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Jeanine A. Ursitti, PhD

Academic Title:

Assistant Professor

Primary Appointment:



660 W. Redwood Street

Education and Training

  • B.S., Biology, Loyola University Maryland, Baltimore, Maryland

  • Ph.D., Membrane Physiology, University of Maryland Baltimore, Baltimore, Maryland
  • Postdoctoral Fellowship, The Wistar Institute, Philadelphia, PA


Research/Clinical Keywords

membrane cytoskeleton, microtubules, spectrin, blood cells, skeletal muscle, aging, muscular dystrophy, cardiovascular disease

Highlighted Publications

Zhang, Y., W.G. Resneck, P.C. Lee, W.R. Randall, R.J. Bloch and J.A. Ursitti. 2010. Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat. J. Mol. Cell Cardiol. 48:1050-9.

Ursitti, J.A., B.G. Petrich, P.C. Lee,X. Ye, J. Yang, W.R. Randall, R.J. Bloch, and Y. Wang. 2007. Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase. J Mol Cell Cardiol. 42:572-81.

Ursitti, J.A., P.C. Lee, W.G. Resneck, M.M. McNally, A.L. Bowman, A. O'Neill, M.R. Stone, R.J. Bloch. 2004. Cloning and Characterization of Cytokeratins 8 and 19 in Adult Rat Striated Muscle: Interaction with the dystrophin glycoprotein complex.  J. Biol. Chem. 279:41830-41838.



Additional Publication Citations

Pumplin, D.W., P.W. Luther, S.J. Samuelsson, J.A. Ursitti, and J. Strong. 1989. Quick-freeze, deep-etch, replication of cells in monolayers. Journal of Electron Microscopy Technique. 14:342-347.

Ursitti, J.A., D.W. Pumplin, J.B. Wade, and R.J. Bloch. 1991. Ultrastructure of the human erythrocyte cytoskeleton and its attachment to the membrane. Cell Motility and the Cytoskeleton. 19:227-243.

Speicher, D.W., T.M. DeSilva, K.D. Speicher, J.A. Ursitti, P. Hembach, and L. Weglarz. 1992. Location of the human red cell spectrin tetramer binding site and detection of a related "closed" hairpin loop dimer using proteolytic footprinting. J. Biol. Chem. 268:4227-4235.

Ursitti, J.A. and J.B. Wade. 1993. Ultrastructure and immunocytochemistry of the isolated human erythrocyte membrane skeleton. Cell Motility and the Cytoskeleton. 25:30-42.

Speicher, D.W. and J.A. Ursitti. 1994. Conformation of a mammoth protein. Current Biology. 4:154-157.

Ursitti, J.A. and V.M. Fowler. 1994. Immunolocalization of tropomodulin, tropomyosin, and actin in spread human erythrocyte skeletons. J. Cell Sci. 107:1633-1639.

Ursitti, J.A., L. Kotula, T.M. DeSilva, P. Curtis and D.W. Speicher. 1996. Mapping the erythrocyte β-spectrin dimer initiation site using recombinant peptides and correlation of its phasing with the α-actinin dimer site. J. Biol. Chem. 271:6636-6644.

Wilmotte, R., S.L. Harper, J.A. Ursitti, J. Marechal, J. Delaunay, and D.W. Speicher. 1997. The exon 46-encoded sequence is essential for stability of human erythroid α-spectrin and heterodimer formation. Blood. 90:4188-4196.

Zhou, D., J.A. Ursitti, and R.J. Bloch. 1998. Developmental expression of spectrins in rat skeletal muscle. Mol.Biol.Cell. 9:47-61.

Williams, M.W., W.G. Resneck, J.A. Ursitti, T. Kaysser, C.S. Birkenmeier, J.E. Barker, and R.J. Bloch. 2001. Na,K-ATPase in skeletal muscle: Two populations of b-spectrin control localization in the sarcolemma but not partitioning between the sarcolemma and transverse tubules. J.Cell Sci. 114:751-762.

Ursitti, J.A., L. Martin, W.G. Resneck, T. Chaney, C. Zeilke, B.E. Alger, and R.J. Bloch. 2001. Spectrins in developing rat hippocampal cells. Devel. Brain Res. 129:81-93.

Bloch R.J., Y. Capetanaki, A. O'Neill, P. Reed, M.W. Williams, W.G. Resneck, N.C. Porter, J.A. Ursitti. 2002. Costameres: repeating structures at the sarcolemma of skeletal muscle. Clin. Orthop. 403:S203-10.               

Zheng, M. K. Dilly, J. Dos Santos Cruz, M. Li, Y. Gu, J.A. Ursitti, J. Chen, J. Ross Jr., K.R. Chien, W.J. Lederer, Y. Wang. 2004. Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. Am. J. Physiol. Heart Circ. Physiol. 286:H424-33.

Stone, M.R., A. O'Neill, R.M. Lovering, J. Strong, W.G. Resneck, P.W. Reed, D.M. Toivola, J.A. Ursitti, M.B. Omary and R.J. Bloch. 2007. Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization. J. Cell Sci. 120:3999-4008.

Antolik, C., D.H. Catino, A.M. O’Neill, W.G. Resneck, J.A. Ursitti and R.J. Bloch. 2007. The actin binding domain of ACF7 binds directly to the tetratricopeptide repeat domains of rapsyn. Neuroscience. 145:56-65.

Benz, P.M., C.J. Merkel, K. Offner, M. Abener, M. Ullrich, T. Fischer, B. Bayer, H. Wagner, S. Gambaryan, J.A. Ursitti, U.M. Adham, W.A. Linke, S.M. Feller, I. Fleming, T. Renne, S. Frantz, A. Unger, K. Schuh. 2013.  Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.Cell Commun. Signal.11:56.