deFilippi, Christopher | University of Maryland School of Medicine

Academic Title:

Professor

Primary Appointment:

Medicine

Additional Title:

Co-Director, CCRL

Biosketch

Dr. Christopher deFilippi is a Professor of Medicine (Division of Cardiology) and Pathology at the University of Maryland School of Medicine. His career has been distinguished by a sustained focus on the discovery, validation, and clinical application of cardiac biomarkers. He has authored more than 300 peer-reviewed publications and has received funding from the NIH and the in vitro diagnostics (IVD) industry to lead biomarker-based clinical trials across the spectrum of cardiovascular disease.

Over the past 25 years, Dr. deFilippi has collaborated extensively with the IVD industry, contributing to the development of multiple FDA-cleared assays and co-authoring pivotal publications that have shaped biomarker use in clinical practice. He has led the design of numerous diagnostic clinical trials and has served as chairperson for adjudication and endpoint committees supporting FDA registration studies.

To further strengthen his expertise in study design and high-dimensional data analysis, Dr. deFilippi recently completed a Master of Science in Clinical Investigation at Harvard Medical School. His current research integrates discovery-based proteomics to identify circulating protein biomarkers that serve as effect measure modifiers, enhancing precision in treatment response across diverse patient populations.

Dr. deFilippi rejoined the University of Maryland following his tenure at the Inova Health System, where he established and directed a successful biomarker core laboratory. His return marks a continuation of a long-standing collaboration with Dr. Robert Christenson, with whom he previously worked for more than 15 years in advancing translational biomarker science.

Highlighted Publications

2025 Publications

Daniels LB, Ajongwen P, Christenson RH, Clark CL, Diercks DB, Fermann GJ, Mace SE, Mahler SA, Pang PS, Rafique Z, Runyon MS, Tauras J, deFilippi CR. Clinical Performance of an N-Terminal Pro-B-Type Natriuretic Peptide Assay in Acute Heart Failure Diagnosis. J Appl Lab Med. 2025;10:325-338. doi: 10.1093/jalm/jfae107.

Shuter J, Davis OA, deFilippi C, Christenson R, Li L, Potts W, Himelhoch S. Nicotine metabolite ratio in people with HIV who smoke cigarettes receiving pharmacologic and behavioral cessation therapy. Cancer Prev Res (Phila). 2025;18:111-115. doi: 10.1158/1940-6207.CAPR-24-0449.

Parashar Y; Awwad A; Bagchi S; Claggett B; Siddiqui SA; Ogheneochuko AW; Christie M Ballantyne CM; deFilippi C. A meta-analysis and systematic review of cardiac troponin I vs. T in community dwelling adults: is specificity at risk? Clin Chem. doi: 10.1093/clinchem/hvaf023. Epub ahead of print.

Chevli PA, Selvaraj S, Jaeger BC, Hammoud A, Connelly MA, deFilippi C, Lima JAC, Khan SS, Herrington DM, Shapiro MD, Vaduganathan M. Integrating Ketone Bodies in Multi-Marker Risk Prediction of Incident Heart Failure in the Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Prev Cardiol. 2025 Mar 21:zwaf168. doi: 10.1093/eurjpc/zwaf168. Epub ahead of print. PMID: 40116814.

Doudesis D, Lee KK, Anwar M, Singer AJ, Hollander JE, Chenevier-Gobeaux C, Claessens YE, Wussler D, Weil D, Kozhuharov N, Strebel I, Sabti Z, deFilippi C, Seliger S, Mesquita ET, Wiemer JC, Möckel M, Coste J, Jourdain P, Kimiaki K, Yoshimura M, Ibrahim I, Ooi SBS, Sen Kuan W, Gegenhuber A, Mueller T, Hanon O, Vidal JS, Cameron P, Lam L, Freedman B, Chung T, Collins SP, Lindsell CJ, Newby DE, Japp AG, Shah ASV, Villacorta H, Richards AM, McMurray JJV, Mueller C, Januzzi JL, Mills NL. Machine learning to optimise use of natriuretic peptides in the diagnosis of acute heart failure. Eur Heart J Acute Cardiovasc Care. 2025 Apr 12:zuaf051. doi: 10.1093/ehjacc/zuaf051. Epub ahead of print. PMID: 40219913.

Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, Halley JD, Rocha S, Hoogeveen RC, Gudnason V, Bakker SJL, Wannamethee SG, Pareek M, Eggers KM, Jukema JW, Hankey GJ, deLemos JA, Ford I, Omland T, Lyngbakken MN, Psaty BM, deFilippi CR, Wood AM, Danesh J, Welsh P, Sattar N, Mills NL, Di Angelantonio E; CAPRICE Co-Investigators. Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis. J Am Coll Cardiol. 2025;85:1471-1484. doi: 10.1016/j.jacc.2025.02.016. PMID: 40204376.

Kushner, PR, Fonseca V, Nichols JH, Shubrook JH, Miller E, Wight E, deFilippi C, Vassalotti JA. Clinical Need for Point-of-Care Testing in Diabetes in CLIA-Waived Environments. Clin Diabetes. 2024;43:227-239. doi: 10.2337/cd24-0071. eCollection 2025 Spring. PMID: 40290824.

