Skip to main content

Konstantin G. Birukov, MD, PhD

Anesthesiology Endowed Professor of Entrepreneurial Research

Academic Title:


Primary Appointment:


Secondary Appointment(s):

Medicine, Physiology

Administrative Title:

Director, University of Maryland School of Medicine Lung Biology Research Program; Associate Chair, Basic Science Research, Dept Of Anesthesiology


HSF-II, S-143 & S-145

Phone (Primary):

(410) 706-2578



Education and Training

1981-1984: Biochemistry, Moscow State Medical School

1986: Medical Doctor, Moscow State Medical School

1989-1994: Research Investigator, Institute of Experimental Cardiology Research Center

1993: Ph.D. Biochemistry, National Cardiology Research Center


2003–2004: Instructor of Medicine, Pulmonary and Critical Care Division, Johns Hopkins University School of Medicine, Baltimore, MD

2004-2005: Assistant Professor, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

2005-2009: Assistant Professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, Chicago, IL

2009-present: Associate Professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, Chicago, IL

2014-present: Tenured Associate Professor, Section of Pulmonary and Critical Care Medicine, Division of Biomedical, University of Chicago, Chicago, IL

2016-present: Tenured Professor of Medicine, Section of Pulmonary and Critical Care, Department of Medicine, Division of Biomedical Sciences, University of Chicago, Chicago, IL

Research/Clinical Keywords

acute lung injury, sepsis, secondary lung injury, lung microbiome, lung aging, endothelial permeability, inflammation, innate immunity, cell junctions, cytoskeleton, cell motility and mechanotransduction, cell-cell interactions, signal transduction, biosensors, lipid mediators, oxidized phospholipids, DAMPs, prostaglandins

Highlighted Publications

Huang H, Zhu J, Gu L, Hu J, Feng X, Huang W, Wang S, Yang Y, Cui P, Lin SH, Suen A, Shimada BK, Williams B, Kane MA, Ke Y, Zhang CO, Birukova AA, Birukov KG, Chao W, Zou L. TLR7 Mediates Acute Respiratory Distress Syndrome in Sepsis by Sensing Extracellular miR-146a. Am J Respir Cell Mol Biol. 2022 Jun 9. doi: 10.1165/rcmb.2021-0551OC. PMID: 35679261. (Editorial Article).

Fang, Y., Wu, D., & Birukov, K. (2019). Mechanosensing and Mechanoregulation of Endothelial Cell Functions. Comprehensive Physiology, 873-904. doi: 10.1002/cphy.c180020

Ke, Y., Karki, P., Zhang, C., Li, Y., Nguyen, T., Birukov, K., & Birukova, A. (2019). Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch. Molecular Biology Of The Cell, 30(8), 959-974. doi: 10.1091/mbc.e18-07-0422

Ke, Y., Karki, P., Kim, J., Son, S., Berdyshev, E., Bochkov, V., Birukova, A., & Birukov, KG. (2019). Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs. The FASEB Journal, 33(3), 3887-3900. doi: 10.1096/fj.201800981r

Hardin CC, Chattoraj J, Manomohan G, Colombo J, Nguyen T, Tambe D, Fredberg JJ, Birukov K, Butler JP, Del Gado E, Krishnan R. Long-range stress transmission guides endothelial gap formation. Biochem Biophys Res Commun. 2018;495(1):749-754.

Additional Publication Citations

Oskolkova O, Sarich N, Tian Y, Gawlak G, Meng F, Bochkov VN, Berdyshev E, Birukova AA, Birukov KG. Incorporation of iloprost in phospholipase-resistant phospholipid scaffold enhances its barrier protective effects on pulmonary endothelium. Sci Rep. 2018;8(1):879.

Karki P, Birukov KG. Lipid mediators in the regulation of endothelial barriers. Tissue Barriers. 2018;6(1):e1385573.

Birukov KG, Karki P. Injured lung endothelium: mechanisms of self-repair and agonist-assisted recovery (2017 Grover Conference Series). Pulm Circ. 2018;8(1):2045893217752660.

Karki, P., Meliton, A., Shah, A., Tian, Y., Ohmura, T., & Sarich, N. Birukova, A., & Birukov, KG. (2018). Role of truncated oxidized phospholipids in acute endothelial barrier dysfunction caused by particulate matter. PLOS ONE, 13(11), e0206251. doi: 10.1371/journal .pone.0206251

Good RJ, Hernandez-Lagunas L, Allawzi A, Maltzahn JK, Vohwinkel CU, Upadhyay AK, Kompella UB, Birukov KG, Carpenter TC, Sucharov CC, Nozik-Grayck E.. (2018). MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability. American Journal Of Physiology-Lung Cellular And Molecular Physiology, 315(4), L584-L594. doi: 10.1152/ajplung.00073.2017

Ke Y, Oskolkova OV, Sarich N, Tian Y, Sitikov A, Tulapurkar ME, Son S, Birukova AA, Birukov KG. Effects of prostaglandin lipid mediators on agonist-induced lung endothelial permeability and inflammation. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2017;313(4):L710-L721.

Oskolkova O, Gawlak G, Tian Y, Ke Y, Sarich N, Son S, Andreasson K, Bochkov VN, Birukova AA, Birukov KG. Prostaglandin E receptor-4 receptor mediates endothelial barrier-enhancing and anti-inflammatory effects of oxidized phospholipids. FASEB J. 2017;31(9):4187-4202.

Tian Y, Gawlak G, O’Donnell JJ 3rd, Birukova AA, Birukov KG. Activation of Vascular Endothelial Growth Factor (VEGF) Receptor 2 Mediates Endothelial Permeability Caused by Cyclic Stretch. J Biol Chem. 2016;291(19):10032-10045.

Birukova AA, Shah AS, Tian Y, Gawlak G, Sarich N, Birukov KG. Selective Role of Vinculin in Contractile Mechanisms of Endothelial Permeability. Am J Respir Cell Mol Biol. 2016;55(4):476-486.

Meliton A, Meng F, Tian Y, Shah AA, Birukova AA, Birukov KG. Role of Krev Interaction Trapped-1 in Prostacyclin-Induced Protection against Lung Vascular Permeability Induced by Excessive Mechanical Forces and Thrombin Receptor Activating Peptide 6. Am J Respir Cell Mol Biol. 2015;53(6):834-843.

Heisler DB, Kudryashova E, Grinevich DO, Suarez C, Winkelman JD, Birukov KG, Kotha SR, Parinandi NL, Vavylonis D, Kovar DR, Kudryashov DS. ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization. Science (New York, N.Y.). 2015;349(6247):535-9. PMID: 26228148.