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Denise L. Orwig, PhD

Academic Title:

Professor

Primary Appointment:

Epidemiology & Public Health

Administrative Title:

Interim Division Director of Gerontology

Additional Title:

Director, Baltimore Hip Studies; Co-Director, Masters in Gerontology in the School of Graduate Studies; Co-Director, Alicia and Yaya Global Initiative in Aging Research

Email:

dorwig@som.umaryland.edu

Location:

Howard Hall 203

Phone (Primary):

(410) 706-8951

Phone (Secondary):

(410) 706-2406

Fax:

(410) 706-4433

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Education and Training

University of Pittsburgh, BS, Business and Psychology, 1989

The Johns Hopkins University, MS, Applied Behavioral Science, 1993 

The Pennsylvania State University, NIA Predoctoral Fellow in Adult Development and Aging, 1998

The Pennsylvania State University, PhD, Biobehavioral Health and Gerontology, 1998

University of Maryland School of Medicine, Postdoctoral Fellowship in Primary Care, Ruth Kirschstein National Research Service Award (NRSA) (T32 PE10009), 2003

Biosketch

Dr. Orwig is a gerontologist specializing in biobehavioral aspects of aging with extensive expertise in studying older adults, both in community and hospital settings. She is Director of the Baltimore Hip Studies (BHS), a research program dedicated to optimizing recovery from hip fracture and building a network of 29 hospitals in the greater Baltimore area, Washington D.C., and southern Pennsylvania. Dr. Orwig’s primary research expertise over 28 years is in the areas of hip fracture recovery, intervention trials, and longitudinal research methods including study design, recruitment and retention strategies, conducting performance measures, developing interventions to maximize recovery, and translating interventions into the community. She has led eight cohort studies including more than 4,000 hip fracture patients, and four randomized trials involving large interdisciplinary research teams. Dr. Orwig's leadership has established an infrastructure for producing significant manuscripts, collaborations with investigators both inside and outside the institution, sustaining a successful portfolio of NIA and PCORI funding, and training new scholars to be independent researchers. Many of the papers from the BHS serve as the impetus for recent intervention trials and current drug development in hip fracture patients. The BHS has gained an international reputation for its ability to successfully conduct research studies with frail older populations, and Dr. Orwig is often consulted for her expertise and collaboration from both academic institutions and drug companies.

Dr. Orwig’s second area of research expertise is in pharmacoepidemiology, particularly in medication management issues of older adults and improving treatment of osteoporosis after hip fracture. She developed an instrument, Medication Management Instrument for Deficiencies in the Elderly (MedMaIDE), to assess older adult’s ability to self-medicate safely in the community. This instrument is unique since it can be used by non-medically trained people (e.g., caregivers) to identify deficiencies of an older adult.

In addition to research activities, Dr. Orwig has been extensively involved in education and training. Dr. Orwig is Co-Director of the MS in Gerontology Program and she was also Co-director of the bi-campus Doctoral Program in Gerontology for 13 years.  She currently serves as Co-PI of the NIA T32 training program in the Epidemiology of Aging. Mentoring and advising doctoral students (and students at all levels) is a large part of Dr. Orwig's academic career having chaired 18 dissertation committees and served as a member on 9 committees.  She served as a mentor/advisor for 25 doctoral students, 6 post-doctoral fellows and 8 junior faculty, of whom 5 received minority supplements and 3 received research supplements to promote diversity in health-related research. These mentees come from numerous programs and schools across 2 campuses and Dr. Orwig has received three awards recognizing her mentoring.     

Research/Clinical Keywords

hip fracture, osteoporosis, mobility, sarcopenia, bone mineral density, medication management