Lu MT, Ribaudo HJ, McCallum S, Zanni MV, deFilippi C, Taron J, Karady J, Foldyna B, Paradis K, Chu SM, Diggs MR, Burdo TH, Currier JS, Bloomfield GS, Fichtenbaum CJ, Malvestutto CD, Aberg JA, Mayrhofer T, Douglas PS, Grinspoon SK; REPRIEVE Investigators. Coronary Plaque, Inflammation, Subclinical Myocardial Injury, and Major Adverse Cardiovascular Events in the REPRIEVE Substudy. JACC Adv. 2025 May 14;4(6 Pt 1):101781. doi: 10.1016/j.jacadv.2025.101781. Epub ahead of print. PMID: 40373520.

Walpert AR, Gupta M, Dunderdale CN, Haptu HH, Manandhar M, deFilippi CR, Burdo TH, Lee H, Kwong RY, Srinivasa S. Exploring the PREVENT HF score and myocardial function among persons with HIV. AIDS. 2025 Jun 5. doi: 10.1097/QAD.0000000000004252. Epub ahead of print. PMID: 40478895.

Cai X, White Q, Johnson WC, Hansen SL, Dardari ZA, Blaha M, Michos ED, Lima JA, deFilippi CR, Budoff MJ, Watson KE, McClelland RL, Yang EH. Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort. JACC Adv. 2025;4(7):101884. doi: 10.1016/j.jacadv.2025.101884. Epub ahead of print. PMID: 40527284; PMCID: PMC12213292.

Tomar S, Lidani KCF, Moraes AAI, Huang S, Oakley C, Nasir K, Blaha MJ, Heckbert SR, Hughes TM, deFilippi CR, Sandoval Y, Jaffe AS, DeFilippis AP. Subclinical Myocardial Injury and Global Cognitive Performance: MESA (Multi-Ethnic Study of Atherosclerosis). JACC Adv. 2025 Jun 23;4(8):101894. doi: 10.1016/j.jacadv.2025.101894. Epub ahead of print. PMID: 40555139; PMCID: PMC12226125.

Goldberg JF, deFilippi CR, Lockhart C, McNair ER, Sinha SS, Kong H, Najjar SS, Lohmar BJ, Tchoukina I, Shah K, Feller E, Hsu S, Rodrigo ME, Jang M, Marboe CC, Berry GJ, Valantine HA, Agbor-Enoh S, Shah P. Proteomics in Acute Heart Transplant Rejection, on Behalf of the GRAfT Investigators. Transplantation. 2025 Jul 1;109(7):1230-1240. doi: 10.1097/TP.0000000000005258. Epub 2024 Dec 3. PMID: 39630098; PMCID: PMC12130342.

Additional Publication Citations

2024 Publications

Ashburn NP, McCord JK, Snavely AC, Christenson RH, Apple FS, Nowak RM, Peacock WF, deFilippi CR, Mahler SA. Navigating the Observation Zone: Do Risk Scores Help Stratify Patients With Indeterminate High-Sensitivity Cardiac Troponins? 2024;149:70-72.

Barasch E, Gottdiener J, Buzkova P, Cappola A, Shah S, deFilippi C, Gardin J and Kizer JR. Association of thyroid dysfunction in individuals≥ 65 years of age with subclinical cardiac abnormalities. The Journal of Clinical Endocrinology & Metabolism. 2024 Sep 16;109(10):e1847-e1856.

deFilippi CR, Parashar Y and Awwad A. Systematic Review and Meta-Analysis of Renal Biomarkers for Cardiovascular Prognosis: A Look Under the Hood. JACC: Advances. 2024;3:100764.

Leung JM, Wu MJ, Kheradpour P, Chen C, Drake KA, Tong G, Ridaura VK, Zisser HC, Conrad WA, Hudson N, Allen J, Welberry C, Parsy-Kowalska C, Macdonald I, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Basit M, Krishnan JA, Parthasarathy S, Prabhakar BS, Salvatore M, Kim CC. Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals. Front Immunol. 2024;15:1348041. doi: 10.3389/fimmu.2024.1348041.

Lu MT, Ribaudo H, Foldyna B, Zanni MV, Mayrhofer T, Karady J, Taron J, Fitch KV, McCallum S, Burdo TH, Paradis K, Hedgire SS, Meyersohn NM, deFilippi C, Malvestutto CD, Sturniolo A, Diggs M, Siminski S, Bloomfield GS, Alston-Smith B, Desvigne-Nickens P, Overton ET, Currier JS, Aberg JA, Fichtenbaum CJ, Hoffmann U, Douglas PS, Grinspoon SK; REPRIEVE Trial Writing Group. Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV: Mechanistic Substudy of the REPRIEVE Randomized Clinical Trial. JAMA Cardiol. 2024 Apr 1;9(4):323-334. doi: 10.1001/jamacardio.2023.5661. Epub ahead of print.

Murtagh G, deFilippi C, Zhao Q, Barac A. Circulating biomarkers in the diagnosis and prognosis of immune checkpoint inhibitor-related myocarditis: time for a risk-based approach. Front Cardiovasc Med. 2024;11:1350585. doi: 10.3389/fcvm.2024.1350585.

Bansal N, Katz R, Seliger S, deFilippi C, Wettersten N, de Lemos JA, Christenson R, Killeen AA, Berry JD, Shlipak MG, Ix JH. Variation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial. Circulation. 2024 Mar 19;149(12):967-969. doi: 10.1161/CIRCULATIONAHA.123.066377.

