Update Your ProfileAcademic Title:
Professor
Primary Appointment:
Surgery
Administrative Title:
Chief, Division of Surgical Oncology
Additional Title:
Principal Investigator, The Precancer Genomics Lab
Education and Training
- University of South Florida Morsani College of Medicine, MD, 2005
- Indiana University School of Medicine, Residency, 2007
- Indiana University School of Medicine, Residency, 2013
- Memorial Sloan-Kettering Cancer Center, Complex General Surgical Oncology, Fellowship, 2015
- NIH/Nci - Surgical Oncology Research and Immunotherapy, Fellowship, 2010
Certifications:
- American Board of Surgery - Complex General Surgical Oncology, 2016
- American Board of Surgery - Surgery, 2013
Biosketch
A surgical oncologist, Dr. Davis specializes in the care of patients with complex and rare cancers of the digestive tract and other abdominal organs. He performs operations on the stomach, liver, pancreas and intestines using traditional and minimally invasive techniques.
Dr. Davis leads the Precancer Genomics Lab, which is dedicated to understanding cancer at its earliest stages, even before it fully develops. The lab's research explores the intricate genomic landscape of precancerous cells and their microenvironment, seeking to identify vulnerabilities and unlock strategies for cancer interception and, ultimately, a future with less cancer.
Dr. Davis is internationally recognized as a leader in the management of people with hereditary gastric and lobular breast cancers.
Research/Clinical Keywords
cancer research, stomach cancer, gastric cancer, lobular breast cancer, CDH1 gene mutations
Highlighted Publications
Gallanis AF, Gamble LA, Oguz C, Samaranayake SG, Kedei N, Hernandez MO, Wong M, Tillo D, Green BL, McClelland P, Bowden C, Gullo I, Raffeld M, Xi L, Kelly M, Miettinen M, Quezado M, Kim SA, Blakely AM, Lack J, Heller T, Hernandez JM, Davis JL. Spatial analysis of hereditary diffuse gastric cancer reveals indolent phenotype of signet ring cell precursors. Mol Cancer Res. 2025 Apr 7. doi: 10.1158/1541-7786.MCR-24-1039. Online ahead of print. PMID: 40192595
Gallanis AF, Bowden C, Sharma D, Rodriguez GV, Lopez R, Payne C, Joyce S, Broesamle R, Blakely AM, Hernandez JM, Korman L, Heller T, Davis JL. Roux limb revision for recalcitrant bile reflux after total gastrectomy. Surgery. 2025 May;181:109214. doi: 10.1016/j.surg.2025.109214. Epub 2025 Feb 16. PMID: 39956091
Gallanis AF, Bowden C, Lopez R, Fasaye GA, Lang D, Rothschild J, Camargo MC, Hernandez JM, Rai A, Heller T, Blakely AM, Davis JL. Adolescents and Young Adults with Germline CDH1 Variants and the Risk of Overtreatment. J Natl Cancer Inst. 2025 Jan 6:djaf002. doi: 10.1093/jnci/djaf002. Online ahead of print. PMID: 39760880
Brooks SD, Ruhl AP, Zeng X, Cruz P, Hassan SA, Kamenyeva O, Hakim MA, Ridley LA, Nagata BM, Kabat J, Ganesan S, Smith RL, Jackson M, Nino de Rivera J, McLure AJ, Jackson JM, Emeh RO, Tesfuzigta N, Laurence K, Joyce S, Yek C, Chea S, Alves DA, Isakson BE, Manning J, Davis JL, Ackerman HC. Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions. Circulation. 2025 Jan 7;151(1):8-30. doi: 10.1161/CIRCULATIONAHA.123.066003. Epub 2024 Dec 5. PMID: 39633569
Additional Publication Citations
A complete listing of Dr. Davis's publications is available on PubMed.
Research Interests
Dr. Davis' research on patients and families with CDH1 gene mutations has had a major impact on improving care for patients with this disease.
Lab Techniques and Equipment
Precancer Genomics Lab
Dr. Davis's Precancer Genomics Lab is dedicated to understanding cancer at its earliest stages, even before it fully develops. The lab's research delves into the intricate genomic landscape of precancerous cells and their microenvironment. It seeks to identify vulnerabilities and unlock strategies for early intervention and, ultimately, a future with less cancer.