Highlighted Publications

  1. Orwig, D. Chan, J., Magaziner, J. Hip fracture and its consequences: Differences between men and women. Orthop Clin North Am. 2006 Oct;37(4):611-22. doi: 10.1016/j.ocl.2006.08.003. PMID: 17141019.
  2. Orwig D, Hochberg M, Gruber-Baldini A, Resnick B, Miller R, Hicks G, Cappola A, Shardell M, Beck T, Sterling R, Hebel JR, Johnson R, Magaziner J. Examining differences in recovery outcomes between male and female hip fracture patients: Design and methodology of a prospective cohort study from the Baltimore Hip Studies. J Frailty Aging. 2018;7(3):162-169.doi: 10.14283/jfa.2018.15. PMID: 30095146.
  3. Orwig DL, Magaziner J, Fielding RA, Zhu H, Binder EF, Cawthon PM, Bhasin S, Correa-de-Araujo R, Manini T, Patel S, Shardell M, Travison TG. Application of SDOC Cut Points for Low Muscle Strength for Recovery of Walking Speed After Hip Fracture. J Gerontol A Biol Sci Med Sci. 2020 Jun 18;75(7):1379-1385. doi: 10.1093/gerona/glaa076. PubMed PMID: 32242218; PubMed Central PMCID: PMC7302178.
  4. Orwig DL, Abraham DS, Hochberg MC, Gruber-Baldini A, Gurlanik JM, Cappola AR, Golden J, Hicks GE, Miller RR, Resnick B, Shardell M, Sterling RS, Bajracharya R, Magaziner J. Sex Differences in Recovery Across Multiple Domains among Older Adults with Hip Fracture. J Gerontol A Biol Sci Med Sci. 2021; glab271, doi.org/10.1093/gerona/glab271.
  5. Orwig D, Brandt N, Gruber-Baldini A. Medication management assessment for older adults in the community. 2006 Oct;46(5):661-8. doi: 10.1093/geront/46.5.661. PMID: 17050757.

Additional Publication Citations

Complete list of publications (120 citations):

https://www.ncbi.nlm.nih.gov/myncbi/denise.orwig.1/bibliography/public/

 

 

Awards and Affiliations

Honors

1997

Pre-doctoral Fellow in Adult Development and Aging, National Institute on Aging

2000

Postdoctoral Fellow in Primary Care, National Research Service Award

2002

National Institutes of Health Extramural Loan Repayment Program Award, National Center on Minority Health and Health Disparities

2004

Penn State Alumni Emerging Professional Graduate Degree Award, Pennsylvania State University College of Health and Human Development

2008

Outstanding Mentor Award, Department of Epidemiology and Public Health

2013

Outstanding Mentor Award, Department of Epidemiology and Public Health

2014

Health Science Section Fellow, The Gerontological Society of America

2015

Outstanding Faculty Mentor, University System of Maryland's PROMISE AGEP (Association for Graduate Education and the Professoriate) recognizes outstanding mentoring and inclusion of underrepresented graduate students in STEM fields within the NIH-sponsored Meyerhoff Biomedical Graduate Fellowship Program at UMBC and UMB.

 

Grants and Contracts

Ongoing and recently completed projects to highlight include:

P30 A028747 (Katzel/Magaziner/Ryan)                                         07/01/16-06/30/26 NIA Claude D. Pepper Older Americans Independence Center (OAIC)                     

R01 AG051647 (MPIs: Binder, Magaziner, Schectman)             09/15/17-8/31/24    NIA Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture                                                                                                              

NIA T32 AG000262 (Co-PIs: Orwig,Gruber-Baldini)                 05/01/18-04/30/23        Research Training in the Epidemiology of Aging                                                        

U44AG074107 (Neelakantan)                                                          09/30/21-08/31/24 NIH [Role: Co-Investigator]                                                                                  Preclinical Development of a Novel Therapeutic To Rejuvenate Aging Muscle Stem Cells and Enhance Muscle Strength and Function Post Hip Fracture (SBIR Phase 2)

R01 AG076441A (Albrecht)                                                             07/01/22- 06/30/27 Recovery Among Older Adult Following Head Injury                                    

OFP-2021C3-24922 (MPIs: Dykes, Orwig)                                      06/01/24-05/31/29 PCORI Integrated multi-modal intervention to improve outcomes of older people post osteoporotic fracture                                                                                    Pragmatic matched pair cluster-randomized controlled trial to evaluate whether OsteoPorotic fracTure preventION System (OPTIONS), an integrated multi-modal intervention, with clinical decision support (CDS) for providers, patients, and care partners improves post osteoporotic fracture care among community-dwelling older adults across transitions to skilled nursing facilities for rehabilitation and back to the community in the first year after lower limb fracture compared to enhanced usual care.

