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Olga B. Ioffe, MD

Academic Title:


Primary Appointment:


Administrative Title:

Division Head, Anatomic Pathology; Associate Chair for Education

Additional Title:

Director, Pathology and Biorepository Shared Service, University of Maryland Marlene and Stewart Greenebaum Cancer Center



Phone (Primary):

(410) 328-1345

Phone (Secondary):

(410) 328-5525


(410) 328-5508

Education and Training

MD - Moscow State Medical Institute; Moscow, Russia

Residency in Internal Medicine - Greater Baltimore Medical Center

Residency in Anatomic and Clinical Pathology - University of Maryland School of Medicine

Fellowship in Surgical Pathology with focus in breast and gynecologic pathology - University of Maryland School of Medicine

Research/Clinical Keywords

Dr. Ioffe is an expert in surgical pathology, specifically in breast and gynecologic pathology. Her research interests are breast cancer and premalignant breast disease and diagnosis and prognostic factors in breast and gynecologic pathology. She is involved in several NIH-funded studies of breast cancer. As a director of the Division of Anatomic Pathology and the Pathology and Biorepository Shared Service, she is in charge of the institutional tissue bank. She serves as the central reviewing pathologist and/or referee for diagnostic confirmation and classification of breast and gynecologic samples for NIH (Resource for Collection and Evaluation of Human Tissues and Cells from Donors with Epidemiological Profiles) and several national cooperative cancer groups such as the Gynecologic Oncology Group, Cancer and Leukemia Group B (CALGB), and The Cancer Genome Atlas project Biospecimen Core Resource. Dr. Ioffe has experience in biomarker clinical research and has been the pathologist in numerous translational studies involving breast and gynecologic pathology.

Highlighted Publications

Simsir, A., Brooks, S.E., Cochran, L., Bourquin, P., Ioffe, O.B.,:  Cervicovaginal smear abnormalities in sexually active adolescents. Implications for management. Acta Cytologica, 46:271-6, 2002

Ioffe, O.B., Sagae S., Moritani S., Dahmoush L., Chen T., and Silverberg, S.G.: Proposal of a new scoring scheme for the diagnosis of non-invasive endocervical glandular lesions. Am J surg Pathol, 27:452-60,2003

Berg, W.A., Gutierrez, L., NessAiver, M.S., Carter, W.B., Bhargavan, M., Lewis, R.S., Ioffe, O.B.: Diagnostic Accuracy of Mammography, Ultrasound, and Magnetic Resonance Imaging in Preoperative Assessment of the Local Extent of Breast Cancer. Radiology, 233:830, 2004

Wolfson, A.H., Brady, M.F., Rocereto, T.F., Mannel, R.S., Lee, Y.-C., Futoran, R., Cohn, D., Ioffe, O.B.: A Gynecologic Oncology Group randomized phase III trial of whole abdominal irradiation vs Cisplatin-Ifosfamide and Mesna as post-surgical therapy in stage I-IV carcinosarcoma of the Uterus. Gynecol Oncol ,107:177-85, 2007

Lacey JV Jr, Ioffe OB, Ronnett BM, Rush BB, Richesson DA, et al. Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan. Br J Cancer. 2008 Jan 15;98(1):45–53. PubMed PMID: 18026193; PubMed Central PMCID: PMC2359718

Ioffe, O.B., Zaino, R.J., Mutter, G.L.: Endometrial changes from short term therapy with CDB-4124, a selective progesterone receptor modulator. Modern Pathology, 22:450-9, 2009

Ma X, Kundu N, Ioffe, O.B., Goloubeva O, Konger R, Baquet C, Gimotty P, Reader J, Fulton AM.: Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparities. Mol Cancer Res. 8:1310-8, 2010

Serrero G, Hawkins DM, Yue B, Ioffe O.B., Bejarano P, et al. Progranulin (GP88) tumor tissue expression is associated with increased risk of recurrence in breast cancer patients diagnosed with estrogen receptor positive invasive ductal carcinoma. Breast Cancer Res. 2012 Feb 8;14(1):R26. PubMed PMID: 22316048; PubMed Central PMCID: PMC3496144

Sherman, M.E., Piedmonte, M., Mai, P.L., Ioffe, O.B., Ronnett, B.M., Van Le, L., Ivanov, I.,  Bell, M.C., Blaml, S.V., DiSilverstro, P.A., Hamilton, Tewari, K.S., Wakeley, K.E., Kauff, N.D., Yamada, S.D., Rodriguez, G.C., C.A., Skates, S.L., Alberts D.S., Walker, J.L., Minasian, L., Lu, K., Greene, M.H.: Pathologic Findings in Risk-Reducing Salpingo-Oophorectomy (RRSO): Primary Results from Gynecologic Oncology Group Trial GOG-0199. J of Clin Oncol, 2014 Epub ahead of press. PMID:  25199754

Serrero, G., Hawkins, D.M., Bejarano, P., Ioffe, O.B., Tkaczuk KR, Elliott RL, Head JF, Phillips JT, Godwin AK, Weaver J, Yue, B. Determination of GP88 (progranulin) expression in breast tumor biopsies improves the risk predictive value of the Nottingham Prognostic Index. Diagn Pathol. 2016; 11(1):71. PMID: 27501955

Clinical Specialty Details

Attending staff pathologist, University of Maryland Hospital

                                - Surgical Pathology and Cytopathology

                                - Special expertise in: Breast and GYN Pathology

                                - Consultation service (directed consults), Breast and GYN pathology

Awards and Affiliations

Editor-in-Chief, American Journal of Surgical Pathology: Reviews and Reports