Naghavi M, Yankelevitz D, Reeves AP, Budoff MJ, Li D, Atlas K, Zhang C, Atlas TL, Lirette S, Wasserthal J, Roy SK, Henschke C, Wong ND, deFilippi C, Heckbert SR, Greenland P. AI-enabled left atrial volumetry in coronary artery calcium scans (AI-CACTM) predicts atrial fibrillation as early as one year, improves CHARGE-AF, and outperforms NT-proBNP: The multi-ethnic study of atherosclerosis. J Cardiovasc Comput Tomogr. 2024 Jul-Aug;18(4):383-391. doi: 10.1016/j.jcct.2024.04.005.

Naghavi M, Reeves A, Budoff M, Li D, Atlas K, Zhang C, Atlas T, Roy SK, Henschke CI, Wong ND, deFilippi C, Levy D, Yankelevitz DF. AI-enabled cardiac chambers volumetry in coronary artery calcium scans (AI-CACTM) predicts heart failure and outperforms NT-proBNP: The multi-ethnic study of Atherosclerosis. J Cardiovasc Comput Tomogr. 2024 Jul-Aug;18(4):392-400. doi: 10.1016/j.jcct.2024.04.006.

Greene SJ, Chambers R, Lerman JB, Harrington J, deFilippi CR, Wendell DC, Kim HW, Green CL, Butler J, Felker GM. Sacubitril/valsartan and cardiovascular biomarkers among patients with recent COVID-19 infection: The PARACOR-19 randomized clinical trial. Eur J Heart Fail. 2024 Jun;26(6):1393-1398. doi: 10.1002/ejhf.3199. Epub ahead of print. PMID: 38733160.

Neumann JT, Twerenbold R, Weimann J, Ballantyne CM, Benjamin EJ, Costanzo S, de Lemos JA, deFilippi CR, Di Castelnuovo A, Donfrancesco C, Dörr M, Eggers KM, Engström G, Felix SB, Ferrario MM, Gansevoort RT, Giampaoli S, Giedraitis V, Hedberg P, Iacoviello L, Jørgensen T, Kee F, Koenig W, Kuulasmaa K, Lewis JR, Lorenz T, Lyngbakken MN, Magnussen C, Melander O, Nauck M, Niiranen TJ, Nilsson PM, Olsen MH, Omland T, Oskarsson V, Palmieri L, Peters A, Prince RL, Qaderi V, Vasan RS, Salomaa V, Sans S, Smith JG, Söderberg S, Thorand B, Tonkin AM, Tunstall-Pedoe H, Veronesi G, Watanabe T, Watanabe M, Zeiher AM, Zeller T, Blankenberg S, Ojeda F. Prognostic Value of Cardiovascular Biomarkers in the Population. JAMA. 2024;331:1898-1909. doi: 10.1001/jama.2024.5596.

Tromp J, Lam CSP, Alemayehu W, de Filippi CR, Melenovský V, Sliwa K, Lopatin Y, Arango JL, Bahit MC, Roessig L, O'Connor CM, Shah P, Westerhout CM, Voors AA, Pieske B, Armstrong PW; VICTORIA Study Group. Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial. Eur J Heart Fail. 2024 Oct;26(10):2231-2239. doi: 10.1002/ejhf.3397.

Vigen R, Ayers C, Berry J, Rohatgi A, Nambi V, Ballantyne CM, Omland T, deFilippi CR, de Lemos J. Individual and Joint Associations of High-Sensitivity Troponin I and High-Sensitivity Troponin T with Cardiac Phenotypes and Outcomes in the General Population: An Analysis From the Dallas Heart Study. J Am Heart Assoc. 2024 Jul 2;13(13):e034549. doi: 10.1161/JAHA.124.034549.

deFilippi CR, McCallum S, Markella ZV, Fitch KV, Diggs MR, Bloomfield GS, Fichtenbaum CJ, Aberg JA, Malvestutto CD, Pinto-Martinez A, Stapleton A, Duggan J, Robbins GK, Taron J, Karady J, Foldyna, B, Lu MT, Ribaudo HJ, Douglas PS, Grinspoon SK. Association of cardiac troponin T with coronary atherosclerosis in asymptomatic primary prevention people with HIV. JACC: Advances 2024 Aug 16;3(9):101206. doi.org/10.1016/j.jacadv.2024.101206.

Barac, A, Wadlow, R, Deeken, J, deFilippi CR. Cardiac Troponin I and T in ICI Myocarditis Screening, Diagnosis, and Prognosis. J Am Coll Cardiol CardioOnc. 2024 Aug 6;6(5):804-807. .https://doi.org/10.1016/j.jaccao.2024.07.001

Phan V, Richards T, Kang K, Sheridan M, Levorson R, deFilippi C, Yang E. Seroprevalence of SARS-CoV-2 in pediatric hematology-oncology patients. Pediatr Blood Cancer. 2024:e31212. 2024;71:e31212. doi: 10.1002/pbc.31212. doi: 10.1002/pbc.31212.

deFilippi CR, Shah P, Shah SJ, Alemayehu W, Lam CP, Butler J, Roessig L, O’Connor CM, Westerhout CM, Armstrong PW. Proteomics identify clinical phenotypes and predict functional outcomes in heart failure with preserved ejection fraction: Insights from VITALITY-HFpEF. Circ Heart Fail. 2024 Sep;17(9):e011792. doi: 10.1161/CIRCHEARTFAILURE.124.011792

Cai X, White Q, Wang DR, deFilippi CR, Bertoni AG, Wu CO, Liu K, Lima JAC, Budoff MJ, Fonarow GC, Watson KE, McClelland RL, Yang EH. Cardiovascular Risks and Outcomes Among Chinese American Immigrants: Insights From the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2024 Sep 17;13(18):e037114. doi: 10.1161/JAHA.124.037114.

Damluji AA, Bruce SA, Reeves G, Pastva AM, Bertoni AG, Mentz RJ, Whellan DJ, Kitzman DW, deFilippi CR. Circulating Biomarkers as Predictors of Improvement in Physical Function in Hospitalized Older Adults with Geriatric Syndromes: Findings from the REHAB-HF Trial. medRxiv 2024.09.13.24313662; doi: https://doi.org/10.1101/2024.09.13.24313662 (pre-press)

Tan ESJ, Choi H, deFilippi CR, Oon YY, Chan SP, Gong L, Lunaria JB, Liew OW, Chong JP, Tay EL, Soo WM, Yip JW, Yong QW, Lee EM, Daniel Yeo PS, Ding ZP, Tang HC, Ewe SH, Chin CWL, Chai SC, Goh PP, Ling LF, Ong HY, Richards AM, Ling LH. Circulating Plasma Proteins in Aortic Stenosis: Associations With Severity, Myocardial Response, and Clinical Outcomes. J Am Heart Assoc. 2024 Sep 30:e035486. doi: 10.1161/JAHA.124.035486. Epub ahead of print.

Awwad A, Parashar Y, Bagchi S, Siddiqui SA, Ogheneochuko AW, deFilippi C. Preclinical Screening for Cardiovascular Disease with High-Sensitive Cardiac Troponins:Ready, Set, Go? Front Cardiovasc Med. 2024 Nov 14:11:1350573. doi: 10.3389/fcvm.2024.1350573.

Kolossváry M, Schnittman SR, Zanni MV, Fitch KV, Fichtenbaum CJ, Aberg JA, Bloomfield GS, Malvestutto CD, Currier J, Diggs MR, deFilippi C, Eckard AR, Curran A, Centinbas M, Sadreyev R, Foldyna B, Mayrhofer T, Karady J, Taron J, McCallum S, Lu MT, Ribaudo HJ, Douglas PS, Grinspoon SK. Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial. JAMA Cardiol. 2025;10:254-264. doi: 10.1001/jamacardio.2024.4115.

2023 Publications

Sigurdardottir FD, Bertisch SM, Reid ML, deFilippi CR, Lima JAC, Redline S, Omland T. Association between insomnia phenotypes and subclinical myocardial injury: The Multi-Ethnic Study of Atherosclerosis. Sleep. 2023 Apr 12;46(4):zsac318. doi: 10.1093/sleep/zsac318.

Barasch E, Gottdiener JS, Tressel W, Bartz TM, Buzkova P, Massera D, deFilippi C, Biggs ML, Psaty BM, Kizer JR, Owens D. The Associations of Aortic Valve Sclerosis, Aortic Annular Increased Reflectivity, and Mitral Annular Calcification with Subsequent Aortic Stenosis in Older Individuals: Findings from the Cardiovascular Health Study. J Am Soc Echocardiogr. 2023;36:41-49.e1.

Minciunescu A, Genovese L, deFilippi C. Cardiovascular Alterations and Structural Changes in the Setting of Chronic Kidney Disease: a Review of Cardiorenal Syndrome Type 4. SN Compr Clin Med. 2023;5(1):15. doi: 10.1007/s42399-022-01347-2.

Saha A, Patel KV, Ayers C, Ballantyne CM, Correa A, defilippi C, Hall ME, Mentz RJ, Seliger SL, Yimer W, Butler J, Berry JD, De Lemos JA, Pandey A. Longitudinal Changes in Cardiac Troponin and Risk of Heart Failure Among Black Adults. J Card Fail. 2023;29:6-15.

Patel KV, Saha A, Ayers CR, Rohatgi A, Berry JD, Almandoz JP, Johannsen NM, deFilippi CR, Church TS, de Lemos JA, Pandey A. JACC Adv. 2023 Jan, 2 (1) 100174.

deFilippi CR, Alemayehu WG, Voors AA, Kaye D, Blaustein RO, Butler J, Ezekowitz JA, Hernandez AF, Lam CSP, Roessig L, Seliger S, Shah P, Westerhout CM, Armstrong PW, O'Connor CM; VICTORIA Study Group. Assessment of Biomarkers of Myocardial injury, Inflammation, and Renal Function in Heart Failure with Reduced Ejection Fraction: The VICTORIA Biomarker Substudy. J Card Fail. 2023 Jan 9:S1071-9164(23)00002-7. doi: 10.1016/j.cardfail.2022.12.013.

deFilippi CR, Tran H, Gattani R, Daniels LB, Shah P, Ilkhanoff L, Christenson R, Lima JA, Seliger S. Association of Prognostic Cardiac and Non-Cardiac Specific Circulating Biomarkers with Replacement and Interstitial Cardiac Fibrosis in Community Dwelling Adults: The Multi-Ethnic Study of Atherosclerosis. Front Cardiovasc Med. 10:1104715. doi: 10.3389/fcvm.2023.1104715.

Tedla YG, Driver S, Szklo M, Kuller L, Lima JA, Michos ED, Ning H, deFilippi CR, Greenland P. Joint effect of highly-sensitive cardiac troponin T and ankle-brachial index on incident cardiovascular events: The MESA and CHS. Am J Prev Cardiol. 2023;13:100471. doi: 10.1016/j.ajpc.2023.100471.

