additional Publication Citations

Research Interests

My scientific interest has been to determine mechanisms underlying association of obesity, a chronic positive energy balance, and development of metabolic diseases, e.g. Type 2 Diabetes. I built a research program at UMB focused on understanding contributions of cytosolic lipid droplets (CLD) to cellular and systemic lipid homeostasis in both physiological and pathological conditions, with funding support from NIH, American Diabetes Association (ADA) and American Heart Association (AHA). Key questions addressed in my laboratory are the following: what gene products regulate CLD degradation and their tissue specificity; how and what links CLD in adipose, liver, and muscle with metabolic disease? My work has contributed significantly to understanding how perilipin protein family members regulate tissue specific CLD hydrolysis via each member’s ability to protect the CLD neutral lipid core from key lipolytic enzymes.  My work also helped develop a concept that ectopic CLD are an adaptive response to changes in lipid homeostasis, and not necessarily pathologic. Rather, defects in CLD regulation and metabolism can lead to disease. My lab learned to use perilipin proteins as effective discovery tools to study CLD function, and we developed important tools and methodologies for the field to study CLD biology and lipid metabolism in cell culture systems and tissues.

            As the Director of the Biological Mechanisms Core Laboratory (NIH Mid-Atlantic Nutrition Obesity Research Center (NORC)), I developed strong interactions with the entire NORC scientific community, and in particular members involved in studying the genetics of complex disorders in the Old Order Amish including T2D, insulin resistance obesity and cardiovascular diseases (CVD). An example of this is illustrated by a major contribution made to elucidate the molecular mechanisms underlying a novel 19 base pair deletion that disrupts the coding region of the LIPE gene in Amish subjects with dyslipidemia. LIPE encodes hormone sensitive lipase (HSL), a key lipolytic enzyme, recently published in New England Journal of Medicine (with two press releases), and reviewed in Cell Metabolism. The accelerating pace of genomic discovery among NORC users has increased the need for mechanistic studies to elucidate the physiological roles of novel genes in cells, tissues, and whole organisms. To achieve this goal, with the help of my Co-Director Dr. Zaghloul, we have developed three types of services: i) adipose tissue phenotyping and tissue/cell banking; ii) whole animal functional genomics (zebrafish genetic models) and iii) functional genomics in tissue culture cells (including over-expression and knockdown in cultured cells, analytical and metabolic assays, and confocal imaging). Combining my expertise in CLD biology, lipid metabolism, and molecular and imaging technologies with Dr. Zaghoul expertise in zebrafish system, we are now evaluating the impact of TM6SF2 variants in human triglyceride-rich lipoprotein secretion. Our on-going takes advantage of a unique ‘genetic experiment of nature’ which offers opportunities to gain molecular insights in human regulation of TRL secretion, a pathway associated with unmet medical needs.

Awards and Affiliations

Honors and Awards

1981-1982       Grant from the Univ. of Paris

1982-1982       Grant from the French Ministry of Research

1984-1986       Grant from the French Foundation for Nutrition Research

1986-1987       Feasibility Grant from the ObesityCoreCenter (NIH)

1989-1991       Grant from Weight Watchers

1993-1995       Grant from State of CA, Effect of Nicotine on Weight Gain

1995-1996       Grant in Aid, CA Amer. Heart Association, Insulin Regulation of LPL

2005-2010       ADA Career Development Award 1-05 CD-`17. Perilipin regulation of HSL

2014                  best publication award of the department of Medicine

Professional Activity

Institutional Service

2005-2008       Adipocyte Core Biology Manager, UMSOM

2008-present Adipocyte Core Biology, Director UMSOM

2006-2012       Member of the Department of Gerontology and GRECC Biosafety Committee

Review and provide guidelines for Biosafety protocols in use in the GRECC, VAMC

2007-present Ad Hoc Grant reviewer for CNRU pilot feasibility grants, UMSOM

2008-present University of Maryland School of Medicine Council Representative (alternate)

2008-2014       VA grant review subcommittee, VAMC

2008-2012School of Medicine council member


Local and National Service

 2003-2009       Special volunteer, NIDDK/LCDB

2004-present Ad Hoc Reviewer (Diabetes, J. Cell Biology, J..Lipid Research, Nature commons, ,Am. J. of Clin. Nutrition, Obesity, European J. of Physiology, J.Mol. Medicine, In Vitro Cellular and Development Biology,BBA lipids, Diabetologia, PNAS,Science reports, Biochmistry, Journal of Biological Chemistry, PNAS, Am. J.  of Physiology, Endocrinology, FEBBS, FASEB Journal, , Traffic, Biochemistry, Obesity J.)

2006-2010       Grant reviewer for NIH seeds grant, VillaJulieCollege

2006-present Grant reviewer for NIH funded Nutrition, Obesity and Research Center seeds grant

2007-2008       Grant reviewer for American Heart Association, national chapter: lipids study section

2008-2013      Ad Hoc Grant reviewer for American Heart Association, Mid-Atlantic chapter: lipids study section

2007-2015      Grant reviewer for American Diabetes Association Research Review Grant Committee

2016-present   NIDDK Diabetes COMP reviewer

2011-present  ad Hoc reviewer for welcome trust

2011-present  maryland and Stanford DRC Pilot & Feasibility Grant Reviewer

2005-present  Maryland U NORC Pilot & Feasibility Grant reviewer

2007-present Member of the editorial board of the Journal of Obesity (Nature Publishing Group)

2008-present   Ad Hoc Grant reviewer for NIH CADO, IPOD, NSF, Wellcome Trust, British Diabetes          Association study sections

2011                American Diabetes Association, Chair, Lipid droplet session

2013                Gordon conference, discussion leader, Lipid droplet session

2013                Co-organizer of the Society for Heart and Vascular Metabolism “lipids in cardiac health and diseases: from toxicity and protection, Cambridge, Maryland.

2014                FASEB summer meetings. Chair, Lipid Droplet session


Lab Techniques and Equipment

Unltracentrifuge bexkamn and rotors

French press

in vitro metabolic labeling

Adipose tissues phenotyping