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Mariana Guerrero, PhD

Academic Title:


Primary Appointment:

Radiation Oncology

Additional Title:

Medical Physics Residency Program Director


UMMC/Gudelsky, GGJ-82

Phone (Primary):




Education and Training

1989     Licentiate (B. S.), Physics, University of Buenos Aires, Buenos Aires, Argentina

1995      Ph.D., Physics, University of California, Irvine, California, Thesis Advisor - Professor Clare C. Yu


I am a Medical Physicist in the Radiation Oncology Department. I received my PhD from the University of California, Irvine. I trained as a post-doctoral fellow at T-11, Los Alamos National Laboratory, Los Alamos, New Mexico. In 2001 I joined the University of Maryland School of Medicine as a post-doctoral fellow and in 2004 as an Assistant Professor at the Department of Radiation Oncology. From 2006 to 2009 I worked as a Medical Physicist at the Veterans Administration Hospital in Washington DC. In 2009, I re-joined the Department of Radiation Oncology at the University of Maryland School of Medicine as a Clinical Assistant Professor and I am currently a Clinical Associate Professor. I participate of a wide range of clinical activities: I am responsible for overseeing Medical Physics coverage of our prostate seed implants program (I-125 and Cs-131); I provide Physics clinical coverage of external beam treatments, high-dose rate brachytherapy treatments, Yttriym-90 liver infusions and external and interstitial thermal therapy. I am board-certified in Therapeutic Medical Physics by the American Board of Radiology (ABR). I enjoy my many teaching responsibilities and eagerly participate in Clinical Research projects that advance our field and improve cancer treatments for our patients. I am also interested in Radiobiological Modeling as a way to better understand the basic principles of radiation biological effects.


Research/Clinical Keywords

Radiation Therapy, Clinical Medical Physics, Radiobiological Modelling, Multi-Criteria Optimization, Portal Dosimetry.

Highlighted Publications

M. Guerrero, Robert D. Stewart, Jian Z. Wang and X. Allen Li “Equivalence of the linear-quadratic and two-lesion kinetic models.” Phys Med Biol. 47(17), 3197-209 (2002).

Wang JZ, M. Guerrero, Li XA “How low is the alpha/beta ratio for prostate cancer?” Int J Radiat Oncol Biol Phys. 2003 Jan 1;55(1):194-203.

M Guerrero, Li XA, Ma L. “A technique to sharpen the beam penumbra for Gamma Knife radiosurgery” Phys Med Biol. 2003 Jun 21;48(12):1843-53.

M Guerrero, Li XA “Analysis of a large number of clinical studies for breast cancer radiotherapy: estimation of radiobiological parameters for treatment planning” Phys Med Biol. 2003 Oct 21;48(20):3307-26.

M. Guerrero, X. Allen Li, M.A. Earl, M. Sarfaraz E. Kiggundu “IMRT Concomitant Boost for Breast Radiotherapy: a feasibility study”, Int J Radiat Oncol Biol Phys. 2004 Aug 1;59(5):1513-2

M. Guerrero and  X. Allen Li, “Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy”, Phys Med Biol. 2004 Oct 21;49(20):4825-35.

David J. Carlson,  Robert D. Stewart, X. Allen Li, Ph.D., Kristofer Jennings, Ph.D.,* Jian Z. Wang, Ph.D. and M Guerrero, Ph.D., “Comparison of in vitro and in vivo α/β ratios for prostate cancer”, Phys Med Biol. 2004 Oct 7;49(19):4477-91.

M. Guerrero, X. Allen Li, Lijun Ma, Jeannette Linder, Chad DeYoung, Beth Erickson “Simultaneous integrated IMRT boost for locally advanced gynecological cancer: radiobiological and dosimetric considerations.”  Int J Radiat Oncol Biol Phys. 62(3):933-9 (2005).

M. Guerrero, X. Allen Li “Halftime for repair of sublethal damage in normal bladder and rectum: an analysis of clinical data from cervix brachytherapy” Phys Med Biol. 51: 4063-4071 (2006).

M. Guerrero, “Comparison of fractionation schedules in the large heterogeneity limit”, Med Phys. 36(4): 1384-8. (2009).

M. Guerrero, M. Carlone “Mechanistic Formulation of a Lineal-Quadratic-Linear (LQL) Model: Split-Dose Experiments and Exponentially Decaying Sources”, Med Phys. 37(8):4173-81 (2010).

Jidong Hou, M. Guerrero, Warren D. D’Souza “Deformable planning CT to cone-beam CT image registration in head-and-neck cancer”, Med Phys., 38(4):2088-94 (2011).

G. Lasio, M. Guerrero, W. Goetz, F. Lima and J. Baulch, “Effect of Dose-Per-Pulse and Pulse Repetition Frequency in X-Ray Beam Irradiation of In-Vitro Cell Cultures”, Radiation and Environmental Biophysics 53(4): 671-676 (2014).

M. Guerrero, Shan Tan and Wei Lu “Radiobiological Modeling based on FDG PET data for Esophageal Cancer”, J Nucl Med Radiat Ther 5(4):190 (2014).

Jidong Hou, M. Guerrero, Warren D. D’Souza “Response Assessment in Locally Advanced Head and Neck Cancer Based on RECIST and Volume Measurements Using Cone Beam CT Images”, Technology in Cancer Research and Treatment 14(1):19-27 (2015).

Community Service

Science fair judge for elementary and middle school.