Bakhshi H, Michelhaugh SA, Bruce SA, Seliger SL, Qian X, Venkatesh BA, Varadarajan V,Bagchi P, Lim JA, deFilippi Association between proteomic biomarkers and myocardial fibrosis measured by MRI: The Multi-ethnic Study of Atherosclerosis. EBioMedicine. 2023; Apr:90:104490. doi: 10.1016/j.ebiom.2023.104490.

Shah P, Arias R, deFilippi CR. Redefining Pre–Heart Failure With Cardiac Biomarkers: Clinical and Research Implications. JACC Heart Fail. 2023;11:451-453.

Butler J, Zheng Y, Khan MS, Bonderman D, Lund LH, deFilippi CR, Blaustein RO, Ezekowitz JA, Freitas C and Hernandez AF. Ejection Fraction, Biomarkers, and Outcomes and Impact of Vericiguat on Outcomes Across EF in VICTORIA. JACC Heart Fail. 2023;11:583-592.

Tsutsui H, Albert NM, Coats AJ, Anker SD, Bayes‐Genis A, Butler J, Chioncel O, deFilippi CR, Drazner MH and Felker GM. Natriuretic peptides: role in the diagnosis and management of heart failure: a scientific statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society. Eur J Heart Fail. 2023;25:616-631.

Kolossváry M, deFilippi C, McCallum S, Fitch KV, Diggs MR, Fulda ES, Ribaudo HJ, Fichtenbaum CJ, Aberg JA, Malvestutto CD, Currier JS, Casado JL, Gutiérrez F, Sereti I, Douglas PS, Zanni MV and Grinspoon SK. Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV. EBioMedicine. 2023;90:104538. doi: 10.1016/j.ebiom.2023.104538.

Shemesh E, Chevli PA, Islam T, German CA, Otvos J, Yeboah J, Rodriguez F, deFilippi C, Lima JAC, Blaha M, Pandey A, Vaduganathan M and Shapiro MD. Circulating ketone bodies and cardiovascular outcomes: the MESA study. Eur Heart J. 2023;44:1636-1646. doi: 10.1093/eurheartj/ehad087.

Damluji AA, Alfaraidhy M, AlHajri N, Rohant NN, Kumar M, Al Malouf C, Bahrainy S, Ji Kwak M, Batchelor WB, Forman DE, Rich MW, Kirkpatrick J, Krishnaswami A, Alexander KP, Gerstenblith G, Cawthon P, deFilippi CR, Goyal P. Sarcopenia and Cardiovascular Diseases. 2023;147:1534-1553.

O'Lone E, Apple FS, Burton JO, Caskey FJ, Craig JC, deFilippi CR, Forfang D, Hicks KA, Jha V, Mahaffey KW, Mark PB, Rossignol P, Scholes-Robertson N, Jaure A, Viecelli AK, Wang AY, Wheeler DC, White D, Winkelmayer WC and Herzog CA. Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI Expert Working group. Kidney Int. 2023;103:1028-1037.

Goldberg JF, Truby LK, Agbor-Enoh S, Jackson AM, deFilippi CR, Khush KK and Shah P. Selection and Interpretation of Molecular Diagnostics in Heart Transplantation. 2023;148:679-694.

Ilkhanoff L, Qian X, Lima JA, Tran H, Soliman EZ, Yeboah J, Seliger S and deFilippi CR. Electrocardiographic Associations of Cardiac Biomarkers and Cardiac Magnetic Resonance Measures of Fibrosis in the Multiethnic Study of Atherosclerosis (MESA). Am J Cardiol. 2023;204:287-294.

deFilippi C and Barac A. Cardiac Troponins for Diagnosis and Prognostic Assessment of Immune Checkpoint Inhibitor Myocarditis and Myositis: The Emerging Importance of Peripheral Vision. 2023;148:1135-1137.

Rogawski McQuade ET, Becker L, Stroup SE, Khan F, Shah B, Brush J, Goldsmith G, Mullin R, Guilliams D, deFilippi C, Barackman K, Mohr AB, Farrell F, Bearman G, Peake L and Houpt ER. Risk factors and titers of COVID-19 infection in a longitudinal statewide seroepidemiology cohort. BMC Infect Dis. 2023;23:676.

2022 Publications

Chiang CH, Chiang CH, Pickering JW, Stoyanov KM, Chew DP, Neumann JT, Ojeda F, Sörensen NA, Su KY, Kavsak P, Worster A, Inoue K, Johannessen TR, Atar D, Amann M, Hochholzer W, Mokhtari A, Ekelund U, Twerenbold R, Mueller C, Bahrmann P, Buttinger N, Dooley M, Ruangsomboon O, Nowak RM, deFilippi CR, Peacock WF, Neilan TG, Liu MA, Hsu WT, Lee GH, Tang PU, Ma KS, Westermann D, Blankenberg S, Giannitsis E, Than MP, Lee CC. Performance of the European Society of Cardiology 0/1-Hour, 0/2-Hour, and 0/3-Hour Algorithms for Rapid Triage of Acute Myocardial Infarction: An International Collaborative Meta-analysis. Ann Intern Med. 2022 Jan;175(1):101-113. doi: 10.7326/M21-1499.

Cooper LB, Bruce S, Psotka M, Mentz R, Bell R, Seliger SL, O'Connor C, deFilippi C. Proteomic differences among patients with heart failure taking furosemide or torsemide. Clin Cardiol. 2022 Mar;45(3):265-272. doi: 10.1002/clc.23733.

