Tarique Anwar, PhD

2008- B.Sc., Biology/Zoology (Hons), Magadh University, Bodh Gaya, India.

2010- M.Sc., Biotechnology, University of Pune, Pune, India.

2017- Ph.D., Biotechnology, Manipal University, Manipal, India. Thesis Title- “Evaluation of molecular signatures unique to growth arrest
conditions of quiescence and senescence”.

2017-2018 Postdoctoral Scientist, Sutterwala and Cassel Laboratory, Cedars-Sinai Medical Center, Los Angeles, USA.

2019-2022 Postdoctoral Scholar, Dr. Elaine Reed and Dr. Enrique Rozengurt Laboratory, University of California, Los Angeles, USA. 

I am working as a postdoctoral fellow in the Department of Obstetrics, Gynecology and Reproductive Sciences at University of Maryland, Baltimore. My current research potentially aimed on hyperglycemia-induced embryopathy in diabetic pregnancy. Previously, I worked as a postdoctoral scholar in Dr. Elaine Reed Laboratory and Dr. Enrique Rozengurt, University of California, Los Angeles, USA. As a postdoctoral fellow, I was exploring the role of YAP/TEAD signaling in promoting proliferation and migration of endothelial cells challenged with antibodies directed against HLA-I and HLA-II (Anwar T et al., 2020; Anwar T et al., 2023). In addition, I also contributed to another project where our results provide rationale for considering a combination(s) of FDA-approved SFK inhibitors (e.g., dasatinib) and MEK inhibitors (e.g., trametinib) in prospective trials for the treatment of Pancreatic ductal adenocarcinoma (PDAC) (Sinnett-Smith J* and Anwar T* et al., 2022).

Embryopathy, Congenital Birth Defects, Antibody-mediated rejection (AMR), Transplant vasculopathy, Pancreatic ductal adenocarcinoma (PDAC)

1. Anwar T, Sinnett-Smith J, Jin YP, Reed EF, Rozengurt E. Lipophilic Statins Inhibit YAP Nuclear Localization, Coactivator Activity, and Migration in Response to Ligation of HLA class I Molecules in endothelial cells: Role of YAP Multisite Phosphorylation. J Immunol.
(2023); 210(8), 1134-1145.

2. Anwar T, Sinnett-Smith J, Jin YP, Reed EF, Rozengurt E. Ligation of HLA class I Molecules Induces Yes-Associated Protein (YAP) Activation through Src in Human Endothelial Cells. J Immunol. (2020); 205(7), 1953-1961.

3. Sinnett-Smith J*, Anwar T*, Reed EF, Teper Y, Eibl G, Rozengurt E. (2022). Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy. Mol Cancer Ther. (2022); 21(11), 1652-1662. (*Equal Contribution).

4. Anwar T, Khosla S and Ramakrishna G. Increased Expression of SIRT2 is a Novel Marker of Cellular Senescence and is Dependent on Wild Type p53 Status. Cell Cycle. (2016); 15, 1883-1897.

5. Anwar T, Sen B, Aggarwal S, Nath R, Pathak N, Katoch A, Aiyaz M, Trehanpati N, Khosla S, Ramakrishna G. Differentially Regulated Gene Expression in Quiescence versus Senescence and Identification of ARID5A as a Quiescence Associated Marker. J Cell Physiol. (2018); 233(5), 3695-3712.