Student Publications

  1. Ryder PT, Wolpert B, Orwig D, Carter-Pokras O, Black SA. Complementary and alternative medicine (CAM) use among older urban African Americans: Individual and neighborhood associations. J Natl Med Assoc. 2008 Oct;100(10):1186-92. doi: 10.1016/s0027-9684(15)31475-9. PMID: 18942280
  2. Blanchette C, Simoni-Wastila, L, Shaya, F, Orwig, D, Noel J, Stuart, B. Healthcare utilization in elderly cardiac patients with depression and the impact of antidepressant utilization.  Am J Health Syst Pharm. 2009 Feb 15;66(4):366-72. doi: 10.2146/ajhp080092. PMID: 19202046
  3. Reider L, Beck TJ, Hochberg MC, Hawkes WG, Orwig D, Yu-Yahiro J, Hebel R, Magaziner J. Women with hip fracture experience greater loss of geometric strength in the contralateral hip during the year following fracture compared to age-matched controls. Osteoporos Int. 2010 May;21(5):741-50. doi: 10.1007/s00198-009-1000-4. Epub 2009 Jul 2. PMID: 19572093
  4. Blanchette CM, Simoni-Wastilla LJ, Shaya FT, Orwig DL, Noel JM, Stuart B. Depression following thrombotic cardiovascular events in elderly Medicare beneficiaries: Risk of morbidity and mortality. 
  5. D’Adamo C, Miller R, Hicks G, Orwig D, Hochberg M, Semba R, Yu-Yahiro J, Ferrucci L, Magaziner J, Shardell M. Serum vitamin E concentrations and recovery of physical function during the year after hip fracture. J Gerontol A Biol Sci Med Sci. 2011 Jul;66(7):784-93. doi: 10.1093/gerona/glr057. Epub 2011 Apr 12. PMID: 21486921.
  6. D’Adamo C, Shardell M, Hicks G, Orwig D, Hochberg M, Semba R, Yu-Yahiro J, Ferrucci L, Magaziner J, Miller R. Serum vitamin E concentrations among highly-functioning hip fracture patients are higher than in non-fracture controls. Nutr Res. 2011 Mar;31(3):205-14. doi: 10.1016/j.nutres.2011.03.005. PMID: 21481714
  7. Matheny ME, Miller RR, Shardell MD, Hawkes WG, Magaziner J, Orwig DL. Inflammatory cytokine levels and depressive symptoms in the year after hip fracture: The Baltimore Hip Studies. J Am Geriatr Soc. 2011 Dec;59(12):2249-55. doi: 10.1111/j.1532-5415.2011.03727.x. PMID: 22188073
  8. D’Adamo CR, Miller RR, Shardell MD, Orwig DL, Hochberg MC, Ferrucci L, Semba RD, Yu-Yahiro JA, Magaziner J, Hicks GE. Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture.  Clin Nutr. 2012 Oct;31(5):659-65. doi: 10.1016/j.clnu.2012.01.013. Epub 2012 Feb 25. PMID: 22365613
  9. Reider L, Hawkes W, Hebel R, D’Adamo C, Magaziner J, Miller R, Orwig D, Alley DE. The association between body mass index, weight loss, and physical function in the year following hip fracture. J Nutr Health Aging. 2013 Jan;17(1):91-5. doi: 10.1007/s12603-012-0073-5. PMID: 23299386
  10. Lloyd JT, Alley DA, Hawkes WG, Hochberg MC, Waldstein SR, Orwig DL. Body mass index is positively associated with bone mineral density in US older adults. Arch Osteoporos. 2014;9:175. doi: 10.1007/s11657-014-0175-2. Epub 2014 Mar 25. PMID: 24664472
  11. Lloyd JT, Alley DE, Hawkes WG, Hochberg MC, Waldstein SR, Harris TB, Kritchevsky SB, Schwartz AV, Strotmeyer ES, Womack C, Orwig DL. Changes in bone mineral density over time by body mass index in the Health ABC Study. Osteoporos Int. 2016 Jun;27(6):2109-16. doi: 10.1007/s00198-016-3506-x. Epub 2016 Feb 8. PMID: 26856584
  12. Zanjani F, Gruber-Baldini A, Resnick B, Orwig D, Hochberg M, Magaziner J. The relationship between alcohol consumption and hip fracture recovery among older adults. J Appl Gerontol. 2020 Sep;39(9):1046-1051. doi: 10.1177/0733464819845802. Epub 2019 Apr 26. PMID: 31027444
