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Rosemary A. Kozar, MD, PhD

Academic Title:


Primary Appointment:


Administrative Title:

Acting Director of the National Study Center (NSC); Co-Director of STAR-ORC

Additional Title:

Director of Translational Research, Shock Trauma Center


22 S. Greene Street Baltimore, MD 21201

Phone (Primary):




Education and Training


  • Indiana University of PA, BS, Rehabilitation, 1980
  • University of Pittsburgh, Post-baccalaureate, 1982
  • Temple University School of Medicine, MD, 1986
  • Baylor College of Medicine, PhD, Molecular Physiology and Biophysics, 1992

Post Graduate Education and Training

  • University of TX Health Science Center at Houston, Internship, General Surgery, 1987
  • University of TX Health Science Center at Houston, Residency, General Surgery, 1988
  • Temple University School of Medicine, Residency, General Surgery, 1995
  • University of TX Health Science Center at Houston, Fellowship, Surgical Critical Care, 2000


Dr. Rosemary Kozar is currently a Tenured Professor of Surgery, Co-Director of the Shock Trauma Anesthesia Research (STAR) Center at the University of Maryland and Director of Translational Research at the University of Maryland R Adams Cowley Shock Trauma Center. She completed medical school at Temple University School of Medicine then surgical and surgical critical care training at the University of Texas Houston and Temple University while also obtaining a PhD in Molecular Physiology and Biophysics at Baylor College of Medicine.  Her research interests focus on endothelial dysfunction after shock.

She has published over 250 peer-reviewed basic/translational and clinical articles and 16 book chapters. She has been continuously funded by the NIH for over 20 years.  Dr. Kozar has served in a number of national leadership positions including the Board of Managers of the American Associaition for the Surgery of Trauma, Chair of the American College of Surgeons Verification Review Committee for Trauma, Chair of the American College of Surgeons  Women in Surgery Committee, and President of the Shock Society. She is currently Chair of the Scientific Advisory Committee for the Coalition for National Trauma Research and President-Elect of the Western Trauma Association. She is also an Associate Editor for Trauma Surgery Acute Care Open and Deputy Editor for the Journal of Trauma and Acute Care Surgery.

Research/Clinical Keywords

hemorrhagic shock, syndecan-1, endothelial dysfunction, injured elderly

Highlighted Publications

Basic Science Publications

Wu F, Wang JY, Chao W, Sims C, Kozar RA. miR-19b targets pulmonary endothelial syndecan-1 following hemorrhagic shock. Sci Rep. 2020 Sept 25;10(1):15811.

Zeineddin A, Dong JF, Wu F, Terse P, Kozar RA. Role of Von Willebrand Factor after injury: It may do more than we think. Shock. 2021 June 1;55(6):717-72.

Chipman AM, Wu F, Kozar RA. Fibrinogen inhibits microRNA-19b, a novel mechanism for repair of haemorrhagic shock-induced endothelial cell dysfunction. Blood Transfus. 2021 Sep;19:(5):420-427.

Zeineddin A, Wu F, Dong JF, Huang H, Zou L, Chao W, Dorman B, Kozar RA. Trauma-derived extracellular vesicles are sufficient to induce endothelial dysfunction and coagulopathy. Shock. 2022 Jul 1;58(2):38-44. Epub 2022 Jul 19. PMID: 35984759.

Barry M, Wu F, Pati S, Chipman A, Geng H, Kozar R. Lyophilized plasma resuscitation downregulates inflammatory gene expression in a mouse model of sepsis. J Trauma Acute Care Surg. 2022 Aug 1;93(2S Suppl 1):S119-S127. Epub 2022 Apr 21. PMID: 35881828.

Wu F, Wang JY, Dorman B, Zeineddin A, Kozar RA. C-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock. Mol Med. 2022 Oct 12;28(1):123. PMID: 36224531.

Clinical Publications

Xu X, Kozar R, Zhang J, Dong JF. Diverse activities of von Willebrand factor in traumatic brain injury and associated coagulopathy. J Throm Haemost. 2020 Dec;18(12):3154-3162.

Richards JE, Fedeles BT, Chow JH, Morrision JJ, Renner C, Trinh AT, Schlee CS, Koerner K, Grissom TE, Betzold RD, Scalea TM, Kozar RA. Is tranexamic acid associated with mortality or multiple organ failure following severe injury? Shock. 2021. Jan 1;55(1):55-60.

Tominaga GT, Crandall M, Cribari C, Zarzaur BL, Bernstein M, Kozar R; AAST Patient Assessment Committee. Organ injury scaling 2020 update: Bowel and mesentery. J Trauma Acute Care Surg. 2021 Sep 1;91(3):e73-e77.

Zeineddin A, Hu P, Yang S, Floccare D, Lin C, Scalea TM, Kozar RA. Prehospital continuous vital signs predict need for REBOA and resuscitative thoracotomy. J Trauma Acute Care Surg. 2021 Nov 1;91(5):798-802.

Zeineddin A, Crandall M. tominaga GT, Kozar RA. Validation of the American Association for the Surgery of Trauma Organ Injury Scale for Penetrating Colon Injuries. Am Surg. 2022 Jul;88(7):1563-1565. Epub 2022 Mar 25. PMID: 35333107.

