Skip to main content

Joshua J. Chiappelli, MD

Academic Title:

Assistant Professor

Primary Appointment:


Phone (Primary):


Education and Training

  • St. Mary’s College of Maryland, B.A., Psychology, 2004
  • Drexel University College of Medicine, MD, 2008
  • University of Maryland / Sheppard Pratt, Psychiatry Residency, 2008-2012 


Dr. Chiappelli is a board-certified psychiatrist who specializes in treatment and research of severe mental illness, in particular schizophrenia. Since completing residency in psychiatry in 2012 he has been at the Maryland Psychiatric Research Center, first as a postdoctoral fellow then as assistant professor in the University of Maryland, School of Medicine, Department of Psychiatry. He also practices at the Fayette Adult Clinic of the Walter P. Carter Center and at the First Episode Clinic at MPRC. His research group has published extensively on the role of white matter structural abnormalities in schizophrenia, and the role of these white matter changes in cognitive deficits and treatment resistance.

Research/Clinical Keywords

White matter plasticity, Bioenergetics, Magnetic resonance spectroscopy, Diffusion tensor imaging, Phenomenology of psychotic symptoms

Highlighted Publications

Chiappelli J, Beason T. Ontological Adaptation in Transition to Adulthood: A Theoretical Framework for Integrating Phenomenology and Neuroscience in Psychosis Research. J Nerv Ment Dis. 2023 Feb 1;211(2):95-99. 

Chiappelli J, Kvarta M, Bruce H, Chen S, Kochunov P, Hong LE. Stressful life events and openness to experience: Relevance to depression. J Affect Disord. 2021; 295:711-716. 

Chiappelli J, Rowland LM, Wijtenburg SA, Chen H, Maudsley AA, Sheriff S, Chen S, Savransky A, Marshall W, Ryan MC, Bruce HA, Shuldiner AR, Mitchell BD, Kochunov P, Hong LE. Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns. Proc Natl Acad Sci U S A. 2019; 116(50):25243-25249.

Chiappelli J, Postolache TT, Kochunov P, Rowland LM, Wijtenburg SA, Shukla DK, Tagamets M, Du X, Savransky A, Lowry CA, Can A, Fuchs D, Hong LE. Tryptophan Metabolism and White Matter Integrity in Schizophrenia. Neuropsychopharmacology 2016 41(10):2587-95.

Chiappelli J, Pocivavsek A, Nugent KL, Notarangelo FM, Kochunov P, Rowland LM, Schwarcz R, Hong LE. Stress Induced Kynurenic Acid as a Potential Biomarker for Schizophrenia Patients with Distress Intolerance. JAMA Psychiatry. 2014 71(7):761-8.

Additional Publication Citations

Chiappelli J, Shi Q, Kodi P, Savransky A, Kochunov P, Rowland LM, Nugent KL, Hong LE. Disrupted glucocorticoid-Immune interactions during stress response in schizophrenia. Psychoneuroendocrinology. 2016 Jan;63:86-93.

Chiappelli J, Rowland LM, Wijtenburg SA, Muellerklein F, Tagamets M, McMahon RP, Gaston F, Kochunov P, Hong LE. Evaluation of myo-Inositol as a Potential Biomarker for Depression in Schizophrenia. Neuropsychopharmacology. 2015 Aug;40(9):2157-64.