Academic Title:
Professor
Primary Appointment:
Medicine
Additional Title:
Scientist, Center for Vaccine Development and Global Health
Email:
Education and Training
EDUCATION
- Bachelor of Arts in English Literature, Dartmouth College, 1995
- Post baccalaureate pre-medical training, Colorado State University, 1996
- Doctor of Medicine, University of California San Francisco, School of Medicine, 2002
- Certificate in Vaccinology, ADVAC Advanced Course of Vaccinology, 2011
- Master of Science in Epidemiology, University of Washington School of Public Health, 2012
POSTGRADUATE TRAINING
- Internship and Residency, Categorical Internal Medicine, University of California San Francisco, Department of Medicine, 2005
- Epidemic Intelligence Service Officer, Centers for Disease Control and Prevention, Influenza Division, 2007
- Pulmonary and Critical Care Medicine Fellowship, University of Washington, Department of Medicine, 2010
Biosketch
Justin R. Ortiz, MD, MS, is a physician-scientist and Professor of Medicine at the University of Maryland School of Medicine whose research focuses on the epidemiology, prevention, and clinical investigation of respiratory viral infections, particularly influenza and other emerging respiratory pathogens. His work integrates clinical trials with observational studies of influenza disease burden and vaccine performance, as well as other analytical research—including systematic reviews and policy analyses—to inform vaccine development, regulatory strategy, and immunization policy.
Dr. Ortiz directs the Clinical Core of the NIH-funded Collaborative Influenza Vaccine Innovation Centers (CIVICs), where he leads early-phase clinical trials and controlled human infection studies designed to accelerate the development of next-generation influenza vaccines. His research portfolio includes investigator-initiated and industry-sponsored trials of vaccines for influenza, COVID-19, and other high-consequence pathogens.
Earlier in his career, Dr. Ortiz served as the influenza vaccine research and policy lead in the Immunization Department at the World Health Organization, where he directed international projects to strengthen the evidence base for influenza vaccination and to support immunization policy in low- and middle-income countries. His work helped shape global guidance on vaccine effectiveness evaluation and maternal immunization strategies. Prior to this, as an Epidemic Intelligence Service Officer at the U.S. Centers for Disease Control and Prevention, he helped design international hospital-based influenza surveillance systems that now support global monitoring for multiple respiratory viruses.
Across academic medicine, global public health, and vaccine development, Dr. Ortiz has led multidisciplinary collaborations to advance respiratory virus vaccine development and to inform immunization strategies worldwide. His work has addressed key policy questions—including influenza disease burden, vaccine effectiveness, risk factors for severe disease, and the health and economic value of vaccination—to support evidence-based immunization policy and program implementation.
Research/Clinical Keywords
influenza, respiratory viruses, vaccine development, vaccine clinical trials, vaccine effectiveness, influenza vaccines, pandemic preparedness, emerging infectious diseases, vaccinology, immunization policy, global health
Highlighted Publications
- Ortiz JR, Sotomayor V, Uez OC, Oliva O, Bettels D, McCarron M, Bresee JS, Mounts AW. Strategy to enhance influenza surveillance worldwide. Emerg Infect Dis. 2009 Aug;15(8):1271-8.
- Fell DB, Azziz-Baumgartner E, Baker MG, Batra M, Beauté J, Beutels P, Bhat N, Bhutta ZA, Cohen C, De Mucio B, Gessner BD, Gravett MG, Katz MA, Knight M, Lee VJ, Loeb M, Luteijn JM, Marshall H, Nair H, Pottie K, Salam RA, Savitz DA, Serruya SJ, Skidmore B, Ortiz JR; WHO taskforce to evaluate influenza data to inform vaccine impact and economic modelling. Influenza epidemiology and immunization during pregnancy: Final report of a World Health Organization working group. Vaccine. 2017 Aug 31. pii: S0264-410X(17)31125-8. doi: 10.1016/j.Vaccine.2017.08.037. [Epub ahead of print] PubMed PMID: 28867508.