Koechlin L, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Shrestha S, Wussler D, Haeni N, Walter JE, Twerenbold R, Eckstein FS, Reuthebuch O, McCord J, Nowak RM, Christenson RH, deFilippi CR, Apple FS, Mueller C; APACE and High-US investigators. Lower diagnostic accuracy of hs-cTnI in patients with prior coronary artery bypass grafting. Int J Cardiol. 2022 Feb 18;S0167-5273.

Rosner CM, Atkins M, Saeed IM, de Lemos JA, Khera A, Maghsoudi A, Min J, Tehrani BN, O'Connor CM, deFilippi CR. Patients With Myocarditis Associated With COVID-19 Vaccination. J Am Coll Cardiol. 2022;79:1317-1319.

Massera D, Hu M, Delaney JA, Bartz TM, Bach ME, Dvorak SJ, deFilippi CR, Psaty BM, Gottdiener JS, Kizer JR, Shah SJ. Adverse cardiac mechanics and incident coronary heart disease in the Cardiovascular Health Study. 2022;108:529-535.

Gottdiener JS, Buzkova P, Kahn PA, deFilippi C, Shah S, Barasch E, Kizer JR, Psaty B, Gardin JM. Relation of Cigarette Smoking and Heart Failure in Adults ≥65 Years of Age (From the Cardiovascular Health Study). Am J Cardiol. 2022;168:90-98.

Kolossváry M, deFilippi C, Lu MT, Zanni MV, Fulda ES, Foldyna B, Ribaudo H, Mayrhofer T, Collier AC, Bloomfield GS, Fichtenbaum C, Overton ET, Aberg JA, Currier J, Fitch KV, Douglas PS, Grinspoon SK. Proteomic Signature of Subclinical Coronary Artery Disease in People with HIV: Analysis of the REPRIEVE Mechanistic Substudy. J Infect Dis. 2022 Nov 11;226(10):1809-1822. doi: 10.1093/infdis/jiac196.

Saha A, Patel KV, Ayers C, Ballantyne CM, Correa A, deFilippi C, Hall ME, Mentz RJ, Seliger SL, Yimer W, Butler J, Berry JD, de Lemos JA, Pandey A. Longitudinal changes in cardiac troponin and risk of heart failure among Black adults. J Card Fail. 2023 Jan;29(1):6-15.

Lee KK, Doudesis D, Anwar M, Astengo F, Chenevier-Gobeaux C, Claessens YE, Wussler D, Kozhuharov N, Strebel I, Sabti Z, deFilippi C, Seliger S, Moe G, Fernando C, Bayes-Genis A, van Kimmenade RRJ, Pinto Y, Gaggin HK, Wiemer JC, Möckel M, Rutten JHW, van den Meiracker AH, Gargani L, Pugliese NR, Pemberton C, Ibrahim I, Gegenhuber A, Mueller T, Neumaier M, Behnes M, Akin I, Bombelli M, Grassi G, Nazerian P, Albano G, Bahrmann P, Newby DE, Japp AG, Tsanas A, Shah ASV, Richards AM, McMurray JJV, Mueller C, Januzzi JL, Mills NL; CoDE-HF investigators. Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study. 2022 Jun 13;377:e068424. doi: 10.1136/bmj-2021-068424.

Austin TR, McHugh CP, Brody JA, Bis JC, Sitlani CM, Bartz TM, Biggs ML, Bansal N, Buzkova P, Carr SA, deFilippi CR, Elkind MSV, Fink HA, Floyd JS, Fohner AE, Gerszten RE, Heckbert SR, Katz DH, Kizer JR, Lemaitre RN, Longstreth WT, McKnight B, Mei H, Mukamal KJ, Newman AB, Ngo D, Odden MC, Vasan RS, Shojaie A, Simon N, Smith GD, Davies NM, Siscovick DS, Sotoodehnia N, Tracy RP, Wiggins KL, Zheng J, Psaty BM. Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing. Eur J Epidemiol. 2022 Jul;37(7):755-765. doi: 10.1007/s10654-022-00888-z.

deFilippi CR, Damluji AA. At the Crossroad Between Skeletal and Cardiac Muscle Cells. Circulation. 2022;145:1780-1783.

Shah P, Agbor-Enoh S, Bagchi P, deFilippi CR, Mercado A, Diao G, Morales DJ, Shah KB, Najjar SS, Feller E, Hsu S, Rodrigo ME, Lewsey SC, Jang MK, Marboe C, Berry GJ, Khush KK, Valantine HA; GRAfT Investigators. Circulating microRNAs in cellular and antibody-mediated heart transplant rejection. J Heart Lung Transplant. 2022;S1053-2498

Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coron Artery Dis. 2022;33:376-384.

Bansal N, Katz R, Seliger S, deFilippi C, Wettersten N, Zelnick LR, Berry JD, de Lemos JA, Christenson R, Killeen AA, Shlipak MG, Ix JH. Kidney Function Specific Reference Limits for N-terminal Pro Brain Natriuretic Peptide and High Sensitivity Troponin T: The Systolic Blood Pressure Intervention Trial. Kidney Med. 2022;4:100517.

Tehrani BN, Sherwood MW, Rosner C, Truesdell AG, Ben Lee S, Damluji AA, Desai M, Desai S, Epps KC, Flanagan MC, Howard E, Ibrahim N, Kennedy J, Moukhachen H, Psotka M, Raja A, Saeed I, Shah P, Singh R, Sinha SS, Tang D, Welch T, Young K, deFilippi CR, Speir A, O'Connor CM, Batchelor WB. A Standardized and Regionalized Network of Care for Cardiogenic Shock. JACC Heart Fail. 2022;10:768-781.

deFilippi CR, Seliger S. Malignant Left Ventricular Hypertrophy and Epidemiology 101. J Am Coll Cardiol. 2022;80:1526-1528.

