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Yi Ning, PhD

Academic Title:


Primary Appointment:


Additional Title:

Director of Cytogenetics Lab


BRB 7-025

Phone (Primary):




Education and Training

Shanghai First Medical College, Shanghai, China, MD, 1984

Baylor College of Medicine, Houston, TX, PhD, 1991

National Human Genome Research Institute, NIH, Bethesda, MD, Fellow, 1997


Dr. Ning is an American Board of Medical Genetics and Genomics certified Clinical Cytogeneticist. She served as Director of Cytogenetics Lab at University of Maryland from 2001 to 2013. She was Associate Professor of Pathology and Director of Cytogenetics Lab in the Molecular Pathology Division of Johns Hopkins University from 2013 to 2018, and was Professor of Pathology and Laboratory Medicine and Co-Director of Cytogenetics Lab at Weill Cornell Medical College and New York Presbyterian Hospital in 2018 and 2019. She returned to University of Maryland School of Medicine in 2019. Currently, she is Professor of Pathology and Director of Cytogenetics Lab. Her interest and experience are in cell growth regulation, clinical cytogenetics, and characterization of cryptic chromosomal rearrangements with clinical significance. She also serves on Cytogenetics Committee of Eastern Cooperative Oncology Group (ECOG) and participates in clinical trial studies of hematological malignancies.

Research/Clinical Keywords

Cytogenetic diagnoses of hematological malignancies and genetic disorders

Highlighted Publications

Schrock E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA, Ning Y, Ledbetter DH, Bar-Am I, Soenksen D, Garini Y, Ried T. Multicolor spectral karyotyping of human chromosomes. Science. 1996; 273:494-497.

Ning Y, Roschke A, Smith AC., Macha M, Precht K, Riethman H, Ledbetter DH (group 1), Flint J, Horsley S, Regan R, Kearney L, Knight S, Kvaloy K, Brown WRA. (group 2). A complete set of human telomeric probes and their clinical application. Nature Genetics. 1996; 14:86-89.

Ho H, Skaist AM, Pallavajjala A, Yonescu R, Batista D, Wheelan SJ, Ning Y. NUP98-PHF23 fusion is recurrent in acute myeloid leukemia and shares gene expression signature of leukemic stem cells. Leuk Res. 2016; 45:1-7.

Nguyen D, Haley L, Pallavajjalla A, Gojo I, Ning Y. Identification of a novel KMT2A-SEPT14 fusion in acute myeloid leukemia. Leuk Lymphoma. 2018; 59:265-267. 

Pallavajjala A, Kim D, Li T, Ghiaur G, Jones RJ, Burns KH, Salzberg SL, Ning Y. Genomic characterization of chromosome translocations in patients with T/Myeloid mixed-phenotype acute leukemia. Leuk Lymphoma. 2018; 59:1231-1238.

Gallia GL, Zhang M, Ning Y, Haffner MC, Batista D, Binder ZA, Bishop JA, Hann CL, Ishii M, Reh DD, Rooper LM, Salmasi VA, Tamargo RJ, Wang Q, Williamson T, Zhao T, Zou Y, Klein A, Hruban RH, Meeker AK, Agrawal N, Vogelstein B, Kinzler KW, Papadopoulos N, Bettegowda C. Genomic analysis identifies frequent deletions of dystrophin in olfactory neuroblastoma. Nature Comm. 2018; 9:5410.