Academic Title:
Post Doc Fellow
Primary Appointment:
Neurosurgery
Education and Training
2026 CARTI Scholar, Clinical and Translational Research Training Track University of Maryland School of Medicine
2026 Neurodevelopmental Disorders (NDD) Research Training Program (NIH Blueprint Grant Scholar) UC Davis and Johns Hopkins University
2023 – Present Postdoctoral Fellow, Department of Neurosurgery University of Maryland School of Medicine
2021 – 2023 Postdoctoral Fellow, Center for Nanomedicine, Wilmer Eye Institute Johns Hopkins University School of Medicine
2020 – 2021 Postdoctoral Fellow, Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST), South Korea
2014 – 2020 Ph.D. in Chemistry (Advisor: Prof. Haeshin Lee) Korea Advanced Institute of Science and Technology (KAIST), South Korea
Biosketch
Dr. Daiheon Lee is a Postdoctoral Fellow in the Department of Neurosurgery at the University of Maryland School of Medicine. His research focus has evolved from a fundamental understanding of chemical-level interactions of biomolecules to the strategic surface modification of functional materials.
Currently, Dr. Lee leverages this expertise to design fusion proteins and engineer the surface of nanoparticles or drug carriers to overcome complex biological barriers. His work emphasizes translational research, aiming to bridge the gap between bench-top innovations and clinical applications in immunomodulation and the targeted delivery of therapeutic drugs and genetic materials.
Research/Clinical Keywords
Translational Nanomedicine, Drug and Gene Delivery, Immunotherapy, Biological Barriers, Protein Nanocages, Surface Chemistry
Highlighted Publications
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Lee D, Kong B, Kwak G, Kang B, Swaby C, Fanaroff R, et al. Clinically translatable anti-fibrotic nanosuspension for inhaled treatment of idiopathic pulmonary fibrosis. Drug Deliv Transl Res. 2025.
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Kwak G*, Lee D*, Suk JS. Advanced approaches to overcome biological barriers in respiratory and systemic routes of administration for enhanced nucleic acid delivery to the lung. Expert Opin Drug Deliv. 2023. (* Co-first author)
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Kim JS, Hwang H, Lee D#, Lee H#. Electrospinnable, neutral coacervates for facile preparation of solid phenolic bioadhesives. ACS Appl Mater Interfaces. 2021. (# Co-corresponding author)
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Lee D*, Hwang H*, Kim JS, Park J, Youn D, Kim D, et al. VATA: Poly(vinyl alcohol)- and tannic acid-based nontoxic underwater adhesive. ACS Appl Mater Interfaces. 2020. (* Co-first author)
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Lee D, Park JP, Koh MY, Kim P, Lee J, Shin M, et al. Chitosan-catechol: a writable bioink under serum culture media. Biomater Sci. 2018.
Research Interests
My research is dedicated to clinical translational science, aiming to bridge the gap between fundamental biomolecular interactions and therapeutic applications. I focus on developing clinically translatable platforms to overcome complex biological barriers and enhance the efficacy of drug and gene delivery.
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Translational Nanomedicine: Designing fusion proteins and engineering the surface of nanoparticles, with a particular focus on protein nanocages (e.g., Ferritin) and antibody-drug conjugates for clinical translation.
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Advanced Vectors for Gene Therapy: Developing and optimizing viral (AAV) and non-viral (peptide, polymer) vectors to improve targeted delivery and safety profiles.
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Immunotherapy & Immunomodulation: Engineering delivery systems to modulate immune responses for the effective treatment of malignant diseases, including brain tumors.
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Functional Biomaterials: Utilizing catechol/phenolic surface chemistry to control interface behaviors, serving as a core technology for diverse medical applications.
Awards and Affiliations
Selected Awards and Scholarships
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2026 Early Career Investigator Travel Award (ECITA), 30th Annual Society on Neuroimmune Pharmacology (SNIP)
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2018 Outstanding Paper Award, Korean Society of Industrial and Engineering Chemistry
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2012 – 2014 NGK Scholarship, NGK Foundation for International Students, Japan (Full Scholarship)
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2007 – 2012 Korea-Japan Joint Government Scholarship Program of Science and Technology Universities (Full Scholarship)
Grants and Contracts
Active Support
- 2025 – 2026 Principal Investigator (PI), NIH Support Award (UMGCCC)
Selected Past Project
- 2017 – 2019 Leading Investigator, Ministry of Small and Medium Enterprises and Startups, Republic of Korea
- Role: Led R&D from invention to successful technical transfer and commercialization