Alshaikh LM, Apple FS, Christenson RH, deFilippi CR, Limkakeng AT Jr, McCord J, Nowak RM, Singer AJ, Peacock WF. Outcomes in ED patients with non-specific ECG findings and low high-sensitivity troponin. J Am Coll Emerg Physicians Open. 2022;3:e12844.

Eltelbany M, Shah P, deFilippi C. Biomarkers in HFpEF for Diagnosis, Prognosis, and Biological Phenotyping. Curr Heart Fail Rep. 2022;19:412-424.

2021 Publications

Kula AJ, Katz R, Zelnick LR, Soliman E, Go A, Shlipak M, Deo R, Ky B, DeBoer I, Anderson A, Christenson R, Seliger SL, deFilippi C, Feldman HI, Wolf M, Kusek J, Shafi T, He J, Bansal N. Association of circulating cardiac biomarkers with electrocardiographic abnormalities in chronic kidney disease. Nephrol Dial Transplant. 2021 Dec 2;36(12):2282-2289. doi: 10.1093/ndt/gfaa296.

Bansal N, Zelnick LR, Soliman E, Anderson A, Christenson R, deFilippi C, Deo R, Feldman HI, He J, Ky B, Kusek J, Lash J, Seliger S, Shafi T, Wolf M, Go AS, Shlipak MG; CRIC Study Investigators. Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2021 Jun;77(6):907-919.

Nowak RM, Jacobsen G, Limkakeng A Jr, Peacock WF, Christenson RH, McCord J, Apple FS, Singer AJ, deFilippi CR. Outpatient versus observation/inpatient management of emergency department patients rapidly ruled-out for acute myocardial infarction: Findings from the HIGH-US study. Am Heart J. 2021;231:6-17.

Rogawski McQuade ET, Guertin KA, Becker L, Operario D, Gratz J, Guan D, Khan F, White J, McMurry TL, Shah B, Garofalo S, Southerland M, Bear K, Brush J, Allen C, Frayser A, Vokes R, Pershad R, Peake L, deFilippi C, Barackman K, Bearman G, Bidanset A, Farrell F, Trump D, Houpt ER. Assessment of Seroprevalence of SARS-CoV-2 and Risk Factors Associated With COVID-19 Infection Among Outpatients in Virginia. JAMA Netw Open. 2021;4:e2035234.

Cooper LB, Cotugno A, deFilippi C. Efficacy of Neprilysin in Women with HFpEF: Beyond Phenotypes and Natriuretic Peptides. Circulation. 2021;143:618-620.

Damluji AA, Christenson RH, deFilippi C. Clinical Application of Serologic Testing for Coronavirus Disease 2019 in Contemporary Cardiovascular Practice. J Am Heart Assoc. 2021;10:e019506. DOI: 10.1161/JAHA.120.019506.

deFilippi CR, Mills NL. Rapid Cardiac Troponin Release After Transient Ischemia. Circulation. 2021;143:1105-1108.

Pandey A, Vaduganathan M, Patel KV, Ayers C, Ballantyne CM, Kosiborod MN, Carnethon M, deFilippi C, McGuire DK, Khan SS, Caughey MC, de Lemos JA, Everett BM. Biomarker-Based Risk Prediction of Incident Heart Failure in Pre-Diabetes and Diabetes. JACC Heart Fail. 2021;9:215-223.

Januzzi JL Jr, Canty JM, Das S, deFilippi CR, Gintant GA, Gutstein DE, Jaffe A, Kaushik EP, Leptak C, Mehta C, Pina I, Povsic TJ, Rambaran C, Rhyne RF, Salas M, Shi VC, Udell JA, Unger EF, Zabka TS, Seltzer JH. Gaining Efficiency in Clinical Trials With Cardiac Biomarkers: JACC Review Topic of the Week. J Am Coll Cardiol. 2021;77:1922-1933.

Bansal N, Zelnick LR, Soliman EZ, Anderson A, Christenson R, deFilippi C, Deo R, Feldman HI, He J, Ky B, Kusek J, Lash J, Seliger S, Shafi T, Wolf M, Go AS, Shlipak MG; CRIC Study Investigators. Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2021;77:907-919.

Stevenson LG, deFilippi CR. Swab-Free Transport as an Optimized Preanalytical Workflow for SARS-CoV-2 Molecular Testing. J Appl Lab Med. 2021;6:580-583.

Damluji AA, Rajan D, Haymond A, deFilippi C. Serological Testing for COVID-19 Disease: Moving the Field of Serological Surveillance Forward. J Appl Lab Med. 2021;6:584-587.

Haymond A, Damluji AA, Narayanan A, Mueller C, Reeder A, Alem F, Maxwell GL, Petricoin EF, Liotta L, deFilippi CR. Durability of Viral Neutralization in Asymptomatic Coronavirus Disease 2019 for at Least 60 Days. J Infect Dis. 2021;223:1677-1680.

Rao A, Ranka S, Ayers C, Hendren N, Rosenblatt A, Alger HM, Rutan C, Omar W, Khera R, Gupta K, Mody P, deFilippi C, Das SR, Hedayati SS, de Lemos JA. Association of Kidney Disease With Outcomes in COVID-19: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry. Am Heart Assoc. 2021 Jun 15;10(12):e020910.