Zeineddin A, Wu F, Chao W, Zou L, Vesselinov R, Chipman AM, Dong JF, Huang H, Pati S, Kozar RA. Biomarkers of endothelial cell dysfunction persist beyond resuscitationin patients with hemorrhagic shock. J Trauma Acute Care Surg. 2022 Nov 1;93(5):572-578. Epub 2022 Aug 5. PMID: 35939376.

Additional Publication Citations

Dr. Kozar's complete list of publications can be found in

Research Interests

Dr. Kozar's research interests are in nutrition in the critically ill and endothelial dysfunction after hemorrhagic shock.

Clinical Specialty Details

  • Board certified in general surgery
  • Added qualifications in surgical critical care
  • Clinical and research focus are in trauma and critical care

Awards and Affiliations

  • 1985 - Boehringer Ingelheim National Pharmacology Award
  • 1986 - The Doctor Herman Brown Award for Excellence in the Study of the Art and Science of Surgery, Temple University School of Medicine
  • 1990 - Career Development Award (NRSA). NIH.
  • 1994 - Delaware Valley Vascular Society Residents Competition, First prize
  • 1998 - Mary Dewitt Petit Research Fellowship. Medical College of Pennsylvania
  • 2002 - Frank Webber Prize for Student Research, Third Place, University of Texas - Houston, Research Mentor for Craig Messick, medical student.
  • 2002 - Dean’s Teaching Excellence Award, University of Texas-Houston
  • 2002 - Career Development Award (K08). NIH.
  • 2003 - Dean’s Teaching Excellence Award, University of Texas-Houston
  • 2004 - Research Mentor for Alpha Omega Alpha Student Research Fellowship recipient, Keith Gates, Medical student at the University of Texas-Houston
  • 2004 - Dean’s Teaching Excellence Award, University of Texas- Houston
  • 2005 - Research Mentor for the winner of the Dr. Edward S. Reynolds Memorial Award in Pathology, Adam Childs, Medical student, at the 46th Annual National Student Research Forum in Galveston, TX
  • 2005 - Dean’s Teaching Excellence Award, University of Texas- Houston
  • 2005-2006 - Master Teachers Research Award, University of Texas-Houston
  • 2006-2007 - Master Teacher Research Award, University of Texas-Houston
  • 2008 - T.R.U.E. Research Foundation Endowment Award
  • 2010 - C. Frank Webber Prize for Student Research, First Place, University of Texas- Houston, Research Mentor for Ryan Brown, medical student
  • 2013 - Top Doctors 2013 Houstonia, Houston, TX
  • 2014 - American Medical Association Seed Grant, Research mentor for Anthony LeBlanc
  • 2015 - Nina Starr Braunwald Award by the Association of Women Surgeons
  • 2015 - Honorary member, Eastern Association for the Surgery of Trauma
  • 2017 - Shock Society Distinguished Servcie Award

Grants and Contracts

Active Grants:

Endothelial injury and repair following hemorrhagic shock
Role: PI



Predictors of trauma-induced coagulopathy

Role: Co-I


US Army Medical Research Acquisition Activity

Genomics, Microbiomics, and Bioenergetics-based personalized treatment for trauma

Role: Co-I

Novel dried cryoprecipitate-based itervention to improve outcomes from trauma and hemorrhagic shock: applicability for multi-domain
Role: PI


National Trauma Institute/Patient Centered Outcomes Research Institute

Implementing best-practice, patient-centred venous thromboembolism (VTE) prevention in trauma centers

Role: PI

Plasma Resuscitation without lung injury (PROpOLIs)
Role Co-PI



Surgical studies of gut permeability

Role: Co-I

Trauma and shock-induced microvascular dysregulation and coagulopathy
Role: Multi-PI


National Institute on Aging

Recovery amon golder adults following head injury



Coalition for National Trauma Reseach

A prospective randomized oopen label blinded endpoin tresponse adaptive clinical trial of timing to restart direct oral anticoagulants after traumatic intracranial hemorrhage (Restart TICrH)

Role: PI



Interdisciplinary training program in cardiovascular disease

Role: Co-PI



Fibrogen-based resuscitation to improve outcomes from sepsis after hemorrhagic shock

Role: PI


Professional Activity

Professional Society Memberships

  • 1990 - Initiate, American College of Surgeons
  • 1991 - Member, Association of Academic Surgeons
  • 1995 - Member, Association of Women Surgeons
  • 1998 - Fellow, American College of Surgeons
  • 1998 - Member, Society of Critical Care Medicine
  • 1999 - Member, American Society of Parenteral and Enteral Nutrition
  • 2000 - Member, Shock Society
  • 2002 - Member, Society of University Surgeons
    2004 - Member, Western Trauma Association
  • 2004 - Member, American Association for the Surgery of Trauma
  • 2006 - Member, American Physiology Society
  • 2011 - Member, American Surgical Association


  • 1987 - Diplomate, American Board of Medical Examiners
  • 1996 - Diplomate, American Board of Surgery (Recertification 2015)
  • 2000 - Certificate of Added Qualifications in Surgical Critical Care (Recertification 2011)