  13. Lloyd JT, Waldstein SR, Hochberg MC, Orwig DL, Alley DE. Overweight and obese have similar burden of hip fracture as normal weight older adults. J Gen Intern Med. 2019 Nov;34(11):2333-2335. doi: 10.1007/s11606-019-05151-y. PMID: 31325126
  14. Abraham DS, Ostir GV, Hebel JR, Barr E, Golden J, Gruber-Baldini A, Guralnik JM, Hochberg MC, Orwig DL, Magaziner J. Residual disability, mobility, and nursing home placement after hip fracture over two decades. Arch Phys Med Rehabil. 2019 May;100(5):874-882. doi: 10.1016/j.apmr.2018.10.008. Epub 2018 Nov 2. PMID: 30391413
  15. Chiles Shaffer N, Huang Y, Lu W, Cheng Y, Gruber-Baldini A, Guralnik J, Magaziner J, Orwig D. Sex differences in the prevalence of sarcopenia after hip fracture comparing different measures. J Am Geriatr Soc. 2020 Apr 1. doi: 10.1111/jgs.16417. Epub 2020 Apr 1. PMID: 32239496
  16. Mutchie HL, Orwig DL, Beamer B, Conroy V, Guralnik J, Magaziner J, Gruber-Baldini A. Four Square Step Test Performance in Hip Fracture Patients. J Geriatr Phys Ther. 2021 Apr 28. doi: 10.1519/JPT.0000000000000310. Epub ahead of print. PMID: 33935219
  17. Kirk JM, Magaziner J, Shardell M, Ryan AS, Gruber-Baldini AL, Orwig D, Hochberg MC, Rathbun AM. Depressive symptom heterogeneity among older adults after hip fracture. Age Ageing. 2021 Aug 16:afab168. doi: 10.1093/ageing/afab168. Epub ahead of print. PMID: 34405224.
  18. Mutchie HL, Albrecht JS, Orwig DL, Huang Y, Boscardin WJ, Hochberg MC, Magaziner JS, Gruber-Baldini AL. Differential misclassification of cognitive impairment by sex among hip fracture patients. J Am Geriatr Soc. 2021 Dec 10. doi: 10.1111/jgs.17594. Epub ahead of print. PMID: 34890469.
  19. Bajracharya R, Guralnik, JM, Magaziner JS, Shardell MD, Rathbun AM, Yamashita T, Orwig DL. Long-term Sex Differences in All-cause and Infection-Specific Mortality Post Hip Fracture. J Am Geriatr Soc. 2022 Jul;70(7):2107-2114. doi: 10.1111/jgs.17800. Epub 2022 Apr 12. PMID: 35415882; PMCID: PMC9283265.
  20. Bajracharya R, Guralnik JM, Shardell MD, Hochberg MC, Orwig DL, Magaziner JS. Predictors of Mobility Status One Year Post Hip Fracture. J Am Geriatr Soc. 2022 Jul;70(7):2107-2114. doi: 10.1111/jgs.17800. Epub 2022 Apr 12. PMID: 35415882; PMCID: PMC9283265.
  21. Mutchie HL, Orwig DL, Gruber-Baldini AL, Johnson A, Magaziner J, Falvey J. Impact of Sex and Alzheimer’s Disease and Related Dementias on Days Spent at Home After Hip Fracture Among Older Medicare Beneficiaries. J Am Geriatr Soc. 2023 Oct;71(10):3134-3142. doi: 10.1111/jgs.18492. Epub 2023 Jul 4. PMID: 37401789.
  22. Mehta R, Orwig DL, Chen C, Dong Y, Shardell MD, Yamashita T, Falvey JR. Association Between Pre-Hip Fracture Depression and Days at Home After Fracture and Assessing Sex Differences. J Am Geriatr Soc. 2024 Jul 20. doi: 10.1111/jgs.19096. Epub ahead of print. PMID: 39032025.
  23. Kirk JM, Rathbun AM, Gruber-Baldini AL, Hochberg MC, Magaziner JS, Orwig D. Sex differences and predictors of anti-osteoporosis medication use in the 12 months after hip fracture surgery in adults 65 or older. Osteoporos Int. 2024 Nov;35(11):1943-1950. doi: 10.1007/s00198-024-07211-4. Epub 2024 Aug 2. PMID: 39093438.
  24. Mehta R, Falvey JR, Chen C, Dong Y, Shardell MD, Yamashita T, Orwig DL. Association Between Prehip Fracture Antidepressant Use and Posthip Fracture Length of Hospital Stay in Medicare Beneficiaries and Assessing Sex Differences. Am J Geriatr Psychiatry. 2024 Nov 14:S1064-7481(24)00526-8. doi: 10.1016/j.jagp.2024.11.001. Epub ahead of print. PMID: 39609242
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