Damluji AA, Wei S, Bruce SA, Haymond A, Petricoin EF, Liotta L, Maxwell GL, Moore BC, Bell R, Garofalo S, Houpt ER, Trump D, deFilippi CR. Seropositivity of COVID-19 among asymptomatic healthcare workers: A multi-site prospective cohort study from Northern Virginia, United States. Lancet Reg Health Am. 2021 Oct;2:100030. doi: 10.1016/j.lana.2021.100030. Epub 2021 Jul 29.

Patel KV, Simek S, Ayers C, Neeland IJ, deFilippi C, Seliger SL, Lonergan K, Minniefield N, Mentz RJ, Correa A, Yimer WK, Hall ME, Rodriguez CJ, de Lemos JA, Berry JD, Pandey A. Physical Activity, Subclinical Myocardial Injury, and Risk of Heart Failure Subtypes in Black Adults. JACC Heart Fail. 2021;9:484-493.

Rosner CM, Genovese L, Tehrani BN, Atkins M, Bakhshi H, Chaudhri S, Damluji AA, de Lemos JA, Desai SS, Emaminia A, Flanagan MC, Khera A, Maghsoudi A, Mekonnen G, Muthukumar A, Saeed IM, Sherwood MW, Sinha SS, O'Connor CM, deFilippi CR. Myocarditis Temporally Associated With COVID-19 Vaccination. Circulation. 2021;144:502-505.

Aurora L, McCord J, Nowak R, Giannitsis E, Christenson R, deFilippi C, Lindahl B, Christ M, Body R, Jacobsen G, Mueller C; TRAPID-AMI Investigators. Prognostic Utility of a Modified HEART Score When Different Troponin Cut Points Are Used. Crit Pathw Cardiol. 2021;20:134-139.

Ezekowitz JA, Zheng Y, Cohen-Solal A, Melenovský V, Escobedo J, Butler J, Hernandez AF, Lam CSP, O'Connor CM, Pieske B, Ponikowski P, Voors AA, deFilippi C, Westerhout CM, McMullan C, Roessig L, Armstrong PW; VICTORIA Study Group. Hemoglobin and Clinical Outcomes in the VerICiguaT Global Study in Patients With Heart Failure and Reduced Ejection Fraction (VICTORIA). Circulation. 2021 Nov 2;144(18):1489-1499.

Garg PK, Lima J, deFilippi CR, Daniels LB, Seliger SL, de Lemos JA, Maisel AS, Criqui MH, Bahrami H. Associations of cardiac injury biomarkers with risk of peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis. Int J Cardiol. 2021:S0167-5273(21)01495-9.

Bansal N, Zelnick LR, Ballantyne CM, Chaves PHM, Christenson RH, Coresh J, deFilippi CR, de Lemos JA, Daniels LB, Go AS, He J, Hedayati SS, Matsushita K, Nambi V, Shlipak MG, Taliercio JJ, Seliger SL; CRIC Study Investigators. Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD. Am J Kidney Dis. 2022;79:383-392.

Srinivasa S, deFilippi C, Fitch KV, Iyengar S, Shen G, Burdo TH, Walpert AR, Thomas TS, Adler GK, Grinspoon SK. Evaluation of Mineralocorticoid Receptor Antagonism on Changes in NT-proBNP Among Persons With HIV. J Endocr Soc. 2021 Nov 19;6(1):bvab175. doi: 10.1210/jendso/bvab175.

Shavadia JS, Alemayehu W, deFilippi C, Westerhout CM, Tromp J, Granger CB, Armstrong PW, van Diepen S. Novel multi-marker proteomics in phenotypically matched patients with ST-segment myocardial infarction: association with clinical outcomes. J Thromb Thrombolysis. 2022 May;53(4):841-850. doi: 10.1007/s11239-021-02582-5. Online ahead of print.

Ezekowitz JA, Zheng Y, Cohen-Solal A, Melenovský V, Escobedo J, Butler J, Hernandez AF, Lam CSP, O'Connor CM, Pieske B, Ponikowski P, Voors AA, deFilippi C, Westerhout CM, McMullan C, Roessig L, Armstrong PW. Hemoglobin and Clinical Outcomes in the Vericiguat Global Study in Patients With Heart Failure and Reduced Ejection Fraction (VICTORIA). Circulation. 2021;144:1489-1499.

Yang Y, Bartz TM, Brown MR, Guo X, Zilhão NR, Trompet S, Weiss S, Yao J, Brody JA, defilippi CR, Hoogeveen RC, Lin HJ, Gudnason V, Ballantyne CM, Dörr M, Jukema JW, Petersmann A, Psaty BM, Rotter JI, Boerwinkle E, Fornage M, Jun G, Yu B. Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. Circ Genom Precis Med. 2021;14:e003460. 10.1161/CIRCGEN.121.003460. Epub 2021 Nov 4.

Bakhshi H, Bagchi P, Meyghani Z, Tehrani B, Qian X, Garg PK, Ambale-Venkatesh B, Bhatia HS, Ohyama Y, Wu CO, Budoff M, Allison M, Criqui MH, Bluemke DA, Lima JAC, deFilippi CR. Association of coronary artery calcification and thoracic aortic calcification with incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis (MESA). Eur Heart J Open. 2021 Dec 3;1(3):oeab042. doi: 10.1093/ehjopen/oeab042.