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William F. Regine, MD, FACR, FACRO

Isadore & Fannie Schneider Foxman Chair of Radiation Oncology

Academic Title:


Primary Appointment:

Radiation Oncology

Secondary Appointment(s):

Diagnostic Radiology Nuclear Medicine

Administrative Title:

Chair, Department Of Radiation Oncology; Senior Associate Dean for Clinical Affairs; President, University of Maryland Faculty Physicians, Inc.

Additional Title:

Executive Director, Maryland Proton Treatment Center (MPTC)


UMMC/Gudelsky, 22 S.Greene St, suite GGK-0101

Phone (Primary):

(410) 328-2326


(410) 328-6911

Education and Training

  • State University of New York at Albany, BS, 1983
  • State University of New York Health and Science Center at Syracuse, MD, 1987
  • Residency, Thomas Jefferson University Hospital, Radiation Oncology, 1991
  • Fellowship, Thomas Jefferson University and University of Florida Hospitals, Radiation Oncology-Head and Neck and Gastrointestinal Malignancies, 1992


Dr. Regine leads a department which has achieved a Top 5 national ranking in National Institutes of Health research funding. He is recognized nationally and internationally in the areas of gastrointestinal and central nervous system malignancies and in the use of stereotactic radiosurgery (SRS). As Executive Director of the Maryland Proton Treatment Center, he leads the first and most advanced facility of its kind in the Baltimore-Washington, DC region -- providing nearly 2,000 cancer patients a year with precise, "pencil-beam" technology to treat solid tumors.

Dr. Regine has served as principal or co-principal Investigator in at least four National Cancer Institute (NCI)-sponsored cooperative group clinical trials. He has been a member of the GI and Brain Tumor steering committees for the NCI sponsored national cooperative clinical trials group known as NRG Oncology, and has been the chairman of the GI section of the National Oral Board examination for trainees in radiation oncology. Dr. Regine served as the principal investigator of a study evaluating adjuvant therapy in patients with pancreatic cancer, which defined a new standard of care. He also has been the principal investigator/study chairman for two institutional clinical trials that defined new standards of care for patients with brain metastases and malignant spinal cord compression. Dr. Regine is co-editor of Principles and Practices of Stereotactic Radiosurgery, the first comprehensive textbook of its kind. He is also co-inventor of the first of its kind treatment device completely dedicated to the stereotactic radiation treatment of early stage breast cancer, known as the GammaPod.

Research/Clinical Keywords

Pancreas/Gastrointestinal Cancers, Central Nervous System Malignancies, Brain Metastases/Tumors, Head and Neck Cancers, Sarcomas, Stereotactic Radiosurgery (SRS), Proton Treatment.

Highlighted Publications

Chin LS, Regine WF. Editors. Principles and Practice of Stereotactic Radiosurgery, Second Edition, Springer Publishing, 2015.

Regine WF, Winter K, Abrams R, Safran H, Kessel I, Chen Y, Fugazzi J, Donnelly E, DiPetrillo T, Narayan S, Plastaras J, Gaur R, Delouya G, Suh J, Meyer J, Haddock M, Didolkar M, Padula G, Johnson D, Hoffman J, Crane C. Postresection CA19-9 and margin status as predictors of recurrence after adjuvant treatment for pancreatic carcinoma: Analysis of NRG oncology RTOG trial 9704. Advances in Radiation Oncology, 3(2), p154-162, June 2018.

Remick J, Kowalski E, Khairnar R, Sun K, Morse E, Cherng H, Poirier Y, Lamichhane N, Becker S, Chen S, Patel A, Kwok Y, Nichols E, Mohindra P, Woodworth G, Regine WF, Mishra M. A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery in the treatment of brain metastasis. Clinical Radiation Oncology Journal, Vol 15, Article number: 128 (2020), May 2020.

Snider J, Molitoris J, Shyu S, Diwanji T, Rice S, Kowalski E, Decesaris C, Remick J, Yi B, Zhang B, HallA, Hanna N, Ng V, Regine WF. Spatially Fractionated Radiotherapy (GRID) Prior to Standard Neoadjuvant Conventionally Fractionated Radiotherapy for Bulky, High-Risk Soft Tissue and Osteosarcomas: Feasibility, Safety, and Promising Pathologic Response Rates. Radiation Research, Vol. 194, Issue 6, p. 707–714, October 2020.

Koroulakis A, Molitoris J, Kaiser A, Hanna N, Bafford A, Jiang Y, Bentzen S, Regine WF. Re-Irradiation for Rectal Cancer Using Pencil-Beam Scanning Proton Therapy: A Single Institutional Experience. Advances in Radiation Oncology, Vol. 6, Issue 1, February 2021.

Koroulakis A, Molitoris J, Sullivan M, Jiang Y, Hausner P, Hanna N, Bafford A, Miller R, Regine WF. Radiation Therapy and Malignant Fistulae of Anorectal Cancers. Pract Radiat Oncol.,12(6), p. e517-e521, December 2022.

Additional Publication Citations

Patchell RA, Tibbs PA, Regine WF, et. al. Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain: A Randomized Trial. JAMA 280(17): 1485-1489, 1998.

Patchell RA, Tibbs P, Regine WF, et. al. Randomized Trial of Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression caused by metastatic cancer. The Lancet 366: 643-648, 2005.

Regine WF, et. al. Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-based Chemoradiation Following Resection of Pancreatic Adenocarcinoma: A Randomized Controlled Trial. JAMA; 299(9):1019-1026, 2008.

Remick J, Bentzen S, Simone C, Nichols E, Suntharalingam M, Regine WF. The Downstream Effect of a Proton Treatment Center on an Academic Medical Center. Int J Radiat Oncol Biol Phys., Vol 104, Issue 4, p. 756–764, July 2019.

Research Interests

Dr. Regine's research interests include the study and treatment of pancreas/gastrointestinal cancers, brain metastases/ tumors, sarcomas and head and neck cancers. He is also Nationally recognized for his expertise in Stereotactic Radiosurgery (SRS).

Clinical Specialty Details

Gastrointestinal Malignancies, Pancreatic cancer, Central Nervous System malignancies, Brain metastases, Head and Neck cancers, Sarcomas, Stereotactic Body Radiation Therapy (SBRT), Stereotactic Radiosurgery (SRS)and Proton Therapy.

Awards and Affiliations

  • Fellowship Award, American Cancer Society Clinical Oncology, 1991
  • Selected among: "Best Doctors in America", “Best Doctors in Baltimore”, “Super Doctors”, “Top 1% of Doctors”; “Top Doctor”, 2002 – Present
  • National Department Rank of "Top 5" in NIH Funding, 2006
  • Lifetime Volunteer Service Award, American Board of Radiology, 2015
  • University of Maryland, Department of Radiation Oncology, “Never Be Afraid to Try”, Teacher of the Year Award, 2016
  • University of Maryland Baltimore Entrepreneur of the Year, 2016
  • The Daily Record Health Care Heroes 2019 “Lifetime Achievement Award”, 2019
  • Recognized with the American Cancer Society MileOne Visionary Award, 2021

Previous Positions

  • Assistant Member, Department of Radiation Oncology, St. Jude Children’s Research Hospital, 1992-1994
  • Assistant Professor, Section of Radiation Oncology, University of Tennessee, 1992-1994 (Acting Clinical Chief, 1994)
  • Associate Director for Clinical Research, Markey Cancer Center, University of Kentucky, 1998-2000
  • Professor, Joint Appointment, Department of Radiation Medicine and Department of Neurosurgery, University of Kentucky, 2002