- Ortiz JR, Bernstein DI, Hoft DF, Woods CW, McClain MT, Frey SE, Brady RC, Bryant C, Wegel A, Frenck RW, Walter EB, Abate G, Williams SR, Atmar RL, Keitel WA, Rouphael N, Memoli MJ, Makhene MK, Roberts PC, Neuzil KM. A Multicenter, Controlled Human Infection Study of Influenza A(H1N1)pdm09 in Healthy Adults. J Infect Dis. 2023 Aug 11;228(3):287-298. doi: 10.1093/infdis/jiad021. PMID: 36702771; PMCID: PMC10420403.
- Zar HJ, Cacho F, Kootbodien T, Mejias A, Ortiz JR, Stein RT, Hartert TV. Early-life respiratory syncytial virus disease and long-term respiratory health. Lancet Respir Med. 2024 Oct;12(10):810-821. doi: 10.1016/S2213-2600(24)00246-7. Epub 2024 Sep 9. PMID: 39265601.
- Deming ME, Toapanta FR, Pasetti M, Golding H, Khurana S, Hamouda T, Fattom A, Liang Y, Tennant SM, McGilvray MF, Bernal PJ, Oshinsky JJ, Datta S, Booth JP, Coughlan L, Neuzil KM, Costley CD, Kotloff KL, Sztein MB, Ortiz JR; rH5 Writing Group. An intranasal adjuvanted, recombinant influenza A/H5 vaccine primes against diverse H5N1 clades: a phase I trial. Nat Commun. 2025 Nov 6;16(1):9321. doi: 10.1038/s41467-025-64686-3. PMID: 41198655; PMCID: PMC12592354.
Full bibliography at Google Scholar: https://scholar.google.com/citations?hl=en&user=orZMnLQAAAAJ
Research Interests
Dr. Ortiz’s research focuses on the development, evaluation, and implementation of vaccines and other interventions to prevent respiratory viral diseases. His work spans early-phase clinical trials of next-generation vaccines, controlled human infection studies, observational studies of vaccine effectiveness and disease burden, and analytic research designed to inform immunization policy. He collaborates with academic, governmental, and industry partners to accelerate development of broadly protective influenza vaccines and to strengthen evidence supporting global immunization strategies.
Clinical Specialty Details
Dr. Ortiz completed residency training in internal medicine followed by fellowship training in pulmonary and critical care medicine. This clinical background shaped his research focus on the health consequences of respiratory viral infections, including severe disease, hospitalization, and other complications that contribute to morbidity and mortality. His work also examines the longer-term respiratory sequelae of viral infections and their impact on chronic respiratory health.
His research addresses the epidemiology, prevention, and clinical investigation of respiratory viral infections, with particular emphasis on influenza and other emerging respiratory pathogens. His expertise in pulmonary and critical care medicine informs the design and conduct of clinical studies evaluating vaccines and other interventions aimed at preventing severe respiratory viral disease.
Awards and Affiliations
- Harold Amos Medical Faculty Development Award, Robert Wood Johnson Foundation (2010–2014)
- Early Career Award, Thrasher Research Fund (2009–2011)
- Fellow, American College of Physicians (FACP)
- Fellow, American College of Chest Physicians (FCCP)
- Innovation in Fellowship Education Award, American Thoracic Society (2015)
Grants and Contracts
Dr. Ortiz has served as principal investigator on multiple NIH- and industry-funded clinical trials evaluating vaccines and other interventions for respiratory viral diseases. He has also led epidemiologic and analytical studies supported by the World Health Organization and the Bill & Melinda Gates Foundation to inform global immunization policy and vaccine strategy.
Professional Activity
- Co-Chair, Organizing Committee, Options for the Control of Influenza International Conference (2026)
- Steering Committee Member, Council of Medical Specialty Societies Initiative to Improve Adult Immunization
- Co-Chair, American Thoracic Society Advancing Adult Immunization Initiative
- Member, Global Influenza Hospital Surveillance Network Scientific Committee
Links of Interest
LinkedIn Profile
https://www.linkedin.com/in/justinrortiz/
ORCID
https://orcid.org/0000-0002-3138-5965
PubMed Bibliography
https://www.ncbi.nlm.nih.gov/myncbi/justin.ortiz.1/bibliography/public/