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Gustavo Costa Medeiros, MD

Academic Title:

Assistant Professor

Primary Appointment:


Education and Training

Ribeirão Preto Medical School, University of São Paulo, Brazil, MD


Institute of Psychiatry, University of São Paulo, Brazil Medical Residency 


Univ. of Texas Southwestern (Dallas, TX) & Univ. of Maryland/Sheppard Pratt Medical Residency 


The Johns Hopkins University School of Medicine Postdoctoral Fellow 





I conduct clinical research with patients suffering from major depressive disorder (MDD), particularly those who are dealing with treatment-resistant depression (TRD), also known as difficult-to-treat depression. TRD is a heterogenous disorder with individual patients showing substantial variability in response to different therapeutic interventions. In this context, my research focuses on precision psychiatry for TRD involving the performance of studies to identify clinical and biological variables (e.g., brain-based measures, peripheral measures) that allow us to match an individual patient with the most effective and least harmful treatment. My research vision is to reduce the gap between research and clinical practice by developing practical and clinician-friendly predictive tools that can be easily applied in real clinical settings. 

Research/Clinical Keywords

Mood disorders, major depression, bipolar depression, treatment-resistant depression, precision medicine

Highlighted Publications

Medeiros GC, Matheson M, Demo I, Reid MJ, Matheson S, Twose C, Smith GS, Gould TD, Zarate CA, Barrett FS, Goes FS. Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies. The Lancet Psychiatry. 2023 Aug 22.


Medeiros GC, Gould TD, Prueitt WL, Nanavati J, Grunebaum MF, Farber NB, Singh B, Selvaraj S, Machado-Vieira R, Achtyes ED, Parikh SV, Frye MA, Zarate Jr CA, Goes, FS. Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis. Molecular Psychiatry 2022, Jun 27.


Medeiros GC, Rush AJ, Jha MK, Carmody T, Furman JL, Czysz AH, Trombello JM, Cooper CM Trivedi MH. Positive and negative valence systems in major depression have distinct clinical features, response to antidepressants and relationships with immunomarkers. Depression & Anxiety 2020, Mar 18.


Medeiros GC, Prueitt WL, Minhajuddin A, Patel S, Czysz AH, Furman JL, Mason BL, Rush AJ, Jha MK, Trivedi MH. Childhood maltreatment and impact on clinical features of major depression in adults. Psychiatry research. 2020 Nov 1;293:113412.d.


Medeiros GC, Prueitt WL, Rush AJ, Minhajuddin A, Czysz AH, Patel SS, Trombello J, Trivedi MH. Impact of childhood maltreatment on outcomes of antidepressant medication in chronic and/or recurrent depression. Journal of affective disorders. 2021 Aug 1;291:39-45.