David Serre, Dr. rer. nat.

• Ecole Nationale Sup. de Chimie, Montpellier, France, Engineering degree, Chemistry, 2000
• Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, PhD, Biology, 2004
• McGill and Genome Quebec Inn. Centre, Montreal, Canada, Postdoctoral Fellowship, 2007

I am interested in in developing novel genomic approaches to study human infectious diseases and to address outstanding biological and clinical questions that cannot be easily studied with classical molecular biology approaches.

My laboratory primarily focuses on the investigation of Plasmodium parasite biology and host/parasite interactions using various genomic assays, including whole genome sequencing, RNA sequencing, scRNA-seq and spatial transcriptomics.

Genomics, Transcriptomics, Gene expression, Plasmodium, Malaria, Eukaryotic pathogens.

Sá JM, Cannon MV, Caleon RL, Wellems TE, Serre D (2020) Single-cell transcription analysis of Plasmodium vivax blood-stage parasites identifies stage- and species-specific profiles of expression. PLoS Biol. 18(5):e3000711.

Bogale HN, Pascini TV, Kanatani S, Sá JM, Wellems TE, Sinnis P, Vega-Rodriguez J, Serre D (2021) Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development. PNAS. 118(10):e2023438118.

Hazzard B, Sá JM, Bogale HN, Pascini TV, Ellis AC, Amin S, Armistead JS, Adams JH, Wellems TE, Serre D (2024) Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission. Nat Commun. 15(1):7625.

Tebben K, Yirampo S, Coulibaly D, Koné A, Laurens M, Stucke E, Dembélé A, Tolo Y, Traoré K, Niangaly A, Berry A, Kouriba B, Plowe C, Doumbo O, Lyke K, Takala-Harrison S, Thera M, Travassos M, Serre D (2024) Gene expression analyses reveal differences in children's response to malaria according to their age. Nat Commun. 15(1):2021.

Eng V, Lek D, Sin S, Feufack-Donfack LB, Orban A, Salvador J, Seng D, Heng S, Khim N, Tebben K, Flamand C, Sommen C, van der Pluijm RW, White M, Witkowski B, Serre D*, Popovici J* (2025) 14 days of high-dose versus low-dose primaquine treatment in patients with Plasmodium vivax infection in Cambodia: a randomized, single-center, open-label efficacy study. Lancet Infect Dis. 25(8):884-895.

Ko K, Tebben K, Andrianinarivomanana T, Orban A, Grünebast J, Eng V, Eam R, Khim N, Feufack-Donfack L, Salvador J, Sá J, Wellems T, Lek D, Popovici J*, Serre D* (2026) A common DNA deletion altering the 3’UTR of mdr1 is associated with reduced mefloquine susceptibility in vivax parasites from Cambodian patients. Nat Commun. 17(1):1748.

Tebben K, Eng V, Seng D, Tat B, Feufack Donfack LB, Orban A, Yeat R, Salvador J, Sin S, Ko K, Khim N, Flamand C, Sommen C, Lek D, Serre D*, Popovici J* (2026) Parasite clearance in patients with Plasmodium vivax monoinfection treated with artesunate in Cambodia: an observational secondary analysis of trial data. Lancet Microbe. 101256.