Biochemistry and Molecular Biology
BIOPARK 1 - 218
Education and Training
M.S., Biophysics, T. Shevchenko National University of Kyiv, Ukraine (1977)
Ph.D., Biochemistry, Institute of Biochemistry, Natl. Acad. Sci. Ukraine, Kyiv, Ukraine (1980)
D.Sc., Biochemistry, Institute of Biochemistry, Natl. Acad. Sci. Ukraine, Kyiv, Ukraine (1991)
Dr. Medved graduated from T. Shevchenko National University of Kyiv, Ukraine, and received his Ph.D. and then D.Sc. degrees in Biochemistry from the Institute of Biochemistry, Kyiv, Ukraine. From 1980, he was working at the same Institute as a Junior Scientist, Senior Scientist, and then as a Head of the Department of Protein Structure and Function. In 1997, Dr. Medved joined the Department of Biochemistry of the American Red Cross J. Holland Laboratory, Rockville, MD, as a Scientist II and then became Senior Scientist in the same Department. In 2000, while conducting research at the J. Holland Laboratory, he became involved in teaching at the George Washington University, Washington, DC, as an Associate Professor and then as a Professor. Dr. Medved joined the University of Maryland Baltimore, School of Medicine (UMB SOM) as a Professor in the Department of Biochemistry and Molecular Biology in 2004 and since then he is working at the UMB SOM Center for Vascular and Inflammatory Diseases.
Dr. Medved’s major research interests are in the field of blood coagulation and fibrinolysis, particularly, in the structure and interactions of blood coagulation and fibrinolytic proteins with the emphasis on fibrinogen and fibrin and their role in various (patho)physiological processes. His major contributions to this field include establishing multidomain structure of the fibrinogen molecule, elucidation of the molecular mechanism of fibrinogen to fibrin conversion, establishing the molecular mechanism initiating fibrinolysis, and discovering a novel fibrin-VLDL receptor-dependent pathway of transendothelial migration of leukocytes that promotes inflammation. His current research focuses on establishing the molecular mechanisms underlying this and other fibrin-dependent inflammatory pathway(s) of leukocyte transmigration, and identification of specific antagonists of such pathways that may be developed as potent therapeutics for treatment of inflammation-related cardiovascular disorders.
Dr. Medved has been continuously funded by the National Institutes of Health as a principal investigator since 1998; he also received several grants from other funding agencies. His current research is funded by R01 grant from NIH/NHLBI. During his scientific career, Dr. Medved has published more than 100 scientific articles in peer-reviewed journals, received four US patents, and presented his research at numerous national and international scientific meetings. He also received several awards for his scientific achievements including Outstanding Investigator award from the International Fibrinogen Research Society (IFRS). Dr. Medved is a member of several scientific societies and served as a Vice Chairman and then as a President of IFRS. He also served as grant reviewer for various national and international funding agencies, and as an editorial board member and a reviewer for a number of international scientific journals.
Blood Coagulation, Fibrinolysis, Plasma Proteins Structure and Interaction, Fibrinogen, Fibrin, Fibrin(ogen) Receptors, Fibrin-Dependent Inflammation.
Medved, L., and Nieuwenhuizen, W. (2003) Molecular mechanisms of initiation of fibrinolysis by fibrin. Thromb. Haemost. 89: 409-419.
Pechik, I., Madrazo, J., Mosesson, M.W., Hernandez, I., Gilliland, G.L., and Medved, L. (2004) Crystal structure of the complex between thrombin and the central ‘E’ region of fibrin. Proc. Natl. Acad. Sci. U.S.A. 101: 2718-2723.
Yakovlev, S., Gao, Y., Cao, C., Chen, L., Strickland, D., Zhang, L., and Medved, L. (2011) Interaction of fibrin with VE-cadherin and anti-inflammatory effect of fibrin-derived fragments. J. Thromb. Haemost. 9: 1847-1855.
Tsurupa, G., Pechik, I., Litvinov, R., Hantgan, R.R., Tjandra, N., Weisel, J., and Medved, L. (2012) On the mechanism of alphaC polymer formation in fibrin. Biochemistry 51: 2526-2538.
Yakovlev, S., Mikhailenko, I., Cao, C., Zhang, L., Strickland, D., and Medved, L. (2012) Identification of VLDLR as a novel endothelial cell receptor for fibrin that modulates fibrin-dependent transendothelial migration of leukocytes. Blood 119: 637-644.
Complete List of my Publication in MyBibliography: